Provigil

This page contains recent news articles, when available, and an overview of Provigil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Provigil
(when available)

Pharmacology and use:
Modafinil is a stimulant drug marketed as a 'wakefulness promoting agent' and is one of the stimulants used in the treatment of narcolepsy. Narcolepsy is caused by dysfunction of a family of wakefulness-promoting and sleep-suppressing peptides, the orexins, whose neurons are activated by modafinil. The prexin neuron activation is associated with psychoactivation and euphoria. Modafinil is not indicated for complaints of lack of energy or fatigue; but it appears to be very helpful for some patients. Also, it has been used in the treatment of hypersomnia, a disorder in which patients lack the capacity for meaningful sleep and may require ten or more hours per day. Recent studies have have found that modafinil may help recovering cocaine addicts fight their addiction. To improve wakefulness in patients with excessive daytime sleepiness (EDS) associated with narcolepsy

Mechanism Of Action:
The exact mechanism of action is unclear, although in vitro studies have shown it to inhibit the reuptake of dopamine by binding to the dopamine reuptake pump, and lead to an increase in extracellular dopamine. Modafinil activates glutamatergic circuits while inhibiting GABA. Modafinil is thought to have less potential for abuse than other stimulants due to the absence of any significant euphoric or pleasurable effects. It is possible that modafinil acts by a synergistic combination of mechanisms including direct inhibition of dopamine reuptake, indirect inhibition of noradrenalin reuptake in the VLPO and orexin activation. Modafinil has partial alpha 1B-adrenergic agonist effects by directly stimulating the receptors.

News Articles on Modafinil

Cephalon Boosts Price Of Top Drug 29% Amid Switch Effort  -  ‎Dec 22, 2009‎
In late November, Cephalon raised the wholesale price of Provigil by 29% to $13.62 per pill. The price hike follows the Frazer, Penn. ... Wall Street Journal

Why Cephalon's Provigil Price Hike May Prove FTC's Antitrust Case  -  ‎Dec 23, 2009‎
The company is hoping that when its patent on Provigil expires — and the drug faces competition from cheap generics — that ... BNET

Report: More teens smoking marijuana  -  ‎Dec 14, 2009‎
The survey also added salvia and Provigil to its survey this year. Salvia — not currently illegal — is an herb in the mint family that gives chewers a brief ... Philadelphia Metro

Real-Life Sleeping Beauty Struggles With Rare Condition  -  ‎Dec 16, 2009‎
The teen keeps her KLS under control with a prescription of Provigil. After four years of approval, the family's prescription medical plan denied the drug, ... ThePittsburghChannel.com

FDA Approval For Jetlag Drug Delayed  -  ‎Jan 1, 2010‎
Nuvigil (armodafinil) is a follow-on version of Provigil (modafinil) which contributed about 50% to revenues in 2008. Cephalon received FDA approval for ... MedIndia

Soleil Securities Reiterates a 'Buy' on Cephalon (CEPH); Raises Estimates on ...  -  ‎Dec 28, 2009‎
...for 2010 (consensus of $6.24) based primarily on higher Treanda sales and strong sleep franchise pricing (recent 30% price hike on Provigil). ... StreetInsider.com (subscription)

Piper Jaffray Maintains an 'Overweight' on Cephalon (CEPH), Names as Top Mid ...  -  ‎Dec 22, 2009‎
...flow (FCF) in excess of $600M in 2010 (and we believe likely to grow beyond 2010, even if CEPH loses both Provigil and Nuvigil to generics in 2012). ... StreetInsider.com (subscription)

Top 7 Disruptions of the Year  -  ‎Dec 27, 2009‎
The upshot of it all: Add “get a prescription to Provigil� to your list of New Year's resolutions if you hope to keep up. This year the world got its first ... Wired News

Anti-smoking drugs in health basket  -  ‎Dec 23, 2009‎
Avonex, Aricept, Exelon, Provigil and Targin for neurology; Byetta and Victoza for diabetes; Humira, Enbrel, Remicade and Amevive for dermatology; ... Jerusalem Post

More meds in the state-subsidized basket  -  ‎Dec 23, 2009‎
Azilect for the treatment of 3000 people with Parkinson's disease is to be added to the basket, as is Provigil for the treatment of daytime sleepiness among ... Ha'aretz

By: Zacks Equity Research  -  ‎Dec 11, 2009‎
With Provigil slated to face generics from 2012, Cephalon is looking to protect its sleep franchise sales by switching patients to Nuvigil. ... Zacks.com

Biotech stocks buck market's rally, slide in 2009  -  ‎Dec 31, 2009‎
Cephalon, based in Frazer, Pa., saw its shares fall 19 percent over concerns that sales of its blockbuster sleep disorder drug Provigil are lagging. ... BusinessWeek

Tired of Being Tired?Cancer-related fatigue doesn't have to slow you down.  -  ‎Dec 23, 2009‎
Stimulants such as Ritalin (methylphenidate), a treatment for attention deficit disorder, and Provigil (modafinil), which is approved for narcolepsy, ... Curetoday.com (press release)

A Look at 2010 and Beyond  -  ‎Jan 2, 2010‎
Indeed, that's already happening across the drug business: Shire's Adderall (for ADHD) and Cephalon's Provigil (for sleep disorders) lost exclusivity in ... Brandweek Magazine

ING投信全ç?ƒæŠ•資週報  -  ‎Jan 4, 2010‎
...因生產é?Žç¨‹ä¸?順利而影響銷售;美國生技公å?¸Cephalon生產的治療失眠藥物Provigil銷售ä¸?如é ?期等原因,使生技類股表ç?¾ä¸?如大型製藥公å?¸å?Šé†«ç™‚ä¿?險類股。 ... 聯合新聞網

美 ë°”ì?´ì˜¤í…? 제약산업, 새해 활기 ë?˜ì°¾ì?„까?  -  ‎Jan 4, 2010‎
...펜실바니아 후레저 소재 세팔론(Cephalon)사는 ì?¸ê¸° 제품 Provigilì?˜ 매출ì?´ ê°?소ë?˜ì–´ 주가가 19% 하ë?½í–ˆë‹¤. 그러나 S&P ë¶„ì„?ê°€ 실버 씨는 ë°”ì?´ì˜¤í…? 주가는 제약회사 ... 메디포뉴스

Baja consumo de cigarro pero crece el de marihuana en EUA  -  ‎Dec 15, 2009‎
El seis por ciento de los alumnos del doceavo grado dijo que había usado Salvia y sólo 1.8 por ciento el Provigil. En lo que respecta al consumo de alcohol, ... El Diario de Yucatán

세팔론 '누비길' 시차 치료제로 승ì?¸ 연기ë?¼  -  ‎Dec 21, 2009‎
...누비길ì?€ 세팔론ì?˜ 수면장애 치료제 '프로비길(Provigil)'ì?˜ 후ì†?품으로 지난 6월부터 미국ì—?서 시íŒ?ë??었다. ë?°ì?¼ë¦¬íŒœ ì?´ì˜?ì•„ 기ìž?. 데일리팜

Boost je blok: studiebevorderende middelen  -  ‎Dec 13, 2009‎
Minder bekende namen zijn Provigil (op basis van modafinil) en Strattera (op basis van atomoxetine). Het eigenlijke gebruik van deze middelen dient onder ... Veto

Ungesunde Nächte in Kopenhagen  -  ‎Dec 18, 2009‎
Eine gewisse Wirkung hat auch das Medikament Provigil, das Patienten mit Narkolepsie verabreicht wird. Diese Menschen schlafen alle drei bis vier Stunden ... Tages-Anzeiger Online

Biotech firm Cephalon 3Q profit falls 2.7 percent  -  ‎Oct 27, 2009‎
In the quarter, Cephalon's blockbuster sleep disorder drug Provigil, saw sales slip slightly to $258 million. The drug alone accounts for half of total ... The Associated Press

Security system is scaring criminals off, except for the 'knuckleheads'  -  ‎Nov 11, 2009‎
The company is called ProVigil and it produces camera security systems, which have proven to be especially useful around construction sites. ... KENS 5 TV

Stock Review: Cephalon  -  ‎Nov 6, 2009‎
The star product over the past few years has been Provigil, a treatment for sleep disorders, that has accounted for about half of sales. ... Motley Fool

Adderall and the need for speed  -  ‎Nov 4, 2009‎
It is just one in a family of neuroenhancing drugs, including Ritalin and Provigil. For a person with ADHD, stimulants have a calming effect, ... Minnesota Daily

Teva seeks to market generic version of Nuvigil  -  ‎Oct 23, 2009‎
It is actually an improved version of Cephalon's Provigil, another sleep disorder drug. In its application, Teva Pharmaceuticals says that Cephalon patents ... Shift Work Disorder News

Smart Pills: More Focus or Hocus Pocus?  -  ‎Oct 29, 2009‎
They also include Provigil (modafinil), the drug used off-label to keep pilots alert and approved to treat narcolepsy and sleep apnea. ... HealthNewsDigest.com

Pill-powered brains?  -  ‎Oct 21, 2009‎
McGehee, who was prescribed Adderall and Provigil after experiencing chronic fatigue, argued that illegal users often ignore safety risks, and also pointed ... Diamondback Online

Cephalon Q3 2009 Earnings Call Transcript  -  ‎Oct 27, 2009‎
The daily consumption for NUVIGIL is currently 1.04 pills per day compared to 1.4 for PROVIGIL demonstrating its extended effectiveness. ... Seeking Alpha (blog)

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 27, 2009‎
TREANDA® for Injection, FENTORA® (fentanyl buccal tablet) [C-II], PROVIGIL® (modafinil) Tablets [C-IV], TRISENOX® (arsenic trioxide) injection, ... Reuters

Can drugs help you get A's?  -  ‎Nov 11, 2009‎
...such as the narcolepsy drug Provigil, which is shown in studies to provide the greatest improvements in cognitive performance in those with lower IQs. ... Medill Reports: Chicago

Pivotal Data Published in the Journal Cancer Demonstrate that TREANDA Induced ...  -  ‎Nov 5, 2009‎
PROVIGIL® (modafinil) Tablets [C-IV] and ACTIQ® (oral transmucosal fentanyl citrate) [C-II]. The company also markets numerous products internationally. ... Reuters

Cephalon, Inc. to Webcast R&D Day  -  ‎Nov 4, 2009‎
TREANDA® (bendamustine hydrochloride) for Injection, FENTORA® (fentanyl buccal tablet) [C-II], PROVIGIL® (modafinil) Tablets [C-IV], TRISENOX® (arsenic ... Reuters

Mayo Clinic Proceedings Publishes Study of NUVIGIL in Patients with Shift Work ...  -  ‎Nov 2, 2009‎
GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Reuters

Police report  -  ‎Nov 10, 2009‎
A 19-year-old Keller woman was arrested on suspicion of possession of the analeptic medication provigil. She was stopped at 1:12 am Nov. ... Keller Citizen

Nurse arrested in theft of medicine  -  ‎Oct 31, 2009‎
She surrendered her state nursing license Oct. 15, according to the state's Board of Nursing The charges allege that Wilson took Adderall and Provigil, ... Concord Monitor

Cephalon Appoints Bob Repella as Senior Vice President of U.S. Pharmaceutical ...  -  ‎Oct 27, 2009‎
...trioxide) injection, GABITRIL® (tiagabine hydrochloride), PROVIGIL® (modafinil) Tablets [C-IV], and ACTIQ® (oral transmucosal fentanyl citrate) (C-II). ... Reuters

Going to Extremes  -  ‎Oct 31, 2009‎
Nuvigil, an upgraded version of one of its premier offerings, Provigil, is being tested as treatment for, among other things, bipolar depression and cancer ... Barron's

Teva seeking to sell generic version of Cephalon's Nuvigil sleep  -  ‎Oct 21, 2009‎
Cephalon (NASDAQ: CEPH) of Frazer, Pa., launched Nuvigil — an improved version of its older sleep disorder drug Provigil — in June. ... MSN Money

Cephalon Net Sales Increase 9% and Net Cash from Operations Surpasses $200 ...  -  ‎Oct 28, 2009‎
TREANDA® for Injection, FENTORA® (fentanyl buccal tablet) [C-II], PROVIGIL® (modafinil) Tablets [C-IV], TRISENOX® (arsenic trioxide) injection, ... PharmaLive.com (press release)

Cephalon Appoints Bob Repella as Senior Vice President of US Pharmaceutical ...  -  ‎Oct 27, 2009‎
GABITRIL(R) (tiagabine hydrochloride), PROVIGIL(R) (modafinil) Tablets [C-IV], and ACTIQ(R) (oral transmucosal fentanyl citrate) (C-II). ... Trading Markets (press release)

Au travail, à l'école, au lit… bientôt, tous dopés !  -  ‎Nov 2, 2009‎
Commercialisée en France sous le nom de Modiodal et aux Etats-Unis sous celui de Provigil, la molécule anti-sommeil modafinil est un succès : ses ventes ont ... Viva Presse

è?ªæ˜Žè?¯è®©å¤§è„‘快速充电?  -  ‎Nov 4, 2009‎
...需è¦?处方的兴奋剂,属于这个类别的å?ˆæ³•è?¯ç‰©åŒ…括派醋甲酯(methylphenidate,商å“?å??为利他ç?µ)ã€?安é?žä»–命缓释制剂(Adderall)和莫待芬å®?(商å“?å??为ä¿?你醒,Provigil)。 ... 中新网

è?°æ˜Žè—¥å¹«å¤§è…¦å¿«é€Ÿå……電?  -  ‎Oct 28, 2009‎
...的興奮劑,屬於這個類別的å?ˆæ³•藥物包括派醋甲酯(methylphenidate,商å“?å??為利他é?ˆï¼‰ã€?安é?žä»–命緩釋製劑(Adderall)和莫待芬寧(商å“?å??為ä¿?你醒,Provigil)。 ... 科學人雜誌 (需訂閲)

FDA adds warning to Cephalon's Provigil sleep drug  -  Oct 24, 2007
WASHINGTON, Oct 24 (Reuters) - A warning is being added to Cephalon Inc's (CEPH.O) drug Provigil for excessive sleepiness because of the risk of serious ... Reuters

Cephalon's Provigil Settlements Will Insulate Earnings  -  Jan 10, 2006
Credit Suisse First Boston analyst Ken Kulju raised the price target on Cephalon (nasdaq: CEPH - news - people ) to $75 from $66 following Tuesday's ... Forbes

Cephalon gets subpoena on Provigil settlement  -  Mar 23, 2007
NEW YORK, March 23 (Reuters) - Cephalon Inc. (CEPH.O) said on Friday it received a subpoena this week to provide US antitrust regulators information ... Reuters

Provigil Drives Cephalon's Results  -  May 2, 2006
By Robert Steyer. Cephalon (CEPH - commentary - Cramer's Take) turned in first-quarter results Tuesday in which earnings beat Wall Street's predictions, ... TheStreet.com - TheStreet.com (subscription)

Study: Provigil aids night-shift workers - Provigil helps ease night...  -  Aug 4, 2005
Workers in night-shift jobs who took Cephalon Inc.'s stimulant drug Provigil had significant improvements in alertness and attention lapses, but continued ... $2.95 - Philadelphia Inquirer - NewsBank

How Many Silicon Valley Startup Executives Are Hopped Up On Provigil?  -  Jul 14, 2008
Is someone you work with taking Provigil to give them an extra competitive edge? I've spoken with one executive who says he uses it regularly to work twenty ... Washington Post

Provigil Drives Cephalon's Results  -  May 1, 2006
Cephalon's dance card for the year could become quite crowded. By the end of the quarter, the company will begin marketing Vivitrol, an alcoholism treatment ... TheStreet.com - TheStreet.com (subscription)

Cephalon reaches another settlement over Provigil license  -  Dec 22, 2005
Cephalon Inc. said Thursday it has settled its patent-infringement dispute in the United States with Ranbaxy Laboratories Ltd. over Cephalon's ... Bizjournals.com

Cephalon Ends Sales Agreement With Takeda on Provigil  -  Sep 3, 2008
By Robert Greene. Sept. 3 (Bloomberg) -- Cephalon Inc. will end its co- promotion agreement with Takeda Pharmaceutical Co. in North America for the ... Bloomberg

Eyes Wide Open  -  Apr 18, 2006
With the resulting drug, called Provigil, Cephalon has done more than create a ... Provigil, approved to treat narcolepsy and other causes of drowsiness, ... BusinessWeek

Investors bet on Cephalon drug, but risks abound  -  Mar 29, 2007
Provigil has been on the market for nearly a decade and has a relatively clean safety ... Sparlon was little more than a higher-dose version of Provigil, ... Reuters

Cephalon's annual revenue reaches $1 billion.  -  Feb 16, 2005
Baldino acknowledged investors are worried about patent challenges to Provigil, which is promoted as a treatment for sleepiness. ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

FDA recommends against treating ADHD with modafinil  -  Mar 24, 2006
Modafinil is being marketed as Provigil for treating sleep disorders. Cephalon is seeking to sell the drug under the name Sparlon for children with ADHD. ... 新�网

Cephalon accused of blocking generics  -  Feb 13, 2008
Regulators said the company paid four pharmaceutical firms more than $200 million to halt sales of generic versions of Provigil until 2012. ... Forbes

Provigil drug gets new warning on label  -  Oct 25, 2007
Cephalon Inc. has added a new warning to the label of its sleep disorder drug Provigil to inform patients about the potential risk for a serious skin rash ... Bizjournals.com

Scientists: Drugs to boost brain power should be legal for wider use  -  Dec 8, 2008
Another drug called Provigil is approved for sleep disorders but is also prescribed for healthy people ... Provigil is made by Cephalon Inc. of Frazer, Pa. ... USA Today

Cephalon Nears Crucial Stage  -  Oct 18, 2005
Attenace is a version of Provigil, Cephalon's best-selling drug prescribed ... For the six months ended June 30, Provigil produced sales of $230 million, ... TheStreet.com - TheStreet.com (subscription)

Report: Stronger warning urged for off-label Provigil use  -  Nov 29, 2007
A Food and Drug Administration panel is recommending that doctors receive more forceful warnings about prescribing Provigil to children, the Wall Street ... Bizjournals.com

Cephalon Granted Six Months of Pediatric Exclusivity for PROVIGIL(R)  -  Mar 28, 2006
FRAZER, Pa., March 28 /PRNewswire-FirstCall/ -- Cephalon, Inc. today announced that the US Food and Drug Administration (FDA) will apply an additional six ... RedOrbit

Caraco close to OK on generic Provigil  -  Jul 20, 2007
DETROIT, July 20 (UPI) -- Caraco Pharmaceutical Laboratories said Friday it has been granted tentative US approval to market a generic version of Cephalon's ... United Press International

Cephalon and Teva settle patent suits over Provigil  -  Dec 9, 2005
Cephalon Inc., which has a manufacturing plant in Salt Lake City, will end two lawsuits against Teva Pharmaceutical Industries Ltd. under an agreement ... deseretnews.com

Pay Attention  -  Feb 14, 2006
Under the brand name Provigil, modafinal is already Cephalon's ... Provigil was approved in 1998 to treat narcolepsy, a condition in which patients suffer ... Forbes

Professionals Use Drugs to Sharpen Their Minds, Survey Finds  -  Apr 9, 2008
Coming in second was the stimulant Provigil (modafinil), followed by blood-pressure drugs called beta blockers, which can also help to reduce anxiety. ... Washington Post

Cephalon: Wide Awake on Wall Street  -  Apr 2, 2007
Cephalon developed Nuvigil as a modified version of Provigil with the intention of ... Provigil tricks the body into believing it has slept when it has not. ... BusinessWeek

Role of pilot's sleep medication probed  -  Jan 19, 2008
Cephalon Inc., which manufactures Provigil, cautions users: "Do not drive a ... One of the conditions Provigil is prescribed to treat is called "shift work ... San Francisco Chronicle

Cephalon and Teva settle patent suits over Provigil | Article from...  -  Dec 10, 2005
Cephalon and Teva settle patent suits over Provigil ... find Deseret News (Salt Lake City) articles. Cephalon Inc., which has a manufacturing plant in Salt ... Pay-Per-View - Deseret News - HighBeam Research

… Barr Laboratories, Inc. Regarding Settlement of PROVIGIL(R) and...  -  Feb 1, 2006
..."Continued PROVIGIL sales provide a new foundation for further accelerating ... "While we remain confident in the strength of the PROVIGIL patent, ... Free with registration - PR Newswire - AccessMyLibrary.com

… FOR BLOCKING SALE OF GENERIC VERSIONS OF PROVIGIL UNTIL …  -  Feb 13, 2008
The copying, republication or redistribution of Thomson Financial News Content, including by framing or similar means, is expressly prohibited without the ... Forbes

Cephalon's Nuvigil Cleared  -  Jun 18, 2007
Cephalon(CEPH Quote) said Monday that it received Food and Drug Administration approval for Nuvigil, an updated version of its Provigil drug for several ... TheStreet.com - TheStreet.com (subscription)

Cephalon expected to buy British drugmaker.  -  Dec 6, 2005
1 that "2006 will be a transitional year" as the firm's two biggest products, Provigil for sleep disorders and Actiq for severe cancer pain, face generic ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

Cephalon settles charges for $425 million  -  Sep 30, 2008
Cephalon's best-selling drug, Provigil, is approved to treat excessive ... Analysts have estimated that 80 percent of Provigil prescriptions are for ... Philadelphia Inquirer - Philadelphia Inquirer

Cephalon Drug May Be Delayed  -  Dec 7, 2006
In about three years, Cephalon will begin encouraging patients to switch to Nuvigil from its cousin Provigil, the company's best-seller. ... TheStreet.com - TheStreet.com (subscription)

Event Brief of Cephalon and Alkermes Announce Agreement for the …  -  Jun 24, 2005
As Provigil provided a medical solution for patients suffering from excessive ... Just as CEPH has done with Provigil, it will ensure that physicians ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Drug company payoffs to stall generics under US government scrutiny  -  May 7, 2008
The Defense Department buys Provigil to help soldiers in Iraq stay alert. "This is a major priority for the commission because we strongly believe these ... New York Times

Cephalon Overcomes Sparlon Scare  -  Mar 22, 2006
Provigil and Sparlon both contain modafinil, although Sparlon would be given in doses of 345 milligrams to 420 milligrams vs. the recommended 200-milligram ... TheStreet.com - TheStreet.com (subscription)

Local earnings  -  Feb 13, 2007
Provigil sales rose 38 percent to $204.7 million. Sales of the pain pill Fentora were $29.3 million. The company began marketing the drug in the third ... $2.95 - Deseret News - NewsBank

Conditional OK for Cephalon Drug  -  Oct 21, 2005
Provigil is approved for adults with excessive sleepiness associated with narcolepsy, sleep apnea and a sleep disorder related to shift work. TheStreet.com - TheStreet.com (subscription)

US judge moves FTC's Cephalon suit to Pennsylvania  -  Apr 28, 2008
O) of trying to keep generic versions of its Provigil sleep disorder drug ... Provigil, used to treat excessive sleepiness, is Cephalon's biggest product ... Reuters

Cephalon Has Loss on Settlement Reserve, Slower Sales  -  Jul 31, 2007
Sales of Provigil, a treatment for excessive sleepiness from narcolepsy or sleep apnea, ... ``I wouldn't call it a particularly good Provigil quarter.'' ... Bloomberg

Green Light For Growth  -  Feb 3, 2006
..."We underestimated the ability of Cephalon to effectively defend the Provigil franchise via strategic patent settlement," wrote Credit Suisse analyst Ken ... Forbes

The Difference Between Steroids and Ritalin Is . . .  -  Mar 20, 2005
Lawyers take the anti-sleep drug Provigil to finish that all-night brief, in hopes of concentrating better. Classical musicians take beta blockers, ... New York Times

Manufacturer to Pay $425M for Improper Drug Marketing  -  Sep 29, 2008
Provigil, which is approved for narcolepsy, was marketed for fatigue, among other things, authorities said. Cephalon also announced it agreed to pay $6.15 ... FOXNews

Cephalon's revenue soars with Provigil  -  Aug 4, 2006
Cephalon Inc. yesterday reported a 54 percent increase in second-quarter revenue on strong sales of its biggest-selling sleep-disorder drug, Provigil, ... $2.95 - Philadelphia Inquirer - NewsBank

'Genius Pill' Relieves Chemobrain  -  Jun 5, 2007
The researchers looked at the effects of Provigil, a drug used to treat excessive ... The new analysis looked at whether Provigil, designed to promote ... WebMD

Mixed Outlook for Cephalon | Robert Steyer News | Print Financial & …  -  Nov 1, 2005
The next drug in the line-up should be Nuvigil, a cousin of Provigil, which Cephalon expects to be available in early 2006, assuming FDA approval. ... TheStreet.com - TheStreet.com (subscription)

Cephalon 1Q profit cut by higher costs and charges  -  May 1, 2008
Sales of the company's central nervous system drugs rose 4 percent to $226.7 million, with the bulk coming from Provigil, a drug for excessive sleepiness. ... Boston Globe

Cephalon agrees to buy muscle relaxant drug  -  Aug 23, 2007
Cephalon, which sells the narcolepsy drug Provigil, said it expects to launch Amrix early in the fourth quarter in the United States. Reuters

Hurdles ahead for Cephalon  -  Mar 17, 2006
Provigil, the company's sleep-disorder medication, generated sales of $512.8 ... Cephalon maintains it has valid patents for Provigil until that time frame. ... Bizjournals.com

Sleep worry girl's US visa fight  -  Feb 3, 2005
He also said Rachel would have trouble obtaining the stimulant he prescribes her, Provigil, which was not recommended for children in the UK. ... BBC News

US generics case puts Ranbaxy under spotlight  -  Feb 15, 2008
In a release issued on February 13, FTC alleged that Cephalon's 'anti-competitive' scheme denies patients access to lower cost, generic versions of Provigil ... Rediff

Can a pill REALLY make you brainy?  -  Dec 25, 2007
Another prescription drug, Provigil, is widely used by businessmen and other ... 'I was offered Provigil by a colleague to help me give a presentation after ... Daily Mail

Article: Charges sink Cephalon profit: The biotech's quarterly...  -  May 3, 2006
PROVIGIL and NUVIGIL each are indicated to improve wakefulness in adults with ... PR Newswire. Article: Study Demonstrates That Cephalon's PROVIGIL ... ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

Brain boost drugs 'growing trend'  -  Oct 13, 2008
Of that one in five, 62% had taken Ritalin and 44% Provigil - a drug normally prescribed to alleviating daytime tiredness in people suffering from the rare ... BBC News

Ranbaxy settles patent suit with Cephalon for sleep-disorder drug  -  Dec 24, 2005
Provigil accounted for $364.5 million, or 44 per cent of Cephalon's sales in the first nine months of the year. Besides this, the two companies have also ... Hindu Business Line

Several companies with Utah connections announced quarterly financial...  -  Feb 15, 2006
Cephalon Inc., the maker of the Provigil sleep-disorder medicine, said fourth-quarter profit fell 77 percent on costs tied to the acquisition of UK ... $2.95 - Deseret News - NewsBank

Cephalon profit tops expectations, advances Nuvigil  -  Jul 29, 2008
Increased Provigil revenue and sales of two new products helped offset steadily declining sales of its Actiq cancer pain drug, which is facing generic ... Reuters UK

Cephalon's 1st quarter beats forecasts: Revenue hit $437 million due...  -  May 2, 2007
Cephalon's top-selling drug, Provigil, a sleep-disorder medication, had $201.3 million in first-quarter sales ... Provigil prescriptions were up 15 percent. ... Free with registration - Philadelphia Inquirer - AccessMyLibrary.com

Shire shines as US regulators block rival hyperactivity drug  -  Mar 25, 2006
Late on Thursday a panel of outside experts advising the US Food and Drug Administration ruled that Provigil — a drug used to treat sleep disorders — is not ... Times Online

Reviewing ADHD Drugs - FDA Goes Through The Motion  -  Mar 14, 2006
The drug Sparlon is manufactured by Cephalon and is a clone of Provigil, ... And anyone who believes Provigil is free of the side effects associated with ... scoop.co.nz

… revenue soars with Provigil. - Philadelphia Inquirer (Philadelphia,...  -  Aug 4, 2006
Cephalon's revenue soars with Provigil. ... find Philadelphia Inquirer (Philadelphia, PA) articles. Byline: Linda Loyd Aug. 4--Cephalon Inc. yesterday ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

Cephalon Hopes to Ease FDA Fears  -  Apr 18, 2006
Sparlon contains modafinil, the same ingredient in Provigil, a sleep-disorders drug that's ... Sparlon has a higher dose of modafinil than Provigil does. ... TheStreet.com - TheStreet.com (subscription)

Sandoz drops challenge over a drug patent  -  May 3, 2005
Provigil is the biggest product for Cephalon, which is based in Frazer, Pa. ... Provigil sales are projected to reach as much as $600 million this year. ... $2.95 - Deseret News - NewsBank

Event Brief of Sparlon Conference Call - Final.  -  Aug 9, 2006
CEPH is seeing growth in PROVIGIL today, and the impact of the Takeda Pharmaceuticals on the ... We-- you saw the Provigil scripts are continuing to move. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Lind v. Aetna Health, Inc., 466 F.3d 1195 (10th Cir. 10/31/2006)  -  Oct 31, 2006
In February 2003, Mr. Lind went to a pharmacy to pick up his Provigil renewal, ... Aetna re-authorized payment for Provigil several days later, ... $2.95 - U.S. Court of Appeals, Tenth Circuit - VersusLaw

Cephalon's Provigil to piggyback Rozerem in promotion deal  -  Jun 13, 2006
In hopes of gaining marketing momentum from the push behind Rozerem, Cephalon has entered into agreement with Takeda Pharmaceutical to co-promote the ... Medical Marketing & Media - Medical Marketing and Media

Cephalon Completes Provigil Label Updates  -  Sep 18, 2007
Cephalon has finalized revisions to the label for Provigil tablets, its product to improve wakefulness in adults with obstructive sleep apnea/hypopnea ... FDA news - FDA news (subscription)

Cephalon's Short Squeeze Setup  -  Apr 27, 2006
Cephalon already sells Provigil, a medication to treat excessive sleepiness caused by certain sleep disorders, including narcolepsy, obstructive sleep ... Forbes

Cephalon Expects Second Quarter 2006 Results to Exceed Prior …  -  Jul 26, 2006
The company currently markets five proprietary products in the United States: PROVIGIL, GABITRIL(R) (tiagabine hydrochloride), ACTIQ, TRISENOX(R) (arsenic ... Genetic Engineering News - Genetic Engineering News (press release)

$1.2 million to state in drug settlement  -  Dec 30, 2008
Cephalon, Inc. manufacturers three drugs: Provigil, which treats narcolepsy and sleep disorders; Gabitril, which treats seizures, and Actiq, which treats ... Rocky Mountain News

Event Brief of Q2 2006 Cephalon, Inc. Earnings Conference Call -...  -  Aug 3, 2006
PROVIGIL: 1. Prescriptions increased 17% vs. 2Q05. 2. To further accelerate the recent resurgence in PROVIGIL growth, the Co. entered into an agreement with ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Event Brief of Q3 2006 Cephalon, Inc. Earnings Conference Call - Part...  -  Nov 2, 2006
Our focus for the next several years is going to be on Provigil. The future of Nuvigil will be focused on the transition to the Provigil market some time ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Pharma Roundup: Cephalon Hikes Provigil Prices, Icahn Eyes Amylin, …  -  Nov 18, 2008
By John Maas | Nov 18, 2008. Cephalon hikes Provigil prices — The drug maker is playing a cunning game. Provigil loses patent protection in 2012, ... BNET

Big Pharma payments to generics face court challenge - Feb. 20, 2008  -  Feb 20, 2008
The government's case against Cephalon centers on a 2006 deal to keep a generic version of Provigil, which treats sleepiness in patients with narcolepsy and ... CNNMoney.com

Cephalon, Inc. Provides Update on Regulatory Status of SPARLON(TM)  -  Jan 25, 2006
As a result of recent settlements of three patent infringement suits related to PROVIGIL (modafinil) Tablets [C-IV], the closing of the Zeneus acquisition, ... biotech-intelligence.com

Cephalon Gains Provigil Patent Extension  -  Mar 30, 2006
The FDA has granted Cephalon an extra six months of pediatric market exclusivity for its sleep disorder treatment, Provigil. ... RedOrbit

Article: Provigil information sought by regulators - Deseret News...  -  Mar 26, 2007
Provigil information sought by regulators ... find Deseret News (Salt Lake City) articles. Cephalon Inc. said US antitrust regulators demanded information ... Pay-Per-View - Deseret News - HighBeam Research

FDA Grants Tentative Approval for Caraco's Generic Provigil  -  Jul 23, 2007
Caraco Pharmaceutical Laboratories announced that the FDA granted tentative approval for the company's abbreviated new drug application for Modafinil in ... FDA news - FDA news (subscription)

Modafinil (generic): Provigil (brand).(YOUR MEDICATION INFORMATION …  -  Jun 1, 2006
COMMON USAGE: Modafinil is used to improve wakefulness in patients with excessive daytime sleepiness associated with narcolepsy. It is also approved for use ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Apotex CEO Bernard Sherman fights drug patent settlements - February...  -  Feb 5, 2007
Here's how that has worked with Provigil, made by Cephalon. Four generic-drug makers file with the FDA to make a version of Provigil. ... CNNMoney.com

Britney Spears Didn't Fail Drug Test - Provigil  -  Nov 12, 2007
OK! magazine has exclusively that Britney Spears has not failed a drug test. A source close to the Brit-Brit tells OK! the widespread reports are “100 ... TheInsider.com

'BRAINIACS' JUICING UP A STORM  -  Dec 23, 2007
...of choice are prescription stimulants, mainly the Attention Deficit Hyperactivity Disorder drugs Adderall and Ritalin and the narcolepsy pill Provigil. ... New York Post

… , Cephalon reach agreement over Provigil - India Abroad | HighBeam ...  -  Dec 30, 2005
Ranbaxy, Cephalon reach agreement over Provigil ... find India Abroad articles. Mozumder, Suman Guha India Abroad 12-30-2005 A pending patent infringement ... Pay-Per-View - India Abroad - HighBeam Research

Cephalon settles drug marketing probe for $425M  -  Nov 8, 2007
The probe was believed to be looking at whether company sales representatives were improperly marketing Cephalon's flagship drug Provigil, which is approved ... Bizjournals.com

Pharmaceutical Company Cephalon To Pay $425 Million For Off-label …  -  Oct 16, 2008
...-Provigil, FDA-approved to treat narcolepsy and sleep disorders. Cephalon marketed the drug as a non-stimulant drug to treat sleepiness, tiredness, ... The Chattanoogan

Federal Trade Commission v. Cephalon, Inc., No. 08-0244 (DDC 04/28/ …  -  Apr 28, 2008
That patent covers Provigil and expires on October 6, 2014, although a "pediatric exclusivity" ... Id. Provigil received FDA approval in December 1998, id. ... $2.95 - U.S. District Court, District of... - VersusLaw

Cephalon shares rise on earnings - That was last quarter. Some...  -  Feb 13, 2008
Cephalon's top drug, Provigil, a sleep-disorder medication, ... Provigil sales for the quarter were $219.5 million, up from $204.7 million in the ... $2.95 - Philadelphia Inquirer - NewsBank

No Panic Yet at Cephalon | Pharmaceuticals News | Print Financial & …  -  Aug 7, 2006
Cephalon's top-selling drug is Provigil, a medication for sleep disorders ... In return, they get 180-day exclusive marketing rights when Provigil loses ... TheStreet.com - TheStreet.com (subscription)

FDA warns about 'stay awake drug' Provigil  -  Oct 28, 2007
The US Food and Drug Administration (FDA) has issued a warning in connection with the drug Provigil because of dangerous side effects. ... News-Medical.net

Britney Spears Urine Sample -- It's Not Provigil  -  Nov 14, 2007
...by Staff. Britney Spears has denied allegations of substance abuse after testing positive in a court-ordered drug test, insisting the results only show the ... postchronicle.com

Cephalon, Inc. at JPMorgan 25th Annual Healthcare Conference - Final.  -  Jan 8, 2007
The Company's key drugs include PROVIGIL for excessive sleepiness and FENTORA, ... Our CNS franchise, largely driven by PROVIGIL, our pain franchise. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Cephalon shares fall after FDA rejects hyperactivity drug  -  Aug 11, 2006
Its main drug, Provigil, has been approved by the FDA to treat sleep disorders in ... About 5 percent to 10 percent of Provigil use is for hyperactivity. ... $2.95 - Deseret News - NewsBank

In a stressed world, drugs can keep us on our toes  -  Dec 29, 2008
Stay sharp as a knife — no matter how overworked and sleep-deprived — with a mental alertness-boosting drug like the anti-narcolepsy drug Provigil? ... Brisbane Times

Disabled man running out of 'miracle drug'.  -  Nov 6, 2005
But in July, he ran out of the free samples of Provigil. ... Provigil is marketed to treat narcolepsy, an irresistible desire to sleep. ... Free with registration - Charleston Gazette - AccessMyLibrary.com

'BRAIN DOPING' STARTING TO GAIN FAVOR IN VALLEY  -  Sep 3, 2008
..."I use Provigil when we have a large amount of work that needs to be done," ... But it also notes that Provigil, approved for sale in the United States in ... $2.95 - San Jose Mercury News - NewsBank

Pringle: Psych Drugs Used To Manufacture Insanity  -  Mar 7, 2006
Next, he prescribed Provigil, "as an antidote to psychotropics that had me ... Provigil was approved to treat narcolepsy. According to the August 4, ... scoop.co.nz

… With Cephalon Regarding Settlement of PROVIGIL(R) Patent Litigation...  -  Dec 9, 2005
In connection with the settlement, Cephalon will grant Teva a non-exclusive royalty-bearing right to market and sell a generic version of PROVIGIL. ... RedOrbit

FDA warns Cephalon over doctor's Provigil statements  -  Mar 2, 2007
The Food and Drug Administration has issued a warning letter to Cephalon Inc. over information that, the FDA said, should not have been part of a promotion ... Philadelphia Business Journal

FIGHTING FORGETFULNESS - MENTAL CHALLENGES CAN KEEP …  -  Apr 24, 2007
But you liked Provigil, a lesser-known drug created to deal with sleep ... When I began studying it, Provigil was not commonly being prescribed for ... $2.95 - Charlotte Observer - NewsBank

Nuvigil may have major advantages compared to Provigil  -  Jun 21, 2007
1. Nuvigil may have fewer side effects than Provigil 2. Nuvigil may have more rapid onset than Provigil 3. May have broader clinical applications, eg, ... Gerson Lehrman Group

FDA warns of Provigil risks  -  Oct 25, 2007
The FDA slapped a new warning on Provigil, a drug for narcolepsy and other sleeping disorders made by Cephalon. The agency warned doctors of sensitivity ... FiercePharma

Brand Names/Synonyms:
Provigil is also known by the following brand names and/or synonymsCEP 1538; CHEMBANK1788; CRL 40476; Dea No. 1680; MODAFINIL; Modafinil; Modafinil [Usan:Inn]; Modafinilo [Spanish]; Modafinilum [Latin]; Moderateafinil; Modiodal; Provigil

Drug Category:
Provigil is categorized under the following by the FDA: Neuroprotective Agents; Central Nervous System Agents; Anorexigenic Agents; Stimulants; ATC:N06BA07

Dosage Forms:
TABLET

Absorption:
Rapid

Interactions:
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Chemical IUPAC Name:
2-benzhydrylsulfinylethanamide





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