Rebetol

This page contains recent news articles, when available, and an overview of Rebetol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Rebetol
(when available)

Pharmacology and use:
Ribavirin is an anti-viral drug active against a number of DNA and RNA viruses. It is a member of the nucleoside antimetabolite drugs that interfere with duplication of the viral genetic material. The drug inhibits the activity of the enzyme RNA dependent RNA polymerase, due to it's resemblence to building blocks of the RNA molecules. The oral form is used in the treatment of hepatitis C, in combination with interferon drugs. The aerosol form is used to treat respiratory syncytial virus-related diseases in children. The primary serious adverse effect of ribavirin is hemolytic anemia, which may worsen preexisting cardiac disease. For the treatment of chronic hepatitis C and for respiratory syncytial virus (RSV)

Mechanism Of Action:
Ribavirin is readily phosphorylated intracellularly by adenosine kinase to ribavirin mono-, di-, and triphosphate metabolites. Ribavirin triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral). Guanylyltranserase inhibition stops the capping of mRNA . These diverse effects result in a marked reduction of intracellular guanosine triphosphate (GTP) pools and inhibition of viral RNA and protein synthesis. Ribavirin is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity.

News Articles on Ribavirin

Schering-Plough Reports Potent Antiviral Activity With Narlaprevir (SCH 900518 ...  -  ‎Nov 2, 2009‎
The study includes two treatment arms in which patients receive a 4-week lead-in of PEGINTRON and REBETOL prior to receiving narlaprevir 200 mg or 400 mg ... Reuters

Schering-Plough reports encouraging results from Phase IIa hepatitis study  -  ‎Nov 4, 2009‎
In the lead-in arms of the study, in which patients received a four-week lead-in of Pegintron and Rebetol followed by the addition of narlaprevir, ... Trading Markets (press release)

AASLD: Treating Before Transplant Cuts HCV Recurrence  -  ‎Nov 6, 2009‎
...a course of pegylated interferon and ribavirin (Rebetol) before liver transplant may help them avoid recurrence of infection, a researcher said here. ... MedPage Today

Vertex pitches hepatitis drug to key doctors  -  ‎Nov 1, 2009‎
Consalvo said his company markets a combination of two drugs, PegIntron and Rebetol, as interferon treatments for hepatitis C, competing with Swiss drug ... Boston Globe

Aurobindo Pharma pares early losses on US nod for generic drug  -  ‎Nov 11, 2009‎
Ribavirin tablet is the generic Copegus and Ribavirin Capsules is generic equivalent to Rebetol of Schering Corporation. Ribavirin tablets and capsules are ... India Infoline.com

AASLD: New Drug Boosts HCV Clearance  -  ‎Nov 3, 2009‎
...weeks of pegylated interferon-alfa-2b (PEGIntron) and ribavirin (Rebetol) in a Phase II trial, said Paul Kwo, MD, of Indiana University in Indianapolis. ... MedPage Today

US nod for generic drug boosts Aurobindo Pharma  -  ‎Nov 5, 2009‎
Ribavirin tablet is the generic Copegus and Ribavirin Capsules is generic equivalent to Rebetol of Schering Corporation. Ribavirin tablets and capsules are ... India Infoline.com

UPDATE 1-FDA concerns remain over new use for Schering drug  -  ‎Oct 30, 2009‎
WASHINGTON, Oct 30 (Reuters) - The US Food and Drug Administration has "outstanding concerns" about Schering-Plough Corp's (SGP. ... Reuters

Schering-Plough Reports Financial Results for 2009 Third Quarter  -  ‎Oct 22, 2009‎
NUVARING 131 118 11% 375 330 14% CLARITIN Rx 95 87 9% 323 326 (1%) AVELOX 70 65 7% 250 274 (9%) INTEGRILIN 74 84 (12%) 223 236 (5%) REBETOL 64 63 1% 197 ... Reuters

La tua opinione è importante  -  ‎Nov 11, 2009‎
...o Peg-IFN alfa2b (PegIntron®) e ribavirina (Rebetol®) nel trattamento di pazienti naive (mai trattati) con infezione cronica da HCV genotipo 1. ... Associazione EpaC Onlus

Schering-Plough's Pegintron and Rebetol combination therapy approved ...  -  Nov 15, 2007
KENILWORTH, NJ (Thomson Financial) - Schering-Plough Corp said the European Commission last month approved its 48-week standard-dose Pegintron and Rebetol ... Forbes

Schering-Plough: FDA OKs label revisions for Pengintron, Rebetol …  -  Mar 27, 2008
Thursday said the Food and Drug Administration has approved label revisions for Pengintron and Rebetol combination therapy for the treatment of chronic ... Forbes

… Approval Of PEGINTRON(TM) And REBETOL(R) Combination Therapy …  -  Dec 13, 2008
The anemia associated with REBETOL therapy may result in a worsening of cardiac disease. Ribavirin is genotoxic and mutagenic and should be considered a ... Medical News Today - Medical News Today (press release)

… Hepatitis C Treatment, Peg-Intron(R) And Rebetol(R) Approved In...  -  Dec 28, 2005
Schering-Plough Corporation (NYSE: SGP) announced that Schering-Plough KK, the company's country operations in Japan, has received marketing approval for a ... Medical News Today - Medical News Today (press release)

Results of PEG-INTRON(R) and REBETOL(R) Study in Retreating …  -  Oct 27, 2006
BOSTON, Oct. 27 /PRNewswire-FirstCall/ -- Schering-Plough today reported data from EPIC3, a large ongoing clinical study, showing that retreatment with ... RedOrbit

Schering-Plough hepatitis combo gets OK EU opinion  -  Sep 24, 2007
Peg-Intron is approved in the United States as a single agent treatment and for use in combination with Rebetol. Schering-Plough said it tested the ... Reuters

… Course of PEG-INTRON(R) and REBETOL(R) Combination Therapy …  -  May 10, 2005
KENILWORTH, NJ, Oct. 5 /PRNewswire-FirstCall/ -- Schering-Plough Corporation today announced that the European Commission has approved revised dosing ... Euro am Sonntag

PEG-INTRON(R) and REBETOL(R) Combination Therapy Demonstrates …  -  Nov 12, 2005
SAN FRANCISCO, Nov. 12 /PRNewswire-FirstCall/ -- Patients with chronic hepatitis C treated with PEG-INTRON(R) (peginterferon alfa-2b) and REBETOL(R) ... RedOrbit

Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted In Higher SVR …  -  Mar 28, 2008
Schering-Plough Corporation (NYSE: SGP) reported that the US Food and Drug Administration (FDA) has approved label revisions for PEGINTRON(TM) ... Medical News Today - Medical News Today (press release)

Pegintron and Rebetol Combination Therapy Approved in EU  -  Jun 26, 2007
Schering-Plough announced that the European Commission (EC) approved Pegintron and Rebetol combination therapy for previously untreated chronic hepatitis C ... FDA news - FDA news (subscription)

Schering-Plough Announces PEG-Intron and Rebetol Approved in Japan …  -  Dec 22, 2005
KENILWORTH, NJ -- December 22, 2005 -- Schering-Plough Corporation today announced that Schering-Plough KK, the company's country operations in Japan, ... DG News

Press Release: Results of PEG-INTRON(R) and REBETOL(R) Study in …  -  Oct 27, 2006
Results of PEG-INTRON(R) and REBETOL(R) Study in Retreating Hepatitis C Patients Who Failed Previous Combination Therapy Presented at AASLD. from PR ... Pay-Per-View - PR Newswire - HighBeam Research

… Efficacy of Shorter PEG-Intron and Rebetol Regimen in Hepatitis C ...  -  Apr 28, 2006
In the weight- based Rebetol dosing arms, the rate of sustained virologic response ... PEG-Intron and Rebetol are registered trademarks of Schering-Plough. ... DG News

… Release: PEGINTRON(TM) and REBETOL(R) Combination Therapy …  -  Jun 25, 2007
PEGINTRON(TM) and REBETOL(R) Combination Therapy Approved in European Union for Treating Hepatitis C in Patients Coinfected With HIV. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

… Course of PEGINTRON(R) and REBETOL(R) Combination Therapy  -  Aug 1, 2005
PEGINTRON and REBETOL combination therapy was previously approved in the EU for ... "The important results of this clinical study with PEGINTRON and REBETOL ... Medical News Today - Medical News Today (press release)

Interim Results From Boceprevir Phase II Study In Genotype 1 Treatment...  -  Apr 27, 2008
For patients receiving 4 weeks of PEGINTRON and REBETOL therapy prior to the ... The anemia associated with REBETOL therapy may result in a worsening of ... Medical News Today - Medical News Today (press release)

… Opinion on PEGINTRON(Tm) and REBETOL(R) Combination Therapy for …  -  Apr 30, 2007
The CHMP recommendation for approval of PEGINTRON and REBETOL combination ... PEGINTRON and REBETOL combination therapy for chronic hepatitis C was approved ... RedOrbit

… Course of Peg-Intron and Rebetol Combination Therapy Approved in …  -  Oct 5, 2005
KENILWORTH, NJ -- October 5, 2005 -- Schering-Plough Corporation today announced that the European Commission has approved revised dosing instructions ... DG News

Schering-Plough Initiates PEG-INTRON(R) Maintenance Study In Patients...  -  Jan 16, 2006
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEG-INTRON therapy must not be used by women ... Medical News Today - Medical News Today (press release)

Schering-Plough Reports Top-Line Results of the IDEAL Study.  -  Jan 14, 2008
Also, fewer of these patients treated with PEGINTRON and REBETOL ... The anemia associated with REBETOL therapy may result in a worsening of cardiac disease ... Free with registration - PR Newswire - AccessMyLibrary.com

Schering-Plough Initiates PEG-INTRON 'PROTECT' Study in Liver …  -  May 23, 2006
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEG-INTRON therapy must not be used by women ... Free with registration - PR Newswire - AccessMyLibrary.com

Press Release: Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in...  -  Mar 27, 2008
Pegintron(TM) Plus Weight-Based Rebetol(R) Resulted in Higher SVR Than Flat Dosing; Low Relapse Rates in Patients With Chronic Hepatitis C. from PR Newswire ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: PEG-INTRON(R) and REBETOL(R) Combination Therapy …  -  Nov 12, 2005
PEG-INTRON(R) and REBETOL(R) Combination Therapy Demonstrates Consistently High Response Rates Across Patient Weight Groups in 'Real-Life' Treatment ... Pay-Per-View - PR Newswire - HighBeam Research

Older HCV Patients Have Tough Time with Combination Therapy  -  Jan 9, 2006
Patients also received Rebetol in a dose of 600 mg to 800 mg daily. Patients who weighed less than 60 kg received six million units of Intron A and 600 mg ... MedPage Today

Pegintron plus Rebetol achieves consistent SVR.  -  Nov 12, 2007
At the 58th annual meeting of the American Association for the Study of Liver Diseases, held in Boston, Massachusetts, US drug major Schering-Plough ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Interim Results from Boceprevir Phase II Study in Genotype 1 Treatment...  -  Apr 26, 2008
For patients receiving 4 weeks of PEGINTRON and REBETOL therapy prior to the addition of boceprevir, SVR 12 was 57 percent (59/103), compared to 55 percent ... Genetic Engineering News - Genetic Engineering News (press release)

… in Japan for Use in Combination with REBETOL for Chronic Hepatitis...  -  Jan 7, 2005
PEG-INTRON and REBETOL combination therapy is the first and only ... PEG-INTRON is administered once weekly in combination with REBETOL daily for 48 weeks. ... businesswire.com

EU Label Change for Intron A (Interferon Alfa-2b) Incorporates Long...  -  Apr 26, 2006
Anemia associated with Rebetol therapy may exacerbate cardiac disease that ... Rebetol and combination Rebetol/PEG-Intron therapy must not be used by women ... DG News

International Approvals: DCVax-Brain, PegIntron/Rebetol, Revlimid  -  Jul 16, 2007
July 16, 2007 — The Swiss Institute of Public Health has approved the world's first brain cancer vaccine. The European Commission (EC) has approved an ... Medscape

… Trial in US Patients Shows Weight-Based REBETOL in Combination...  -  Nov 14, 2005
These results from WIN-R (Weight-Based Dosing of PEG-INTRON and REBETOL), ... PEG-INTRON and REBETOL are registered trademarks of Schering-Plough. ... Web Services Journal - Web Services Journal

… Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy …  -  Dec 12, 2008
Schering-Plough Announces FDA Approval of PEGINTRON(TM) and REBETOL(R) Combination Therapy for Treating Pediatric Hepatitis C. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Schering-Plough Announces Hepatitis C Data Presentations at Digestive...  -  May 18, 2006
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEG-INTRON therapy must not be used by women ... Free with registration - PR Newswire - AccessMyLibrary.com

SP's Pegintron plus Rebetol gets expanded indication.  -  Jul 9, 2007
The European Commission has approved US drug major Schering-Plough's Pegintron (peginterferon alfa-2b, 1.5mcg/kg once-weekly) and Rebetol (ribavirin, ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

… Course of PEG-INTRON(R) and REBETOL(R) Combination Therapy …  -  Oct 5, 2005
Shorter Course of PEG-INTRON(R) and REBETOL(R) Combination Therapy Approved in European Union for Certain Hepatitis C Patients With Genotype 1 and Low Viral ... Pay-Per-View - PR Newswire - HighBeam Research

FDA Safety Changes: Keppra, Naropin, Rebetol  -  Dec 22, 2006
December 22, 2006 — The US Food and Drug Administration (FDA) has approved safety label revisions to advise of the expected similarity of levetiracetam's ... Medscape

Press Release: PEGINTRON(TM) and REBETOL(R) Approved in …  -  Nov 15, 2007
PEGINTRON(TM) and REBETOL(R) Approved in European Union for Retreating Hepatitis C Patients Who Failed Previous Pegylated or Non-Pegylated Interferon ... Pay-Per-View - PR Newswire - HighBeam Research

AASLD: Weight-Based Dosing of Rebetol Improves Outlook for HCV  -  Nov 17, 2005
By Michael Smith,. SAN FRANCISCO, Nov. 17 - Giving Rebetol (ribavirin) based on the weight of a chronic hepatitis C (HCV) patient, rather than a flat dose, ... MedPage Today

FDA Grants Fast Track Designation To Oral HCV Protease Inhibitor SCH ...  -  Jan 30, 2006
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEG-INTRON therapy must not be used by women ... Medical News Today - Medical News Today (press release)

PEGINTRON(TM) Approved In China For Treating Chronic Hepatitis B  -  Apr 8, 2007
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEGINTRON therapy must not be used by women ... Medical News Today - Medical News Today (press release)

USA pharma: Pegintron/Rebetol approved in children  -  Dec 17, 2008
US drug major Schering-Plough has received marketing approval from the US Food and Drug Administration for a combination of Pegintron (peginterferon ... $34.00 - EIU Country Analysis - Alacra Store

… ; Study finds PegIntron and Rebetol achieved sustained virological ...  -  Jan 11, 2005
..."PegIntron and Rebetol combination therapy previously has been shown ... Schering-Plough supplied the PegIntron, Intron A and Rebetol used in the study. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Initial Results of Phase II Study with HCV Protease Inhibitor...  -  Oct 18, 2007
Boceprevir is being evaluated in combination with PEGINTRON and REBETOL for the treatment of patients chronically infected with hepatitis C virus (HCV) ... Free with registration - PR Newswire - AccessMyLibrary.com

… ; Study finds PegIntron and Rebetol achieved sustained virological ...  -  Jan 14, 2005
..."PegIntron and Rebetol combination therapy previously has been shown ... Schering-Plough supplied the PegIntron, Intron A and Rebetol used in the study. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Boceprevir Phase II Study Showed High Rate of Sustained Response …  -  Nov 1, 2008
These results compared to a 38 percent SVR rate (SVR 12) for patients in the control group receiving 48-weeks of PEGINTRON and REBETOL alone (ITT).(2-4) ... International Business Times

Combination of PEG-INTRON and REBETOL effective for HCV: Schering- …  -  Dec 4, 2006
According to Schering-Plough, chronic hepatitis patients who are treated with a combination of PEG-INTRON (peginterferon alfa -2a) and REBETOL (ribavirin) ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

Initial Results Of Phase II Study With HCV Protease Inhibitor...  -  Oct 19, 2007
Boceprevir is being evaluated in combination with PEGINTRON and REBETOL for the treatment of patients chronically infected with hepatitis C virus (HCV) ... Medical News Today - Medical News Today (press release)

International Approvals: Remicade, Vasovist, Peg-Intron, Rebetol  -  Oct 10, 2005
Oct. 10, 2005 — The European Commission has approved infliximab injection for the treatment of moderate to severe plaque psoriasis in patients who are ... Medscape

Press Release: Final Results of Ideal Study Presented at Annual...  -  Apr 26, 2008
Article: PEGINTRON and REBETOL Recommended for Approval as ... ... Plough Spain. "PegIntron and Rebetol combination therapy is just one example ... ... Pay-Per-View - PR Newswire - HighBeam Research

Vertex Pharmaceuticals (VRTX) Falls On Positive Data From Competing …  -  Oct 18, 2007
Schering-Plough's drug, in combination with PEGINTRON and REBETOL, showed a response of 79% after 12 weeks of treatment. Schering-Plough called the response ... StreetInsider.com - StreetInsider.com (subscription)

Press Release: PEG-INTRON(R) and REBETOL(R) Combination Therapy …  -  Nov 12, 2005
PEG-INTRON(R) and REBETOL(R) Combination Therapy Demonstrates Consistently High Response Rates Across Patient Weight Groups in 'Real-Life' Treatment ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Boceprevir Phase II Study Showed High Rate of Sustained Response …  -  Jan 11, 2008
These results compared to a 38 percent SVR rate (SVR 12) for patients in the control group receiving 48-weeks of PEGINTRON and REBETOL alone (ITT).(2-4) ... FinanzNachrichten.de

… Opinion on PEGINTRON(Tm) and REBETOL(R) Combination Therap  -  Apr 30, 2007
..."PegIntron and Rebetol combination therapy is just one example . ... In addition to examining the ability of PegIntron and Rebetol to achieve ... studies in ... Pay-Per-View - PR Newswire - HighBeam Research

Invasive Fungal Infections - CHMP Adopts Positive Opinion for...  -  Aug 1, 2005
There are no guarantees about the market performance of PEG-INTRON and REBETOL combination therapy, Schering-Plough stock or Schering-Plough's business. ... Medical News Today - Medical News Today (press release)

… With PegIntron and Rebetol Combination Therapy Demonstrated in...  -  Apr 18, 2005
Clinical Benefits of Retreatment With PegIntron and Rebetol Combination Therapy Demonstrated in Difficult-to-Treat Hepatitis C Patients. ... find PR ... Pay-Per-View - PR Newswire Europe - HighBeam Research

… With PegIntron and Rebetol Combination Therapy Demonstrated in  -  Apr 18, 2005
Clinical Benefits of Retreatment With PegIntron and Rebetol Combination Therapy Demonstrated in Difficult-to-Treat Hepatitis C Patients; PegIntron Achieves ... Pay-Per-View - PR Newswire - HighBeam Research

… For Shorter Course of PEGINTRON(R) and REBETOL(R) Combination T  -  Jul 29, 2005
PEGINTRON and REBETOL combination therapy was previously approved in the EU for ... "The important results of this clinical study with PEGINTRON and REBETOL ... RedOrbit

… Opinion on PEGINTRON(TM) and REBETOL(R) Combination Therap  -  Apr 30, 2007
PEGINTRON and REBETOL Combination Therapy PEGINTRON and REBETOL combination ... dose in ... Article: New Study Reports Results of PegIntron and Rebetol ... ... Pay-Per-View - PR Newswire Europe - HighBeam Research

… -Plough Announces PEG-INTRON(R) and REBETOL(R) Approved in …  -  Dec 22, 2005
Schering-Plough Announces PEG-INTRON(R) and REBETOL(R) Approved in Japan for Expanded Use in Treating Chronic Hepatitis C. from PR Newswire Europe. Pay-Per-View - PR Newswire Europe - HighBeam Research

… : Data on PEG-INTRON(R) and REBETOL(R) Combination Therapy in …  -  May 12, 2005
Data on PEG-INTRON(R) and REBETOL(R) Combination Therapy in Diverse Patient Populations to Be Presented at 2005 Digestive Disease Week (DDW) Meeting. from ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Positive results from Visudyne(R) combination therapy ...  -  Mar 28, 2008
INTRON and REBETOL combination therapy trial, the incidence ... INTRON/REBETOL groups was similar to ... INTRON A/REBETOL group. In many but . ... Pay-Per-View - PR Newswire - HighBeam Research

Weight-based Dosage Increases Hepatitis C Treatment Efficacy  -  Dec 28, 2007
The study of over 5000 patients with hepatitis C virus (HCV) showed that the treatment with weight-based REBETOL (ribavirin, USP) (RBV) in combination with ... MedIndia

… recommendations for SP's PEG-Intron and Rebetol by CHMP.(Committee...  -  Aug 8, 2005
The European Union's Committee for Medicinal Products for Human Use has issued a positive opinion recommending approval of revised dosing instructions which ... $4.95 - Pharma Marketletter - ECNext

PegIntron/Rebetol in HCV: positive data.(pharmaceutical industry)(Brie...  -  Apr 25, 2005
Interim results from the ongoing EPIC (Evaluation of PegIntron in Control of Hepatitis C Cirrhosis) clinical study, presented at the European Association ... $4.95 - Pharma Marketletter - ECNext

… Commission approves shorter Pegintron+Rebetol combo therapy.(Brief...  -  Oct 10, 2005
US drug major Schering-Plough says that the European Commission has approved revised dosing instructions allowing for a shorter, 24-week course of Pegintron ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

Cholesterol drugs boost Schering-Plough  -  May 1, 2005
...drugs and renewed vigour in Schering's older drugs all but one of them, hepatitis C treatment Rebetol, reporting first quarter sales increases. ... Pharmafocus

Schering-Plough Announces Hepatitis C Data Presentations At Digestive...  -  May 19, 2007
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEGINTRON therapy must not be used by women ... Medical News Today - Medical News Today (press release)

Press Release: European Union's CHMP Issues Positive Opinion on …  -  Sep 24, 2007
PEGINTRON and REBETOL(R) will be the only available hepatitis C therapy ... Upon European Commission approval, PEGINTRON and REBETOL will be the only ... Pay-Per-View - PR Newswire - HighBeam Research

… Positive Opinion for Shorter Course of PEGINTRON(R) and REBETOL(R)  -  Jul 29, 2005
PEGINTRON and REBETOL combination therapy was previously approved in the EU for ... "The important results of this clinical study with PEGINTRON and REBETOL ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Schering-Plough Announces Hepatitis C Data Presentations at Digestive...  -  May 18, 2007
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEGINTRON therapy must not be used by women ... Free with registration - PR Newswire - AccessMyLibrary.com

Livers Under Wrap: AASLD 2005  -  Nov 25, 2005
The patients received consensus interferon at 15 mcg daily plus Rebetol at 11 mg/kg/day, with treatment planned to last for 48 weeks. ... MedPage Today

REGULATORY NEWS IN BRIEF  -  Jun 13, 2005
Pegintron is the first peginterferon preparation in Japan approved for combination therapy with Rebetol. It was launched last December after being approved ... Pay-Per-View - Pharma Japan - Factiva, from Dow Jones

Schering-Plough Provides Update on Boceprevir Clinical Development …  -  Nov 24, 2008
The anemia associated with REBETOL therapy may result in a worsening of cardiac disease. Ribavirin is genotoxic and mutagenic and should be considered a ... International Business Times

Schering-Plough Initiates PEG-INTRON(R) Maintenance Study in Patients...  -  Jan 13, 2006
Anemia associated with REBETOL therapy may exacerbate cardiac disease that ... REBETOL and combination REBETOL/PEG-INTRON therapy must not be used by women ... biotech-intelligence.com

New Data Evaluating 'Real World' Treatment Results With PEGINTRON(R …  -  Apr 15, 2005
About PEGINTRON and REBETOL Combination Therapy PEGINTRON and REBETOL combination ... Treatment with PegIntron and Rebetol ... with Genotype 1 Chronic ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Press Release: Top-Line Results of Boceprevir Phase II Study Showed …  -  Aug 4, 2008
Importantly, for patients who received the PEGINTRON and REBETOL lead in and had ... Article: PEGINTRON(TM) and REBETOL(R) Combination Therapy Approved ... ... Pay-Per-View - PR Newswire - HighBeam Research

First large head-to-head comparison of Schering and Roche HCV …  -  Jan 16, 2008
The standard daily dose of Rebetol is 800mg, although studies have suggested that ... (1) PegIntron 1.5mcg/kg/week (the standard dose) plus Rebetol, ... Aidsmap

CHMP Issues Positive Opinion On PEGINTRON For Retreating Hepatitis …  -  Sep 25, 2007
Upon European Commission approval, PEGINTRON and REBETOL will be the only ... PEGINTRON and REBETOL combination therapy for chronic hepatitis C was approved ... emaxhealth.com

Press Release: Schering-Plough To Initiate Phase III Studies With HCV...  -  May 21, 2008
..."We are excited to advance to Phase III clinical studies with boceprevir in combination with PEGINTRON and REBETOL," said Fred Poordad, M.D., ... Pay-Per-View - PR Newswire - HighBeam Research

Results of Peginterferon Alfa-2b and Ribavirin Study in Retreating …  -  Oct 30, 2006
..."The results of this study demonstrate that retreatment with PEG-Intron and Rebetol combination therapy may help address this unmet medical need in this ... DG News

Press Release: PEGINTRON(TM) Approved in China for Treating Chronic …  -  Apr 5, 2007
PEGINTRON and REBETOL were ... patients with chronic hepatitis C alone. "Effective ... HCV genotype. PEGINTRON in the European Union PEGINTRON and REBETOL ... Pay-Per-View - PR Newswire - HighBeam Research

A press release distributed by PR Newswire Europe  -  Apr 18, 2005
..."Our research demonstrates that this difficult-to-treat patient group can be successfully retreated with PegIntron and Rebetol combination therapy." ... prnewswire.co.uk

Press Release: Schering-Plough Highlights PEGINTRON(TM) and …  -  Apr 17, 2008
Article: PEGINTRON(TM) and REBETOL(R) Combination Therapy ... ... Powder for Injection for use in combination therapy with REBETOL(R) (ribavirin ... only ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Boceprevir Phase II Study Showed High Rate of …  -  Nov 1, 2008
Article: PEGINTRON(TM) and REBETOL(R) Combination Therapy Approved . ... The study showed that PEGINTRON (1.5 mcg/kg once weekly) and REBETOL ... virologic ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Has added Schering-Plough Corp. to their watch list. -...  -  Jan 15, 2008
Powder for Injection for use in combination therapy with Rebetol ... "Peg-Intron and Rebetol combination therapy gives new hope to some of the estimated . ... Pay-Per-View - M2 Presswire - HighBeam Research

… von kürzerer PEG-INTRON- und REBETOL-Therapie bei Hepatitis C- …  -  Apr 28, 2006
Im gewichtsbasierten REBETOL-Dosierungsarm betrug die Rate der anhaltenden ... PEG-INTRON und REBETOL sind eingetragene Markenzeichen von Schering-Plough. ... presseportal.de

Press Release: Initial Results of Phase II Study with HCV Protease …  -  Oct 18, 2007
Article: PEGINTRON and REBETOL Recommended for Approval as ... ... 79% In clinical studies, the combination of PEGINTRON and REBETOL had ... ... Pay-Per-View - PR Newswire - HighBeam Research

… para la terapia de combinación PEGINTRON(TM) y REBETOL(R) para la ...  -  Apr 30, 2007
La terapia de combinación de PEGINTRON y REBETOL para la hepatitis C crónica recibió la autorización de comercialización en la UE en marzo de 2001. ... elEconomista.es

… mit PegIntron und Rebetol Kombinationstherapie bei schwer zu  -  Apr 18, 2005
..."Unsere Forschung zeigt, dass diese Gruppe von schwer zu behandelnden Patienten erfolgreich mit der PegIntron und Rebetol Kombinationstherapie ... presseportal.de

… .- La terapia de 'PegIntron' más 'Rebetol' (Schering-Plough),...  -  Jun 23, 2008
La terapia individualizada de peginterferón alfa-2b y ribavirina, comercializado por Schering-Plough como 'PegIntron' y 'Rebetol' respectivamente, ... ecodiario

Modifiche AIC in GU: Pegintron, Rebetol  -  May 16, 2008
...pazienti in cui un precedente trattamento di combinazione con interferone alfa (pegilato o nonpegilato) e ribavirina o la monoterapia con interferone alfa ... Pillole.org

DDW: Novel HCV Protease Inhibitor Promising in Early Trial  -  May 24, 2006
The 12 patients were continued on weight-based Rebetol therapy for 12 weeks. ... That patient is being continued on Pegysys and Rebetol. ... MedPage Today

COMUNICADO: Schering-Plough consigue grandes avances en el …  -  Apr 11, 2007
Entre ellas están varios estudios de la terapia de combinación PEGINTRON(R) (peginterferon alfa-2b) y REBETOL(R) (ribavirina), un método estándar de cuidado ... elEconomista.es

DDW: Relapsed HCV Patients Achieve Sustained Response with 72- …  -  May 22, 2006
LOS ANGELES, May 22 — Daily consensus interferon plus Rebetol (ribavirin) for 72 weeks ... Patients in both treatment arms received weight-based Rebetol. ... MedPage Today

Meeting Highlights From The Committee For Medicinal Products For …  -  Apr 23, 2007
Rebetol must be used in combination with peginterferon alfa-2b in this indication. ... As Rebetol, also from Schering Plough Europe, is used in combination ... Medical News Today - Medical News Today (press release)

Press Release: Largest US Hepatitis C Trial Provides Insight Into …  -  May 24, 2006
In the weight-based REBETOL dosing arms, the SVR rate was 68 percent for the ... Article: Clinical Benefits of Retreatment With PegIntron and Rebetol ... ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Adalimumab looks good for psoriasis.(Skin Disorders) -...  -  Jun 1, 2005
INTRON and REBETOL combination therapy in all HCV virus ... effectiveness of ... Article: Clinical Benefits of Retreatment With PegIntron and Rebetol ... ... Pay-Per-View - Family Practice News - HighBeam Research

Schering-Plough's 3rd-Qtr Profit More Than Tripled  -  Oct 24, 2005
Schering-Plough introduced its Peg-Intron and Rebetol hepatitis drugs in Japan ... The December 2004 introduction into Japan of the Peg-Intron and Rebetol ... Bloomberg

Press Release: Schering-Plough Corp. Review in Progress. - M2 …  -  Apr 18, 2008
Schering-Plough Corp. was in the red less than ... REBETOL (ribavirin, USP) combination therapy vs. Pegasys (peginterferon ... ... Pay-Per-View - M2 Presswire - HighBeam Research

Hepatitis; PEG-INTRON is now available in Japan for hepatitis C …  -  Jan 14, 2005
PEG-INTRON and REBETOL are marketed worldwide by Schering-Plough Corporation (NYSE: SGP). PEG-INTRON and REBETOL combination therapy is the first and only ... Pay-Per-View - Genomics & Genetics Weekly - Factiva, from Dow Jones

… la UE la terapia de combinación PEGINTRON(TM) y REBETOL(R) para la …  -  Jun 25, 2007
PEGINTRON y REBETOL fueron aprobados anteriormente en la UE para el ... La terapia de combinación de PEGINTRON y REBETOL para la hepatitis C crónica fue ... elEconomista.es

Brand Names/Synonyms:
Rebetol is also known by the following brand names and/or synonymsBiopolymers; Copegus; DRG-0028; HSDB 6513; ICN 1229; ICN-1229; RBV; RIBAV; RTC; RTCA; RTP; Rebetol; Rebetron; Rebretron; Ribamide; Ribamidil; Ribamidyl; Ribasphere; Ribavirin; Ribavirin Capsules; Ribavirin Triphosphate; Ribavirin [Usan:Inn]; Ribavirin-Tp; Ribavirina [Inn-Spanish]; Ribavirine; Ribavirine [Inn-French]; Ribavirinum [Inn-Latin]; Tribavirin; Varazid; Vilona; Viramid; Virazid; Virazole; Virazole 5'-Triphosphate

Drug Category:
Rebetol is categorized under the following by the FDA: Antiviral; ATC:J05AB04

Dosage Forms:
Inhalation solution, Tablets

Absorption:
Ribavirin was rapidly and extensively absorbed following oral administration. However, due to first-pass metabolism, the absolute bioavailability averaged 64% (44%).

Interactions:
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Chemical IUPAC Name:
1-[3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-1H-1,2,4-triazole-3-carboxamide





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