Rezulin

This page contains recent news articles, when available, and an overview of Rezulin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Rezulin
(when available)

Pharmacology and use:
Troglitazone is an oral antihyperglycemic agent which acts primarily by decreasing insulin resistance. Troglitazone is used in the management of type II diabetes (noninsulin-dependent diabetes mellitus (NIDDM) also known as adult-onset diabetes). It improves sensitivity to insulin in muscle and adipose tissue and inhibits hepatic gluconeogenesis. Troglitazone is not chemically or functionally related to either the sulfonylureas, the biguanides, or the g-glucosidase inhibitors. Troglitazone may be used concomitantly with a sulfonylurea or insulin to improve glycemic control. For the treatment of Type II diabetes mellitus

Mechanism Of Action:
Troglitazone is a thiazolidinedione antidiabetic agent that lowers blood glucose by improving target cell response to insulin. It has a unique mechanism of action that is dependent on the presence of insulin for activity. Troglitazone decreases hepatic glucose output and increases insulindependent glucose disposal in skeletal muscle. Its mechanism of action is thought to involve binding to nuclear receptors (PPAR) that regulate the transcription of a number of insulin responsive genes critical for the control of glucose and lipid metabolism. Unlike sulfonylureas, troglitazone is not an insulin secretagogue.

News Articles on Troglitazone

Testing method has Cellumen poised for growth  -  ‎Nov 13, 2009‎
Diabetes drug Rezulin was taken off the market in 2000 because of liver damage, which also was a side effect of the pain reliever Vioxx, pulled from the ... Pittsburgh Business Times

Effective Use Of A Regulatory Expert In Product Liability Litigation  -  ‎Nov 2, 2009‎
See, eg, In re Rezulin Products Liability Litigation , 309 F. Supp. 2d 531, 547 (SDNY 2004) ("Such testimony usurps the role of the trial judge in ... The Metropolitan Coporate Counsel

Swine Flu Vaccine Propaganda Reaches New Levels Of Absurdity  -  ‎Oct 30, 2009‎
It's how Rezulin got approved. It's the reason Alli was approved as an over-the-counter weight loss drug even though it may be linked to liver damage. ... Prison Planet.com

Rezulin suit disruptive, Pfizer tells US high court  -  Feb 25, 2008
By Kim Dixon. WASHINGTON, Feb 25 (Reuters) - A state law allowing suits against drugmakers when fraud against federal regulators is proven disrupts the ... Reuters

Pfizer Rezulin Case to Proceed; US Court Deadlocks  -  Mar 3, 2008
WASHINGTON (Reuters) - A deadlocked US Supreme Court upheld a lower court decision against Pfizer Inc's (PFE.N) Warner-Lambert unit over withdrawn diabetes ... Reuters UK

IN BRIEF / DRUGS; Pfizer Must Face Suit in Michigan Over Rezulin  -  Oct 6, 2006
Pfizer Inc. must defend a lawsuit in which people claim its diabetes drug Rezulin damaged their livers. A federal appeals court in New York reinstated a ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  May 9, 2005
The lead defendants have moved for an order requiring plaintiffs to produce case-specific expert reports. (Docket Item 3044). The motion is granted, ... $2.95 - U.S. District Courts - VersusLaw

US judge dismisses Louisiana Rezulin case vs Pfizer  -  Nov 26, 2007
NEW YORK, Nov 26 (Reuters) - A US judge on Monday dismissed a case against Pfizer Inc in which the state of Louisiana sought to recover Medicaid payments ... Reuters

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Jan 3, 2005
In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: Pearl Ellis, et al. Warner-Lambert Company, et al. ... $2.95 - U.S. District Courts - VersusLaw

US Supreme Court agrees to hear Pfizer patent case  -  Sep 25, 2007
N) unit Warner-Lambert, the maker of Rezulin, appealed to the high court ... Rezulin was pulled from the market in March 2000 at the request of the FDA ... Reuters

Court Allows Suit Against Drug Maker  -  Mar 4, 2008
Rezulin was approved by the Food and Drug Administration in 1997 and withdrawn ... But the lawsuit by the Rezulin patients was brought under the specific ... New York Times

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK), …  -  Feb 10, 2005
In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: Esly Alvarado-Umanzor, et al. ... $2.95 - U.S. District Courts - VersusLaw

Bush nominee broke law  -  Jan 23, 2006
Chambers' case was one of thousands of lawsuits provoked by the diabetes drug Rezulin, which was withdrawn from the market after being linked to liver ... Salon

In re Rezulin Products Liability Litigation, 524 F.Supp.2d 436 (SDNY...  -  Nov 26, 2007
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Court, Southern District... - VersusLaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Jun 1, 2005
In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: Laverne B. Hoke. Warner-Lambert, et al. Civil Action Number 01cv10853 ... $2.95 - U.S. District Courts - VersusLaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Feb 2, 2005
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (SDNY 2005) In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: Margaret ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Supreme Court allows Rezulin suit to go to trial.(News)  -  Mar 10, 2008
WASHINGTON-A divided US Supreme Court last week allowed a group of plaintiffs to sue the manufacturer of the diabetes drug Rezulin in a case that centered ... Free with registration - Business Insurance - AccessMyLibrary.com

… : New Orleans Racial Trash, Road Home, Rezulin, Noose, Lott, Bonds  -  Nov 27, 2007
The lawsuit attempted to recover state Medicaid payments for prescriptions for a diabetes drug Rezulin which had been pulled off of the market. ... bayoubuzz.com

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Jul 26, 2006
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (SDNY 2006) 441 F. Supp.2d 567 In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). No. 00 Civ. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Kos Names Chief Flack  -  Oct 19, 2005
..."Warner-Lambert had a number of significant corporate and product events including the launch of Lipitor, the launch and subsequent recall of Rezulin, ... TheStreet.com - TheStreet.com (subscription)

Avandia Risks May Cost Glaxo $300 Million in Alzheimer's Sales  -  Dec 13, 2007
...s Rezulin diabetes pill, which belongs to the same class of drugs as ... When Rezulin was linked to liver damage and withdrawn from the market in 2000, ... Bloomberg

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Mar 15, 2006
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (SDNY 2006) In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL NO. 1348). This Document Relates to: Master File ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  May 9, 2005
JANET, JENNER & SUGGS, LLC, Gerald D. Jowers, Jr., Columbia, South Carolina, Attorneys for Plaintiffs. KAYE SCHOLER LLP, Alan F. Goott, Warner-Lambert ... $2.95 - U.S. District Courts - VersusLaw

Years Ago, Agency Was Warned of a Drug's Risks  -  May 24, 2007
At the time, the FDA was considering removing Rezulin from the market, ... Rezulin was made by Parke-Davis, a division of the Warner Lambert Company. ... New York Times

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Feb 2, 2005
Now before the Court are motions by the manufacturer defendants for summary judgment dismissing the complaint insofar as it is brought by plaintiff ... $2.95 - U.S. District Courts - VersusLaw

Settlement of Rezulin suit will provide $8 million for research  -  Sep 14, 2008
By Michelle James. Diabetes treatment and research in West Virginia recently received a nearly $8 million boost thanks to a unique settlement arrangement ... Beckley Register-Herald

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Apr 12, 2005
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Courts - VersusLaw

Supreme Court Affirms Rezulin Liability Case  -  Mar 10, 2008
The Supreme Court has affirmed a lower court ruling in favor of patients claiming to have been injured by Rezulin, allowing them to bring a product ... FDA news - FDA news (subscription)

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jan 13, 2005
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Courts - VersusLaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Nov 26, 2007
Facts Plaintiff here seeks to recover amounts paid to fill Rezulin ... Discussion The Merits Louisiana's Legal Obligation to Pay for Rezulin Federal ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

US Bankruptcy Court Opinions - IN RE CHANEY (NDAla. 12-14-2006)  -  Dec 14, 2006
9) Her amended Schedule B listed a "potential class action Rezulin claim" ... Since proceeds of the Rezulin claim were not committed to completion of the ... Pay-Per-View - U.S. Bankruptcy Court Opinions - Loislaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Courts - VersusLaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Nov 26, 2007
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (S.D.N.Y. 2007) ... Facts Plaintiff here seeks to recover amounts paid to fill Rezulin prescriptions for ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Supreme Court allows Rezulin suit to go to trial.(News) | Article...  -  Mar 10, 2008
Supreme Court allows Rezulin suit to go to trial.(News) ... find Business Insurance articles. Byline: DAVE LENCKUS WASHINGTON-A divided US Supreme Court ... Pay-Per-View - Business Insurance - HighBeam Research

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Courts - VersusLaw

US Bankruptcy Court Opinions - IN RE WEED (NDAla. 12-20-2006)  -  Dec 20, 2006
1) They did not schedule the Rezulin claim as personal property on ... Apparently, the Weeds advised the trustee of the Rezulin class action lawsuit at the ... Pay-Per-View - U.S. Bankruptcy Court Opinions - Loislaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
Supreme Court Cases - Research for US Supreme Court Cases, Federal Circuit Court Cases, and Federal District Court Cases. Whether you need decisions in ... $2.95 - U.S. District Courts - VersusLaw

US Bankruptcy Court Opinions - IN RE SHAMERY (NDAla. 12-15-2006)  -  Dec 15, 2006
1) The debtor listed her Rezulin claim on Schedule B as personal property with ... She also scheduled the Rezulin claim on Schedule C valued at $2650.00 and ... Pay-Per-View - U.S. Bankruptcy Court Opinions - Loislaw

Deadlines on FDA calls may compromise drug safety: study  -  Mar 28, 2008
WASHINGTON -- Vioxx, Bextra, Rezulin, Baycol. Looking at drugs yanked off the market, Harvard University researchers found a disturbing pattern: Medicines ... China Post

US Bankruptcy Court Opinions - IN RE TURNER (NDAla. 1-11-2007)  -  Jan 11, 2007
The debtor's schedules did not list her Rezulin claim as an asset and she did not commit any of her Rezulin claim to be paid to her creditors. ... Pay-Per-View - U.S. Bankruptcy Court Opinions - Loislaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 8, 2005
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US Bankruptcy Court Opinions - IN RE GRIFFIN (NDAla. 11-22-2006)  -  Nov 22, 2006
December, 2004 — The parties reached a global group settlement in the Rezulin group cases that debtor Griffin had joined. The settlement was structured so ... Pay-Per-View - U.S. Bankruptcy Court Opinions - Loislaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jan 18, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jun 9, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2270(JP),,01- …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jan 13, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ:2843(LAK),, …  -  Feb 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Feb 10, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jul 7, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jan 13, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jan 13, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Feb 3, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  May 19, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jun 21, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Feb 1, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Apr 14, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jun 21, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Feb 10, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jul 20, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  May 9, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Apr 19, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Jan 5, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jun 8, 2005
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IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  May 19, 2005
In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: 02cv1696 (L. Martin. Parke-Davis, et al.), 02cv4537 (E. Moe v. ... $2.95 - U.S. District Courts - VersusLaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK), …  -  Jan 3, 2005
In Re REZULIN PRODUCTS LIABILITY LITIGATION. (MDL 1348). This document relates to: LOUISIANA HEALTH SERVICE INDEMNITY COMPANY d/b/a/ BLUECROSS/BLUESHIELD OF ... $2.95 - U.S. District Courts - VersusLaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Jun 20, 2005
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Antidote - Medical Marketing and Media  -  Jul 1, 2007
When Rezulin was removed from the market several years ago, the top endocrinologist I worked with was quite upset. Of course he knew about the few cases of ... Medical Marketing & Media - Medical Marketing and Media

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 04CV08524-LAK( …  -  Feb 10, 2005
GIRARDI/KEESE, THOMAS V. GIRARDI, DAVID N. BIGELOW, VINCENT J. CARTER, RYAN M. McNAMARA, Los Angeles, California, Attorneys for Plaintiff(s). ... $2.95 - U.S. District Courts - VersusLaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  May 19, 2005
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IN RE: REZULIN PRODUCTS LIABILITY LITIGATION, 00Civ.2843(LAK). ( …  -  Jul 13, 2005
PTO 387 granted the motion of Ken R. Adcock, Esq., to withdraw as counsel for the plaintiffs and dismissed these actions for lack of prosecution subject to ... $2.95 - U.S. District Courts - VersusLaw

IN RE REZULIN PRODUCTS LIABILITY LITIGATION, 00cv2843(LAK). ( …  -  Apr 8, 2005
Warner-Lambert, et al.) 01cv6041 (B. Smith v. Warner-Lambert, et al.) 01cv6046 (Ratliff v. Warner-Lambert, et al.) 01cv7759 (Hamilton v. ... $2.95 - U.S. District Courts - VersusLaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Apr 14, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Mar 18, 2005
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… Court Opinions - IN RE REZULIN PRODUCT LIABILITY LITIGATION ( …  -  Aug 2, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Apr 27, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Apr 8, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Jun 14, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Mar 10, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Apr 21, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Jan 13, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Feb 16, 2005
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (SDNY 2005) In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: 00 Civ. 9168. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  May 19, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Jun 7, 2005
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… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Aug 22, 2005
IN RE REZULIN PRODUCTS LIABILITY LITIGATION (SDNY 2005) In re: REZULIN PRODUCTS LIABILITY LITIGATION (MDL No. 1348). This Document Relates to: 00 Civ. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

… Court Opinions - IN RE REZULIN PRODUCTS LIABILITY LITIGATION ( …  -  Mar 14, 2005
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Brand Names/Synonyms:
Rezulin is also known by the following brand names and/or synonymsRomglizone; Rezulin; Troglitazone [USAN:BAN:INN]; Prelay; Noscal; Mesylate

Drug Category:
Rezulin is categorized under the following by the FDA: Vasodilator Agents; Hypoglycemic Agents; Platelet Aggregation Inhibitors; Fibrinolytic Agents; Antineoplastic Agents; ATC:A10BG01

Dosage Forms:
Not Available

Absorption:
Absorbed rapidly. Food increases the extent of absorption by 30% to 85%.

Interactions:
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Chemical IUPAC Name:
5-[[4-[(6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)methoxy]phenyl]methyl]thiazolidine-2,4-dione





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