Riluzole

This page contains recent news articles, when available, and an overview of Riluzole but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Riluzole
(when available)

Pharmacology and use:
Riluzole, a member of the benzothiazole class, is indicated for the treatment of patients with amyotrophic lateral sclerosis (ALS). Riluzole extends survival and/or time to tracheostomy. It is also neuroprotective in various in vivo experimental models of neuronal injury involving excitotoxic mechanisms. The etiology and pathogenesis of amyotrophic lateral sclerosis (ALS) are not known, although a number of hypotheses have been advanced. One hypothesis is that motor neurons, made vulnerable through either genetic predisposition or environmental factors, are injured by glutamate. In some cases of familial ALS the enzyme superoxide dismutase has been found to be defective. For the treatment of amyotrophic lateral sclerosis (ALS, Lou Gehrig's Disease)

Mechanism Of Action:
The mode of action of Riluzole is unknown. Its pharmacological properties include the following, some of which may be related to its effect: 1) an inhibitory effect on glutamate release, 2) inactivation of voltage-dependent sodium channels, and 3) ability to interfere with intracellular events that follow transmitter binding at excitatory amino acid receptors.

News Articles on Riluzole

UPI NewsTrack Health and Science News  -  05 Jan 2010
The promise of talampanel is especially important in ALS because only one other drug, riluzole, exists to treat the fatal neurodegenerative disease. ... UPI.com

New ALS Drug Slips Through Telling Phase II Clinical Trials  -  ‎Jan 4, 2010‎
With the exception of riluzole, the single FDA-approved drug for the disease, there's no other treatment to slow or stop it. "Riluzole can extend life only ... Science Daily (press release)

Best Treatment Outlined For ALS Patients  -  ‎Dec 28, 2009‎
But the AAN's recently updated treatment guidelines do recommend that patients be offered riluzole, the only FDA-approved medication for ALS, which is also ... Boston Channel.com

Fresno doctor joins ALS study  -  ‎Dec 27, 2009‎
So far, only one drug -- riluzole -- has been approved by the federal Food and Drug Administration to slow progression of the disease. ... Fresno Bee

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
...anxiolytics (alprazolam), the opioid antagonists naloxone and naltrexone, and miscellaneous other drugs (eg clonidine or riluzole). ... British Journal of Psychiatry

Olesoxime has the potential to revolutionise treatment of ALS and other orphan ...  -  ‎Nov 10, 2009‎
Drug interaction studies with riluzole, the only registered treatment for ALS, showed no interaction of TRO19622 on riluzole pharmacokinetics. ... Therapeutics Daily (press release) (registration)

What is Lou Gehrig Disease?  -  ‎Oct 25, 2009‎
The drug riluzole may add 3 months to life expectancy. Creatine may help improve strength. Physical, occupational, and speech therapy are helpful. ... 24 Medica

The bright side of cancer treatment?  -  ‎Oct 22, 2009‎
To slow the disease's progression, the guidelines advocate the use of the drug riluzole. They also say that people may live longer and have a better quality ... Belleville News Democrat

Avanir Pharmaceuticals Announces Zenvia Safety and Efficacy Data from Star ...  -  ‎Nov 10, 2009‎
Riluzole prescribing information, Sanofi-Aventis (survival time from initiation of therapy) 4. Testa D, et al, Amyotroph Lateral Scler Other Motor Neuron ... RTT News (press release)

정형외과학회, ì˜?문학술지 SCI 등재 추진  -  ‎Oct 19, 2009‎
...만례재단 본�� '�� 척수 ��후 메틸프레드니솔론과 Riluzole� 투여가 축색 재�� 미치는 �향'� 발표한 �창화 순천향�대 �수와 양준� 충남�대 �수팀�게 ... KMA Times

Treatments for other ailments mulled for use against manic depression  -  Sep 2, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... USA Today

An Association Study of Riluzole Serum Concentration and Survival and...  -  Apr 19, 2007
Patients with amyotrophic lateral sclerosis (ALS) who are treated with the antiglutamatergic drug riluzole receive a fixed-dose regimen of 50 mg bid The ... Nature.com

Drug Proves Effective in Slowing Melanomas  -  Apr 15, 2008
Riluzole (brand name Rilutek) inhibits the release of glutamate. ... With low toxicity likely, riluzole could potentially be given for long periods of time ... Washington Post

Amyotrophic Lateral Sclerosis - Symptoms, Diagnosis, Treatment of …  -  Sep 11, 2008
The first drug treatment for the disease is a medicine called riluzole. Riluzole may prolong life, but does not reverse or stop the disease from getting ... New York Times

Atlanta health, diet and fitness news | ajc.com  -  Jul 30, 2005
The Yale research team tested the study participants with a drug called riluzole, which modulates glutamate content. Riluzole has been effective in treating ... Atlanta Journal Constitution

Cell Protein Might Help Treat ALS  -  Nov 28, 2007
For comparison purposes, Riluzole increases the lifespan of humans affected by ALS by about 60 days, the scientists noted. Treatment with Hsp70 -- which was ... Washington Post

… Court of Appeals Remands Earlier Riluzole Patent Validity Decision...  -  Nov 22, 2006
IMPAX Laboratories, Inc. (OTC: IPXL) ("IMPAX" or "the Company") today announced that the United States Court of Appeals for the Federal Circuit ruled that ... Genetic Engineering News - Genetic Engineering News (press release)

Riluzole (Systemic).(Drug overview)  -  May 1, 2006
Riluzole (RIL-yoo-zole) is used to treat patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Riluzole is not a cure for ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Riluzole (Systemic).  -  Oct 27, 2005
Riluzole (RIL-yoo-zole) is used to treat patients with amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease. Riluzole is not a cure for ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Chronic riluzole treatment increases glucose metabolism in rat...  -  Feb 19, 2008
This work was supported in part by grants from the National Institutes of Health, NIMH 1K02 MH076222 (GS), NIMH R01 MH071676 (GS), NIDDK R01 DK027121 (KB), ... Nature.com

Protein might lead to new ALS treatment  -  Dec 3, 2007
...total lifespan by 10 percent -- significantly more than the drug Riluzole, the only ALS treatment approved by the US Food and Drug Administration. ... United Press International

NNIPPS: No Benefit of Riluzole on Survival in MSA and PSP  -  Jun 7, 2007
June 7, 2007 (Istanbul) — A randomized trial of the neuroprotectant drug riluzole (Rilutek, Sanofi-Aventis) in patients with the "Parkinson plus syndromes" ... Medscape

… Drug Reaction; Minocycline and riluzole combination therapy safe  -  Nov 29, 2005
2005 NOV 29 - (NewsRx.com) -- Minocycline and riluzole combination therapy is safe for patients with amyotrophic lateral sclerosis (ALS). ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Lithium slows ALS progression  -  Feb 4, 2008
At the end of a 15-month trial that began in October 2005, about 30 percent of the patients that took riluzole, a drug known to have modest benefit in ALS, ... News-Medical.net

ALS Drug Riluzole has several important potential uses in patients w ...  -  Mar 14, 2007
1. Altered glutamate levels first found in obsessive compulsive disorder which affects 2-3% of the population worldwide. Riluzole also shown to be effective ... Gerson Lehrman Group

United States Federal Circuit Court of Appeals Reports - IMPAX LAB....  -  Nov 20, 2006
...fn1] Aventis owns the '814 patent, which involves the use of riluzole to treat ALS. Aventis sells riluzole under the trade name Rilutek. ... Pay-Per-View - United States Federal Circuit Court of... - Loislaw

Treatment Implications for Melanoma with ALS Drug Explored  -  Apr 4, 2008
Riluzole is used in those being treated for ALS, commonly known as Lou Gehrig's disease, which affects nerve cells in the brain and spinal cord. ... newswise.com

Study Shows Antibiotic Harms ALS Patients  -  Nov 1, 2007
Only one drug, Riluzole, has been approved by the US Food and Drug Administration for treatment of ALS. It provides a slight improvement in survival time. ... HealthCentral.com

Clinical: Motor neurone disease - part two  -  Mar 31, 2006
There is no cure, but riluzole modestly prolongs survival. ... Riluzole modestly prolongs survival and is approved by NICE for prescription by a neurologist ... Pay-Per-View - GP - Factiva, from Dow Jones

United States Federal Circuit Court of Appeals Reports - IMPAX v. …  -  Oct 3, 2008
I The ′814 patent relates to the use of riluzole to treat amyotrophic lateral ... The trial court rejected the notion that "the mere mention of riluzole is ... Pay-Per-View - United States Federal Circuit Court of... - Loislaw

United States: Prior Art Patent´s Dosage Guidelines Failed To Provide...  -  Dec 28, 2008
The '814 patent relates to the use of riluzole to treat Lou Gehrig's disease or amyotrophic lateral sclerosis ("ALS"). Impax Laboratories, Inc. ("Impax") ... Mondaq News Alerts - Mondaq News Alerts (Registration)

Julian FR Paton, Ana PL Abdala, Hidehiko Koizumi, Jeffrey C Smith & …  -  Feb 12, 2006
...(a–e) Examples of phrenic, central vagal and hypoglossal motor nerve activity, recorded simultaneously before (left) and after application of riluzole in a ... Nature.com

Early Clinical Trial Results Back New Drug For Melanoma  -  Apr 18, 2008
..."We fixed on riluzole because it is a known inhibitor of glutamate release, ... Moving forward with animal studies, riluzole demonstrated the same ... sciencedaily.com

Loislaw Federal District Court Opinions - IMPAX LABORATORIES, INC. v....  -  Jul 19, 2007
Since that time, Impax has been enjoined from marketing generic riluzole tablets ... Aventis contends that the exclusion of riluzole cannot be sufficient to ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

《探索》æ?‚志评出2008å¹´100大科学故事(三)  -  Dec 30, 2008
...在研究中,他们招募了44å??肌è?Žç¼©ä¾§ç´¢ç¡¬åŒ–患者,所有这些患者都æœ?用力如泰(riluzole, 这是目å‰?唯一被è¯?实对肌è?Žç¼©ä¾§ç´¢ç¡¬åŒ–有一定作用的è?¯ç‰©ã€‚) 44å??å?—试者中的16ä½?肌 ... æ–°å?Žç½‘

ALS drug appears to ease resistant depression.(News)(amyotrophic …  -  Feb 1, 2007
NEW YORK -- Riluzole, a drug for amyotrophic lateral sclerosis that targets ... Riluzole is a fairly unknown medication approved by the Food and Drug ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

United States: Anticipatory Prior Art Reference Must Enable Invention...  -  Mar 12, 2008
Aventis markets riluzole under the trade name RILUTEK. Impax Laboratories, Inc. filed an Abbreviated New Drug Application (ANDA) with the FDA seeking ... Mondaq News Alerts - Mondaq News Alerts (Registration)

A Twitch of Potential  -  Apr 24, 2006
Experts' understanding of the disease remains sketchy, and riluzole falls way ... Starting patients earlier on riluzole, which works by blocking the effects ... TIME

Medication eases obsessive-compulsive symptoms  -  Jul 29, 2005
Seven of the patients treated with riluzole experienced a 35 percent ... "The use of glutamate modulating agents, such as riluzole, may represent a novel ... PsychCentral.com

Press Release: A Lack of New Entrants, And the Possibility of...  -  Feb 6, 2008
The ... treatment for ALS, Sanofi-Aventiss Rilutek (riluzole), facing generic ... polytherapy, results in Sanofi-Aventiss Rilutek (riluzole) dominating ... Pay-Per-View - M2 Presswire - HighBeam Research

Anticipatory Prior Art Reference Must Enable Invention Without Undue ...  -  Dec 3, 2008
Aventis markets riluzole under the trade name RILUTEK. Impax Laboratories, Inc. filed an Abbreviated New Drug Application (ANDA) with the FDA seeking ... $9.94 - Mondaq Business Briefing - Alacra Store

Test reveals effectiveness of potential Huntington's disease drugs  -  Oct 30, 2006
A test using cultured cells provides an effective way to screen drugs against Huntington's disease and shows that two compounds – memantine and riluzole ... PhysOrg.com

Amyotrophic Lateral Sclerosis; Study falls short of showing efficacy...  -  Jul 26, 2005
Keywords: Paris, France, ALS, Alpha Tocopherol (vitamin E), Amyotrophic Lateral Sclerosis, Diet and Nutrition, Drugs, Pharmaceuticals, Riluzole, Therapy. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Medication Eases OCD Symptoms  -  Aug 22, 2005
Coric and colleagues tested riluzole, a glutamate modulating agent, ... Seven of the patients treated with riluzole experienced a 35-percent reduction in ... Connecticut Business News Journal

A case of celiac disease mimicking amyotrophic lateral sclerosis  -  Apr 6, 2007
No drugs, including riluzole or other agents with neuroprotective potential, were given. At a follow-up examination 9 months after initiation of treatment, ... Nature.com

Delving into Depression.  -  Dec 31, 2006
A drug called riluzole, which is already used to treat Lou Gehrig's ... The efficacy of riluzole on depression suggests that depression may be linked to a ... Free with registration - New Haven Register - AccessMyLibrary.com

Growing Pains for Metabolomics  -  Apr 25, 2005
More importantly, Metabolon has also analyzed the cellular effects of riluzole, the only drug approved for treating ALS. Riluzole can provoke an array of ... Scientist

United States, Intellectual Property, Prior Art Need Not Be "Effective...  -  Aug 1, 2007
Riluzole is the chemical compound 6-trifluoromethoxy-2-benzothiazolamine, ... 5527814 (the '814 patent), with claims directed to the use of riluzole to ... Mondaq News Alerts - Mondaq News Alerts (Registration)

Emerging Bipolar Therapies  -  Sep 11, 2007
Riluzole has been shown to have antidepressant properties in a number of recent ... Riluzole was tested for bipolar depression by Dr. Husseini Manji and ... PsychCentral.com

Test Reveals Effectiveness of Potential Huntington's Disease Drugs  -  Oct 26, 2006
However, a drug called memantine, which is used to treat Alzheimer's disease, and riluzole, used in amyotrophic lateral sclerosis, did protect the cells. ... newswise.com

Managing motor neurone disease  -  Sep 7, 2005
...recent changes in care, such as management in multidisciplinary teams, increased use of tube feeding and assisted ventilation, and the drug riluzole, ... Pay-Per-View - The Practitioner - Factiva, from Dow Jones

Scientists Test New Bipolar Remedies | Article from AP Online | …  -  Sep 3, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Is pentoxifylline safe and effective in patients with amyotrophic...  -  Mar 3, 2006
Pentoxifylline therapy was associated with reduced survival in ALS patients who also received riluzole; pentoxifylline had no effect on the rate of ... Nature.com

Prior Art Need Not Be "Effective" To Be Enabling And Thus Anticipating...  -  Jan 8, 2007
Riluzole is the chemical compound 6-trifluoromethoxy-2-benzothiazolamine, ... 5527814 (the '814 patent), with claims directed to the use of riluzole to ... $9.94 - Mondaq Business Briefing - Alacra Store

Scientists Discover Why Animal Studies May Lead to Ineffective ALS …  -  Jan 22, 2008
The study included the drug riluzole, the only drug approved by the US Food and ... The therapeutic effect of the FDA-approved drug riluzole is known to be ... Free with registration - PR Newswire - AccessMyLibrary.com

New Bipolar Disorder Treatments Tested | Article from AP Online | …  -  Sep 2, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Scientists Test New Bipolar Remedies | Article from AP Online | …  -  Sep 3, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

New Bipolar Disorder Treatments Tested | Article from AP Online | …  -  Sep 2, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Why hasn't neuroprotection worked in Parkinson's disease?  -  Dec 13, 2006
The most notable of these studies have been of selegiline hydrochloride with or without vitamin E, 1, 2 riluzole, 3 coenzyme Q10, 4 and, recently, ... Nature.com

EUR 7 Million Grants Boost Trophos Cholesterol-oxime Programs For …  -  Dec 23, 2008
Drug interaction studies with riluzole, the only registered treatment for ALS, ... The only drug approved for ALS is riluzole (Sanofi-Aventis), ... Medical News Today - Medical News Today (press release)

Seasickness patches, other drugs being tested for bipolar disorder  -  Sep 4, 2007
That's the story with riluzole, now used to treat the paralyzing disorder Lou ... So the researchers tried riluzole in a small number of depressed bipolar ... Orangeburg Times Democrat

DepressionComfortably numb : Article : Nature  -  Oct 12, 2006
Another candidate, riluzole — already used in patients with Lou Gehrig's ... Patients taking the drug have reported some improvement, but riluzole has yet ... Nature.com

Research Suggests New Direction for ALS Treatment  -  Nov 20, 2007
The mice were treated with either a placebo, Riluzole, or Hsp70, a protein made by the cells of ... In humans, Riluzole increases lifespan by about 60 days. ... newswise.com

Govt mulls framing guidelines to prevent misuse of INNs  -  May 26, 2005
In April 2005, the WHO asked the DCGI to prevent approval of brand name Riluzole by Rajvi Vipul Bhagat, Mumbai as Riluzole is an INNs. ... Express Pharma

Inland News | PE.com | Southern California News | News for Inland …  -  Dec 25, 2006
Riluzole, the only medication prescribed for ALS, offers only to prolong ... De Luca is not taking Riluzole. With what's known about ALS providing a grim ... Press-Enterprise

Amyotrophic Lateral Sclerosis (ALS) - Treatment Overview  -  Aug 14, 2008
A medicine called riluzole (Rilutek) may prolong survival by about 2 months. ... Riluzole is the only medicine approved for the treatment of ALS. WebMD

Experimental Therapies Hold Promise for Treating Amyotrophic Lateral ...  -  Mar 2, 2005
Although numerous agents have been tested for their efficacy against amyotrophic lateral sclerosis (ALS), only one to date—riluzole—has been shown to slow ... Journal of American Medical Association - Journal of American Medical Association...

Red Herring's Bioscience Report  -  Jan 30, 2007
But right now, Aventis Pharmaceuticals' Riluzole is the only US ... The problem with Riluzole is that it only extends the lives of patients three months, ... Red Herring

Ausschalten eines Gens verlängert das Leben von Mäusen mit ALS  -  Oct 9, 2007
Es gibt keine Heilung und das einzige verfügbare Medikament, Riluzole, verlangsamt den Verlauf lediglich um einige Monate. Mäuse entwickeln ALS-Symptome, ... Tagesspiegel

EE.UU.- Inyecciones de una proteína natural aumentan un 10% la vida …  -  Nov 27, 2007
Los ratones fueron tratados con un placebo Riluzole o Hsp70 una proteína que producen las ... En los humanos el Riluzole aumenta la vida en unos dos meses. ... Medicinatv.com

Is vitamin E useful for the prevention or treatment of Amyotrophic...  -  Feb 1, 2005
They were all treated with Riluzole. They were randomly assigned to receive either vitamin E (5000 mg/d) or placebo for 18 months. ... Pay-Per-View - Neurology Alert - Factiva, from Dow Jones

Leo Greene: Lithium treatment offers tentative hope for PALS  -  Jan 26, 2008
Not everyone in Humberto's and Karen's trial is taking Riluzole along with the ... Riluzole was thought to have been included in the trial because most ... Inland Valley Daily Bulletin

Researcher receives grant from MDA.  -  Dec 20, 2006
Only one drug, riluzole, is on the market to treat ALS; it costs more than $1000 a ... Riluzole, he said, is "not anywhere near as effective as we'd like. ... Free with registration - Daily Oklahoman - AccessMyLibrary.com

BODY BLOW  -  Feb 23, 2005
Some sufferers use Rilutek (also known as Riluzole), a drug said to stem the ... Riluzole (also known as Rilutek) has a modest impact on life expectancy, ... Pay-Per-View - Nelson Mail - Factiva, from Dow Jones

7 millions d'euros de subventions dopent les programmes de cholesterol...  -  Dec 19, 2008
Les études d'interaction de médicament avec le Riluzole, seul traitement ... Le seul médicament approuvé pour la SLA est le Riluzole (Sanofi-Aventis), ... Le fermenteur à bioréaction

IMPAX Laboratories Announces The United States Court of Appeals …  -  Nov 28, 2006
...(riluzole) 50mg tablets was approved on January 29, 2003. IMPAX expects to request that the injunction preventing the Company from launching its generic ... Free with registration - M2 Presswire - AccessMyLibrary.com

Article: Body blow; The anatomy of a killer disease - The Nelson Mail...  -  Feb 23, 2005
Some sufferers use Rilutek (also known as Riluzole), a drug said to stem the ... Riluzole (also known as Rilutek) has a modest impact on life expectancy, ... Pay-Per-View - Nelson Mail - HighBeam Research

New Clinical Trials Could Open 'Golden Era' In Spinal Cord Injury And...  -  Nov 9, 2007
Riluzole, now used to treat people with amyotrophic lateral sclerosis (ALS), prevents neurons from releasing too much sodium. In lab animal studies, ... sciencedaily.com

ALS Patients Experience Slower Disease Progression, Are Living Longer  -  Aug 29, 2006
In addition, more patients in this group received the drug riluzole and underwent noninvasive ventilation (NIV) therapy. On the other hand, patients in the ... Medscape

Emory scientists use NIH grant to develop biomarkers for ALS tracking...  -  Aug 16, 2007
Currently only one drug, riluzole, is effective in treating ALS. Riluzole is aimed at relieving symptoms, preventing complications and optimizing patients' ... eurekalert.org

A Case of Celiac Disease Mimicking Amyotrophic Lateral Sclerosis  -  Oct 4, 2007
No drugs, including riluzole or other agents with neuroprotective potential, were given. At a follow-up examination 9 months after initiation of treatment, ... Medscape

MARKET`S NEWS- GAINERS & HIGH VOLUME PROFILES: IPXL, …  -  Nov 28, 2006
IMPAX's ANDA for its generic version of Rilutek(R) (riluzole) 50mg tablets was approved on January 29, 2003. IMPAX expects to request that the injunction ... Free with registration - M2 Presswire - AccessMyLibrary.com

Motor neurone disease drug more available  -  Feb 5, 2007
...“While riluzole is not a cure, it is the only treatment available for people diagnosed with ALS, a form of motor neurone disease, and can extend survival by ... Pharmacy News

Healthcare Republic - Search results for guideli  -  Mar 31, 2006
USE OF RILUZOLE Riluzole is a sodium channel blocker and its use has been shown to be associated... Read more. Click on a filter below to refine your search ... Healthcare Republic - Healthcare Republic

Impax Loses Generic Rilutek Case  -  Aug 7, 2007
At the time there was no riluzole patent listed in the FDA's Orange Book, according to appeals court documents. Impax filed suit in 2002 seeking a ... FDA news - FDA news (subscription)

Article - TechJournal South - The Southeast's Source for Technology …  -  Aug 21, 2007
Currently only one drug, riluzole, is effective in treating ALS. Riluzole is aimed at relieving symptoms, preventing complications and optimizing patients' ... TechJournal South - TechJournal South

Treatment Options for Bipolars  -  Jun 29, 2008
I am now on depakote and riluzole. riluzole they use off lable for bipolar depression. It is used for leugarigs disease NOt sure of spelling ... HealthCentral.com

Orphan Drug Approvals Increasing, Report Says  -  May 1, 2006
Riluzole is the first drug to show any increase in survival for ALS patients, the report said. Another important drug, Genzyme's Fabrazyme (agalsidase beta) ... Pay-Per-View - Washington Drug Letter - Factiva, from Dow Jones

Adesivos contra enjôos podem ser a nova arma contra o transtorno …  -  Sep 3, 2007
Outro possível tratamento foi descoberto em uma droga chamada riluzole, ... Ao ser testada em pacientes bipolares, a riluzole fez com que os sintomas da ... Terra Brasil

Amyotrophic lateral sclerosis (ALS).(Adult Health Advisor 2006)(Diseas...  -  Nov 1, 2006
One medicine, riluzole (Rilutek), is sometimes used for treatment. ... Ask your health care provider if riluzole would be recommended in your case. ... $4.95 - Clinical Reference Systems - ECNext

Press Release: Avicena Reports Second Quarter 2007 Results. - PR …  -  Aug 31, 2007
Article: RILUTEK (riluzole) CLEARED FOR USE IN 15 COUNTRIES OF EUROPEAN ... ... Article: IMPACT OF RILUTEK (TM) (riluzole) ON SURVIVAL IN ... ... Pay-Per-View - PR Newswire - HighBeam Research

Researcher receives grant from MDA. | Article from Daily Oklahoman ( …  -  Dec 20, 2006
Only one drug, riluzole, is on the market to treat ALS; it costs more than $1000 a ... Riluzole, he said, is "not anywhere near as effective as we'd like. ... Pay-Per-View - Daily Oklahoman - HighBeam Research

Amyotrophic lateral sclerosis (ALS).(Adult Health Advisor 2007)(Diseas...  -  May 31, 2007
One medicine, riluzole (Rilutek), is sometimes used for treatment. ... Ask your healthcare provider if riluzole would be recommended in your case. ... $4.95 - Clinical Reference Systems - ECNext

Press Release: Trophos successfully completes Phase Ib ALS clinical …  -  Dec 7, 2006
The only drug approved for ALS is riluzole (Sanofi-Aventis), which has been demonstrated to give some survival benefit to ALS patients. ... Pay-Per-View - M2 Presswire - HighBeam Research

Trophos successfully completes Phase Ib ALS clinical trials for...  -  Dec 7, 2006
The only drug approved for ALS is riluzole (Sanofi-Aventis), which has been demonstrated to give some survival benefit to ALS patients. ... $4.95 - M2 Presswire - ECNext

Amyotrophic lateral sclerosis (ALS).(disease overview)(Disease/Disorde...  -  May 24, 2006
One medicine, riluzole (Rilutek), is sometimes used for treatment. ... Ask your health care provider if riluzole would be recommended in your case. ... $4.95 - Clinical Reference Systems - ECNext

Motor neurone disease  -  Jun 1, 2006
Riluzole, a medicine that inhibits the production of glutamate, has been shown ... Even in cases where Riluzole has proven effective it has only slowed the ... Pay-Per-View - Cover - Factiva, from Dow Jones

Smog's heavy impacts.(ENVIRONMENT)(Brief article) | Article from …  -  Jan 5, 2008
Article: Drug extends life of Lou Gehrig patients. (riluzole advances ... ... 202). That study suggested that riluzole worked primarily in people whose ... ... Pay-Per-View - Science News - HighBeam Research

Drug shows promise against Lou Gehrig's disease, OMRF finds | Article...  -  Mar 29, 2006
Riluzole is the only drug approved by the Food and Drug Administration for ALS. Clinical trials are being conducted on thalidomide in the United States and ... Pay-Per-View - Journal Record - HighBeam Research

Drug shows promise against Lou Gehrig's disease, OMRF finds  -  Mar 29, 2006
...p><p>Riluzole is the only drug approved by the Food and Drug Administration for ALS. Clinical trials are being conducted on thalidomide in the United States ... $2.95 - Journal Record - NewsBank

Drug fails in US study to help people with ALS  -  Nov 24, 2008
PA) riluzole, or Rilutek, is the only medication approved by the US Food and Drug Administration for ALS and it seems to slow the disease's progression and ... Reuters

Motor neurone disease killed my father  -  Aug 11, 2008
The one drug on the market - Riluzole - has a marginal effect. It slows the wasting of muscles by two months, which means roughly the same period without a ... Times Online

When Worry Hijacks The Brain  -  Aug 2, 2007
The best medication so far, riluzole, was originally developed for Lou Gehrig's disease and works simply by turning down the glutamate spigot, reducing the ... TIME

Why GPs have to patronise their patients  -  May 24, 2008
...the place of riluzole in its treatment and the likelihood of developing an associated dementia to a consumer-friendly soundbite to allow the recently ... Times Online

Article: For Free: Super Advice - The Washington Post | HighBeam …  -  Jan 31, 2005
Center operates within the Johns Hopkins School of Medicine in Baltimore ... Riluzole was developed at Johns Hopkins and is the only drug to ... ... Pay-Per-View - Washington Post - HighBeam Research

ALS remains unrelenting, and there's no cure in sight  -  Aug 20, 2006
Riluzole (Rilutek), the first and only medication to be approved by the Food and Drug Administration for treatment of ALS, has been shown in research ... Pay-Per-View - Chicago Tribune - ProQuest Archiver

Hello, Good Buys: Four Sites That Offer Fare Help | Article from The ...  -  Sep 10, 2006
Riluzole was distributed free of charge during the testing phase; the company has not yet announced what price it intends to charge now that the drug is to ... Pay-Per-View - Washington Post - HighBeam Research

Antioxidant fights ALS, study finds  -  Dec 4, 2008
Only one drug, riluzole, has been approved to treat the disease, and that only slows its course by two months, said Fred Gage, the genetics professor who ... San Diego Union - Tribune - San Diego Union Tribune

A life without fear  -  Feb 11, 2007
Treatment: There is only one FDA-approved drug to treat ALS: riluzole. It extends life for up to a few months. A one-month dosage costs around $1000. ... Seattle Times

Fighting back against ALS  -  Jan 15, 2006
At present, ALS is totally untreatable; there is only one drug - known commercially as Rilutek and generically as riluzole - that has been approved by the ... Jerusalem Post

Brand Names/Synonyms:
Riluzole is also known by the following brand names and/or synonymsRilutek; Riluzole; Riluzole Hcl

Drug Category:
Riluzole is categorized under the following by the FDA: Neuroprotective Agents; Anticonvulsants; Anesthetics; Central Nervous System Agents; ATC:N07XX02

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
6-(trifluoromethoxy)benzothiazol-2-amine





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