Rosiglitazone maleate

This page contains recent news articles, when available, and an overview of Rosiglitazone maleate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Rosiglitazone maleate
(when available)

Pharmacology and use:
Rosiglitazone, a member of the drug group known as the thiazolidinediones or "insulin sensitizers", is not chemically or functionally related to the alpha-glucosidase inhibitors, the biguanides, or the sulfonylureas. Rosiglitazone targets insulin resistance and, hence, is used alone or with metformine or sulfonylurea to improve glycemic control in patients with type 2 diabetes mellitus. For the treatment of Type II diabetes mellitus

Mechanism Of Action:
Rosiglitazone acts as an agonist at peroxisome proliferator activated receptors (PPAR) in target tissues for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR-gamma receptors regulates the transcription of insulin-responsive genes involved in the control of glucose production, transport, and utilization. In this way, rosiglitazone enhances tissue sensitivity to insulin.

News Articles on Rosiglitazone

New research finds physicians seek more novel diabetes drugs  -  ‎Dec 17, 2009‎
...which is not surprising given the cardiovascular safety concerns associated with GlaxoSmithKline's Avandia (rosiglitazone maleate) and the more recent ... Drug Store News (blog)

Avandia(R) (rosiglitazone Maleate) Reduced Risk Of Progression From …  -  Sep 16, 2006
In thelargest completed diabetes-prevention trial to date, Avandia(R) (rosiglitazone maleate) reduced the risk of developing type 2 diabetes by 62 percent ... Medical News Today - Medical News Today (press release)

… to revise Avandia® (rosiglitazone maleate) label in Europe...  -  Jan 26, 2008
GlaxoSmithKline (GSK) announced today that it will revise its European label for Avandia® (rosiglitazone maleate). The EMEA's Committee for Medicinal ... webwire.com

… The Launch Of Avandamet(R) (Rosiglitazone Maleate And Metformin...  -  Jul 14, 2006
It is a combination of two drugs - rosiglitazone maleate and metformin HCl. A small number of people who have taken metformin, one of the components of ... Medical News Today - Medical News Today (press release)

FDA Approves Avandamet(R) (rosiglitazone Maleate And Metformin HCl) …  -  Jul 16, 2006
GlaxoSmithKline announced today FDA approval of Avandamet (R) (rosiglitazone maleate and metformin HCl) for use as initial treatment of type 2 diabetes as ... Medical News Today - Medical News Today (press release)

METFORMIN AND ROSIGLITAZONE (Oral route) - met-FOR-min hye-droe …  -  May 1, 2007
Treatment with rosiglitazone maleate and metformin hydrochloride should not ... Once a patient is stabilized on any dose level of rosiglitazone maleate and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

New Data Show Avandia(R) (rosiglitazone maleate) May Reduce Blood …  -  Jun 13, 2005
SAN DIEGO, June 11 /PRNewswire/ -- New research presented today at the 65th Annual Scientific Sessions of the American Diabetes Association (ADA) suggests ... $4.95 - PR Newswire - ECNext

Data Affirms Avandia (Rosiglitazone Maleate) Cardiovascular Safety …  -  May 30, 2007
PHILADELPHIA and LONDON, May 30 /PRNewswire-FirstCall/ -- GlaxoSmithKline today confirms that a letter to the editor summarizing additional Avandia ... RedOrbit

… Treated With Avandia(R) (Rosiglitazone Maleate) Incurred Lower...  -  Jun 24, 2007
Important Safety Information for Avandia(R) (rosiglitazone maleate) Avandia, along with diet and exercise, helps improve blood sugar control. ... Free with registration - PR Newswire - AccessMyLibrary.com

… of Initial Use of Rosiglitazone Maleate and Glimepiride Combination...  -  Jun 21, 2006
Avandaryl is a combination of two drugs – rosiglitazone maleate and glimepiride. Avandaryl may cause low blood sugar. Lightheadedness, dizziness, shakiness ... DG News

Avandia - Rosiglitazone maleate - Medical Drug  -  Sep 7, 2008
Avandia is used in the treatment of type 2 diabetes mellitus. Avandia can be used as a single drug in treating diabetes mellitus, or it can be used in ... Virtual Medical Centre - The Virtual Medical Centre

New Data Show Avandia(R) (rosiglitazone maleate) May Reduce Blood …  -  Jun 11, 2005
SAN DIEGO, June 11 /PRNewswire-FirstCall/ -- New research presented today at the 65th Annual Scientific Sessions of the American Diabetes Association (ADA) ... $4.95 - PR Newswire - ECNext

… of Initial Use of Avandaryl(R) (Rosiglitazone Maleate and Glimepiri...  -  Jun 10, 2006
Avandaryl is the only therapy available that combines a thiazolidinedione (TZD), rosiglitazone maleate -- separately marketed as Avandia(R) -- with a ... RedOrbit

Press Release: Data Affirms Avandia (Rosiglitazone maleate) …  -  May 30, 2007
Data Affirms Avandia (Rosiglitazone maleate) Cardiovascular Safety Profile. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Press Release: GSK Believes There Is No Liver Safety Issue With …  -  Oct 31, 2008
Important Safety Information about AVANDIA(R) (rosiglitazone maleate) ... NYSE: GSK] presentation of data on Avandia(R) (rosiglitazone maleate) to an ... Pay-Per-View - PR Newswire - HighBeam Research

An Association Between Avandia® and Avandamet® and Vision …  -  Dec 23, 2005
MISSISAUGA, ONTARIO, CANADA -- December 23, 2005 -- Avandia(R) (rosiglitazone maleate) tablets and Avandamet(R) (rosiglitazone maleate/metformin ... DG News

… Treated With Avandia(R) (Rosiglitazone Maleate) Incurred Lower...  -  Jun 24, 2007
New Data Show Patients Treated With Avandia(R) (Rosiglitazone Maleate) Incurred Lower Medical Costs and Used Fewer Healthcare Resources When Compared to ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Avandia(R) (rosiglitazone maleate) Reduced Risk of …  -  Sep 15, 2006
Avandia(R) (rosiglitazone maleate) Reduced Risk of Progression From Pre-Diabetes To Type 2 Diabetes by 62 Percent in Largest Completed Diabetes Prevention ... Pay-Per-View - PR Newswire - HighBeam Research

GSK Updates Prescribing Information for Avandia  -  Aug 15, 2007
...the company to implement changes in the label for Avandia (rosiglitazone maleate). ... Avandamet (rosiglitazone maleate and metformin hydrochloride) and ... FDA news - FDA news (subscription)

Press Release: Two Large, Independent Outcomes Trials Offer New …  -  Jun 9, 2008
Article: FDA Approves Avandia(R) (Rosiglitazone Maleate) for Use in ... PR Newswire; March 3, 2003 ; 700+ words ... ... and Drug Administration (FDA) ... Pay-Per-View - PR Newswire - HighBeam Research

… Study Shows Avandia(R) (rosiglitazone maleate) Is More Effective...  -  Dec 4, 2006
Landmark Study Shows Avandia(R) (rosiglitazone maleate) Is More Effective Than Metformin or a Sulfonylurea in Long-Term Blood Sugar Control in Type 2 ... Pay-Per-View - PR Newswire - HighBeam Research

New patent laws lure pharma MNCs to India.  -  Nov 18, 2005
GSK, for instance, plans to launch its blockbuster anti-diabetic drug Avandia (rosiglitazone maleate) soon. This will be the company's first patent ... Free with registration - Economic Times - AccessMyLibrary.com

Teva Announces Settlement of Generic Avandia(R), Avandamet(R), and …  -  Sep 27, 2007
...enter the US market with its generic versions of Avandia[R] (Rosiglitazone Maleate), Avandamet[R] (Rosiglitazone Maleate/Metformin HCl) and Avandaryl[R] ... Free with registration - Business Wire - AccessMyLibrary.com

No sufficient data on heart attack risk for diabetes drug  -  Dec 14, 2007
GSK recently announced that it is implementing changes to the US product label for its type 2 diabetes treatment rosiglitazone maleate. ... Inquirer.net

Avandia Rosiglitazone Maleate Tablets .  -  Aug 20, 2006
Read the Patient that comes with AVANDIA before you start taking the medicine and each time you get a refill. There may be new Information. ... Rome News-Tribune - Google News Archive

Diabetes; Pharmaceutical company gets tentative approval of generic …  -  Jan 21, 2005
Teva's Rosiglitazone Maleate Tablets are the AB-rated generic equivalent of SB Pharmaco's Avandia Tablets. This product is indicated as an adjunct to diet ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

GlaxoSmithKline revises US labeling for Avandia  -  Nov 21, 2007
GlaxoSmithKline announced today that it is implementing changes to the US product label for Avandia® (rosiglitazone maleate), based on an extensive and ... webwire.com

Article: Results support safety of Avandia.(What's New in Diabetes...  -  Jun 30, 2008
It says that this conclusion was reached from the Veterans Affairs Diabetes Trial, in which more than 1700 patients took Avandia (rosiglitazone maleate). ... Pay-Per-View - Chain Drug Review - HighBeam Research

EMEA Recommends New Warnings and Contraindications for …  -  Jan 24, 2007
Rosiglitazone is available in the European Union as Avandia (rosiglitazone maleate), Avandamet (rosiglitazone maleate/metformin) and Avaglim (rosiglitazone ... DG News

… Approval And Availability Of Avandaryl(TM) (rosiglitazone Maleate...  -  Feb 2, 2006
Avandaryl is a combination of two drugs - rosiglitazone maleate and glimepiride. ... The GSK diabetes franchise includes Avandia(R) (rosiglitazone maleate), ... Medical News Today - Medical News Today (press release)

Article: Fed: 30,000 diabetics urged to see doctor - AAP General News...  -  Aug 20, 2008
Avandia (rosiglitazone maleate) is indicated for use in combination with a ... diabetes and for combination use with a sulfonylurea and metformin (triple ... Pay-Per-View - AAP General News - HighBeam Research

What's New With PCOS?  -  Jul 5, 2005
The two active ingredients in Avandamet-rosiglitazone maleate and metformin-are ... Rosiglitazone maleate is available as Avandia, also by GlaxoSmithKline. ... RedOrbit

GSK Revises US Labeling for Avandia(R).  -  Nov 14, 2007
14 /PRNewswire-FirstCall/ -- GlaxoSmithKline announced today that it is implementing changes to the US product label for Avandia(R) (rosiglitazone maleate), ... Free with registration - PR Newswire - AccessMyLibrary.com

EMEA Recommends New Warnings and Contraindications for …  -  Jan 28, 2008
Rosiglitazone is available in the European Union as Avandia (rosiglitazone maleate), Avandamet (rosiglitazone maleate/metformin) and Avaglim (rosiglitazone ... Lifescience-online

… Benefits of Initial Use of Avandaryl(R) (Rosiglitazone Maleate and...  -  Jun 10, 2006
Article: Data Affirms Avandia (Rosiglitazone maleate) Cardiovascular ... PR Newswire; May 30, 2007 ; 700+ words ... ... control in patients with type 2 ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: GlaxoSmithKline Responds to NEJM Article on Avandia. -...  -  May 21, 2007
Article: FDA Approves Avandia(R) (Rosiglitazone Maleate) for Use in ... ... NYSE: GSK] presentation of data on Avandia(R) (rosiglitazone maleate) to an ... Pay-Per-View - PR Newswire - HighBeam Research

Article: FDA approves Merck drug for growing diabetes market. - …  -  Oct 17, 2006
DPP-IV data from Merck and the competition ... rosiglitazone maleate), Merck also presented a meta ... multiple studies of its DPP-IV inhibitor Galvus . ... Pay-Per-View - Philadelphia Inquirer - HighBeam Research

ACTOS® (pioglitazone HCl) significantly improved components of …  -  Jun 29, 2005
ACTOS® (pioglitazone HCl) Avandia® (rosiglitazone maleate) are insulin sensitizers belonging to the thiazolidinedione (TZD) class of oral anti-diabetes ... eurekalert.org

Article: Diabetes drug Avandia carries a warning - Deseret News (Salt...  -  Nov 16, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Deseret News - HighBeam Research

ACTOS(R) (pioglitazone HCl) significantly improved components of …  -  Jun 30, 2005
ACTOS(R) (pioglitazone HCl) Avandia(R) (rosiglitazone maleate) are insulin sensitizers belonging to the thiazolidinedione (TZD) class of oral anti-diabetes ... Medical News Today - Medical News Today (press release)

Rosiglitazone may delay onset of proliferative diabetic retinopathy,...  -  Jun 12, 2008
Rosiglitazone maleate, an oral peroxisome-proliferating activated receptor gamma-agonist, may delay the onset of proliferative diabetic retinopathy and ... OSN SuperSite

GlaxoSmithKline PLC - Avandia Positive ADOPT Result.  -  Dec 4, 2006
Every ten seconds, a person dies from diabetes-related causes.23 Important Information Regarding Avandia (rosiglitazone maleate) Globally, ... Free with registration - Europe Intelligence Wire - AccessMyLibrary.com

SCOLR Pharma, Inc. Files Provisional Patent for Rosiglitazone  -  Jul 11, 2005
Rosiglitazone is the active pharmaceutical ingredient used in the prescription drugs Avandia(R) (Rosiglitazone maleate) and Avandamet(R) (Metformin ... businesswire.com

Article: Study links diabetes drug Avandia with greater risk of heart...  -  May 22, 2007
Article: FDA Approves Avandia(R) (Rosiglitazone Maleate) for ... PR Newswire; March 3, 2003 ; 700+ words ... ... Food and Drug Administration (FDA) approved ... Pay-Per-View - Washington Times - HighBeam Research

PULSE  -  Jan 29, 2006
The generic name for Avandia is rosiglitazone maleate, which also is used in Avandamet, a combination drug for diabetes. Both are made by pharmaceutical ... Pay-Per-View - Tampa Tribune - ProQuest Archiver

FDA Approvals: Avelox, Avandaryl, Trileptal  -  Dec 1, 2005
On November 23, the FDA approved rosiglitazone maleate plus glimepiride tablets (Avandaryl, made by SB Pharmco Puerto Rico, Inc, a GlaxoSmithKline company), ... Medscape

Article: Drug-safety 'advocates'.(EDITORIALS) - The Washington Times...  -  Aug 2, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Washington Times - HighBeam Research

DR REDDY'S GETS TENTATIVE US APPROVAL FOR ANTI-DIABETIC …  -  Dec 15, 2005
The tentative approval is for 2mg, 4mg, 8mg strengths of Rosiglitazone maleate. The drug is a generic equivalent of GlaxoSmithKlines Plc's anti-diabetic ... Free with registration - AsiaPulse News - AccessMyLibrary.com

… the Approval and Availability of Avandaryl(TM) (rosiglitazone...  -  Feb 1, 2006
Article: Landmark Study Shows Avandia(R) (rosiglitazone maleate) Is More ... PR Newswire; December 4, 2006 ; 700+ words ... ... delaying the progressive ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: GSK Revises US Labeling for Avandia(R). - PR Newswire …  -  Nov 14, 2007
Article: GlaxoSmithKline's Avandia(R) (rosiglitazone maleate) ... PR Newswire; November 7, 2002 ; 700+ words ... ... GlaxoSmithKline announced today its ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: GlaxoSmithKline Responds to JAMA Articles. - PR …  -  Sep 11, 2007
Article: FDA Approves Avandia(R) (Rosiglitazone Maleate) for Use in ... PR Newswire; March 3, 2003 ; 700+ words ... ... and Drug Administration (FDA) ... Pay-Per-View - PR Newswire - HighBeam Research

GlaxoSmithKline Revises US Labeling For Avandia  -  Nov 19, 2007
GlaxoSmithKline announced that it is implementing changes to the US product label for Avandia® (rosiglitazone maleate), based on an extensive and thorough ... Medical News Today - Medical News Today (press release)

EMEA Statement On Recent Publication On Cardiac Safety Of …  -  May 24, 2007
...maleate) Tablets, Avandamet (rosiglitazone maleate and metformin hydrochloride) Tablets, and Avaglim (rosiglitazone maleate and glimepiride) Tablets are ... Medical News Today - Medical News Today (press release)

Article: Avandia should remain on market, advisers say - Deseret News...  -  Aug 6, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Oakland Tribune - HighBeam Research

Article: Warnings, Not Ban, Urged for Diabetes Drug - The Washington ...  -  Aug 6, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Topeka Capital-Journal - HighBeam Research

Diabetes; Pharmaceutical company gets tentative approval of generic …  -  Jan 17, 2005
Teva's Rosiglitazone Maleate Tablets are the AB-rated generic equivalent of SB Pharmaco's Avandia Tablets. This product is indicated as an adjunct to diet ... Pay-Per-View - Clinical Trials Week - Factiva, from Dow Jones

Press Release: FDA Updates Label for AVANDIA(R) to Include Clinical …  -  Jul 14, 2008
Article: Data Affirms Avandia (Rosiglitazone maleate) ... PR Newswire; May 30, 2007 ; 700+ words ... ... of events - 0.6% for both Avandia and the control ... Pay-Per-View - PR Newswire - HighBeam Research

GSK maintains its stance on Avandia in face of criticism.(Diabetes...  -  Jun 25, 2007
GSK asserts that the conclusions about the drug, also known as rosiglitazone maleate, are based "on incomplete evidence and a methodology that the author ... Pay-Per-View - Chain Drug Review - HighBeam Research

Press Release: Newly Published Data From Large Study Support …  -  Jun 6, 2007
Newly Published Data From Large Study Support Cardiovascular Safety of Avandia (rosiglitazone maleate). from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Press Release: GlaxoSmithKline Responds to Press Release from …  -  May 22, 2007
Chain Drug Review; December 17, 2007 ; 700+ words ... ... that it has changed the product label for Avandia (rosiglitazone maleate), based on an ... alerts ... Pay-Per-View - M2 Presswire - HighBeam Research

Press Release: GlaxoSmithKline Presents Avandia Data To FDA. - PR …  -  Jul 30, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - PR Newswire - HighBeam Research

… Study Support Cardiovascular Safety Of Avandia (rosiglitazone...  -  Jun 7, 2007
It is a combination of two drugs -- rosiglitazone maleate and metformin HCl. A small number of people who have taken metformin, one of the components of ... Medical News Today - Medical News Today (press release)

Press Release: Interim Data From RECORD Study Show No Significant …  -  Jun 5, 2007
Article: Data Affirms Avandia (Rosiglitazone maleate) ... PR Newswire; May 30, 2007 ; 700+ words ... ... editor summarizing additional Avandia ... Pay-Per-View - PR Newswire - HighBeam Research

Patents; Pharma company announces amino acid patent filing  -  Jan 17, 2005
Rosiglitazone is the active pharmaceutical ingredient used in the prescription drugs Avandia (Rosiglitazone maleate) and Avandamet (Metformin ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

IN BRIEF - Pharma/Life sciences  -  Feb 6, 2006
GLAXOSMITHKLINE has received Food and Drug Administration approval for Avandaryl (rosiglitazone maleate and glimepiride), a new fixed-dose combination drug ... ICIS

Article: Avandia to Carry Stronger Warning Label - AP Online |...  -  Jun 7, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: AP Analysis: How a Drug's Risks Emerge - AP Online |...  -  May 23, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: DRUG COMPANIES FACING NEW CHALLENGES SCIENTISTS …  -  May 24, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - Wisconsin State Journal - HighBeam Research

Press Release: More evidence suggests diabetes drug may be …  -  Dec 11, 2007
Chain Drug Review; December 17, 2007 ; 700+ words ... ... that it has changed the product label for Avandia (rosiglitazone maleate), based on an ... alerts ... Pay-Per-View - PR Newswire - HighBeam Research

BRIEF: Teva settles with GSK on diabetes drugs: Teva can start...  -  Sep 28, 2007
...drugs: Avandia (Rosiglitazone Maleate), Avandamet (Rosiglitazone Maleate/Metformin HCl) and Avandaryl (Rosiglitazone Maleate/Glimepiride). ... Pay-Per-View - Globes - HighBeam Research

Press Release: FDA Issues Safety Alert on Avandia. - M2 Presswire | …  -  May 22, 2007
SmithKline Beecham's Avandia (rosiglitazone maleate ... Drug Administration (FDA) for the treatment ... quickly as possible. Avandia Effective and Safe The ... Pay-Per-View - M2 Presswire - HighBeam Research

Article: Avandia deemed 'safe enough'.(Business) - Daily Herald ( …  -  Jul 31, 2007
PR Newswire; June 20, 2002 ; 700+ words ... ... presented today indicate that Avandia(R) (rosiglitazone maleate ... receiving up to 42 months of Avandia as ... Pay-Per-View - Daily Herald - HighBeam Research

European Medicines Agency Confirms Positive Benefit-Risk Balance For ...  -  Oct 19, 2007
Rosiglitazone is available as Avandia (rosiglitazone maleate), Avandamet (rosiglitazone/metformin) and Avaglim (rosiglitazone maleate/glimepiride). ... Medical News Today - Medical News Today (press release)

Major Canadian Type 2 Diabetes Study Shows Significant Improvement …  -  Feb 21, 2006
Rosiglitazone maleate (Avandia®) used alone, or in combination with metformin or a sulfonylurea, along with diet and exercise helps to control blood sugar. ... DG News

Adding a 2nd Glucose Lowering Drug is More Effective than Maximizing...  -  Mar 7, 2006
Rosiglitazone maleate (Avandia®) used alone, or in combination with metformin or a sulfonylurea, along with diet and exercise helps to control blood sugar. ... Diabetes In Control

GSK's Avandaryl available in US  -  Feb 3, 2006
GlaxoSmithKline is launching Avandaryl (rosiglitazone maleate and glimepiride), a new fixed-dose combination product for type 2 diabetes in the United ... pharmabiz.com

SCOLR Pharma files provisional patent for rosiglitazone.(Brief...  -  Jan 3, 2005
...ingredient used in the prescription drugs Avandia (rosiglitazone maleate) and Avandamet (metformin HCl/rosiglitazone maleate) to treat type 2 diabetes. ... $4.95 - Pharma Marketletter - ECNext

Article: Commentary: Office Visit: Watching the watchers - THE...  -  Jul 11, 2007
Article: FDA Approves Avandia(R) (Rosiglitazone Maleate) for ... PR Newswire; March 3, 2003 ; 700+ words ... ... Food and Drug Administration (FDA) approved ... Pay-Per-View - Journal Record - HighBeam Research

GlaxoSmithKline gets FDA approval for Avandament to treat type 2 …  -  Jul 11, 2006
Almost 18 mln Americans have type 2 diabetes, the most common form of diabetes. Avandamet is a combination of two drugs: rosiglitazone maleate and metformin ... Forbes

DR REDDY'S GETS TENTATIVE US APPROVAL FOR ANTI-DIABETIC …  -  Dec 15, 2005
The tentative approval is for 2mg, 4mg, 8mg strengths of Rosiglitazone maleate. The drug is a generic equivalent of GlaxoSmithKlines Plc's anti-diabetic ... $4.95 - AsiaPulse News - ECNext

FDA tentative generics approvals--2005.(Special Report)(Illustration)  -  Feb 27, 2006
Rosiglitazone maleate tablets, 2 mg Dr. Reddy's Laboratories (base), 4 mg (base), and 8 mg (base) Ltd. Rivastigminetartrate capsules, ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Press Release: ACTOS(R) (pioglitazone HCl) Significantly Improved …  -  Jun 29, 2005
Results From the First Head-to-Head Study Between ACTOS and Avandia(R) (rosiglitazone maleate) Published in Diabetes Care ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Avandia under fire; new warning added to label.(Branded...  -  Dec 17, 2007
PHILADELPHIA -- GlaxoSmithKline PLC (GSK) announced that it has changed the product label for Avandia (rosiglitazone maleate), based on an extensive review ... Pay-Per-View - Chain Drug Review - HighBeam Research

BRIEFING - ASIA HEALTH - DEC 15, 2005.  -  Dec 15, 2005
The tentative approval is for 2mg, 4mg, 8mg strengths of Rosiglitazone maleate. S. KOREA TO BEGIN TALKS ON US BEEF IMPORTS, MINISTER SAYS ... $4.95 - AsiaPulse News - ECNext

Press Release: First Global Guidelines Endorse metformin ( …  -  Oct 3, 2005
Avandamet(TM) (rosiglitazone maleate and metformin HCl) for the treatment of type 2 diabetes ... The combination of rosiglitazone and metformin provides two ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: FDA Advisory Panel Votes 22 to 1 for Avandia(R) to …  -  Jul 30, 2007
PR Newswire; May 19, 2000 ; 700+ words ... ... its anti-diabetes drug, Avandia(R) (rosiglitazone maleate ... Endocrinology and Metabolic Advisory Committee ... Pay-Per-View - PR Newswire - HighBeam Research

Article: ADA Avandia recommendations.(Noted) - Pharmaceutical …  -  Dec 1, 2007
According to news announced by the ADA, AVANDIA(R) (rosiglitazone maleate) was used in a majority of patients in the study and was not associated with ... Pay-Per-View - Pharmaceutical Processing - HighBeam Research

Article: Avandamet approved as initial Tx.(PRODUCTS) - Internal …  -  Oct 1, 2006
...find Internal Medicine News articles. Avandamet (rosiglitazone maleate and metformin HC1) is approved for use as initial treatment of type 2 diabet... Pay-Per-View - Internal Medicine News - HighBeam Research

GSK launches Avandaryl in USA.(GlaxoSmithKline PLC)(Brief Article)  -  Feb 6, 2006
UK drug major GlaxoSmithKline has launched Avandaryl (rosiglitazone maleate and glimepiride), a new fixed-dose combination product for type 2 diabetes, ... $4.95 - Pharma Marketletter - ECNext

2糖尿病常用藥女性æœ?用易骨折  -  Mar 13, 2007
...衛生署藥政處指出,這兩種藥物包括rosiglitazone maleate(商å“?å??Avandia梵å¸?雅膜衣錠, ... 藥政處說,å?°ç?£æ ¸å‡†å?«rosiglitazone maleateæˆ?分藥å“?許å?¯è­‰ä¸€å…±ä¹?張, ... è?¯å?ˆæ–°è?žç¶²

PATIENT INFORMATION Rx on  -  Nov 17, 2006
Rosiglitazone Maleate Tablets .Read the Patient Information that comes with AVANDIA the medicine and ... The active ingredient is rosiglitazone maleate. ... Merced Sun-Star - Google News Archive

[쿠키뉴스] ê°“ 구워낸 바삭바삭한 뉴스  -  Jan 31, 2008
...한편, rosiglitazone maleate 경구제(품명: 아반디아정)ì?˜ 경우 ì‹?약청ì?˜ ì?˜ì•½í’ˆ 허가 사항 변경 지시ì—? ë”°ë?¼ ì?¸ìŠ?린과ì?˜ 병용 투여 권장부문ì?´ ì‚­ì œë??다. ... 쿠키뉴스

GlaxoSmithKline says stands firm behind safety of Avandia, disagrees ...  -  May 21, 2007
GlaxoSmithKline PLC said it disagrees with a report in the New England Journal of Medicine regarding the drug Avandia (rosiglitazone maleate), ... Forbes

FDA tentative generics approvals--2005.(Special Report)(Illustration)...  -  Feb 27, 2006
Rosiglitazone maleate tablets, 2 mg Dr. Reddy's Laboratories (base), 4 mg (base), and 8 mg (base) Ltd. Rivastigminetartrate capsules, 1.5Watson Laboratories ... Pay-Per-View - Chain Drug Review - HighBeam Research

Article: Rosiglitazone cuts type 2 incidence in those at high risk:...  -  Oct 15, 2006
Article: Landmark Study Shows Avandia(R) (rosiglitazone maleate) Is ... PR Newswire; December 4, 2006 ; 700+ words ... ... presented at the 19th World ... Pay-Per-View - Family Practice News - HighBeam Research

Press Release: Year in Review: Federal Commitment to Diabetes …  -  Dec 22, 2005
Article: Avandia(R) (rosiglitazone maleate) Reduced Risk of Progression ... PR Newswire; September 15, 2006 ; 700+ words ... ... Sept. ... Pay-Per-View - PR Newswire - HighBeam Research

GSK Believes There Is No Liver Safety Issue With AVANDIA; Responds to...  -  Oct 30, 2008
...(FDA) on AVANDIA(R) (rosiglitazone maleate), a highly effective therapy for treating type 2 diabetes when used in the appropriate patient population. ... RedOrbit

DIABETES DRUG TO STAY ON SHELVES - DESPITE FDA FINDING …  -  Jul 31, 2007
But the panel then voted 22-1 to recommend against pulling Avandia -- rosiglitazone maleate -- from the market, citing a lack of clear conclusions from ... $2.95 - Pittsburgh Post-Gazette - NewsBank

Larger and Longer Trials Needed to Reduce Cardiac Risk in Diabetes …  -  Jul 3, 2008
The FDA recently sent GSK a warning letter for not reporting several postmarketing studies testing Avandia (rosiglitazone maleate), which is a Type 2 ... FDA news - FDA news (subscription)

GSK drug's safety questioned  -  May 22, 2007
Ohio, undertook a meta-analysis of clinical studies comparing patients treated with GSK's Avandia (rosiglitazone maleate) with controls. ... Chemistry World

Senior Citizens at Greater Risk of Heart Failure, Death Taking...  -  Nov 24, 2008
Rosiglitazone maleate and pioglitazone hydrochloride were approved and marketed beginning in 1999. Not long after, it became apparent that these drugs had ... SeniorJournal.com

Brand Names/Synonyms:
Rosiglitazone maleate is also known by the following brand names and/or synonymsAvandia; Rosigliazone Maleate; Rosiglitazone; Rosiglitazone Maleate; Rosiglitazone and Its Intermediates; Rosiglizole

Drug Category:
Rosiglitazone maleate is categorized under the following by the FDA: Vasodilator Agents; Hypoglycemic Agents; Fibrinolytic Agents; Thazolidinediones; ATC:A10BG02

Dosage Forms:
Tablets

Absorption:
The absolute bioavailability of rosiglitazone is 99%. Peak plasma concentrations are observed about 1 hour after dosing. Administration of rosiglitazone with food resulted in no change in overall exposure (AUC), but there was an approximately 28% decrease in Cmax and a delay in Tmax (1.75 hours). These changes are not likely to be clinically significant; therefore, AVANDIA may be administered with or without food.

Interactions:
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Chemical IUPAC Name:
5-[[4-[2-(methyl-pyridin-2-yl-amino)ethoxy]phenyl]methyl]thiazolidine-2,4-dione





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