Rosuvastatin

This page contains recent news articles, when available, and an overview of Rosuvastatin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Rosuvastatin
(when available)

Pharmacology and use:
Rosuvastatin is an antilipemic agent and a competitive HMG-CoA reductase inhibitor effective in lowering LDL cholesterol and triglycerides. It is used to treat primary hypercholesterolemia and mixed dyslipidemia (Fredrickson types IIa and IIb). For the treatment of pure hypercholesterolaemia and mxed hyperlipidaemia

Mechanism Of Action:
Rosuvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, this results in a decrease in mevalonate, a precursor of cholesterol, and a subsequent decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol.

News Articles on Rosuvastatin

Simcere Pharmaceutical Group to Acquire China Manufacturing License for ...  -  ‎Nov 9, 2009‎
Rosuvastatin was first marketed by Astrazeneca as Crestor in 2003 and is an effective statin to treat high cholesterol and related conditions. ... CNNMoney.com (press release)

Statins may reduce severe H1N1 death risk  -  ‎Nov 13, 2009‎
One group will receive the statin rosuvastatin, Crestor, every day for the duration of their hospital stay, and the other group will receive a placebo. ... United Press International

CORONA analysis reopens door for statins in heart failure  -  ‎Nov 3, 2009‎
..."Patients with lower plasma concentrations of NT-proBNP had a lower event rate but seemed to obtain greater benefit from rosuvastatin," according to ... TheHeart.Org

What Risks Are Associated With High-Dose Rosuvastatin?  -  ‎Oct 22, 2009‎
Rosuvastatin, a hydroxy-methylglutaryl coenzyme A reductase inhibitor, is approved in doses ranging from 5 mg to 40 mg daily. [1] Rosuvastatin is a potent ... Medscape

Patients With Type 2 Diabetes Can Reach LDL Target With Single Uptitration of ...  -  ‎Oct 27, 2009‎
In the algorithm, those with a baseline LDL cholesterol level of >2.0 but <2.5 mmol/L were initiated on rosuvastatin 10 mg. If the baseline LDL cholesterol ... DG News

AstraZeneca's CRESTOR approved for treating pediatric patients with HeFH  -  ‎Oct 19, 2009‎
In July, AstraZeneca announced the FDA had granted an additional six-month period of exclusivity to market CRESTOR® (rosuvastatin calcium) for its approved ... News-Medical.net

Protecting patients during influenza season especially important this year  -  ‎Nov 2, 2009‎
Bernard and colleagues are examining the utility of rosuvastatin (Crestor, AstraZeneca) vs. placebo in hospital mortality to 28 days, or time to resolution ... Cardiology Today

SCR: To Acquire Manufacturing License in China for Rosuvastatin (Crestor)  -  ‎Nov 9, 2009‎
Simcere Pharmaceutical Group (SCR) announced an agreement to acquire the manufacturing license in China of Rosuvastatin from Tianjin Tianda Pharmaceutical ... Trading Markets (press release)

Cholesterol Drug Crestor Approved for Children  -  ‎Oct 27, 2009‎
The US Food and Drug Administration (FDA) has approved the use of Crestor, generic name rosuvastatin, for lowering cholesterol for children and teens with a ... eMaxHealth

Buy On-line - crestor side effects  -  ‎Oct 31, 2009‎
Daily use of CRESTOR side effects of rosuvastatin between the elderly patients. You may need legal help. Low those listed above contact your healthcare ... Newstalk ZB

Statin drugs may lower deaths from flu: study  -  ‎Oct 29, 2009‎
Statin drugs include AstraZeneca's Crestor, known generically as rosuvastatin, Bristol-Myers Squibb Pravachol or pravastatin and Merck's Mevacor, ... Reuters

Crestor Reduces Lipids Better Than Pravachol in People With HIV  -  ‎Oct 27, 2009‎
Crestor (rosuvastatin) is better than Pravachol (pravastatin) in reducing triglycerides and low-density lipoprotein (LDL) levels—“bad� cholesterol levels—in ... AIDSmeds.com HIV/AIDS Treatment News

BREAKING NEWS: AstraZeneca sales boosted by swine flu vaccine  -  ‎Oct 29, 2009‎
Turnover from Crestor (rosuvastatin) increased 30% to $1.15 billion and in the USA, total prescriptions increased 25%, compared with 6% for the statin ... Pharma Times

Red Yeast Rice and Hyperlipidemia: How Strong Is the Evidence?  -  ‎Oct 28, 2009‎
For example, in a 2009 study, within 12 months of the initiation of treatment, rosuvastatin was associated with significant regression of carotid ... Medscape

AstraZeneca withdraws filings for lung cancer drug  -  ‎Nov 2, 2009‎
Seroquel (quetiapine) for schizophrenia and cholesterol-lowerer Crestor (rosuvastatin). Just ahead of the marketing submissions, analysts at Jefferies ... Pharmafocus

AZ-BMS launch Onglyza in Europe  -  ‎Oct 19, 2009‎
Also in the US, the FDA has approved AstraZeneca's Crestor (rosuvastatin calcium) for use in children ages 10-17 with genetic disease heterozygous familial ... Pharmafocus

Simcere Pharma收购中国的Rosuvastatin制造许å?¯  -  ‎Nov 10, 2009‎
Simcere Pharma签署å??议,将å?‘Tianjin Tianda Pharmaceutical Co收购中国的Rosuvastatin制造许å?¯ã€‚ æ ¹æ?®å??议,Simcere Pharmaå°†é€?过入股Tianda,以å?ŠTianda转移特定 ... 凤凰网

Simcere Pharmaæ”¶è´­Rosuvastatin在中国的制造许å?¯  -  ‎Nov 9, 2009‎
...(SCR) 7.69 :Simcere Pharma宣布签署å??议,跟Tianjin Tianda Pharmaceutical Co收购中国的Rosuvastatin制造许å?¯ï¼Œå°†é€?过入股Tianda,以å?ŠTianda转移特定技术 ... 凤凰网

FDA одобри rosuvastatin при педиатрична фамилна хиперхолеÑ?теролемиÑ? 20 ...  -  ‎Oct 20, 2009‎
Ð?мериканÑ?ката админиÑ?трациÑ? по храните и лекарÑ?твата (FDA) одобри rosuvastatin (Crestor, AstraZeneca) за употреба при деца на възраÑ?Ñ‚ между 10 и 17 години Ñ? ... DoctorBG.com

í?¬ë ˆìŠ¤í† , 죽ìƒ?ë?™ë§¥ê²½í™”ì¦? 퇴행 재입ì¦?  -  ‎Nov 1, 2009‎
...코스모스(COSMOS, COronary atherosclerosis Study Measuring effects Of rosuvastatin using intravascular ultrasound in Japanese Subjects; ì?¼ë³¸ì?¸ 환ìž?êµ°ì—? 대한 ... 디지틀보사

FDA, AZ 'í?¬ë ˆìŠ¤í† ' 청소년ì—? 사용토ë¡? 허가  -  ‎Oct 20, 2009‎
...김윤ì˜? 기ìž? 미국 FDA는 í?¬ë ˆìŠ¤í† (Crestor: rosuvastatin)를 10-17세 청소년 가족 유전성 고지혈ì¦? 환ìž? 치료ì—? 사용ì?„ PLUTO ìž„ìƒ?연구 ìž?료ì—? 근거해 허가했다. ... 메디포뉴스

'í?¬ë ˆìŠ¤í† ' ì ?ì?‘ì¦? 플러스‧ '심  -  ‎Oct 18, 2009‎
FDA는 PLUTO 시험(Pediatric Lipid-redUction Trial of rOsuvastatin) 결과를 근거로 ì?´ë²ˆì—? ì ?ì?‘ì¦? 추가를 승ì?¸í•œ 것으로 í’€ì?´ë?˜ê³  있다. ... 약업신문

AUDIO: LAS MEDICINAS GENÉRICAS SON ECONÓMICAS PERO ES IMPORTANTE SABER QUE SU ...  -  ‎Oct 29, 2009‎
NO HAY UNA VERSIÓN GENÉRICA DE LA MEDICINA CONTRA EL COLESTEROL CRESTOR(R) (ROSUVASTATIN CALCIUM). CRESTOR, JUNTO CON LA DIETA, SE INDICA PARA RETRASAR LA ... Hispanic PR Wire (Comunicado de prensa)

í??ê²½ 여성ì?˜ CVD risk factor 어떻게 관리할 것ì?¸ê°€?  -  ‎Nov 9, 2009‎
...최근ì—? JUPITER 연구ì—?서 rosuvastatin 20㎎ì?´ 심혈관질환ì?˜ 위험ì?„ ê°?소하는 효과를 보였다. ë² ì?´ìФë?¼ì?¸ì—? 비해 환ìž?ì?˜ LDL 수치가 최소 50% ê°?소하고 hsCRPê°€ ë² ì?´ìФ ... 코리아헬스로그

FDA aprova uso de Crestor® em doentes pediátricos  -  ‎Oct 19, 2009‎
...de aplicação suplementar do fármaco apresentado pela AstraZeneca, que incluiu dados do estudo PLUTO ((Pediatric Lipid-redUction Trial of rOsuvastatin). ... RCM Pharma

Effects of rosuvastatin on atrial fibrillation occurrence ...  -  30 Aug 2009
In patients with chronic heart failure, treatment with rosuvastatin may result in a lower incidence of atrial fibrillation. Atrial fibrillation (AF) is the Cardiosource

Lower cholesterol naturally without statins  -  ‎Aug 27, 2009‎
Some well-known statins include atorvastatin (Lipitor), simvastatin (Zocor), lovastatin (Mevacor), pravastatin (Pravachol), and rosuvastatin (Crestor). Examiner.com

Fluorine atom drugs breakthrough  -  ‎Aug 18, 2009‎
Experts at Massachusetts Institute of Technology (MIT) explain that attaching fluorine atoms to the carbon aromatic rings of drugs such as rosuvastatin can Hospital Healthcare Europe

It is not universal  -  ‎Aug 25, 2009‎
And among the anticholesterol drugs that belong to a class called statins should be added simvastatin and rosuvastatin. Unless this is done, the government Business Mirror

New Chemical Synthesis Could Streamline Drug Design  -  ‎Aug 13, 2009‎
Drug developers commonly add fluorine atoms to drugs, such as the cholesterol-lowering rosuvastatin, to keep the body from breaking them down too quickly. Science Daily (press release)

NDA Filed for Mixed Dyslipidemia Treatment  -  ‎Aug 19, 2009‎
The treatment will contain the active ingredients of Crestor (rosuvastatin) and Trilipix (fenofibric acid), both FDA-approved medications. Renal and Urology News

Livalo, New Cholesterol-Fighting Drug, Gets FDA Approval  -  ‎Aug 4, 2009‎
Livalo belongs to a class of cholesterol-lowering drugs called statins, a group that includes Crestor (rosuvastatin), Lescol (fluvastatin), Attorney at Law

China Pharma Holdings, Inc. Reports Second Quarter 2009 Financial ...  -  ‎Aug 11, 2009‎
Food and Drug Administration ("SFDA") to enter Phase I and Phase II clinical trials to test the efficacy of its cholesterol-lowering drug, Rosuvastatin. PR Newswire (press release)

Choosing lipid-lowering medication in HIV-associated lipodystrophy  -  ‎Aug 13, 2009‎
Darunavir (Prezista, Tibotec Therapeutics) may increase levels of pravastatin and to a lesser extent atorvastatin and rosuvastatin (Crestor, AstraZeneca). Endocrine Today

Senken Statine bei Dialysepatienten das KHK-Risiko?  -  ‎Aug 5, 2009‎
1391 Patienten erhielten neben ihrer üblichen Medikation einmal täglich 10 mg Rosuvastatin, der Rest ein Placebo. Der kombinierte primäre Studienendpunkt Apotheker Zeitung

美 ì?¸í„°ë„· '중요 마케팅 통로로 ë¶€ìƒ?'  -  ‎Aug 6, 2009‎
...그밖ì—?, 심장학과ì—?ì„  'í?¬ë ˆìŠ¤í† '(Crestor, rosuvastatin), 피부과ì—?ì„  '보톡스', 소아과ì—?ì„  ADHD 치료제 'ë°”ì?´ë°˜ìФ'(Vyvanse, lisdexamfetamine) 제품 사ì?´íЏì?˜ ì?¸ê¸° 디지틀보사

Omega-3 fatty acids cut heart failure mortality; statins do not  -  ‎Jul 7, 2009‎
Meanwhile, in the rosuvastatin GISSI-HF study, during a median of 3.9 years of follow up, rosuvastatin had no effect on the primary endpoints of death and Chiropractic Economics

China Pharma Holdings, Inc. Announces SFDA Approval for ...  -  ‎Jun 22, 2009‎
Rosuvastatin is the generic version of Crestor(R), which is deemed one of the most potent cholesterol-lowering medicines available and has been shown to PR Newswire (press release)

Health trends - Cholesterol drug cuts heart attacks  -  ‎Jun 30, 2009‎
Results from a recent global clinical study have found that the cholesterol-reducing drug, rosuvastatin, decreases the risk of death and heart attack in Jamaica Gleaner

Boosting Representation  -  ‎Jun 25, 2009‎
1 The ARIES (American Rosuvastatin Investigation of Efficacy and Safety) trial is the first to demonstrate the superiority of Crestor in lowering LDL ADVANCE for Physician Assistants

Genetics may make some cancers more lethal for blacks  -  ‎Jul 10, 2009‎
Statins are among the top-selling drugs on the market today and include brand names such as Lipitor (atorvastatin), Crestor (rosuvastatin) and Zocor Globe and Mail

Statins May Cause Muscle Damage in Some Patients  -  ‎Jul 6, 2009‎
17 percent were taking atorvastatin (Lipitor); 7 percent were taking fluvastatin (Lescol), and 3 percent were taking rosuvastatin (Crestor). Forbes

Crestor Patent Invalidity Evidence Uncovered By Article One ...  -  ‎Jul 1, 2009‎
CRESTOR(R) (rosuvastatin calcium) is a prescription drug for treating high cholesterol. The discovery of this patent invalidity evidence can impact the PR Newswire (press release)

China Pharma Wins OK for Generic Cholesterol Drug Trials  -  ‎Jun 23, 2009‎
OB) obtained approval from the SFDA to begin Phase I and Phase II clinical trials of Rosuvastatin, a generic version of the cholesterol-lowering statin drug Seeking Alpha

Stock Profiler.US: Stock Profiler.US: Stock Watch: CVVT, CPHI, CWSI  -  ‎Jun 22, 2009‎
Company News- June 22, 2009: China Pharma Holdings, Inc. Announces SFDA Approval for Rosuvastatin Clinical Trials China Pharma Holdings, Inc. ("China Trading Markets (press release)

The Benefits of Statins in People Without Established ...  -  ‎Jul 9, 2009‎
Four studies used pravastatin (range 10-40 mg), one lovastatin (range 20-40 mg), three atorvastatin (10 mg), and one rosuvastatin (20 mg). Cardiosource

BioMedReports FDA Calendar: Seven Laggard Trades-- (NYSE:ABT ...  -  ‎Jun 19, 2009‎
The NDA submission for this investigational compound, containing the active ingredients of CRESTOR (rosuvastatin) and TRILIPIX (fenofibric acid), OfficialWire

More Patients Across The World Lowering 'Bad' Cholesterol  -  ‎Jun 22, 2009‎
Researchers found that 75 percent of the patients surveyed were taking a statin drug (atorvastatin, simvastatin, rosuvastatin or pravastatin). Science Daily (press release)

Lipids as risk factors for stroke and CHD  -  ‎Jul 1, 2009‎
In this trial, treatment with rosuvastatin (Crestor, AstraZeneca) significantly reduced CHD events, strokes and all-cause mortality. Cardiology Today

Biomarkers and Cardiovascular Disease Determining Causality and ...  -  ‎Jun 30, 2009‎
Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N Engl J Med. 2008;359(21):2195-2207. FREE FULL TEXT 11. Journal of American Medical Association (subscription)

Medtronic subpoenaed on accused doc; FDA eyes Depakote effects on ...  -  ‎Jun 24, 2009‎
Intervet release > China Pharma obtained approval from that country's regulators to begin Phase I and Phase II trials of Rosuvastatin, a generic version of FiercePharma

Meta-analysis gives further weight to long-term statin use  -  ‎Jul 7, 2009‎
In the JUPITER study, AstraZeneca's Crestor (rosuvastatin) was found to reduce the risk of cardiovascular death and heart attacks by 44% compared with Pharma Times

Stockguru.com: China Pharma Holdings Inc. is in the StockGuru ...  -  ‎Jun 23, 2009‎
Food and Drug Administration ('SFDA') to enter Phase I and Phase II clinical trials to test the efficacy of its cholesterol-lowering drug, Rosuvastatin. Trading Markets (press release)

æ—¥ 제약사 항비만제 개발 ê°€ì†?í™”  -  ‎Jul 6, 2009‎
...시노오기는 고지혈ì¦? 치료제 'í?¬ë ˆìŠ¤í† '(Crestor, rosuvastatin)ì?˜ 특허만료 후 유력한 후ì†?약물로서 개발ì?„ 서ë‘?르고 있다. 고바야시가 올 ë´„ì—? 발매한 비만개선제 디지틀보사

Risikoindex soll Statintherapie optimieren  -  ‎Jul 1, 2009‎
Die Statine Atorvastatin, Simvastatin und Lovastatin, werden hauptsächlich über CYP3A4, Fluvastatin über CYP2C9 und zusätzlich CYP2C8, Rosuvastatin über Deutsches Ärzteblatt

Plädoyer für individuelle Zielwerte für das LDL  -  ‎Jun 30, 2009‎
Atorvastatin, Simvastatin und Rosuvastatin senkten das LDL besonders stark. Pravastatin und Fluvastatin hätten das relativ geringste Interaktionspotenzial Ärzte Zeitung

Prewencja chorób sercowo-naczyniowych - postÄ™py 2008  -  ‎Jun 18, 2009‎
Comparison of the efficacy and safety of rosuvastatin versus atorvastatin, simvastatin, and pravastatin across doses (STELLAR Trial). Am. J. Cardiol., 2003; Medycyna Praktyczna

아바스틴, 휴미ë?¼, 맙테ë?¼ 3대 제품 등극  -  ‎Jun 18, 2009‎
...ì?´ì–´ì„œ 항고지혈ì¦?ì œì?¸ 'í?¬ë ˆìŠ¤í† '(Crestor, rosuvastatin)ê°€ 57ì–µ3900만달러ì?˜ 매출로 저분ìž? 제제 가운ë?°ì„  최고제품ì?´ ë?  관측ì?´ë©°, 다ì?Œ 항콜린 COPD 치료제ì?¸ 디지틀보사

Kombinationen ezetimib och simvastatin signifikant mer effektiv än ...  -  ‎Jun 17, 2009‎
Statiner, som simvastatin, rosuvastatin och atorvastatin, hämmar kolesterolsyntesen i levern. Kombinationsbehandling med ezetimib och en statin sänker Newsdesk (pressmeddelande)

Brand Names/Synonyms:
Rosuvastatin is also known by the following brand names and/or synonyms:
Crestor; Rosuvastatin; Rosuvastatin [Inn]; ZD 4522

Drug Category:
Rosuvastatin is categorized under the following by the FDA: Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA07

Dosage Forms:
TABLET

Absorption:
20%

Interactions:
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Chemical IUPAC Name:
7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-(methyl-methylsulfonyl-amino)-pyrimidin-5-yl]-3,5-dihydroxy-hept-6-enoic acid





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