Salmeterol

This page contains recent news articles, when available, and an overview of Salmeterol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Salmeterol
(when available)

Pharmacology and use:
Salmeterol, a highly selective beta(2)-agonist, is used to treat asthma and to prevent bronchospasm in patients with reversible obstructive airway disease. For the treatment of Asthma and chronic obstructive pulmonary disease (COPD).

Mechanism Of Action:
Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.

News Articles on Salmeterol

Summertime use of combo inhaler may reduce asthma events in the fall  -  ‎Jan 1, 2010‎
NEW YORK (Reuters Health) - Summertime use of fluticasone propionate and salmeterol (FSC) in a single inhaler protects against serious asthma-related ... news Stories

Best Evidence Review: Long-acting Beta-Agonists -- Are They Appropriate for ...  -  ‎Dec 30, 2009‎
LABAs have also been scrutinized regarding their safety since the publication of the Salmeterol Multicenter Asthma Research Trial (SMART) in 2006. ... Medscape

New 2010 Anti-doping List  -  ‎Dec 30, 2009‎
Two beta-2 agonists, salbutamol and salmeterol can be used by inhalation without needing a Therapeutic Use Exemption, TUE, but usage will need to be ... Rowing News

Skiers caught doping in Whistler banned for two years  -  ‎Dec 31, 2009‎
For athletes with asthma, salbutamol and salmeterol were knocked down a level but athletes still need to make a declaration of use and cannot exceed ... Pique newsmagazine

WADA List of Prohibited Substances 2010  -  ‎Dec 22, 2009‎
As of 1 January 2010, the therapeutic use of salbutamol and salmeterol does not require a TUE, but a declaration of use. Their use must be declared on the ... World Football Insider

Agência Mundial Antidoping atualiza proibições para 2010  -  ‎Dec 23, 2009‎
Além disso, para o uso dos broncodilatadores salbutamol e salmeterol será necessária uma declaração por parte do esportista e do chefe do departamento ... O Globo

Anti Doping: Änderungen in der Verbotsliste 2010 Wada  -  ‎Dec 14, 2009‎
Die weitere wichtige Änderung ist die Umwandlung des Status von Salbutamol und Salmeterol, die in Klasse S3 Beta-2-Agonisten (zb Asthmasprays) fallen. ... TotalRugby.de

COPD 치료 3대 브랜드 'ì?¼ìž¥ì?¼ë‹¨'  -  ‎Dec 27, 2009‎
...만성í??쇄성í??질환(COPD) 치료 3대 브랜드ì?¸ '애드베어'(Advair, fluticasone/ salmeterol), '스피리바'(Spiriva, tiotropium), '심비코트'(Symbicort, ... 디지틀보사

AMA actualiza lista sustancias prohibidas para 2010 con nuevos estimulantes  -  ‎Dec 23, 2009‎
La lista, que entrará en vigor el próximo 1 de enero, determina que el uso de los broncodilatadores salbutamol y salmeterol no requiere una excepción ... Los Tiempos

Thuốc hen tác dụng tá»›i huyết áp như thế nào?  -  ‎Dec 29, 2009‎
...bao gồm: formoterol (foradil có thá»?i gian tác dụng trung bình, không được sá»­ dụng ở Hoa Kỳ), salmeterol (serevent có thá»?i gian tác dụng dài). ... XãLuận.com tin tức việt nam 24h cập nhật

ACAAI: Fluticasone Plus Salmeterol Cuts Exacerbations in Asthma  -  ‎Nov 12, 2009‎
MIAMI BEACH -- Asthmatic children treated with a fixed-dose combination of fluticasone propionate plus salmeterol experienced fewer serious asthma ... MedPage Today

Fluticasone Plus Salmeterol Associated With Fewer Asthma Exacerbations ...  -  ‎Nov 13, 2009‎
MIAMI BEACH, Fla -- November 13, 2009 -- Paediatric patients with asthma treated with fluticasone propionate plus salmeterol, ... DG News

Effect of Fluticasone With and Without Salmeterol on Pulmonary Outcomes in ...  -  ‎Oct 19, 2009‎
Adding salmeterol improved FEV 1 level. Limitations: The study was not designed to evaluate clinical outcomes. Measurement of primary outcome was not ... Annals of Internal Medicine

CHEST: Novel LABA Improves Lung Function in COPD  -  ‎Nov 5, 2009‎
Indacaterol "shows a trend toward improvement over salmeterol," he reported at the American College of Chest Physicians meeting. ... MedPage Today

CHEST: COPD Treatment Determines Risk of Hospitalization  -  ‎Nov 6, 2009‎
Patients were divided into five groups according to the type of treatment they were prescribed -- tiotropium monotherapy, salmeterol/fluticasone propionate ... MedPage Today

Chronic Obstructive Pulmonary Disease: Part 2: Prevention and Long-term Treatment  -  ‎Nov 6, 2009‎
The prevention of chronic obstructive pulmonary disease exacerbations by salmeterol/fluticasone propionate or tiotropium bromide. Am J Respir Crit Care Med. ... Medscape

WADA Publishes Revised International Standard for TUE  -  ‎Nov 4, 2009‎
Under the 2010 List, salbutamol, salmeterol, platelet-derived preparations, and glucocorticosteroids administered by some routes will require a Declaration ... International Paralymic Committee

On the Pulse - 30th October 2009  -  ‎Oct 30, 2009‎
A trial in Annals of Internal Medicine examines long-term effects on lung function of fluticasone and salmeterol in moderate to severe chronic obstructive ... OnMedica

Inhalers up risk of asthma attack in kids?  -  ‎Oct 24, 2009‎
...salbutamol -- one of the most common asthma drugs also known as albuterol, Ventolin and salmeterol -- is less effective in children with a specific gene ... PRESS TV

Inhaled Corticosteroids May Be Helpful in Steroid-Naive Patients With Moderate ...  -  ‎Oct 27, 2009‎
The addition of salmeterol was associated with improvement in FEV 1 . "ICS therapy decreases inflammation and can attenuate decline in lung function in ... Medscape

Forest Laboratories Inc. F2Q10 (Qtr End 30/09/09) Earnings Call Transcript  -  ‎Oct 20, 2009‎
...a clear trend in the reduction of exacerbations, a secondary end point, when added either to tiotropium in one study, or salmeterol in the other study. ... Seeking Alpha (blog)

BREAKING NEWS: Relenza helps GSK return to sales growth  -  ‎Oct 28, 2009‎
On the positive side, sales of Advair/Seretide (salmeterol and fluticasone) for asthma and chronic obstructive pulmonary disease were up 5% at £1.15 million ... Pharma Times

Conferencia Mundial Antidopaje en París: tolerancia cero  -  ‎Oct 27, 2009‎
Los agentes anabólicos, reglas respecto al empleo de salbutamol y salmeterol, hormonas antagonistas, diuréticos, doping genético, alcohol y bloqueadores ... Prensa Latina

å?¸å…¥åž‹é¡žå›ºé†‡å°?於未使用é?Žé¡žå›ºé†‡çš„中é‡?度COPDç—…æ‚£å?¯èƒ½æœ‰å¹«åŠ©  -  ‎Nov 5, 2009‎
...加上salmeterol與FEV1改善有關。 研究作者寫到,ICS治療減少發炎å??應,å°?é?ŽåŽ»æ²’æœ‰ä½¿ç”¨é¡žå›ºé†‡çš„ä¸­é‡?度COPD患者們,å?¯ä»¥æ¸›ç·©è‚ºåŠŸèƒ½ä¸‹é™?。加上LABA並ä¸?會加強這些效應。 ... 臺灣新浪網

ObiecujÄ…cy lek na POChP- roflumilast  -  ‎Nov 2, 2009‎
...w porównaniu do chorych, u których stosowano wyłącznie standardowe leczenie (salmeterol + roflumilast vs. sam salmeterol, p=0,0015). 2 „. ... Zdrowie WWW

æ—¥ 제네릭 시장 '외ìž?사 진출러시'  -  ‎Nov 2, 2009‎
...ìš°ì„  ë‚´ë…„ì—? '노보믹스'(NovoMix, insulin aspart), '악토넬'(Actonel, risedronate), '세레벤트'(Serevent, salmeterol), '프로그ëž?'(Prograf, tacrolimus)ì?˜ 특허가 ... 디지틀보사

WADA publica padrão revisado para exceções de uso terapêuticas  -  ‎Nov 5, 2009‎
Incluem-se na Lista para 2010, salbutamol, salmeterol, preparações derivadas de plaquetas, e glucocorticosteroides administrados por algumas vias de ... Final Sports

Salmeterol for asthma may cause serious events  -  Jul 17, 2008
NEW YORK (Reuters Health) - Patients with chronic asthma who use the salmeterol on a daily basis are at increased risk for serious adverse events, ... Reuters

Salmeterol shows success in COPD treatment  -  Dec 29, 2007
WASHINGTON, Dec. 29 (UPI) -- A combination of salmeterol and fluticasone may reduce the mortality rate of chronic obstructive pulmonary disease (COPD), ... United Press International

FDA Questions the Safety Of Asthma Drugs for Kids  -  Nov 24, 2007
Serevent and Advair, which both contain the active ingredient salmeterol, ... The reviewers suggested a more in-depth safety review of salmeterol that would ... Wall Street Journal

Experts to Consider Withdrawal of Asthma Drugs  -  Jul 13, 2005
Advair and Serevent contain the same drug, salmeterol; in Serevent, salmeterol ... Foradil does not contain salmeterol; its active ingredient is formoterol. ... New York Times

Warning over common asthma drugs  -  Jul 27, 2006
Serevent, which is the GlaxoSmithKline brand form of salmeterol, ... However, he said that use of salmeterol on its own — without a steroid inhaler such as ... Times Online

FDA panel backs more warnings on Glaxo asthma drugs  -  Nov 28, 2007
Serevent and Advair by GlaxoSmithKline PLC , contain the active ingredient salmeterol while another drug, Foradil, made by Novartis AG and marketed in the ... MarketWatch

Salmeterol Plus Fluticasone Slows Disease Progression in COPD  -  Aug 15, 2008
August 15, 2008 — Pharmacotherapy with salmeterol plus fluticasone propionate, or the individual drugs, is associated with slowing of disease progression in ... Medscape

Death Risk Warning for Asthma Drugs  -  Mar 8, 2006
Advair and Serevent contain an active ingredient called salmeterol. The drugs are used by patients whose asthma cannot be controlled by steroid-based ... FOXNews

Asthma Drug Warning Strengthened  -  Mar 3, 2006
Advair contains two medicines, an inhaled steroid to control inflammation, and salmeterol, which improves symptoms by expanding the airways. ... Forbes

Theravance says asthma drugs effective in trials  -  Apr 2, 2007
Glaxo sells salmeterol under the brand name Serevent. The British company also is the maker of asthma and COPD medicine Advair, which had worldwide sales ... Reuters

Access to inhaler made easier  -  Oct 20, 2005
Salmeterol inhalers, are one of the group of treatments known as long-acting beta agonists (LABAs) that are used by people whose asthma is not adequately ... TVNZ

… When Montelukast Added to Fluticasone/Salmeterol in Secondary...  -  May 23, 2008
In addition, when fluticasone/salmeterol and montelukast were combined, ... Treatment with fluticasone/salmeterol produced significant improvements in ... DG News

Boehringer says Spiriva, formoterol cause 'superior' improvement in...  -  Sep 19, 2005
...combination of the long-acting bronchodilator salmeterol and a high dose of the anti-inflammatory fluticasone,' said lead study investigator Klaus Rabe. ... Forbes

Monarchs forward Brunson issued doping warning by USADA  -  Jun 30, 2008
The US Anti-Doping Agency said Brunson tested positive for Salmeterol on June 5. At the time of the test, Brunson did not have an exemption to use the ... ESPN

Advair, Other Asthma Drug Get Label Alerts  -  Mar 6, 2006
The updated versions of the "black-box" warnings on both drugs caution that salmeterol, one of the active ingredients in Advair and the active ingredient in ... San Francisco Chronicle

Drug Slows Lung Decline in COPD Patients  -  May 21, 2007
The study of 6112 COPD patients from 42 countries found that those treated with Advair (salmeterol/fluticasone propionate) had a slower rate of lung ... ABC News

Study Sends New Warning on Asthma Drugs  -  Jun 9, 2006
Asthma patients taking Advair and other drugs containing salmeterol are advised ... Studies suggest salmeterol can aggravate inflammation in the lungs and ... NPR

Combo Therapy Cuts Complications of Severe COPD  -  Jan 16, 2007
The control group (487 patients) received only salmeterol. In the combined therapy group, 324 patients experienced moderate to severe exacerbations, ... Washington Post

Meta-analysis: Effects of Adding Salmeterol to Inhaled Corticosteroids...  -  Jul 1, 2008
Background: Recent analyses have suggested an increased risk for serious asthma-related adverse events in patients receiving long-acting β-agonists. ... Annals of Internal Medicine

Asthma Drug Combo Could Be Dangerous  -  Aug 24, 2006
Advair and Serevent, both manufactured by GlaxoSmithKline, contain the active ingredient salmeterol. In a study funded by the drug company, asthma-related ... CBS News

Glaxo's Advair Rejected by US FDA for an Added Use  -  Aug 8, 2007
In 2003, US regulators cleared use of the middle strength, with 250 micrograms of fluticasone propionate powder and 50 micrograms of salmeterol powder, ... Bloomberg

Seretide (Salmeterol/Fluticasone Propionate) Provides Greater Control...  -  Sep 19, 2005
COPENHAGEN, DENMARK -- September 19, 2005 -- The results of the CONCEPT (CONtrol CEntred Patient Treatment) study, presented today at the European ... DG News

… /Formoterol Combination Therapy and Fluticasone/Salmeterol Combinat  -  May 20, 2008
The patients originally treated with fluticasone/salmeterol combination therapy ... This finding with salmeterol may apply to formoterol (a long-acting ... newswise.com

FDA panel says Glaxo's Advair doesn't boost COPD survival  -  May 1, 2007
Advair, a combination of fluticasone and salmeterol, is aimed at long-term maintenance of asthma and COPD symptoms in certain strengths. ... MarketWatch

Glaxo disputes charges, Watchdog group says company manipulated …  -  Oct 7, 2005
Serevent or salmeterol, known as Advair when combined with the steroid fluticasone, carries a black box label warning of a small but significant increase in ... Pay-Per-View - Newsday - ProQuest Archiver

Fluticasone, Salmeterol Combination Increases Survival in Moderate- …  -  Oct 25, 2006
By John Gever. SALT LAKE CITY, UT -- October 25, 2006 -- Three years of treatment combining a corticosteroid drug with a long-acting beta agonist cut the ... DG News

… Appear to Work Faster Than Fluticasone/ Salmeterol in Adults With...  -  Mar 19, 2008
...they use pressure-metered dose inhalers containing albuterol or budesonide/ formoterol than with fluticasone/ salmeterol dry-powder inhaler or placebo. ... DG News

… /Formoterol More Cost Effective Than Salmeterol/Fluticasone In...  -  Sep 11, 2006
The relative cost-effectiveness of budesonide/formoterol and salmeterol/fluticasone was then examined showing that switching patients from formoterol to ... Medical News Today - Medical News Today (press release)

Combo Treatment Works Best for COPD  -  Feb 21, 2007
Beta-agonists like salmeterol work by relaxing the smooth muscles of the airways, which improves airflow. Inhaled corticosteroids reduce inflammation, ... WebMD

Learn about Fluticasone and Salmeterol Oral Inhalation from Consumer ...  -  Jan 11, 2008
In a large clinical study more patients with asthma who used salmeterol died of asthma problems than ... Full Alert. The combination of fluticasone and ... consumerreports.org

Salmeterol-fluticasone vs. fluticasone alone for asthma.(POEMs)  -  Feb 15, 2005
Clinical Question: Is guideline-driven care of patients with asthma using stepwise increases in salmeterol-fluticasone therapy more effective than using ... Free with registration - American Family Physician - AccessMyLibrary.com

Combination therapy of salmeterol and fluticasone improves survival...  -  Oct 23, 2006
A combination of two common medications may help patients with chronic obstructive pulmonary disease (COPD) live longer. New research presented at CHEST ... News-Medical.net

Salmeterol and Fluticasone Yield Surprising Results for COPD Death …  -  Sep 18, 2007
Long-acting beta-agonists and inhaled corticosteroids are used to treat chronic obstructive pulmonary disease (COPD), but their effect on survival is ... news Stories

Common asthma medication poses risk to black patients  -  Jan 11, 2006
A large study on the popular asthma medication salmeterol was halted after ... "The bottom line is that, in a very large study in which salmeterol or a ... wtopnews.com

Patients Satisfied With Fluticasone/Salmeterol Treatment by Diskus...  -  Nov 4, 2005
By Ed Susman. MONTREAL, CANADA -- November 4, 2005 -- Patients reported a high degree of satisfaction after 2 months of using a new treatment for chronic ... DG News

Fluticasone and Salmeterol Oral Inhalation Side Effects from Consumer...  -  Jan 11, 2008
In a large clinical study more patients with asthma who used salmeterol died of asthma problems than ... Full Alert. In a large clinical study more patients ... consumerreports.org

Salmeterol and Fluticasone Propionate Slow Decline in COPD Patients  -  May 25, 2007
May 25, 2007 (San Francisco) -- Â Data from the "TOwards a Revolution in COPD Health" (TORCH) study, presented here Tuesday at the American Thoracic ... Medscape

Asthma Therapy; Salmeterol HFA and CFC inhalers have equivalent …  -  Jul 26, 2005
2005 JUL 26 - (NewsRx.com) -- Salmeterol delivered by HFA and CFC inhalers is equally effective for asthma patients. "In accordance with the Montreal ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Fluticasone and Salmeterol ( Inhalation-Local).  -  Feb 1, 2006
Fluticasone(floo-TIK-a-sone) and salmeterol(sal-ME-te-role) is a combination of two medicines that are used to help control the symptoms of asthma and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Formoterol Has Faster Onset of Action Than Salmeterol in Patients...  -  Nov 2, 2008
By Maggie Schwarz. PHILADELPHIA -- November 2, 2008 -- The onset of action of formoterol was significantly faster than salmeterol, with differences reaching ... DG News

Disease Association; Salmeterol and formoterol have no short-term …  -  Nov 22, 2005
2005 NOV 22 - (NewsRx.com) -- Recently published research from Turkey compared the short-term effects of salmeterol and formoterol on heart rate variability ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Tiotropium Plus Fluticasone-Salmeterol Helpful in Moderate or Severe ...  -  Feb 20, 2007
For questions regarding the content of this activity, contact the accredited provider for this CME/CE activity noted above. For technical assistance ... Medscape

Regular salmeterol for asthma: More evidence of long-term problems  -  Jul 15, 2008
People with asthma who regularly use salmeterol are at a greater risk of non-fatal serious adverse events than those using placebos. ... eurekalert.org

Common asthma inhalers may cause death  -  Jun 20, 2006
The trade names of salmeterol is Serevent and Advair and both are made by GlaxoSmithKline. The trade name of formoterol is Foradil and it is made Novartis ... Pay-Per-View - Hindustan Times - Factiva, from Dow Jones

Significant Reduction In Rate Of Lung Function Decline Achieved In …  -  Aug 16, 2008
Those patients who received salmeterol/fluticasone propionate had a lower rate ... Treatment with salmeterol/fluticasone propionate reduced the difference ... Medical News Today - Medical News Today (press release)

… the manufacturers of fluticasone/salmeterol inhalation powder...  -  Dec 1, 2005
FDA has asked the manufacturers of fluticasone/salmeterol inhalation powder (Advair Diskus, GlaxoSmith-Kline), formoterol inhalation powder (Foradil ... $9.94 - Formulary - Alacra Store

… trial: once-daily fluticasone plus salmeterol superior to monteluka...  -  Aug 1, 2007
In a multicenter, randomized, double-blind, controlled trial, investigators demonstrated that in patients whose asthma was well controlled with the use of ... Free with registration - Formulary - AccessMyLibrary.com

… DPI - Fluticasone propionate, Salmeterol xinafoate - Medical Drug  -  Jan 2, 2008
Salmeterol xinafoate dilates the airways in the lungs to keep them open, ... Seretide Accuhaler 100/50: DPI (dry powder inhaler) salmeterol 50mcg, ... Virtual Medical Centre - The Virtual Medical Centre

Asthma Drug Duo Effective Against COPD Inflammation  -  Mar 31, 2006
LONDON - The asthma-fighting drug combination Advair (salmeterol and fluticasone) also packs a synergistic punch against chronic obstructive pulmonary ... MedPage Today

IN BRIEF: New advice over asthma.(Brief Article)  -  Nov 26, 2005
Patients using salmeterol or formoterol should always be prescribed an ... The advice comes after the final results from the Salmeterol Multi- Centre Asthma ... Free with registration - Pulse - AccessMyLibrary.com

GSK Receives Extended Licence Indication For Seretide In Europe …  -  Jul 16, 2007
The brand name for fluticasone propionate / salmeterol in the European Union (excluding ... Salmeterol and fluticasone propionate and survival in Chronic ... Medical News Today - Medical News Today (press release)

Asthma drug effectiveness dependent on genes  -  Jun 19, 2006
Researchers from the >University of Dundee found that a specific genetic variant, known as the Arg/Arg-16 variant, causes the asthma treatment salmeterol to ... DrugResearcher.com

Inhaled Steroid Use and Asthma Control in Patients with Mild Persisten...  -  Jul 1, 2008
Treatment failure occurred in 20.2 percent of patients in the fluticasone group, 20.4 percent in the fluticasone/salmeterol group, and 30.3 percent in the ... AAFP News Now

Abstract and Introduction  -  Feb 10, 2005
Background and Objective: Salmeterol and fluticasone propionate are well ... Salmeterol and FP are well established in the treatment of childhood asthma, ... Medscape

Salmeterol plus fluticasone fails to reduce mortality in patients...  -  Apr 1, 2007
Salmeterol plus fluticasone fails to reduce mortality in patients with COPD. In a randomized double-blind, parallel-group trial, salmeterol plus fluticasone ... $9.94 - Formulary - Alacra Store

Advair(R) (Fluticasone Propionate/Salmeterol) HFA Inhalation Aerosol ...  -  Oct 19, 2006
RESEARCH TRIANGLE PARK, NC -- October 19, 2006 -- Advair HFA Inhalation Aerosol, a new formulation combining fluticasone propionate and salmeterol in a ... DG News

FDA Approves Advair(R) 250/50 for Reduction of Exacerbations in …  -  May 1, 2008
Two identical one-year studies were conducted to evaluate the effect on COPD exacerbations with Advair Diskus 250/50 compared to 50 mcg of salmeterol alone, ... FierceBiotech

… on market; Unanimous vote backs the continued availability of...  -  Sep 15, 2005
In the case of salmeterol--which already has a black-box warning on its label about the ... The current label says that salmeterol should not be used as a ... Pay-Per-View - Internal Medicine News - HighBeam Research

… From CHMP on Seretide (Salmeterol/Fluticasone Propionate) Dosing...  -  May 3, 2006
Salmeterol is a long acting bronchodilator which acts for up to 12 hours to reduce asthma symptoms (chest tightness, wheezing, cough) Seretide, ... DG News

Guidelines on the Use of Fluticasone-Salmeterol  -  Feb 28, 2006
I have a few questions about fluticasone-salmeterol. Is it true that the current guidelines call for dual therapy as opposed to monotherapy, ie, ... Medscape

JournalWatch: Asthma and salmeterol.(Brief Article)  -  Feb 2, 2006
Treatment with salmeterol may increase the risk of respiratory-related death, according to a US study. Researchers conducted a 28-week randomised controlled ... Free with registration - Pulse - AccessMyLibrary.com

Combination Fluticasone-Salmeterol Therapy for Asthma  -  Apr 5, 2006
I have a few questions about fluticasone-salmeterol. Is it true that the current guidelines call for dual therapy as opposed to monotherapy, ie, ... Medscape

New Safety Information on Long-Acting Beta-2 Agonists  -  Mar 21, 2006
The combination product with salmeterol is sold as AdvairR, ... Salmeterol and formoterol can only be used with an appropriate dose of inhaled ... RedOrbit

GSK asks EU for COPD labelling change  -  Sep 13, 2006
GlaxoSmithKline (GSK) has filed an application with EU regulators to change the labelling on its Seretide (salmeterol/fluticasone propionate) treatment. ... Hays Pharma

Inhaled Steroid Plus LABA Reduces Exacerbations in COPD  -  Sep 7, 2006
The investigators randomized the patients to receive twice-daily treatments, so that 1521 received 50 µg of salmeterol per dose; 1534 received 500 µg of ... Medscape

Arformoterol Study Data Presented at European Respiratory Society …  -  Sep 5, 2006
The studies evaluated airway function improvement with arformoterol and salmeterol (SEREVENT(R) metered-dose inhaler) compared with placebo over a period of ... RedOrbit

Study Confirms Superiority of Salmeterol/Fluticasone Propionate  -  Jul 6, 2007
Giving salmeterol/fluticasone propionate is better than doubling the dose of fluticasone propionate in children with asthma uncontrolled by fluticasone ... news Stories

Intranasal Ciclesonide Added to High-Dose Inhaled Fluticasone Does...  -  Mar 2, 2007
..."Ciclesonide had no additive inhibitory effect when used concomitantly with combined fluticasone-salmeterol," according to principal investigator Kenneth ... DG News

Advair,Serevent,Salmeterol,Foradil - The Next Vioxx? Who Is The FDA …  -  Jun 25, 2006
The above article further supports the already voluminous literature (see Sears) regarding the safety issues associated with the extended release beta-2 ... Medical News Today - Medical News Today (press release)

Lung Function Decline Slowed In COPD Patients, TORCH Study Finds  -  May 22, 2007
Patients who received either the long-acting beta2-agonist salmeterol (Serevent) or ... The study compared salmeterol at a dose of 50 mcg plus fluticasone ... Medical News Today - Medical News Today (press release)

Results From First-of-its-Kind Study Show That Combination Therapy …  -  Apr 4, 2006
This study suggests that synergy between salmeterol and fluticasone propionate could ... The combination of salmeterol/fluticasone propionate dry powder for ... DG News

Do asthma/COPD combination drugs stand in the way of innovation?  -  Sep 25, 2007
The salmeterol multicenter asthma research trial (SMART): a comparison of usual pharmacotherapy for asthma or usual pharmacotherapy plus salmeterol. ... Free with registration - M2 Presswire - AccessMyLibrary.com

Ann Intern Med -- Rapid Responses for Aaron et al., 146 (8) 545-555  -  May 29, 2007
Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease: a randomised controlled trial. Lancet 2003; 361:449-456. ... Annals of Internal Medicine

Get SMART: Symbicort gives patients the power to control asthma; New ...  -  Jan 11, 2006
However, if it can be shown that the risks are specific for salmeterol, theclass warning on Foradil and Symbicort could be changed which would give a vital ... Free with registration - M2 Presswire - AccessMyLibrary.com

Asthma Patients Not Adequately Controlled on ICS Alone More Likely to...  -  May 20, 2008
Advair contains salmeterol. In patients with asthma, medicines like salmeterol may increase the chance of asthma-related death. So Advair is not for people ... RedOrbit

Advair reduces asthma-related hospitalization and emergency …  -  Mar 17, 2008
Advair Diskus (fluticasone propionate and salmeterol inhalation powder) was ... Advair contains salmeterol. In patients with asthma, medicines like ... News-Medical.net

… MDI - Fluticasone propionate and Salmeterol xinafoate - Medical...  -  Feb 1, 2008
Seretide MDI (Metered Dose Inhaler) is used for maintenance treatment of asthma, a disease of the airways and lungs characterised by shortness of breath, ... Virtual Medical Centre - The Virtual Medical Centre

Salmeterol with fluticasone licensed for moderate COPD.(Chronic …  -  Sep 8, 2007
Salmeterol with fluticasone (Seretide 500 Accuhaler, GSK) is now licensed for patients with an FEV1 of less than 60 per cent and a history of exacerbations. ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

Novartis Unveils Promising Phase II Data For Bronchodilator QAB149.  -  May 23, 2005
No tachyphylaxis was observed with indacaterol, formoterol or salmeterol.(iv). COPD incurs a significant burden on the US healthcare system in terms of ... $4.95 - PR Newswire - ECNext

AstraZeneca's Symbicort reduces exacerbations  -  Sep 4, 2006
...at reducing exacerbations than fixed doses of either Symbicort or GlaxoSmikthKline's Seretide (salmeterol/fluticasone) plus reliever medication. ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

Advair Reduces Exacerbations in COPD Patients With a History of …  -  May 18, 2008
In an analysis of time to first moderate/severe exacerbation, there was a 25 percent reduction in risk with Advair compared to salmeterol (p=0.003). ... RedOrbit

Fast- Plus Long-Acting Beta Agonist Improves Asthma Maintenance …  -  Mar 24, 2008
Its rapid onset of bronchodilation makes it a more attractive choice than the combination of fluticasone/salmeterol for maintenance of patients with mild to ... DG News

FDA panel recommends warning on salmeterol.  -  Dec 10, 2007
A US Food and Drug Adminstration advisory panel has recommended that three popular asthma drugs should get label warnings about their potential risk to ... $4.95 - Pharma Marketletter - ECNext

FDA Advisers Urge Curbs On Some Asthma Drugs  -  Dec 11, 2008
It comes alone, as Serevent (salmeterol) and Foradil (formoterol). Two other LABAs — Advair (salmeterol plus fluticasone) and Symbicort (formoterol plus ... NPR

Salmeterol warning; Asthma death is more likely if salmeterol is not...  -  Oct 26, 2006
BETA-2 agonists such as salmeterol are frequently prescribed as a therapy additional to corticosteroid inhalers in the long-acting treatment of asthma. ... Pay-Per-View - Pharmacy News - Factiva, from Dow Jones

Salmeterol/fluticasone combination lowers asthma exacerbations.  -  Jul 1, 2006
Salmeterol/fluticasone combination lowers asthma exacerbations. A salmeterol/fluticasone combination (SFC) surpassed a formoterol/budesonide combination ... $9.94 - Formulary - Alacra Store

… on dose; Seretide (fluticasone propionate/salmeterol xinafoate) is...  -  May 11, 2006
All strengths of the Seretide MDI (50mcg fluticasone propionate and 25mcg salmeterol, 125mcg fluticasone propionate and 25mcg salmeterol, ... Pay-Per-View - Pharmacy News - Factiva, from Dow Jones

Article: FDA panel supports two asthma bronchodilators.(News) - …  -  Sep 1, 2005
In the case of salmeterol--which already has a black box warning in its label about the ... The current label says that salmeterol should not be used as a ... Pay-Per-View - Pediatric News - HighBeam Research

… 250/50 (fluticasone propionate 250 mcg and salmeterol 50 mcg...  -  Jun 16, 2008
Advair Diskus 250/50 (fluticasone propionate 250 mcg and salmeterol 50 mcg inhalation powder) has been approved for the reduction of exacerbations in ... $9.94 - Drug Topics - Alacra Store

Next Safety Announces Bid Date for the Sale of the Company's Platform...  -  Dec 22, 2008
...drugs including albuterol and the components of Advair(TM), fluticasone propionate and salmeterol xinofoate, in air timed to the user's inhalation. ... ereleases.com

Biancone fined for medication violation in California  -  Sep 8, 2007
Use of Salmeterol is a Class 3 medication violation. Under an agreement between Biancone and the California Horse Racing Board, the stewards stayed the ... Thoroughbred Times

Prescribing notes - MHRA to review formoterol and salmeterol.(Drug …  -  Mar 12, 2007
Long-acting beta2 agonists formoterol and salmeterol, and their use in asthma and COPD, are being reviewed by the Medicines and Healthcare products ... $4.95 - Pharmacy Today - ECNext

Growing Warnings About Asthma Drug Added To By Experts  -  Aug 26, 2006
The long-acting asthma drug salmeterol used in combination with an inhaled ... Advair, made by GlaxoSmithKine, contains salmeterol in addition to an inhaled ... Medical News Today - Medical News Today (press release)

Combination Inhaler Therapy for Chronic Obstructive Pulmonary Disease  -  Apr 17, 2007
Tiotropium and salmeterol expand (dilate) the bronchial tubes. ... Adding the combination of fluticasone and salmeterol to tiotropium improved lung function ... Annals of Internal Medicine

FDA rejects GSK's 500/50 strength Advair Diskus for COPD.( …  -  Aug 13, 2007
...drug application for the 500/50 strength of Advair Diskus (fluticasone propionate and salmeterol) for chronic obstructive pulmonary disease. ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

FDA warns of long-acting bronchodilator risks.(Rx)  -  Dec 15, 2005
The advisory refers to the Salmeterol Multicenter Asthma Research Trial (SMART), ... The trial compared the safety of salmeterol with that of placebo when ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Combination Therapy in Asthma - Fixed or Variable Dosing in Different...  -  Jan 7, 2005
The efficacy and tolerability of budesonide/formoterol and salmeterol/ fluticasone ... Fixed dosing with budesonide/ formoterol or salmeterol/fluticasone ... RedOrbit

Patients with severe COPD may benefit from the addition of an inhaled...  -  Mar 1, 2007
Kardos P, Wencker M, Glaab T, Vogelmeier C. Impact of salmeterol/fluticasone propionate versus salmeterol on exacerbations in severe chronic obstructive ... $9.94 - Formulary - Alacra Store

Combination therapy reduces emphysema flare-ups  -  Jan 23, 2007
..."We saw a ... highly relevant 35 percent reduction in COPD exacerbations, if fluticasone was given with salmeterol in a combination inhaler Seretide, ... Reuters

Chronic Obstructive Pulmonary Disease; GSK announces positive results...  -  Apr 26, 2006
...for patients receiving Seretide 50/500 micrograms (EU)/Advair (US)(salmeterol/fluticasone propionate) as compared with patients on placebo (p=0.052*). ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Brand Names/Synonyms:
Salmeterol is also known by the following brand names and/or synonymsAeromax; Arial; Astmerole; CHEMBANK1801; SEREVENT; Salmetedur; Salmeterol; Salmeterol Xinafoate; Salmeterol [Usan:Ban:Inn]; Salmeterolum [Latin]; Serevent; [Usan:Ban:Inn]

Drug Category:
Salmeterol is categorized under the following by the FDA: Bronchodilator Agents; Sympathomimetic; Adrenergic beta-Agonists;

Dosage Forms:
METERED-DOSE (AEROSOL); POWDER

Absorption:
Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses (50 mcg of salmeterol inhalation powder twice daily). Following chronic administration of an inhaled dose of 50 mcg of salmeterol inhalation powder twice daily, salmeterol was detected in plasma within 5 to 45 minutes in 7 patients with asthma; plasma concentrations were very low, with mean peak concentrations of 167 pg/mL at 20 minutes and no accumulation with repeated doses.

Interactions:
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Chemical IUPAC Name:
2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-phenol





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