Selegiline

This page contains recent news articles, when available, and an overview of Selegiline but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Selegiline
(when available)

Pharmacology and use:
Dopamine is an essential chemical that occurs in many parts of the body. It is the premature degradation of dopamine that results in the symptoms of Parkinson's disease. Monoamine oxidase (MAO) is an enzyme which accelerates the breakdown of dopamine. Selegiline can prolong the effects of dopamine in the brain by preventing its breakdown through seletively blocking MAO. It also may prevent the removal of dopamine between nerve endings and enhance release of dopamine from nerve cells. For the adjunct treatment for Parkinson's Disease

Mechanism Of Action:
Although the mechanisms for selegiline's beneficial action in the treatment of Parkinson's disease are not fully understood, the inhibition of monoamine oxidase type B (MAO B) is thought to be of primary importance. MAO B is involved in the oxidative deamination of dopamine in the brain. Selegiline is best known as an irreversible inhibitor of MAO. MAO's activity is inhibited when selegiline binds to the isoalloxazine flavin adenine dinucleotide (FAD) at its active center. In addition, there is evidence that selegiline may increase dopaminergic activity through other mechanisms.

News Articles on Selegiline

Successful 2009 for Syntropharma  -  ‎Dec 18, 2009‎
The Company raised its first private equity investment October 2006 in order to develop transdermal versions of two CNS drugs: selegiline, for the treatment ... PharmaLive.com (press release)

FDA Approves Newly Revised Prescribing Information For AZILECT(R) Reducing ...  -  ‎Dec 15, 2009‎
TSFs of various doses of rasagiline were comparable to those of selegiline and placebo. AZILECT® (rasagiline tablets) is indicated for the treatment of the ... Medical News Today (press release)

Four Pharmaceutical Companies Pay $124 Million for Submission of False Claims ...  -  ‎Oct 19, 2009‎
Ibuprofen tablets, Bumetanide, Cephalexin and Cefactor) and several UDL drugs (nifedipine extended release tablets, selegiline HCL, Triamterene & HCTZ, ... Reuters

New systematic study for managing treatment-resistant bipolar depression  -  ‎Oct 27, 2009‎
After 7 weeks of treatment with the selegiline patch 6 mg, her QIDS-SR score was 20 (severe range). Selegiline was discontinued. She was then restarted on ... News-Medical.net

Phentermine para adelgazar, contraindicaciones  -  ‎Nov 10, 2009‎
Las personas que tomen inhibidores de la MAO como isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam), ... Nutricion.pro

FDA Clears Antidepression Patch  -  Feb 28, 2006
Emsam contains selegiline, which is used in tablet form as a treatment for ... Because selegiline can cause many side effects, especially when taken with ... TheStreet.com - TheStreet.com (subscription)

Selegiline (Systemic).  -  Oct 27, 2005
Selegiline ( seh-LEDGE-ah-leen) is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson's disease, sometimes called ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Selegiline for Parkinson's disease  -  Dec 8, 2008
Monoamine oxidase inhibitors (MAOIs) prolong the effects of dopamine in the brain by preventing its breakdown. They also may prevent the removal of dopamine ... WebMD

Learn about Selegiline Transdermal from Consumer Reports Health.  -  Jan 8, 2007
A small number of children, teenagers, and young adults (up to 24 years of age) who took ... Full Alert. Transdermal selegiline is used to treat depression. ... consumerreports.org

Valeant Parkinson's Drug Cleared  -  Jun 15, 2006
Zelapar is a version of selegiline, a compound used in treating depression and Parkinson's. In May, Teva Pharmaceutical Industries (TEVA Quote) received FDA ... TheStreet.com - TheStreet.com (subscription)

Selegiline transdermal patch (Emsam) for major depressive disorder.( …  -  Feb 15, 2008
Unlike oral MAO inhibitors, transdermal selegiline delivers ... Transdermal selegiline is contraindicated in patients taking selective serotonin reuptake ... Free with registration - American Family Physician - AccessMyLibrary.com

First anti-depressant patch is approved  -  Mar 2, 2006
The patch contains a medication called Emsam (selegiline), which can trigger sudden spikes in blood pressure if taken orally with certain foods or drinks, ... New Scientist

How to take Selegiline Transdermal from Consumer Reports Health.  -  Jan 8, 2007
A small number of children, teenagers, and young adults (up to 24 years of age) who took ... Full Alert. tell your doctor and pharmacist if you are allergic ... consumerreports.org

Dodgy doctor prescribes breast cancer drugs to men  -  Jul 3, 2008
Selegiline is said to have anti-aging properties, while Anastrozole is sought after by athletes and body builders for its ability to boost testosterone, ... Brisbane Times

Fast-dissolving Selegiline (Zelapar Zydis) Reduces "Off-Time" in Up...  -  Oct 3, 2005
By Paula Moyer. SAN DIEGO, CA -- October 3, 2005 -- The buccally absorbed formulation of selegiline (Zelapar(R)) using the Zydis(R) fast-dissolving ... DG News

Learn about Selegiline from Consumer Reports Health.  -  Jan 7, 2007
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the ... consumerreports.org

FDA Approves EMSAM(R) (selegiline Transdermal System), The First …  -  Mar 6, 2006
Bristol-Myers Squibb Company (NYSE: BMY) and Somerset Pharmaceuticals, Inc., a joint venture between Mylan Laboratories Inc. (NYSE: MYL) and Watson ... Medical News Today - Medical News Today (press release)

How to take Selegiline from Consumer Reports Health.  -  Jan 7, 2007
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the ... consumerreports.org

… Announces Revised FDA PDUFA Date for EMSAM(R) (Selegiline …  -  Nov 21, 2005
On October 26, 2005 the Psychopharmacologic Drug Advisory Committee voted EMSAM(R) (selegiline transdermal system) could be safely administered without ... $4.95 - PR Newswire - ECNext

SELEGILINE (Oral route) - se-LE-ji-leen.(Drug overview)  -  May 1, 2007
Selegiline is used in combination with levodopa or levodopa and carbidopa combination to treat Parkinson's disease, sometimes called shaking palsy or ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Disease; Rasagiline, in doses equivalent to selegiline, is less...  -  Jan 1, 2005
Scientists writing in the British Journal of Pharmacology report, "Selegiline is used for treating Parkinson disease. Despite its efficacy, the clinical use ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

… to treat major depressive disorder in adults: once daily EMSAM...  -  May 1, 2006
EMSAM (selegiline) is the first FDA-approved transdermal patch to treat major ... According to results from several controlled trials, the selegiline ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

… resistant depression, try transdermal selegiline.(Adult Psychiatry)...  -  Mar 1, 2007
For resistant depression, try transdermal selegiline.(Adult Psychiatry)(Drug overview) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

STEPS - February 15, 2008 -- American Family Physician  -  Feb 15, 2008
The selegiline transdermal patch (Emsam) delivers higher, more sustained blood levels to the ... Unlike oral MAO inhibitors, transdermal selegiline delivers ... AAFP News Now

Taking Selegiline from Consumer Reports Health.  -  Jan 7, 2007
Pending revision, the material in this section should be considered in light of more recently available information in the MedWatch notification at the ... consumerreports.org

Article: Selegiline serves as effective adjunct for PD symptoms.( …  -  May 1, 2006
WASHINGTON -- An orally disintegrating formulation of selegiline appears to be a safe and effective adjunct for patients with Parkinson's disease who are ... Pay-Per-View - Internal Medicine News - HighBeam Research

Article: FDA panel backs selegiline patch for depression.( Food and...  -  Dec 1, 2005
FDA panel backs selegiline patch for depression.( Food and Drug Administration) ... find Clinical Psychiatry News articles. GAITHERSBURG, MD. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Article: Selegiline reduces some adverse events in Parkinson's.( …  -  Oct 1, 2008
CHICAGO -- In a group of patients with motor fluctuations and dopamine agonist-related side effects, adding orally disintegrating selegiline and decreasing ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Monoamine Oxidase Inhibition for Tobacco Pharmacotherapy  -  Oct 5, 2007
Selegiline, while being predominantly an MAO-B inhibitor (at doses 10 ... Because selegiline is non-selective for MAO subtypes at these higher doses, ... Nature.com

First skin patch for depression  -  Mar 8, 2006
The Food and Drug Administration approved the selegiline transdermal patch, ... Selegiline, approved in pill form by the FDA in 1989 to help treat ... Times Herald-Record

selegiline Valeant approvable, USA (Parkinson disease).(Valeant …  -  Oct 17, 2005
Valeant announced on 4 October 2005 that it has received a second approvable letter from the US FDA, requesting additional clarification on issues ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Press Release: FDA approves emsam (selegiline) as first drug patch...  -  Mar 1, 2006
FDA approves emsam (selegiline) as first drug patch for depression lowest dose can be used without restrictions required of MAOI class of depression drugs. Pay-Per-View - M2 Presswire - HighBeam Research

Business Update; Somerset files response to US FDA letter on selegilin...  -  Jul 11, 2005
...to the United States Food and Drug Administration's (FDA) action letter, dated January 30, 2004, related to EMSAM (selegiline transdermal system). ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

… Administration Approves EMSAM(R) (selegiline transdermal system),...  -  Feb 28, 2006
US Food and Drug Administration Approves EMSAM(R) (selegiline transdermal system), the First Transdermal Patch for the Treatment of Major Depressive ... Pay-Per-View - PR Newswire - HighBeam Research

Business Update; Somerset files response to US FDA letter on selegilin...  -  Jul 12, 2005
...to the United States Food and Drug Administration's (FDA) action letter, dated January 30, 2004, related to EMSAM (selegiline transdermal system). ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Article: Selegiline safe, effective as adjunct for Parkinson's.(care...  -  May 1, 2006
Selegiline safe, effective as adjunct for Parkinson's.(care and treatment)(drug use) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Lonnie Ali Champions 'Fight For MORE' Campaign.  -  Apr 26, 2007
Zelapar is a special formulation of the drug selegiline that adds more active ... Do not take Zelapar if you are allergic to selegiline or any of the other ... $4.95 - PR Newswire - ECNext

Business Update; Company submits response to US FDA approvable …  -  Feb 5, 2005
Zelapar (selegiline hydrochloride) is a late-stage candidate under review by the FDA as an oral tablet using the patented Zydis fast-dissolving technology ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

The selegiline transdermal system (Emsam, Bristol-Myers Squibb/ …  -  Mar 1, 2006
The selegiline transdermal system (Emsam, Bristol-Myers Squibb/Somerset) was approved for the treatment of major depressive disorder. ... $9.94 - Formulary - Alacra Store

FDA DELAYS PDUFA DATE FOR ANTIDEPRESSANT PATCH  -  Nov 30, 2005
Selegiline products have been linked to hypertensive reactions associated with tyramine, an ingredient contained in several foods, including smoked meats, ... Pay-Per-View - FDAnews Drug Daily Bulletin - Factiva, from Dow Jones

… has FDA approval for Zelapar (selegiline HCl) Orally Disintegrating...  -  Jul 24, 2006
Valeant Pharmaceuticals has FDA approval for Zelapar (selegiline HCl) Orally Disintegrating Tablets. The monoamine oxidase-B inhibitor, using the Zydis oral ... $4.95 - Drug Topics - ECNext

… States Code of Federal Regulations - 21 CFR § 520.2098 Selegiline ...  -  Jul 11, 2006
21 CFR § 520.2098 Selegiline hydrochloride tablets. (a) Specifications. Each tablet contains either 2, 5, 10, 15, or 30 milligrams of selegiline ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

바른언론 빠른뉴스 ì?¸í„°ë„· 연합뉴스  -  Oct 8, 2008
...� 서울대병�� 같� 복용할 경우 간질�고혈압 등 부작용� �으킬 우려가 있어 병용 처방� 금지� `노르트립틸린(nortriptyline)'과 `셀레길린(selegiline)' 성분� ... 연합뉴스

… has FDA approval for Zelapar (selegiline HCl) Orally Disintegrating...  -  Jul 24, 2006
Valeant Pharmaceuticals has FDA approval for Zelapar (selegiline HCl) Orally Disintegrating Tablets. Valeant Pharmaceuticals has FDA approval for Zelapar ... $9.94 - Drug Topics - Alacra Store

The first transdermal antidepressant.(RX Primer)  -  Sep 22, 2006
...(2) In 2006 a transdermal MAOI selegiline patch (EMSAM) was approved by the ... Selegiline (L-Deprenyl) is a selective inhibitor of the MAO-B isoenzyme and ... $4.95 - Annals of the American Psychotherapy... - ECNext

Medicine helped senile dog -- can it help humans?  -  Aug 7, 2005
What can you tell me about selegiline? The vet prescribed it for my elderly dog. ... Our veterinary consultant, Andrea Frost, says that selegiline can be ... Pay-Per-View - The Sun - ProQuest Archiver

Selegiline; US FDA approves selegiline transdermal patch for treatment...  -  Mar 28, 2006
2006 MAR 28 - (NewsRx.com) -- Bristol-Myers Squibb Company (BMY) and Somerset Pharmaceuticals, Inc., a joint venture between Mylan Laboratories Inc. (MYL) ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Evotec Reports Phase I Safety Data From Tyramine Interaction Study...  -  Oct 27, 2008
At its recommended therapeutic dose selegiline does not require dietary restrictions, ... In this study, the therapeutic dose of selegiline did increase the ... RedOrbit

The first transdermal antidepressant.(RX Primer) | Article from...  -  Sep 22, 2006
...(2) In 2006 a transdermal MAOI selegiline patch (EMSAM) was approved by the ... Selegiline (L-Deprenyl) is a selective inhibitor of the MAO-B isoenzyme and ... Pay-Per-View - Annals of the American Psychotherapy... - HighBeam Research

Management of Parkinson disease: current treatments, recent advances,...  -  Sep 1, 2007
...(8) Selegiline monotherapy can be initiated in patients with early-stage PD who ... (12) One study demonstrated that in patients randomized to selegiline, ... $4.95 - Formulary - ECNext

selegiline Valeant receives US FDA approval for oral disintegrating...  -  Jun 26, 2006
...exhibit deterioration in the quality of their response to this therapy. ....ZELAPAR was developed using Cardinal Health's ZYDIS technology, which allows ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Long-term outcome in Parkinson disease: no advantage to initiating …  -  Aug 18, 2008
6 The treatment arm that included selegiline was terminated after an interim analysis because of concerns about toxicity. As observed in other trials that ... Nature.com

FDA Approvals: Rituxan and Emsam  -  Mar 3, 2006
On February 27, the FDA approved selegiline transdermal system ( Emsam, ... Patients using the selegiline patch reported sexual dysfunction at a rate ... Medscape

Zyvox Oral: Dosage, Uses and Warnings  -  Aug 10, 2006
4) Entacapone may be used with selegiline, provided that the daily dose of selegiline ... At daily doses of 10 mg, selegiline is primarily a selective MAO-B ... Medscape

Send to a friend  -  Oct 20, 2008
The lead product, Selegiline, is an off-patent monoamine oxidase inhibitor (MAOI) primarily indicated for the treatment of depression, but also with ... Scottish Enterprise

Rasagiline preclinical studies: implications for neuroprotection.  -  Aug 1, 2006
Selegiline (also known as deprenyl) was developed to provide symptomatic benefit ... Early on, however, selegiline was also theorized to have possible ... Free with registration - Formulary - AccessMyLibrary.com

Treatment Modalities for Parkinson's Disease  -  Jun 9, 2008
Selegiline is currently approved for use as adjunctive therapy in ... [11-13] Use of selegiline as monotherapy can also be traced back to data suggesting ... Medscape

Article: Orally disintegrating clonazepam.(Brief article) - Clinical ...  -  Jan 1, 2006
WASHINGTON -- An orally disintegrating formulation of selegiline ... Selegiline taken in the orally disintegrating form significantly decreased ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Can Doggy Drug Ward Off Dementia?  -  Aug 1, 2005
Q. What can you tell me about selegiline? The vet prescribed it for my elderly ... Several days after she started on selegiline all those behaviors stopped ... HealthCentral.com

Rasagiline preclinical studies: implications for neuroprotection.  -  Aug 1, 2006
Selegiline (also known as deprenyl) was developed to provide symptomatic benefit ... Early on, however, selegiline was also theorized to have possible ... $4.95 - Formulary - ECNext

Crunch Time at Teva  -  Aug 4, 2005
Before patients start using levodopa, physicians prescribe medications including selegiline, which is part of a class of drugs known as selective ... TheStreet.com - TheStreet.com (subscription)

Parkinson's patients stomach new drug better than conventional meds  -  Jun 13, 2006
A new form of the medication selegiline, used for years to manage motor complications ... "This unique formulation of selegiline delivers a more active drug ... News-Medical.net

Valeant Pharmaceuticals Announces the Launch of the zelaCARD  -  Sep 18, 2007
Zelapar is contraindicated in patients with a known hypersensitivity to any formulation of selegiline or any of the inactive ingredients of Zelapar. ... Bloomberg

Benefits and Risks of Parkinson's Disease Drugs  -  Jan 1, 2005
Most of the research (13 studies) evaluated selegiline. Clinical disability ratings were significantly better with use of selegiline in six of the studies. ... AAFP News Now

Selegiline G Gam - Indications, Contre indications, Effets indésirable...  -  Sep 7, 2006
1) En monothérapie : au début de la maladie, la sélégiline permet de différer le recours à la dopathérapie. - au stade des fluctuations de "fin de dose", ... Santé AZ

Stanford Study Will Test Antidepressant Patch That May Help Smokers …  -  Jan 8, 2007
The drug, selegiline, could help smokers combat the cravings they feel when ... Because selegiline is an antidepressant, it could stave off those feelings. ... Free with registration - Business Wire - AccessMyLibrary.com

Pharmacology and pharmacokinetics of rasagiline: a selective, …  -  Aug 1, 2006
Selegiline is derived from an amphetamine pharmacophore and is converted by cytochrome ... Rasagiline and selegiline are both aromatic N-propargylamines, ... $4.95 - Formulary - ECNext

美藥物管ç?†å±€æ ¸å‡†æ–°åž‹æŠ—憂鬱皮膚貼片上市  -  Mar 3, 2006
...電)美國食å“?暨藥物管ç?†å±€ä»Šå¤©æ ¸å‡†èƒ½æ²»ç™‚é‡?度憂鬱症的新型皮膚貼片,患者æ¯?天貼上 這種å??為「Emsamã€?的貼片,便能將Selegiline藥劑é€?é?Žçš®è†šæ»²å…¥è¡€æ¶²ä¸­ï¼Œé?”到療效。 ... epochtimes.com

FARMACI: USA; VIA LIBERA A CEROTTO CONTRO DEPRESSIONE  -  Feb 28, 2006
...alla spina e con altri farmaci: da evitare quando si usa il cerotto a base di selegiline, una sostanza approvata nel 1989 per combattere il Parkinson. ... Regione Basilicata

FPIN's Clinical Inquiries  -  Aug 1, 2005
Treatment of early Parkinson's disease with either selegiline (Eldepryl), ... Comparisons of therapeutic effects of levodopa, levodopa and selegiline, ... AAFP News Now

Psychiatric Times. Through the Times With Alan F. Schatzberg, MD  -  Aug 1, 2005
The second is the selegiline transdermal patch being developed by Somerset Pharmaceuticals ... When you give selegiline transdermally, Schatzberg explained, ... Psychiatric Times

Patches and sprays are coming to psychiatry.(Adult Psychiatry)  -  Jul 1, 2005
Transdermal selegiline may make it possible to achieve the ... Selegiline is an MAO inhibitor prescribed, in its oral formulation, for Parkinson's disease. ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Article: Emsam, Eraxis.(NEW & APPROVED) - Skin & Allergy News | …  -  May 1, 2006
NEW & APPROVED) ... find Skin & Allergy News articles. Emsam (selegiline transdermal system, Somerset Pharmaceuticals Inc., Bristol-Myers Squibb) A tr... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: FDA approves Emsam as first drug patch for Depression.(Indust...  -  May 1, 2006
...find Pharmaceutical Processing articles. The FDA recently approved Emsam (selegiline), the first skin (transdermal) patch for use in treating major de... Pay-Per-View - Pharmaceutical Processing - HighBeam Research

Evotec AG R&D Update Conference Call - Final.  -  Feb 19, 2007
And selegiline, the older compound, does have a food effect label. ... There has recently been a patch approved for selegiline, which is for use for the ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Pharmacotherapy for Parkinson's disease: current options, promising …  -  Aug 1, 2006
Independent of its MAO-B inhibition, selegiline is believed to protect against ... Selegiline slows the disabling deficits in PD, although its mechanism for ... Free with registration - JAAPA-Journal of the American Academy... - AccessMyLibrary.com

Article: Emsam.(Drug Approval ) - Internal Medicine News | HighBeam …  -  Apr 15, 2006
Drug Approval ) ... find Internal Medicine News articles. Emsam (selegiline transdermal system, Somerset Pharmaceuticals Inc., Bristol-Myers Squibb) ... Pay-Per-View - Internal Medicine News - HighBeam Research

Introduction.  -  Aug 1, 2006
The monoamine oxidase type B (MAO-B) inhibitor selegiline has been shown to ... Unlike selegiline, rasagiline has no intrinsic amphetamine-like effects. ... $4.95 - Formulary - ECNext

FDA approves skin patch to treat major depression.(Brief article) |...  -  May 1, 2006
At its lowest strength (6 milligrams over a 24-hour period), selegiline can be ... For more information about the selegiline patch, visit the FDA Website at ... Pay-Per-View - Journal of Employee Assistance - HighBeam Research

FDA panel backs low-dose MAO inhibitor patch.(Rx) | Article from...  -  Jan 1, 2006
The selegiline patch would be the first transdermal medication approved to ... An oral formulation of selegiline is approved and marketed as Eldepryl for ... Pay-Per-View - Internal Medicine News - HighBeam Research

Levodopa medications for Parkinson's disease  -  Dec 8, 2008
A monoamine oxidase (MAO) inhibitor (such as rasagiline or selegiline), ... Selegiline may be prescribed in some cases, but it is not commonly used. ... WebMD

New understanding of the brain helps smokers kick the habit  -  Mar 18, 2007
The antidepressant patch, called selegiline and marketed under the brand name ... Selegiline has been used for about 20 years to treat Parkinson's disease. ... $2.95 - Oakland Tribune - NewsBank

Article: Emsam, Eraxis.(New & Approved) - Family Practice News | …  -  Apr 15, 2006
New & Approved) ... find Family Practice News articles. Emsam (selegiline transdermal system, Somerset Pharmaceuticals Inc., Bristol-Myers Squibb) A tran... Pay-Per-View - Family Practice News - HighBeam Research

FDA Wants Clarity From Valeant  -  Oct 4, 2005
Zelapar is a faster-acting version of an existing drug, selegiline. Valeant is using a technology that allows the drug to dissolve in seconds and be ... TheStreet.com - TheStreet.com (subscription)

Article: New understanding of the brain helps smokers kick the habit ...  -  Mar 18, 2007
The antidepressant patch, called selegiline and marketed under the brand name ... Selegiline has been used for about 20 years to treat Parkinson's disease. ... Pay-Per-View - Oakland Tribune - HighBeam Research

MAO-B inhibitors do not appear to slow Parkinson's disease progression  -  Aug 25, 2005
I suspect that selegiline delays motor fluctuations as it continuously delivers ... “I would favor selegiline for further study because this is the most ... RxPG NEWS

Valeant Pharmaceuticals Announces Availability of Zelapar(R) for …  -  Jul 18, 2006
Zelapar is contraindicated in patients with a known hypersensitivity to any formulation of selegiline or any of the inactive ingredients of Zelapar. ... Genetic Engineering News - Genetic Engineering News (press release)

Four new Parkinson's disease guidelines hailed: review finds insuffici...  -  Jun 1, 2006
The use of selegiline, levodopa, or a dopamine agonist for the initiation of treatment for PD is supported by the highest level of data. ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Drugs that improve Parkinson's symptoms may not slow disease …  -  Aug 29, 2005
..."I suspect that selegiline delays motor fluctuations as it continuously delivers ... "I would favor selegiline for further study because this is the most ... i-newswire.com

Transdermal and intranasal delivery systems now in pipeline for...  -  Jun 1, 2005
Transdermal selegiline may make it possible to achieve the antidepressant ... Although the MAO inhibitor selegiline is selective at low doses for MAO-B ... Free with registration - Internal Medicine News - AccessMyLibrary.com

New practice parameters for Parkinson's hailed.(Disease/Disorder …  -  Jun 15, 2006
The use of selegiline, levodopa, or a dopamine agonist for the initiation of treatment for PD is supported by the highest level of data. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

A Parkinson's disease primer.(CONTINUING EDUCATION: An ongoing …  -  Oct 22, 2007
Selegiline and rasagiline are both irreversible inhibitors of the enzyme monoamine ... Other results from the trial indicated that selegiline slowed the ... $4.95 - Drug Topics - ECNext

Parkinson Disease: New Insights, New Treatment Options.  -  Oct 1, 2006
Selegiline, available since 1989, has been reformulated in a new ... Selegiline is approved as an adjunct to carbidopa/levodopa for patients who experience ... $4.95 - Consultant - ECNext

EBSCOhost Connection: First Depression Patch Approved.  -  May 1, 2006
Bristol-Myers' skin patch delivers selegiline, a monoamine oxidase inhibitor, through the skin and into the bloodstream. Emsam layers consist of a backing, ... Subscription - FDA Consumer - EBSCO Publishing

Article: Zelapar available for PD.(FYI)(Parkinson disease)(Brief...  -  Nov 1, 2006
...find Clinical Psychiatry News articles. Zelapar (selegiline HC1, orally disintegrating tablets) is available as an adjunct therapy for Parkinson's pa... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Article: Strategies for innovating new treatments in psychiatry: are...  -  Nov 1, 2005
Transdermal delivery increases bioavailability of selegiline to the brain, ... At the same time, transdermal delivery of selegiline by passes the gut and ... Pay-Per-View - Psychopharmacology Educational Updates - HighBeam Research

Company seeks to expand market for mental health patch as sales …  -  Apr 13, 2007
Researchers are investigating whether selegiline, the active ingredient in Somerset's Emsam patch, helps people quit smoking. ... Bizjournals.com

Why hasn't neuroprotection worked in Parkinson's disease?  -  Dec 13, 2006
The most notable of these studies have been of selegiline hydrochloride ... (2006) Selegiline slows the progression of the symptoms of Parkinson disease. ... Nature.com

More than $126,000 in nationwide settlement with Walgreens announced ...  -  Jun 4, 2008
20 mg capsules to tablets and Selegiline (generic Eldepryl) from 5 mg tablets to capsules. The switches allegedly occurred from July 2001 through 2005. ... Stamford Plus Magazine

FDA approves first patch to treat depression | Article from Chicago...  -  Mar 1, 2006
The Food and Drug Administration approved the selegiline transdermal patch, ... Selegiline, approved in pill form by the FDA in 1989 to help treat ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Parkinson Disease: Phenomenology and Treatment of the Most Common …  -  Mar 1, 2008
Antiparkinsonian medications, including selegiline, bromocriptine, pergolide, and pramipexole, are reported to have antidepressant effects. ... Psychiatric Times

Article: BMS awards Interlink Emsam interactive work.(contracts of...  -  May 1, 2006
Emsam (selegiline transdermal system) was developed by Somerset Pharmaceuticals, ... Article: FDA approves emsam (selegiline) as first drug patch for ... ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

New imaging methods may speed diagnosis of Parkinson's.(Neurology) | ...  -  May 15, 2005
Article: Selegiline serves as effective adjunct for PD ... ... WASHINGTON -- An orally disintegrating formulation of selegiline appears to be a safe and ... Pay-Per-View - Internal Medicine News - HighBeam Research

Adding safinamide to dopamine agonists eases Parkinson's.( …  -  Aug 1, 2007
Article: Selegiline reduces some adverse events in ... ... The use of selegiline, levodopa, or a dopamine agonist for the initiation of treatment for PD is ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

FDA Panel Recommends No Warning for Low-Dose Emsam  -  Oct 27, 2005
Currently marketed selegiline products, such as Somerset's Eldepryl, carry warnings about hypertensive reactions associated with tyramine, an ingredient ... Pay-Per-View - Drug Industry Daily - Factiva, from Dow Jones

Brand Names/Synonyms:
Selegiline is also known by the following brand names and/or synonymsApo-Selegiline; Carbex; Eldepryl; Gen-Selegiline; Jumex; L-Deprenalin; L-E 250; Novo-Selegiline; Nu-Selegiline; Sd Deprenyl; Selegeline Hcl; Selegilina [Inn-Spanish]; Selegiline; Selegiline Hcl; Selegiline-5; Selegilinum [Inn-Latin]

Drug Category:
Selegiline is categorized under the following by the FDA: Dopaminergics; Neuroprotective Agents; Antiparkinson Agents; Antidyskinetics; Central Nervous System Agents; ATC:N04BD01

Dosage Forms:
TABLET

Absorption:
Rapidly absorbed from the gastrointestinal tract

Interactions:
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Chemical IUPAC Name:
N-methyl-N-(1-methyl-2-phenyl-ethyl)-prop-2-yn-1-amine





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