Sevoflurane

This page contains recent news articles, when available, and an overview of Sevoflurane but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Sevoflurane (when available)

Pharmacology and use:
Sevoflurane is a general inhalation anesthetic used for induction and maintenance of general anesthesia. It induces muscle relaxation and reduces pains sensitivity by altering tissue excitability. It does so by decreasing the extent of gap junction mediated cell-cell coupling and altering the activity of the channels that underlie the action potential. Used for induction and maintenance of general anesthesia in adult and pediatric patients for inpatient and outpatient surgery

Mechanism Of Action:
Sevoflurane induces a reduction in junctional conductance by decreasing gap junction channel opening times and increasing gap junction channel closing times. Sevoflurane also activates calcium dependent ATPase in the sarcoplasmic reticulum by increasing the fluidity of the lipid membrane. Also appears to bind the D subunit of ATP synthase and NADH dehydogenase. Sevoflurane also binds to the GABA receptor, the large conductance Ca²⁺ activated potassium channel, the glutamate receptor and the glycine receptor.

News Articles on Sevoflurane

Composite Variability Index of Intraoperative Somatic Events Similar With ...  -  ‎Oct 20, 2009‎
The researchers wanted to compare the relation of CVI with somatic responses for propofol/remifentanil and sevoflurane/remifentanil, according to Donald ... DG News

Piramal's critical care business looking at $100m sales  -  ‎Nov 3, 2009‎
Inhalation anaesthetics are gasses that possess anaesthetic qualities like halothane, isoflurane, desflurane, sevoflurane and enflurane. ... Daily News & Analysis

Wastage of Supplies and Drugs in the Operating Room  -  ‎Oct 22, 2009‎
Fortunately, the two most commonly used anesthesia gases, sevoflurane and desflurane, contain neither chloride nor bromide, and thus should not pose a ... Medscape

Dextrose solution decreases postoperative nausea and vomiting  -  ‎Oct 25, 2009‎
All patients underwent a sevoflurane-vecuronium general anesthesia and received one dose of an antiemetic, a drug effective against nausea and vomiting 30 ... News-Medical.net

Chamber Corner  -  30 Aug 2009
Dunkirk Animal Clinic provides medical, surgical, and other services for pet animals including: Surgery; Anesthesia; Sevoflurane; Dentistry; Evening Observer

Dealing with dreaded "pet breath"  -  ‎Aug 19, 2009‎
Quick-acting IV anesthetics (eg propofol) and certain anesthetic gases (eg isoflurane, sevoflurane) are often preferred in older pets. San Francisco Chronicle

Thromboelastometry-guided administration of fibrinogen concentrate ...  -  ‎Aug 20, 2009‎
For maintenance of anesthesia, sevoflurane was titrated to an end-tidal concentration of 1% to 2% until institution of ECC. Propofol was infused at 50 to 80 The Journal of Thoracic and Cardiovascular Surgery

Filipino firm to make inhalation anesthesia  -  ‎Jul 2, 2009‎
With an investment of P39.204 million, the company has proposed to produce 50000 bottles of anesthetics such as Sevoflurane, Enflurane and Isoflurane in the Manila Bulletin

Complications from a general anesthesia  -  ‎Jul 6, 2009‎
General anesthetic drugs that have triggered MH include isoflurane, desflurane, enflurane, sevoflurane, methoxyflurane, cycl-propane halothane, Manila Bulletin

Half a billion worth of new investments get tax perks  -  ‎Jul 2, 2009‎
...as it plans to invest P40 million to set up a production facility of inhalation anesthesia such as Sevoflurane, Enflurane and Isoflurane in liquid form. GMA news.tv

Genomic Copy Number Affects Anesthetic Response Fly study suggests ...  -  ‎Jun 26, 2009‎
They also observed similar responses when these strains were exposed to enflurane, isoflurane, and sevoflurane. "Changes in copy number thus take their Modern Medicine

Anaesthesiological strategies in elective craniotomy: randomized ...  -  ‎Apr 6, 2009‎
Two statistical comparisons have been planned: 1) sevoflurane + fentanyl vs. Secondary end-points include: an assessment of neurovegetative stress based on 7thSpace Interactive (press release)

Breed health spotlight: Saluki  -  ‎Mar 16, 2009‎
Halothane, an older gas anesthetic that is very fat-soluble and metabolized by the liver has been generally replaced by isoflurane and sevoflurane, Examiner.com

Superior Vena Cava Compression During Posterior Spinal Fusion for ...  -  ‎Mar 2, 2009‎
Anesthesia was maintained with propofol and remifentanil intravenous infusions and low-dose sevoflurane (0.2 MAC [minimum alveolar concentration]). Journal of Bone and Joint Surgery (subscription)

..get Out Of Programme Training  -  ‎Feb 28, 2009‎
...puzzled when a hand-over to the ‘PACU’ (Post-anaesthesia care unit) nurse includes terms like ‘FOG’ and ‘SOG’ (isoflurane/ sevoflurane, oxygen and gas), AnaesthesiaUK

Sleep Mutants Increase Anesthesia Requirement Gene mutations ...  -  Jan 28, 2009
The half-maximum effective concentrations for isoflurane and sevoflurane were 0.706 and 1.298 for wild-type flies, 1.599 and 2.329 for the 102 mutant, Modern Medicine,

Piramal Healthcare Limited to Acquire Minrad International  -  Jan 15, 2009
...including process-based intellectual property for both sevoflurane and desflurane and will provide Piramal an immediate entry into the US market for Express Healthcare Management,

Baxter International Inc. Q4 2008 Earnings Call Transcript  -  Jan 22, 2009
We expanded our presence in the global anesthesia market with the continued success of SUPRANE, augmented by the launch of Baxter’s sevoflurane in nine new Seeking Alpha,

Merrill Lynch reiterates 'Neutral' rating on Piramal Healthcare  -  Jan 11, 2009
...business of PHL and broadens its portfolio from two products currently to five (halothane, isoflurane, enflurane, desflurane and sevoflurane). Economic Times,

경찰병�? 입찰 광림약품 초강세  -  Jan 20, 2009
...경찰청 경찰병�?�?� 나�?�장터(www.g2b.go.kr)�?서 Sevoflurane 1ml등 1,52품목�? 대해 품목별 단가입찰과 그룹별 �?액입찰(10개 그룹)�?� 실시한 결과 광림약품�?� 25개 디지틀보사,

Drug firm in India to acquire Minrad  -  Dec 24, 2008
It also gives Piramal an immediate entry into the US market for sevoflurane, the biggest selling inhalation anesthetic in the United States. Buffalo News,

'Goldilocks' Anesthesia Wows Attendees of the Mexican Society of ...  -  Dec 2, 2008
Inhalational anesthesia with drugs like isoflurane, desflurane or sevoflurane, says Friedberg, have been shown to be inflammatory while propofol, MarketWatch

DRE Veterinary Introduces Dynamic Flat Panel Monitor  -  Dec 5, 2008
DRE Veterinary also sells configurations with capnography, dual channel IBP and five anesthetic agents (Isoflurane, Sevoflurane, Halothane, N2O, 1888 Press Release (press release),

Minrad International  -  Nov 21, 2008
Its pharmaceutical line produces inhalation anesthetics including enflurane, isoflurane and sevoflurane. The medical device products incorporate patented OneMedPlace,

Liquidity Crisis: Minrad International Slashes Jobs, Evaluates Options  -  Nov 21, 2008
Last quarter, the company was unable to secure the raw materials needed to manufacture sevoflurane. As a result, Minrad was incapable of shipping $2.5 OneMedPlace,

MINRAD Reports Results for Third Quarter 2008  -  Nov 14, 2008
Our inability to secure additional raw materials to produce sevoflurane left us with insufficient finished goods to ship $2.5 million of these orders. MarketWatch

MINRAD Reports Results for Third Quarter 2008  -  Nov 14, 2008
Our inability to secure additional raw materials to produce sevoflurane left us with insufficient finished goods to ship $2.5 million of these orders. PR Newswire (press release),

Baxter International Inc. Q3 2008 Earnings Call Transcript  -  Oct 16, 2008
Double-digit international growth continues to be driven by penetration of SUPRANE, our proprietary anesthetic, augmented by growth of sevoflurane. Seeking Alpha,

Sevoflurane requirement during elective ankle day surgery: the ...  -  Sep 11, 2008
Methods: The intra-operative requirement of sevoflurane was studied in forty-four ASA 1-2 patients undergoing elective ankle day surgical in general 7thSpace Interactive (press release),

Minrad International, Inc. Q2 2008 Earnings Call Transcript  -  Sep 14, 2008
In particular, US revenue grew significantly versus 2007, where approval to sell sevoflurane did not occur until May 2007. US revenue accounted for 53% of Seeking Alpha,

RxElite Responds to Minrad International Notice of Non-Exclusive ...  -  Sep 12, 2008
...that it had received a letter from its supplier, Minrad International, Inc. Minrad is RxElite's supplier of Isoflurane, Sevoflurane and Enflurane. MarketWatch

MINRAD International, Inc. Announces Change in Distribution ...  -  Sep 11, 2008
Minrad already launched in June a direct selling effort for sevoflurane and isoflurane into the US veterinary market." Contact: David DiGiacinto, President Earthtimes (press release),

Minrad announces change in distribution agreement with RxElite ...  -  Sep 12, 2008
...forces of both companies as well as the in-house support capabilities which RxElite has built to launch sevoflurane in the US human anesthetic market. Trading Markets (press release),

�?�입 마취제 '�?�전'액 �?��? 공급  -  Aug 28, 2008
...경보제약(대표 김�?�?�)�?� 국내 �?�입마취제 시장�?� 70% �?��?�?� �?유 하고 있는 Sevoflurane 제제�?� '�?�전(SOJOURN)' 액�?� 미국 마취제 전문 제조사�?� 민�?�드사 와 �?��? 메디게�?�트뉴스,

MINRAD Announces Three Regulatory Approvals  -  Jul 28, 2008
MINRAD also announces completion of 3-year stability testing of its Sojourn(TM) Sevoflurane anesthetic agent. Sojourn(TM), manufactured at its MarketWatch

Minrad wins key regulatory approvals  -  Jul 30, 2008
Minrad also completed a three-year stability testing of its Sojourn Sevoflurane anesthetic agent. Sojourn, manufactured at its pharmaceutical plant in Pharmaceutical Business Review

BUYINS.NET: AYR, CPL, IMH, TPX, BUF, ASFI Have Been Removed From ...  -  Jul 14, 2008
The company manufactures and markets generic inhalation anesthetics, including isoflurane, enflurane, sevoflurane, and desflurane for use in connection with Trading Markets (press release),

Baxter International Inc. Q2 2008 Earnings Call Transcript  -  Jul 17, 2008
This performance was a result of continued penetration for SUPRANE, our proprietary anesthetic, augmented by growth of sevoflurane which we’ve launched in Seeking Alpha,

les soins dentaires et le détartrage chez les animaux  -  Jul 31, 2008
Elle est faite grâce a un gaz (isoflurane ou sevoflurane) très sécuritaire qui est utilisé pour les anesthésies humaines également. Réseau TVA,

RxElite, Inc. Announces Implementation of Preferred Contract ...  -  07 Jul 2008
Sevoflurane is the most commonly used anesthetic gas in the US and Isoflurane continues to hold share in the anesthetic gas market. CNNMoney.com

Adeka Launches MINRAD Sojourn(TM) Sevoflurane and SabreSource(TM)  -  Jun 12, 2008
Adeka is MINRAD's exclusive Turkish distributor of Terrell(TM) Isoflurane, Compound 347(TM) Enflurane, and now Sojourn(TM) Sevoflurane and the SabreSource Earthtimes (press release),

Painkillers' Surprising Legacy Is More Pain  -  Jun 23, 2008
...mustard oil to the ears of mice, a commonly used model of neurogenic inflammation, and then anesthetized them with either isoflurane or sevoflurane. MedPage Today,

MINRAD International, Inc. (AMEX: BUF) enters new markets  -  Jun 17, 2008
Sevoflurane has already been in the US drug market since May 2007 and has greatly contributed to the company's revenue generation. HotStocked,

Minrad Announces FDA Approval of General Anesthetic Drug, Petrem  -  Jun 9, 2008
Sevoflurane is used for induction and maintenance of general anesthesia. The Orchard Park, New York-based company also stated that earlier this week, RTT News,

Why anaesthetics can make the pain worse  -  Jun 24, 2008
Some newer, more expensive agents, such as sevoflurane, do not activate the TRPA1 receptor, and so should not contribute to pain and inflammation. New Scientist (subscription),

Adeka Launches MINRAD Sojourn(TM) Sevoflurane and SabreSource(TM)  -  Jun 12, 2008
Fundamental data is provided by Zacks Investment Research and market data is provided by AlphaTrade. All information provided "as is" for informational istockAnalyst.com,

Central Glass enters EU API market via Girindus plant  -  Jun 10, 2008
The Japanese firm supplies APIs such as the anaesthetic sevoflurane and antiulcerant lafutidine, as well as other bulk pharmaceuticals and intermediates. OutSourcing-Pharma.com,

BUF: Approval for Tyurkish Distributor to Market Sojourn(TM) and ...  -  Jun 12, 2008
Adeka is MINRAD's exclusive Turkish distributor of Terrell(TM) Isoflurane, Compound 347(TM) Enflurane, and now Sojourn(TM) Sevoflurane and the SabreSource Trading Markets (press release),

Market Report -- In Play (BUF)  -  Jun 9, 2008
Minrad Intl announces FDA approval of Petrem Sevoflurane The co announces it has received approval from the FDA for Veterinary Medicine to market Petrem MSN Money

RxElite Announces Implementation of Preferred Contract Status ...  -  May 27, 2008
RxElite was awarded a preferred contract listing for all classes of trade for Sevoflurane (Sojourn(TM)) and Isoflurane (Terrell(TM)) pursuant to a contract CNNMoney.com

Certain Other Dosage Form New Animal Drugs; Sevoflurane  -  May 7, 2008
SUPPLEMENTARY INFORMATION: Minrad, Inc., 836 Main St., 2nd floor, Buffalo, NY 14202, filed ANADA 200-438 that provides for use of PETREM (sevoflurane) Therapeutics Daily (subscription) (press release),

Minrad revenue up 300%, losses remain  -  May 15, 2008
The Buffalo-based company (AMEX: BUF) said the gains were based on its sevoflurane line. Minrad, an interventional pain management company, also said losses Bizjournals.com,

MINRAD Reports Results for First Quarter 2008  -  May 13, 2008
While we continue to experience start-up issues with our new sevoflurane line, the plant expansion clearly puts us at a new operating plateau. Biloxi Sun Herald,

Effect of Preemptive Epidural Analgesia on Cytokine Response and ...  -  May 9, 2008
The sevoflurane concentration was controlled to maintain a systolic blood pressure within a 20% range of basal systolic pressure. RedOrbit,

Brand Names/Synonyms:
Sevoflurane is also known by the following brand names and/or synonyms:
Bax 3084; CHEMBANK2842; MR6S4; Sevofluran; Sevoflurane; Sevoflurane [Usan:Ban:Inn:Jan]; Sevoflurano [Inn-Spanish]; Sevofluranum [Inn-Latin]; Sevorane; Ultane; [Inn-Latin]

Drug Category:
Sevoflurane is categorized under the following by the FDA: Anesthetics; General Anesthetics; ATC:N01AB08

Dosage Forms:
LIQUID

Absorption:
Rapidly absorbed into the circulation via the lungs

Interactions:
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Chemical IUPAC Name:
1,1,1,3,3,3-hexafluoro-2-(fluoromethoxy)propane

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