Sibutramine

This page contains recent news articles, when available, and an overview of Sibutramine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Sibutramine (when available)

Pharmacology and use:
Sibutramine is an orally administered agent for the treatment of obesity. Sibutramine exerts its pharmacological actions predominantly via its secondary (M1) and primary (M2) amine metabolites. The parent compound, sibutramine, is a potent inhibitor of serotonin and norepinephrine reuptake in vivo, but not in vitro. However, metabolites M1 and M2 inhibit the reuptake of these neurotransmitters both in vitro and in vivo. In human brain tissue, M1 and M2 also inhibit dopamine reuptake in vitro, but with ~3-fold lower potency than for the reuptake inhibition of serotonin or norepinephrine. Sibutramine, M1 and M2 exhibit no evidence of anticholinergic or antihistaminergic actions. In addition, receptor binding profiles show that sibutramine, M1 and M2 have low affinity for serotonin (5-HT₁, 5-HT_1A, 5-HT_1B, 5-HT_2A, 5-HT_2C), norepinephrine (b, b1, b3, a1 and a2), dopamine (D1 and D2), benzodiazepine, and glutamate (NMDA) receptors. These compounds also lack monoamine oxidase inhibitory activity in vitro and in vivo. For the treatment of obesity

Mechanism Of Action:
Sibutramine produces its therapeutic effects by norepinephrine (NE), serotonin reuptake (5-hydroxytryptamine, 5-HT) and dopamine reuptake inhibition. Sibutramine and its major pharmacologically active metabolites (M1 and M2) do not act via release of monoamines.

News Articles on Sibutramine

Healthy Weight Network announces worst diet scams of 2009  -  05 Jan 2010
In an analysis of 28 weight-loss products, the FDA found sibutramine, a controlled substance, in all of them, and some with the substance rimonabant, ... Minot Daily News

Médicament pour maigrir Sibutral (sibutramine): mises en garde de l'Afssaps  -  05 Jan 2010
Récemment, l'Agence a mis en garde contre la commercialisation illégale de produits qui contenaient de la sibutramine non déclarée sur le conditionnement ... PsychoMédia

Heart attack and stroke fears over fat-busting wonder pill  -  ‎Jan 2, 2010‎
Most of those recruited for the Sibutramine Cardiovascular Outcome Trial (SCOUT) were overweight or obese and already had cardiovascular problems. ... Daily Mail

Dangerous chemicals in slimming capsule  -  ‎Jan 3, 2010‎
A Health Ministry source said tests revealed that the slimming product, sold in capsule form, contained not one but two dangerous chemicals, sibutramine and ... New Straits Times

Abbott's Meridia might boost health risks: EU  -  ‎Dec 19, 2009‎
..."Abbott's ongoing evaluation of the SCOUT study data does not change our medical assessment of sibutramine's risk-benefit profile when used appropriately in ... Chicago Sun-Times

FDA, Manufacturers Advise Physicians of Actions Involving Various Drugs  -  ‎Dec 11, 2009‎
The FDA has notified physicians that it is reviewing preliminary data from a study that suggests patients using sibutramine hydrochloride, which is marketed ... AAFP News Now

EU Panel Backs DuoCover From Bristol-Myers Squibb Pharma  -  ‎Dec 18, 2009‎
...-The Committee is reviewing data from the Sibutramine Cardiovascular OUTcomes (SCOUT) trial that indicate an increased risk of serious cardiovascular events ... Wall Street Journal

Alert issued on slimming products  -  ‎Dec 11, 2009‎
The presence of sibutramine and phenolphthalein and two analogues of sibutramine were detected. The products are not registered pharmaceutical products in ... News.gov.hk

Man... for selling slimming product with undeclared drugs on the Internet  -  ‎Dec 17, 2009‎
A department spokesman explained that sibutramine was a western medicine used as an appetite suppressant. Its side effects include increased blood pressure ... Media Newswire (press release)

Phenolphthalein Found in Weight Loss Product, Arrest Made  -  ‎Dec 22, 2009‎
Sibutramine which is the active ingredient of the legal prescription weight loss medicine Reductil should only be taken after consulting with a doctor ... UKMedix Health News

Hong Kong: Public urged not to consume slimming products with undeclared drug ...  -  ‎Dec 10, 2009‎
The appeal was made after laboratory tests on the product showed the presence of sibutramine and its analogue. The spokesman said the product was not a ... Webnewswire.com

Qingzhi Santian Shou Warning  -  ‎Dec 15, 2009‎
Not only is this altered version of sibutramine not registered for sale in Hong Kong or any other country worldwide but it has not been subjected to medical ... UKMedix Health News

Slim chance products are slimming  -  ‎Jan 1, 2010‎
The FDA said 28 weight-loss products contained sibutramine, a controlled substance associated with high blood pressure, heart attack and stroke, ... Grand Forks Herald

Handling Bariatrics  -  ‎Dec 31, 2009‎
Examples include fluoxetine (Prozac) and sibutramine (Merida). Both Prozac and Merida can cause dizziness, nausea, insomnia and significant increases in ... JEMS.com

Arena Pharmaceuticals Submits Application for New Weight Loss Drug Lorcaserin  -  ‎Dec 22, 2009‎
Meridia (sibutramine) made by Abbott Laboratories also works on the serotonin receptors in the brain to promote satiety and reduced calorie intake. ... eMaxHealth

FDA Hands-Off On St. John's wort Cataract Connections (Part 3)  -  ‎Dec 14, 2009‎
...“Slim Waist Formula,�? “21 Double SLIM�? and “24hours Diet�? were found to illegally contain sibutramine, a drug which is the active ingredient in the ... InjuryBoard.com (blog)

�?肥�?�“诺美亭�?安全性�?�质疑心�?病患者慎�?  -  ‎Jan 4, 2010‎
...“诺美亭�?是西布曲明（Sibutramine）的商�?�??，类似�?份�?�物在大多数国家都有销售。这�?�?�物�?�以借助刺激大脑神�?产生抑制食欲功效。英国�?��?与�?�?��?管�?�局�??供数�?� ... 搜狐

�?�有�?�險化學物�?分減肥藥�?�導致心臟病  -  ‎Jan 3, 2010‎
...（�?�隆�?�3日訊）有�?食減肥藥者�?�促�?心，因市�?�上銷售的一些膠囊減肥藥，�?�能�?�有鹽酸西布曲明（sibutramine）和二甲雙�?（metformin），�?�導致心臟病。 ... 中國報

Stand van zaken beoordeling onderzoeksgegevens sibutramine  -  ‎Dec 21, 2009‎
Sibutramine-bevattende geneesmiddelen moeten strikt worden toegepast binnen de huidige goedgekeurde productinformatie. Dit is de voorlopige conclusie van ... apothekersnieuws.nl

Les gels au kétoprofène prochainement retirés du marché  -  ‎Dec 18, 2009‎
L'Agence par ailleurs, resserre son étau sur un médicament anti-obésité déjà sous prescription restreinte : le Sibutral® (sibutramine). ... Destination Santé

อย.เตือนภัยอาหารเสริมอ้างลดอ้วน  -  ‎Dec 16, 2009‎
...มาตรวจวิเคราะห์ที่�?รมวิทยาศาสตร์�?าร�?พทย์ ผลปรา�?�?ว่า พบ "ไซบูทรามีน" (sibutramine) ซึ่งเป็นยาลดความอ้วน�?ละเป็นยาควบคุมพิเศษที่ต้องสั่งจ่ายโดย�?พทย์ ... ไทยรัฐ

市民勿�?用摻雜西藥�?份的產�?  -  ‎Dec 11, 2009‎
...衛生局根據香港衛生署的公告，產�?「清脂三天瘦�?�?�有西藥�?份「西布曲明�?(sibutramine)�?�「西布曲明�?類似物，但有關�?份並沒有標示在產�?標籤上。 ... 中華人民共和國澳門特別行政區政府新聞局

Des recommandations concernant Sibutral, médicament contre l'obésité  -  ‎Dec 22, 2009‎
Elle alerte également sur le risque de se procurer des médicaments pouvant contenir de la sibutramine, molécule composante du Sibutral, en dehors du circuit ... Toute la diététique !

「清脂三天瘦�?�?�西布曲明籲�?��?  -  ‎Dec 10, 2009‎
...一種�??為「清脂三天瘦�?的減肥產�?，被驗出�?�有「西布曲明�?（sibutramine）�?�「西布曲明�?類似物，�?後�?�能會引致嚴�?的副作用，衞生署呼籲市民�?�?購買或�?用。 ... 香港新浪網

Médicaments sur Internet : danger !  -  ‎Dec 10, 2009‎
Parmi les produits les plus populaires sur le Net, l'Afssaps pointe la Sibutramine, une spécialité utilisée dans le traitement contre l'obésité qui peut ... Ouest-France

Behörden prüfen Sicherheit von Abmagerungsmittel Reduktil  -  ‎Dec 21, 2009‎
An der „Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients“ oder SCOUT-Studie ... Deutsches Ärzteblatt

�?콩, '칭즈 싼톈쇼우' 미표기 �?�약품성분 검출  -  ‎Dec 11, 2009‎
...�?� 제품�?� �?�약품 성분�?� 시부트�?�민(Sibutramine)과 그 유사물질�?� 검출�??으며, 시부트�?�민 �? 유사물질�?� 부작용으로 심장마비, 뇌졸�?, 심계항진 등�?� 초래하여 ... 메디포뉴스

Στο 'μικ�?οσκόπιο' φά�?μακα για το αδυνάτισμα  -  ‎Dec 28, 2009‎
Τα δεδομένα π�?οέ�?χονται από την κλινική δοκιμή SCOUT (Sibutramine Cardiovascular OUTcomes). Σε αυτή συμμετείχαν σχεδόν 10.000 ασθενείς για έως και 6 έτη. ... Ιατροnet

EMEA alerta para riscos de fármacos que contêm sibutramina  -  ‎Dec 21, 2009‎
Os dados a ser avaliados surgem do ensaio Sibutramine Cardiovascular OUTcomes (SCOUT), que incluiu quase 10 mil doentes durante 6 anos. ... RCM Pharma

Schlankheitspille Sibutramin: Gefahr fürs Herz  -  ‎Dec 22, 2009‎
SCOUT-Studie ("Study of Sibutramine and the Role of Obesity Management in Relation to Cardiovascular Disease in Overweight and Obese Patients"). ... NetDoktor.de

Π�?οσοχή! Επικίνδυνα φά�?μακα αδυνατίσματος  -  ‎Dec 23, 2009‎
Τα δεδομένα που σήμαναν τον συναγε�?μό στον Ευ�?ωπαϊκό Ο�?γανισμό Φα�?μάκων π�?οέ�?χονται από την κλινική δοκιμή SCOUT (Sibutramine Cardiovascular OUTcomes), ... Madata.gr

Sibutramina sotto la lente dell'EMEA per aumento rischio cardiovascolare  -  ‎Dec 19, 2009‎
I dati provengono dallo studio SCOUT (Sibutramine Cardiovascular Outcome), che include circa 10.000 pazienti arruolati per un periodo massimo di sei anni. ... Pillole.org

Warning issued on slimming product  -  14 Nov 2009
Sibutramine is a Western medicine used as an appetite suppressant. Its side effects include increased blood pressure and heart rate, psychosis and ... News.gov.hk

Xi Zhi Su Is A Dangerous Weight Loss Supplement  -  14 Nov 2009
The testing which was done by the Department of Health in Hong Kong found that not only did Xi Zhi Su contain sibutramine which is the active ingredient of ... UKMedix Health News

減肥產�?之一排油果回收  -  14 Nov 2009
...「排油果�?�?�未有標示的西藥�?分，包括有「西布曲明�?（sibutramine）�?�「酚�?（phenolphthalein）。「西布曲明�?副作用包括�?�能導致血壓上�?��?�心跳加劇，精神異常和 ... 香港新浪網

California Company Recalls Weight Loss Supplement  -  ‎Nov 13, 2009‎
FDA officials warned the supplements pose a health risk because sibutramine can increase blood pressure and pulse rates in some patients. ... Consumer Affairs

Recalls: weight loss and dietary supplements  -  ‎Nov 12, 2009‎
...experiments and a suspected cancer-causing agent that is not approved for marketing in the US The product was also found to contain sibutramine, ... The Associated Press

Will Economic Adulteration Help Bring Down DSHEA?  -  ‎Nov 13, 2009‎
For example, FDA looked at MetaboSlim, from Confidence Inc., a couple of years ago and found it contained sibutramine, a drug approved by FDA for use as an ... Natural Products Industry Insider

Hong Kong: Warning about slimming product with undeclared drug ingredients  -  ‎Nov 13, 2009‎
Laboratory tests on the product showed the presence of sibutramine and phenolphthalein. The spokesman said sibutramine is a Western medicine used as an ... Webnewswire.com

Family Doctor: Fibromyalgia treatment needs more research  -  ‎Nov 9, 2009‎
The recent article on the difficulty in treating fibromyalgia (FM) reinforces the urgency in making available sibutramine hydrochloride monohydrate ... Canton Repository

Warning issued on slimming product  -  ‎Nov 12, 2009‎
Sibutramine is a Western medicine used as an appetite suppressant. Its side effects include increased blood pressure and heart rate, psychosis and ... News.gov.hk

Too fat? Weigh up risks of gastric band  -  ‎Nov 11, 2009‎
An alternative, sibutramine, is an appetite-suppressant. But it can cause nausea, dry mouth and constipation and might bump up your heart rate and blood ... The Sun

Donna H. Ryan, M.D., Elected President of The Obesity Society for 2009-2010  -  ‎Nov 13, 2009‎
Dr. Ryan's interest in obesity research was mentored by George Bray, beginning with a 1992 dose-ranging study of sibutramine. She has been an Investigator ... PR Newswire (press release)

New weight loss drugs on the horizon!  -  ‎Nov 7, 2009‎
In addition to the two medications currently available (Sibutramine (Meridia) and Orlistat (Xenical)), there are at least three new medications that are in ... Drumheller Mail

Chanting, joss sticks fail to stop sex pills raid  -  ‎Oct 25, 2009‎
Sibutramine is a controlled substance and side effects include dry mouth, nausea, upset stomach, constipation, insomnia, dizziness, drowsiness and muscle ... AsiaOne

Jeremy Laurance: A breakthrough – but the real answer lies in exercise and diet  -  ‎Oct 22, 2009‎
This could give it the edge over sibutramine, which raises blood pressure, and orlistat, which has unpleasant, although not unsafe, effects on the digestion ... Independent

Amylin Takes Lead in Obesity Race  -  ‎Nov 3, 2009‎
Also, management is testing pramlintide in a phase II trial with two commonly used anti-obesity agents, phentermine and sibutramine. ... Seeking Alpha (blog)

All of your cycling news – October 21, 2009  -  ‎Oct 21, 2009‎
In September 2007 he was fired by the T-Mobile team after being caught in the illegal substance sibutramine and served a one year suspension. ... Bike World News (blog)

Paper calls for regulation of dietary supplements  -  ‎Oct 24, 2009‎
One FDA analysis found a stimulant, sibutramine, in a product at three times the recommended maximum dose. Other drugs found in the pills that aren't on the ... CalorieLab Calorie Counter News

New Prescription Diet Pills Coming Soon  -  ‎Oct 23, 2009‎
The three prescription drugs presently used to treat obesity include sibutramine (Meridia), which increases satiety; phentermine, which suppresses appetite; ... That's Fit

LC: Speech bySFH on Pharmacy and Poisons Ordinance  -  ‎Oct 22, 2009‎
The four poisons are "Sibutramine; its salts", "Sildenafil; its salts", "Tadalafil; its salts" and "Vardenafil; its salts." We propose that these amendment ... 7thSpace Interactive (press release)

Bernucci, Spezialetti join Lampre  -  ‎Oct 23, 2009‎
Bernucci won stage six of the Tour de France in 2005 with T-Mobile before testing positive for weight control drug Sibutramine two years later. ... Yahoo! Eurosport

Dietary supplement adulteration with prescription drugs: Is it really a ...  -  ‎Oct 19, 2009‎
Analyses by the FDA have found the stimulant sibutramine in weight-loss supplements at levels amounting to three times the maximum recommended daily dose. ... ScienceBlogs (blog)

衛局籲勿�?摻西藥減肥產�?  -  ‎Nov 13, 2009‎
...�?本報訊】根據香港衛生署的公告，產�?“瘦身教館──體內�?�動丸�? �?�有西藥�?份“西布曲明(sibutramine)�?�?�“酚�?�(phenolphthalein)�?，但有關�?份並沒有標示在產�?標籤 ... 新華澳報

減肥藥�?�未標示西藥當局籲勿�?用  -  ‎Nov 13, 2009‎
...衞生署在最近的監察行動中，在一個�?賣網站發�?�該產�?，其樣本經化驗後，顯示�?�有「西布曲明�? (sibutramine) 和「酚酞�? (phenolphthalein) 。香港電台

两�??中国人在海�?�崴因销售�?�险�?肥�?�被罚款  -  ‎Oct 26, 2009‎
...专家在�?��?中�?�现了高�?��?西布曲明(Sibutramine)。这是一�?烈性物质，会引起心�?�?血管�?肾�?和�?�?并�?�症，破�??代谢平衡。�? 戈沃�?什科补充�?�：“中国公民在俄罗斯�?�法 ... 中新网

兩�??中國人在符拉迪沃斯托克因銷售�?�險減肥藥被罰款  -  ‎Oct 26, 2009‎
...專家在藥�?中發�?�了高�?��?西布曲明（Sibutramine）。這是一種烈性物質，會引起心髒�?血管�?腎髒和�?髒並發症，破壞代�?平衡。在俄羅斯境內為處方藥，而在中國，�?�有西 ... 鉅亨網

지침따르는 비만치료 거�?�없어  -  ‎Oct 25, 2009‎
...수년 전�? 시작�?� 1만례 �?��? 환�?를 대�?으로 한 전향�? 시험 Sibutramine Cardiovascular Outcomes Trial(SCOUT)�?서는 과체중과 비만�?�?� 심혈관계 위험환�?를 대�? ... 쿠키뉴스

항비만제 개발 3파전…비버스 선�?  -  ‎Oct 20, 2009‎
...리�?�틸'(Reductil, sibutramine)�?� 혈압과 심박�?� �?가시킬 수 있고, '제니칼'(Xenical, orlistat)�?� 불편한 장 문제를 �?�으킨다는 �?�?서 사용�?� 제한�?�?� �?태다. ... 디지틀보사

Bruising associated with sibutramine: results from postmarketing …  -  Oct 6, 2005
Correspondence: Dr M Harrison Woolrych, Intensive Medicines Monitoring Programme, Department of Preventive and Social Medicine, University of Otago, ... Nature.com

Long-term persistence with orlistat and sibutramine in a population...  -  Sep 18, 2006
Correspondence: Dr R Padwal, Division of General Internal Medicine, 2E3.22 Walter C. Mackenzie Health Sciences Center, University of Alberta Hospital, ... Nature.com

Influence of weight reduction by sibutramine on female sexual function  -  May 25, 2005
Correspondence: Dr HC Kang, Department of Family Medicine, Yonsei University College of Medicine, 134, Shinchon-dong, Seodaemoon-gu, Seoul 120-752, Korea. ... Nature.com

Fat pills give modest weight loss  -  Nov 16, 2007
Orlistat reduced weight by 2.9kg, sibutramine by 4.2kg and rimonabant by 4.7kg. Patients taking the weight loss pills were significantly more likely to ... BBC News

How effective is sibutramine for the treatment of overweight adolescen...  -  Oct 4, 2006
Berkowitz RI et al. (2006) Effects of sibutramine treatment in obese adolescents. Ann Intern Med 145: 81–90 PubMed. Behavioral therapies for adolescents who ... Nature.com

Diet drug 'doubles weight loss'  -  Oct 22, 2008
This is twice the level achieved by drugs such as sibutramine and rimonabant. But UK experts warned that more trials were needed, and expressed concerned ... BBC News

GPs too busy to advise on exercise and diet – so hand out £47m in...  -  Feb 1, 2008
Sibutramine works by altering chemical messages to the brain that control feelings ... Orlistat was licensed in Britain in 1998 and sibutramine in 2001. ... Times Online

Abuse of prescribed slimming drug seen in HK  -  Jun 1, 2007
Sibutramine is known by its brand, Reductil. Phentermine is off-patent ... "GPs don't prescribe sibutramine because phentermine's response is very quick. ... Reuters

Peripheral Mechanisms of Sibutramine Involving Proximal Gastric...  -  Sep 8, 2005
Correspondence: Jiande Chen Gastrointestinal Research, Route 0632, Room 221, Microbiology Building, 1108 The Strand, Galveston, TX 77555-0632. ... Nature.com

Effect of hypocaloric diet plus sibutramine treatment on hormonal and...  -  Jul 11, 2007
Correspondence: Dr D Florakis, Second Department of Obstetrics and Gynecology, Division of Endocrinology and Human Reproduction, Medical School, ... Nature.com

The Safety Profiles of Orlistat and Sibutramine: Results of Prescripti...  -  Nov 8, 2006
Correspondence: Michael Perrio Drug Safety Research Unit, Bursledon Hall, Blundell Lane, Southampton, United Kingdom S031 1AA. E-mail: michael.perrio@dsru. ... Nature.com

Influence of sibutramine treatment on sympathetic vasomotor tone in …  -  Aug 16, 2005
Background: Sibutramine, a serotonin and norepinephrine transporter blocker, is used as adjunctive obesity treatment. Studies in healthy subjects suggested ... Nature.com

Atlanta Metro News | ajc.com  -  Dec 23, 2008
Many contain sibutramine, a powerful appetite suppressant that's a chemical cousin of amphetamines. It can cause heart attacks, strokes, heart palpitations ... Atlanta Journal Constitution

Sibutramine Plus Meal Replacement Therapy for Body Weight Loss and …  -  Mar 24, 2006
James L. Early * , Caroline M. Apovian † , Louis J. Aronne ‡ , Madelyn H. Fernstrom § , Arthur Frank ¶ , Frank L. Greenway , David Heber ** , Robert F. ... Nature.com

T-Mobile cycling team fires rider Lorenzo Bernucci for doping...  -  Sep 4, 2007
15 for the substance sibutramine, an appetite suppressant sold under various brand ... According to UCI rules, a first violation for sibutramine -- if it is ... ESPN

Controversial obesity drug gets final okay  -  Jun 25, 2008
...to diet and exercise for obese or overweight adults who don't respond to or are intolerant of two other weight-loss drugs, orlistat and sibutramine. ... Reuters UK

… Endocannabinoid System Activity in Patients Treated With Sibutramin...  -  Apr 26, 2007
Twenty obese otherwise healthy patients received randomized, double-blind, crossover treatment with placebo and 15 mg/day sibutramine for 5 days each, ... Nature.com

FDA won't ban diet drug Meridia but watching heart risk  -  Aug 17, 2005
There's no way to tell from these vague reports whether Meridia — known chemically as sibutramine — actually increased that risk, while earlier studies ... USA Today

Long-term data needed on anti-obesity drugs  -  Jan 5, 2007
Xenical (known generically as orlistat) and Meridia (sibutramine) are currently approved for long-term use, while Acomplia (rimonabant) is under review by ... Reuters

Live large and you will die young - study  -  Jul 18, 2006
Those given sibutramine, marketed by Abbott Laboratories as Meridia, lost more weight, the researchers reported in a second paper in Annals. ... Independent Online

Weight Loss in Patients Taking Sibutramine Is Greater With Specific …  -  Oct 1, 2008
BETHESDA, Md -- October 1, 2008 -- Obese patients with a specific genetic make-up lose more weight when taking sibutramine and undergoing behavioural ... DG News

The effect of sibutramine-assisted weight loss in men with obstructive...  -  Oct 11, 2005
Correspondence: Dr BJ Yee, Sleep Investigation Unit, Department of Respiratory and Sleep Medicine, Royal Prince Alfred Hospital, Missenden Road, Camperdown, ... Nature.com

Response to "Acute Effects of Sibutramine Administration on the …  -  Jan 24, 2007
We thank Drs Lechin and van der Dijs for their interest in our work "Acute effects of sibutramine administration on the autonomic nervous system in obese ... Nature.com

… with 'combined therapy,' study shows - Sibutramine: Obese people...  -  Nov 22, 2005
Some did not take sibutramine, a prescription drug; others used it alone; and others combined it ... Forty-two percent of those who took sibutramine alone. ... $2.95 - Salt Lake Tribune, The - NewsBank

Sibutramine (Systemic).(Drug overview)  -  Aug 1, 2006
Sibutramine (si-BYOO-tra-meen) is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Neurosearch's Tesofensine weaker than rival treatments - report  -  Mar 14, 2007
BiotekAnalyse gave a follow-up evaulation to previously published tests in which doses of 2.5 mg of Tesofensine and 7.5 mg of competitor drug Sibutramine ... Forbes

HSA warns potent substance found in dietary supplement  -  Jun 25, 2008
..."Sibutramine, the undeclared Western drug ingredient, can cause severe adverse ... "As a Western drug ingredient, Sibutramine is a prescription drug used as ... Channel News Asia

Sibutramine (Systemic).  -  Feb 1, 2006
Sibutramine (si-BYOO-tra-meen) is used together with a reduced-calorie diet to help you lose weight and to help keep the lost weight from returning. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Over-the-counter diet supplement recalled  -  Aug 20, 2007
People taking sibutramine should be monitored by a physician as the drug can ... Sibutramine should not be taken by people who have had a heart attack, ... CTV.ca

Learn about Sibutramine from Consumer Reports Health.  -  Jan 2, 2008
Sibutramine is used in combination with a reduced calorie diet and exercise to help people who are overweight lose weight and maintain their weight loss. ... consumerreports.org

… -Blind, Placebo-Controlled Trial of Sibutramine for Olanzapine...  -  May 22, 2005
Objective: Weight gain is commonly observed with olanzapine treatment and can increase the risk for obesity, cardiovascular disease, hypertension, ... RedOrbit

Weight Loss Produced by Tesofensine in Patients With Parkinson's or …  -  May 16, 2007
Sibutramine—a serotonin and norepinephrine reuptake inhibitor—has been shown ... Sibutramine produces sustained weight loss over years and improves many of ... Nature.com

Don't use these products, ministry warns public  -  Nov 12, 2008
Eishah said the use of Sibutramine without monitoring by doctors could cause cardiovascular complications such as high blood pressure and heart failure. ... Malaysia Star

Alert over bogus herbal helpers  -  Mar 2, 2006
Li Da contains sibutramine, which is prescribed to obese patients who have ... Reductil is the only brand of sibutramine approved for sale in New Zealand ... New Zealand Herald

Sibutramine helps weight, lipids in obese adolescents: not yet...  -  Jan 15, 2005
LAS VEGAS -- Sibutramine (Meridia) enabled obese adolescents to shed weight and improve obesity-related risk factors in a 12-month, randomized, double-blind ... Pay-Per-View - Internal Medicine News - Factiva, from Dow Jones

Sibutramine's weight maintenance lasts 2 years.(Obesity)(Brief...  -  Nov 15, 2008
PHOENIX -- Sibutramine helped people who had lost substantial amounts of weight maintain much of their weight... Pay-Per-View - Family Practice News - HighBeam Research

Article: Genotype may dictate response to sibutramine.(genetic...  -  Nov 15, 2006
Genotype may dictate response to sibutramine.(genetic aspects of obese persons) ... find Family Practice News articles. BOSTON -- Weight loss in an ... Pay-Per-View - Family Practice News - HighBeam Research

Contraindicated Use of Sibutramine and Cardiovascular Adverse …  -  Oct 15, 2007
OTTAWA, CANADA -- October 15, 2007 -- Sibutramine (Meridia), a serotonin and norepinephrine reuptake inhibitor, is an antiobesity agent marketed in Canada ... DG News

Sibutramine Results in Weight Loss in Obese Adolescents  -  Oct 20, 2005
Oct. 20, 2005 — Sibutramine (Meridia) treatment of obese adolescents with dyslipidemia appears to increase high-density lipoprotein (HDL) cholesterol levels ... Medscape

Billions Spent On Quack Health Foods That Don't Help Weight Loss Or …  -  Nov 26, 2008
He said that of all the hundreds of products currently on sale to help people lose weight, only the drugs orlistat and sibutramine, and in some cases ... Sky News

Genotype may dictate response to sibutramine.(genetic aspects of...  -  Nov 15, 2006
BOSTON -- Weight loss in an overweight or obese person taking sibutramine may be governed by whether the individual has a particular genotype related to the ... Free with registration - Family Practice News - AccessMyLibrary.com

Sibutramine for obesity  -  Apr 20, 2007
Sibutramine changes the levels of chemicals in the brain, including serotonin. Serotonin is a neurotransmitter, which is a type of chemical that sends ... MSN Health & Fitness

Article: Sibutramine may help children with hypothalmic disorders...  -  Jun 1, 2005
Sibutramine may help children with hypothalmic disorders lose weight.(Metabolic Disorders) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Meridia sibutramine oral  -  Jan 29, 2006
Off him like a ballalley. Time of the tribe of Oscar meridia sibutramine oral of cardinal Wolsey's words by G. man. Contemporaneously, a bunch of flowers. ... Diario NP Provincial

Review: Fluoxetine, Orlistat, and Sibutramine Modestly Reduce Weight...  -  Jan 25, 2005
Norris SL, Zhang X, Avenell A, et al. Efficacy of pharmacotherapy for weight loss in adults with type 2 diabetes mellitus: a meta- analysis. ... RedOrbit

ESH '07: Blood Pressure Effects of Sibutramine in Hypertensive...  -  Sep 17, 2007
Concerns about the blood pressure effects of sibutramine, an orally administered agent approved worldwide for the management of obesity, were addressed in 2 ... Medscape

Sibutramine is best for weight loss.  -  Jan 30, 2008
Patients lose more weight with sibutramine than orlistat, suggests the first meta-analysis of data from head-to-head trials of obesity medication. ... Free with registration - Pulse - AccessMyLibrary.com

Health Canada Warning On Illegal Use Of Sibutramine  -  Apr 7, 2006
The medical health authority in Canada, Health Canada has sent out a warning to dieters that they mustn't take 2 particular herbal weight loss supplements ... UKMedix Health News - UKMedix Health News

GPs accused of ignoring obesity drug side effects  -  May 21, 2007
Sibutramine prescriptions have risen four-fold from 2001 to reach 227000 a year. LibDem health spokesman Norman Lamb claimed the figures showed ministers ... Daily Mail

Sibutramine can offset pediatric weight disorders.(Clinical Rounds) |...  -  May 1, 2005
Sibutramine can offset pediatric weight disorders.(Clinical Rounds) ... find Pediatric News articles. LAS VEGAS -- Sibutramine (Meridia), an adult diet drug ... Pay-Per-View - Pediatric News - HighBeam Research

Impact Sibutramine Therapy in Children with Hypothalamic Obesity or …  -  Dec 1, 2008
Address all correspondence and requests for reprints to: Professor Claude Marcus, Department of Pediatrics and the National Childhood Obesity Centre, B57, ... Journal of Clinical Endocrinology and...

Director-General's Statement Under Section 98  -  Mar 1, 2006
Sibutramine can cause increased blood pressure and heart rate and cannot safely ... Testing showed that it contained the prescription medicine sibutramine. ... scoop.co.nz

The Health Report: 21 November 2005 - The Effects of Lifestyle …  -  Nov 21, 2005
Thomas Wadden: Sibutramine is the generic name. So one group was assigned to receive sibutramine alone, and they saw a doctor eight times over the course of ... ABC Regional Online - ABC Regional Online

Sibutramine of Little Benefit in Obese Adolescents  -  May 8, 2007
When given in combination with an energy-restricted diet and exercise prescription, sibutramine does not lead to an additional decrease in body mass index ... Diabetes In Control

Miami Herald, The : FYI  -  Dec 27, 2008
Ingredients include sibutramine, rimonabant, phenytoin and phenolphtalein. Products are sold on websites and in retail stores. ... $2.95 - Miami Herald - NewsBank

Sibutramine Reduces Food Intake by Reducing Eating Rate Rather than …  -  Apr 25, 2007
By Thomas S. May. BUDAPEST, HUNGARY -- April 25, 2007 -- Sibutramine effectively reduces food intake by slowing down the rate of eating without extending ... DG News

Sibutramine Found In Detox Peptide Product  -  Aug 29, 2006
Ukmedix is becoming increasingly aware of the problem of Chinese herbal teas and other traditional medications from the East that contain the active ... UKMedix Health News - UKMedix Health News

The effect of sibutramine on energy expenditure and body composition...  -  Jan 23, 2007
Edgar GAH Van Mil * , Klaas R. Westerterp, Arnold DM Kester, Henriette A. Delemarre-van de Waal, Willem JM Gerver, and Wim HM Saris ... Journal of Clinical Endocrinology and...

Diet drug may be of little benefit in obese teens  -  May 3, 2007
In previous studies, sibutramine resulted in weight loss and enhanced the ... In adults, sibutramine reduces calorie intake by increasing the feeling of ... Reuters UK

No reduction in blood pressure found with sibutramine  -  Apr 14, 2008
Compared with patients not participating in a weight-loss intervention, those assigned to diets or orlistat experienced more effective reductions in body ... Endocrine Today

Obesity drug has little effect on heart in teens  -  Jul 2, 2007
NEW YORK (Reuters Health) - When the weight-loss drug sibutramine, marketed under the brand names Meridia or Reductil, is used to treat obesity in ... Reuters

Sibutramine Found In More Weight Loss Products  -  Jan 11, 2007
Yet another health warning regarding the use of slimming supplements has come to our attention at Ukmedix. In this case 3 separate slimming products were ... UKMedix Health News - UKMedix Health News

Sibutramine may help children with hypothalmic disorders lose...  -  Jun 1, 2005
Las Vegas -- Sibutramine (Meridia), an adult diet drug, can help control the weight of children with hypothalamic obesity and other syndromes that make ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Impact sibutramine therapy in children with hypothalamic obesity or …  -  Aug 17, 2007
Objective: Behavioural treatment of children suffering from hypothalamic obesity or uncomplicated obesity in combination with syndromes that aggravate this ... Journal of Clinical Endocrinology and...

Obesity Therapy; Sibutramine therapy should be continued for 3 months...  -  Mar 28, 2006
2006 MAR 28 - (NewsRx.com) -- Sibutramine therapy in obese nondiabetic and diabetic patients should be continued for 3 months before predicting results. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Health Canada advises consumers not to use MIAOZI Slimming Capsules …  -  Mar 15, 2007
The product was tested and found to contain sibutramine, a prescription medication used to ... The use of sibutramine may cause serious side-effects, ... npicenter.com

Mayalsia cracks down on sibutramine  -  Jun 30, 2007
Malacca, Malaysia -- Malaysia's Health Ministry has revoked the license of a factory in Semenyih for manufacturing a diet product containing sibutramine. ... Money Times - The Money Times

Metabolism; Sibutramine improves fat distribution, IR in Korean obese...  -  Mar 1, 2005
They reported that "sibutramine treatment reduced body mass index (p<0.05) ... "Conclusively, sibutramine improved fat distribution and insulin resistance ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Metabolism; Sibutramine improves fat distribution, IR in Korean obese...  -  Feb 28, 2005
They reported that "sibutramine treatment reduced body mass index (p<0.05) ... "Conclusively, sibutramine improved fat distribution and insulin resistance ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Sibutramine helps weight, lipids in obese adolescents: not yet...  -  Jan 15, 2005
Sibutramine helps weight, lipids in obese adolescents: not yet approved for patients under age 16.(News) ... find Internal Medicine News articles. Pay-Per-View - Internal Medicine News - HighBeam Research

Sibutramine helped obese teens cut risk factors: the drug allowed 12-...  -  Jan 15, 2005
Sibutramine helped obese teens cut risk factors: the drug allowed 12- to 16-year-olds to lower BMI and improve triglycerides, HDL, and insulin levels. Pay-Per-View - Family Practice News - HighBeam Research

Metabolism; Sibutramine improves fat distribution, IR in Korean obese...  -  Feb 28, 2005
They reported that "sibutramine treatment reduced body mass index (p<0.05) ... "Conclusively, sibutramine improved fat distribution and insulin resistance ... Pay-Per-View - Obesity & Diabetes Week - Factiva, from Dow Jones

Metabolism; Sibutramine improves fat distribution, IR in Korean obese...  -  Mar 5, 2005
They reported that "sibutramine treatment reduced body mass index (p<0.05) ... "Conclusively, sibutramine improved fat distribution and insulin resistance ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Sibutramine improves obesity factors in teens.(Clinical Rounds) |...  -  Mar 1, 2005
Sibutramine improves obesity factors in teens.(Clinical Rounds) ... find Pediatric News articles. LAS VEGAS -- Sibutramine (Meridia) enabled obese ... Pay-Per-View - Pediatric News - HighBeam Research

Caution issued on slimming products  -  Jun 4, 2008
Sibutramine is a western drug ingredient used as appetite suppressant. ... Products containing sibutramine or spironolactone must be registered before they ... news.gov.hk

Weight Loss; Sibutramine promotes weight loss in patients with...  -  Oct 28, 2005
..."This study aims to determine the efficacy and tolerability of sibutramine hydrochloride in overweight and obese patients with cardiovascular risk factors. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Drugs, counseling, or both for weight loss: What works best?(CLINICAL...  -  Feb 1, 2006
Impact for clinicians At 1 year, subjects who received sibutramine alone had lost 5.0 [+ or -] 6 7.4 kg while those receiving lifestyle-modification ... Free with registration - Patient Care for the Nurse Practitioner - AccessMyLibrary.com

Weight Loss; Sibutramine promotes weight loss in patients with...  -  Oct 25, 2005
..."This study aims to determine the efficacy and tolerability of sibutramine hydrochloride in overweight and obese patients with cardiovascular risk factors. ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

• Weight Loss Found Effective in Reducing Blood Pressure  -  Mar 24, 2008
...“Patients assigned to weight loss diets, orlistat or sibutramine reduced their ... Sibutramine treatment, however, did not lower overall blood pressure and ... Consumer Affairs

Reductil And NICE  -  Aug 1, 2006
Not many people know that Reductil (sibutramine) has the full approval from ... The NICE recommendations for the NHS are that sibutramine must be seen as ... UKMedix Health News - UKMedix Health News

Dieting And Medication May Reduce Blood Pressure In Patients With …  -  Mar 25, 2008
..."Patients assigned to weight loss diets, orlistat or sibutramine reduced their ... Sibutramine treatment, however, did not lower overall blood pressure and ... sciencedaily.com

Article: Sibutramine metaanalysis.(Clinical Capsules)(Brief Article) ...  -  Jul 15, 2005
Sibutramine metaanalysis.(Clinical Capsules)(Brief Article) ... find Family Practice News articles. Sibutramine use was significantly associated with weight ... Pay-Per-View - Family Practice News - HighBeam Research

Generic Meridia  -  Nov 25, 2006
Sibutramine is the generic or chemical name of meridia. Sibutramine is also known as sibutramide hydrochloride monohydrate is a oral medication used in the ... Buzzle

Meridia Online  -  Nov 27, 2006
Sibutramine is the generic or chemical name of meridia. Sibutramine is also known as sibutramide hydrochloride monohydrate is a oral medication used in the ... Buzzle

New Zealand bans Chinese medicines  -  Apr 17, 2007
McKernan said sibutramine could not be safely taken by a range of people, ... Reductil is the only brand of sibutramine approved for sale in New Zealand. ... earthtimes.org

… on slimming aids.(slimming tablets from China contains sibutramine)...  -  Apr 1, 2006
Sibutramine is a prescription medication that suppresses the appetite. If used improperly, sibutramine can have serious health consequences, ... $4.95 - Nutraceuticals International - ECNext

Sibutramine metaanalysis.(CLINICAL CAPSULES)(Brief Article) | Article...  -  Jul 1, 2005
Sibutramine metaanalysis.(CLINICAL CAPSULES)(Brief Article) ... find Internal Medicine News articles. Sibutramine use was significantly associated with ... Pay-Per-View - Internal Medicine News - HighBeam Research

Drug, behavior therapy combat teen obesity.(News)(Disease/Disorder …  -  Aug 1, 2006
Sibutramine is a serotonin-norepinephrine reuptake inhibitor that is marketed ... At 12 months, 33% of those on sibutramine no longer had a BMI that was at ... Pay-Per-View - Family Practice News - HighBeam Research

Slimming Products Found Containing Western Drug Ingredient  -  Jul 25, 2007
DH obtained samples of the two products for laboratory analysis and found that they both contained sibutramine, an appetite suppressant which can cause ... emaxhealth.com

Sibutramine metaanalysis.(Clinical Capsules)  -  Jul 15, 2005
Sibutramine use was significantly associated with weight loss and appears to improve glycemic control and lipid profile in type 2 diabetics, ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

JOURNAL WATCH: Sibutramine in teenage obesity  -  Apr 2, 2005
Sibutramine is highly effective for promoting weight loss in obese adolescents without adversely affecting heart function, a study finds. ... Pay-Per-View - Pulse - Factiva, from Dow Jones

Long-Term Studies Needed for Anti-Obesity Drugs  -  Jan 9, 2007
..."The two FDA-approved weight-loss drugs now available, sibutramine and orlistat, have serious potential side effects, limited efficacy, and work only as ... Diabetes In Control

Fake Reductil Factory Seized  -  Jul 28, 2006
Sibutramine or Reductil is not good for people with elevated blood pressure or who have a history of heart problems. Reductil is sold under the trading name ... UKMedix Health News - UKMedix Health News

Patients taking anti-obesity drugs will only see "modest" weight loss  -  Nov 19, 2007
Professor Raj Padwal and colleagues found orlistat reduced weight by 2.9kg, sibutramine by 4.2kg and rimonabant by 4.7kg. They also found that patients ... News-Medical.net

Drug, behavior therapy combat teen obesity.(Clinical Rounds)  -  Aug 1, 2006
A yearlong study of nearly 500 obese adolescents found that combining the weight loss drug sibutramine with behavioral therapy resulted in statistically ... Free with registration - Pediatric News - AccessMyLibrary.com

The obese older female patient: CV risk and the SCOUT study  -  Jul 1, 2008
The Sibutramine Cardiovascular Outcomes (SCOUT) trial has been designed to determine whether weight management with sibutramine together with a diet- and ... Nature.com

Orlistat Most Effective Antiobesity Drug for Reducing Blood Pressure...  -  May 22, 2008
Sibutramine caused blood pressure to increase, while rimonabant caused total ... Finally, sibutramine actually increased mean systolic and diastolic blood ... DG News

Pharmacologic Therapy with Counseling Is Best for Obesity  -  Jun 1, 2006
Sibutramine (Meridia), a drug that assists with weight loss by modifying ... Participants assigned to sibutramine alone met with physicians the same number ... AAFP News Now

Effects of Drug Treatment for Obesity in Adolescence  -  Jul 18, 2006
The summary below is from the full report titled "Effects of Sibutramine ... In a clinical trial in obese adolescents, sibutramine caused weight loss, ... Annals of Internal Medicine

Three-Pronged Approach to Obesity Helps Patients Lose Weight  -  Jun 7, 2005
In the study, investigators evaluated the efficacy of sibutramine (Meridia, ... Results at one year showed that treatment with sibutramine/low-calorie ... Medscape

Brand Names/Synonyms:
Sibutramine is also known by the following brand names and/or synonymsReductil; Medaria; Sibutraminum [Latin]; Sibutramina [Spanish]; Cyclobutanemethanamine, 1-(4-chlorophenyl)-N,N-dimethyl-alpha-(2-methylpropyl)-; Meridia; Medaria

Drug Category:
Sibutramine is categorized under the following by the FDA: Appetite Depressants; Antidepressants; Anorexigenic Agents; Stimulants; ATC:A08AA10

Dosage Forms:
CAPSULE

Absorption:
Rapid absorption following oral administration. Absolute bioavailability is not know, but at least 77% of a single oral dose of sibutramine is absorbed.

Interactions:
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Chemical IUPAC Name:
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethyl-butan-1-amine

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