Sildenafil

This page contains recent news articles, when available, and an overview of Sildenafil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Sildenafil
(when available)

Pharmacology and use:
Sildenafil is used to treat male erectile dysfunction (impotence) and pulmonary arterial hypertension (PAH). Part of the physiological process of erection involves the release of nitric oxide (NO) in the corpus cavernosum. This then activates the enzyme guanylate cyclase which results in increased levels of cyclic guanosine monophosphate (cGMP), leading to smooth muscle relaxation in the corpus cavernosum, resulting in increased inflow of blood and an erection. Sildenafil is a potent and selective inhibitor of cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum. This means that, with Sildenafil on board, normal sexual stimulation leads to increased levels of cGMP in the corpus cavernosum which leads to better erections. Without sexual stimulation and no activation of the NO/cGMP system, Sildenafil should not cause an erection. For the treatment of erectile dysfunction

Mechanism Of Action:
Sildenafil inhibits the cGMP specific phosphodiesterase type 5 (PDE5) which is responsible for degradation of cGMP in the corpus cavernosum located around the penis. Penile erection during sexual stimulation is caused by increased penile blood flow resulting from the relaxation of penile arteries and corpus cavernosal smooth muscle. This response is mediated by the release of nitric oxide (NO) from nerve terminals and endothelial cells, which stimulates the synthesis of cGMP in smooth muscle cells. Cyclic GMP causes smooth muscle relaxation and increased blood flow into the corpus cavernosum. The inhibition of phosphodiesterase type 5 (PDE5) by Sildenafil enhances erectile function by increasing the amount of cGMP.

News Articles on Sildenafil

German men to get cheap version of Viagra  -  14 Nov 2009
Although Sildenafil citrate, which is the generic name for Viagra, is most commonly used for curing erectile dysfunction, it can also be used to treat ... The Local

Potenzmittel-Patent: Ratiopharm will Billig-Viagra vermarkten  -  14 Nov 2009
Abhängig von der jeweiligen Patentsituation werde dann in den europäischen Ländern ein günstigeres Präparat mit dem Viagra-Impfstoff Sildenafil angeboten ... STERN.DE

Ratiopharm will Deutschen Billig-Viagra verkaufen  -  14 Nov 2009
Abhängig von der jeweiligen Patentsituation werde dann in den europäischen Ländern ein günstigeres Präparat mit dem Viagra-Wirkstoff Sildenafil angeboten ... Nachrichten - AOL.de

Sildenafil Ratiopharm Receives Positive Criticism From The EU Panel  -  ‎Nov 12, 2009‎
Sanofi-Aventis Deutschland GmbH with Leflunomide Winthrop, a treatment intended for active psoriatic arthritis and rheumatoid arthritis in adult patients. ... I-Newswire.com (press release)

Computer store owner admits to selling counterfeit Viagra  -  ‎Nov 12, 2009‎
It contained 372 sildenafil citrate pills without FDA approved labeling, and Yan had no prescription for the pills. Yan at first said the pills were for ... Providence Journal

Popularity: 37th most commonly prescribed drug between 2002 and 2008 (US)  -  ‎Nov 10, 2009‎
Treatment of sexual dysfunction (usually delayed ejaculation) associated with antidepressant drug therapy (requires high dose sildenafil). ... EMS1.com

FDA warns against erectile dysfunction supplement  -  ‎Nov 6, 2009‎
Following a complaint, the FDA investigated the product and found that it contains sulfoaildenafil, an analog of sildenafil -- the active ingredient in ... Los Angeles Times

First 'Viagra baby' conceived through IVF using Sildenafil on a woman to aid ...  -  ‎Oct 23, 2009‎
A technique developed and pioneered by Geoffrey Sher, MD, Sildenafil suppositories are administered during In Vitro Fertilization, prior to transferring ... eNewsChannels

Docs decide the time is right to recommend an erectile dysfunction drug  -  ‎Oct 20, 2009‎
The guideline's drafters did find evidence that for sildenafil (Viagra) and vardenafil (Levitra), slightly higher doses (50 milligrams. and 20 milligrams, ... Los Angeles Times

Herba Gra Is Found Loaded With Sildenafil Citrate After Lab Test  -  ‎Oct 31, 2009‎
...the product to testing in their own laboratory and found it to contain the active ingredient of the prescription medication namely sildenafil citrate. ... UKMedix Health News

European regulators begin Tysabri review  -  ‎Oct 26, 2009‎
The Committee also adopted a positive opinion for Ratiopharm's Sildenafil Ratiopharm (sildenafil), a generic of erectile dysfunction brand Viagra. ... Pharmafocus

Rare-disease drugs policy  -  ‎Nov 10, 2009‎
10, 2009 4:09AM EST Through Exceptional Access provisions, Ontario funds five drug products, including sildenafil, for the treatment of pulmonary arterial ... Globe and Mail

Committee For Medicinal Products For Human Use Summary Of Positive Opinion For ...  -  ‎Oct 23, 2009‎
The active substance of Sildenafil ratiopharm is sildenafil, which belongs to the group of substances used in the treatment of erectile dysfunction ... PharmaLive.com (press release)

'What gives them the right to put a price on my life?'  -  ‎Oct 30, 2009‎
Dr. Davis switched her to a tandem of two oral medications: Bosentan, which can aid blood flow to the lungs, and Sildenafil, which expands blood vessels (a ... Globe and Mail

SEXUALITY: How little pills can be a big boost for sex lives  -  ‎Nov 5, 2009‎
And this is where the magic of sexual pharmaceuticals, among them the drug, sildenafil, makes its presence felt. These drugs allow men to look youthful, ... Business Day

Hong Kong: Public urged not to consume product with undeclared drug ingredients  -  ‎Nov 4, 2009‎
Analysis showed that the product contained sildenafil, a drug used for treating male sexual dysfunction. The spokesman said so far, there was no evidence to ... Webnewswire.com

Sagirra Supplement Contains Noracetildenafil  -  ‎Oct 29, 2009‎
The real ingredient of Viagra namely sildenafil has been subjected to years of controlled clinical testing whereas very little is known about ... UKMedix Health News

GreenMeds Store - norvasc  -  ‎Oct 31, 2009‎
You are taking, sildenafil. ATORVASTATIN Co-administration of NORVASC. Decision could be used for more information. Discuss the risks of using this product ... Newstalk ZB

Daily Q&A: What should I consider before buying dietary supplements?  -  ‎Nov 9, 2009‎
The ingredient in Stiff Nights, sulfoaildenafil, can cause serious injury or death, the FDA said. The active ingredient in Viagra is sildenafil. Tampabay.com

Hormonal Testing and Pharmacologic Treatment of Erectile Dysfunction: A ...  -  ‎Oct 23, 2009‎
Higher doses of sildenafil and vardenafil were associated with a modestly greater magnitude of benefit with respect to erectile function; however, ... Docuticker (blog)

ACP Issues Guidelines for Treatment of Erectile Dysfunction  -  ‎Oct 19, 2009‎
Available PDE-5 inhibitors include sildenafil, vardenafil, tadalafil, mirodenafil, and udenafil. Because available evidence is inconclusive about the ... Medscape

Chiliean Black Widow Spider Venom Irresistable To Scientists  -  ‎Nov 10, 2009‎
Those involved in the black widow venom project say their drug will be a huge success and will be more effective than sildenafil citrate (Viagra) and other ... Today's THV

EU Panel: Positive Opinion On Sildenafil Ratiopharm  -  ‎Oct 23, 2009‎
...adopted a positive opinion for Sildenafil ratiopharm, from ratiopharm GmbH, a generic of Viagra, indicated for the treatment of erectile dysfunction. ... EasyBourse.com

Health Ministry Issues Warning about Herba Gra  -  ‎Oct 29, 2009‎
The additive, which is imported by a Jerusalem company, was found in laboratory testing by the ministry to contain sildenafil citrate, the active ingredient ... Arutz Sheva

New Drug Udenafil for Erectile Dysfunction in US Trials  -  ‎Nov 9, 2009‎
These drugs are Cialis® (tadalafil), Levitra® (vardenafil), and Viagra® (sildenafil). Udenafil is also a PDE-5 inhibitor. Dong-A PharmTech Co. ... eMaxHealth

Pfizer reports 3Q profit rise, revenue drop  -  ‎Oct 20, 2009‎
...of such drugs as the multiple sclerosis treatment Rebif (interferon beta-1a) and the pulmonary arterial hypertension drug Revatio (sildenafil citrate). ... Drug Store News (blog)

Gilead Sciences Announces Plans for Phase IV Clinical Trial Evaluating First ...  -  ‎Nov 2, 2009‎
No clinically relevant interactions of Letairis with warfarin, sildenafil, tadalafil, omeprazole (CYP2C19 inhibitor), ketoconazole (strong CYP3A-inhibitor), ... WELT ONLINE

Viagra not harmful to vision: study  -  ‎Oct 30, 2009‎
...clinical significance for either 5 milligrams of tadalafil (Cialis) or 50 milligrams of sildenafil (Viagra) taken daily for six months," the report noted. AsiaOne

Norco. Buy Tramadol Online!  -  ‎Oct 31, 2009‎
AME services Inc. WHAT should, stop using sildenafil? For not to buy Organic. Consult your doctor. Talk with your health care your doctor may apply. ... Newstalk ZB

Chanting, joss sticks fail to stop sex pills raid  -  ‎Oct 25, 2009‎
..."Investigations revealed the illegal sexual stimulant contained sildenafil nitrate, also a controlled substance, and was sold to the public for RM298 per ... AsiaOne

Two arrested after 30000 fake impotence pills found  -  ‎Oct 24, 2009‎
The ministry's lab found that this active ingredient was sildenafil, which is in fact the main component of Viagra and Cialis. ... Jerusalem Post

Unilab says case vs Pfizer to test cheaper medicines law  -  ‎Oct 27, 2009‎
The two companies have faced off in four previous cases, the first one involving sildenafil (Pfizer's Viagra). In most nof them, the American firm failed to ... Malaya

Ask the sexpert, Saturday, October 31, 2009  -  ‎Nov 1, 2009‎
If all clear, the doctor is likely to prescribe testosterone and possibly sildenafil. I am in a very critical condition. My girlfriend has asked me to bring ... Pune Mirror

CHMP issues latest recommendations, OK for Movetis' Resolor  -  ‎Oct 26, 2009‎
It has also backed Ratiopharm's version of Pfizer's erectile dysfunction blockbuster Viagra (sildenafil) and a new formulation of Allergan's Lumigan ... Pharma Times

LC: Speech bySFH on Pharmacy and Poisons Ordinance  -  ‎Oct 22, 2009‎
The four poisons are "Sibutramine; its salts", "Sildenafil; its salts", "Tadalafil; its salts" and "Vardenafil; its salts." We propose that these amendment ... 7thSpace Interactive (press release)

Crece el consumo de Viagra en Provincia  -  ‎Nov 2, 2009‎
Por otra parte, para hacer frente a la demanda –y ante las ganancias exponenciales que ofrecería el sildenafil-, ya circulan en el mercado diez marcas de la ... InfoBAE.com

衞生署喻å?œæœ?å?«æ˜”多芬產å“?  -  ‎Nov 4, 2009‎
...衞生署呼籲市民å?œç”¨ä¸€ç¨®å??為「增大延時丸ã€?的產å“?,因為它å?«æœ‰ç„¡æ¨™æ˜Žçš„西藥æˆ?分「昔多芬ã€?(Sildenafil)。「昔多芬ã€?用於治療男性性功能障礙,å?¯èƒ½å¼•致嚴é‡?的副作用。 ... 香港新浪網

Postre con Viagra no podría venderse porque los medicamentos no deben ser ...  -  ‎Nov 13, 2009‎
El sildenafil, nombre real del fármaco (Viagra es uno de los nombres comerciales), tiene efectos sobre los vasos sanguíneos y produce su dilatación. ... El Tiempo (Colombia)

Sulaikyti potencijÄ… didinanÄ?ių vaistų falsifikatai  -  ‎Nov 2, 2009‎
LytinÄ™ potencijÄ… didinantys medikamentai „Tadalafil“ ir „Sildenafil“ penkiomis siuntomis buvo siunÄ?iami iÅ¡ Indijos penkiems fiziniams asmenims Lietuvoje. ... Lietuvos rytas

市售壯陽產å“? 4ä»¶å?«è¥¿è—¥ä¸?å?ˆæ ¼  -  ‎Oct 25, 2009‎
...根據衛生局資料,é?•法產å“?包括「我王膠囊ã€?ã€?「å¨?爾壯膠囊狀食å“?ã€?ã€?「寶力勇ã€?å’Œ2度犯法的「貴王精膠囊ã€?,檢出西藥sildenafilç­‰æˆ?分。 å§œéƒ?美表示,已將製造業者ä¾? ... 中央通訊社

Spontaneità e naturalezza, ecco i segreti della vita di coppia  -  ‎Nov 4, 2009‎
In uno studio pubblicato sul Journal Sex Medicine 2008 condotto da Conaglen e colleghi dal titolo Investigating Women's Preference for Sildenafil or ... RomagnaOggi.it

'Dok, paano magiging malakas sa sex?'  -  ‎Nov 4, 2009‎
Andros ang brand name at Sildenafil ang generic name ng gamot sa impotence. Uminom ng Andros 50 mg tablet, isang oras bago makipag-sex. ... Philippine Star

Viagra provoca perda da visão  -  ‎Nov 3, 2009‎
O Viagra (substância activa sildenafil), medicamento usado pelos homens no tratamento da impotência sexual, provoca a perda da visão, parcial ou permanente ... Correio da Manhã

Viagra mister potensen  -  ‎Nov 10, 2009‎
Cialis (tadalafil) produseres av Eli Lilly AS og har nå en markedsandel på 43,5 prosent i Norge – 0,6 prosent bak Viagra (sildenafil). ... Dagens Medisin

La lozione che sostituirà il Viagra  -  ‎Oct 28, 2009‎
Citrato di sildenafil, vi dice qualcosa? Se vi parlassimo invece di una pillola blu, di una “pillola dell'amore�, la vostra risposta sarebbe immediata: ... Tifeoweb

유사 성기능보조제 “조심â€?  -  ‎Nov 5, 2009‎
...하는 실ë?°ë‚˜í•„(Sildenafil) 유사화학물 제제 sulfoaildenafilì?´ 함유ë?¼ 있으며 ì?´ëŠ” 니트로글리세린ì?„ 함유한 질산염과 ìƒ?호작용하여 저혈압ì?„ 유발한다고 ë°?혔다. ... 헬스코리아뉴스

涉嫌賣é?ŽæœŸå?‰å“¥é†«ç”Ÿè¢«æ‰£  -  ‎Nov 1, 2009‎
...據《新海峽時報》報導,æœ?食é?Žé‡?枸酸西地é?žçˆ¾ï¼ˆSildenafil Citrate,新一代治療性功能障礙的藥物),或é?ŽæœŸå?‰å“¥æœƒå?¯å¼•發並發症或çª?然暴斃。 消æ?¯æŒ‡å‡ºï¼Œä¸Šè¿°å?‰å“¥è—¥ä¸¸ ... 中國報

Tres de cada diez hombres sufren andropausia y muchos no lo saben  -  ‎Nov 8, 2009‎
La cifra coincide con un sondeo del Hospital Tornú: 3 de cada 10 hombres que no respondían al Sildenafil (Viagra) estaban andropáusicos. ... Clarín.com

MP obtém liminares para realizar exames e fornecer medicamentos em Presidente ...  -  ‎Nov 13, 2009‎
...a fornecer o medicamento Sildenafil 50 mg, ao idoso daquele município, sob pena de sequestro de numerário suficiente para aquisição nas contas bancárias ... Rondônia Dinâmica

Gyógyszer-dílert ítéltek el Angliában  -  ‎Nov 12, 2009‎
A nyomozás során lefoglaltak nála erektilis diszfunkció elleni készítményeket is, így a Pfizer Viagráját (hatóanyag: sildenafil), a GlaxoSmithKline ... Weborvos

Viagra May Aid Treatment of Enlarged Hearts  -  Jan 23, 2005
White, who was not part of Kass' research team, noted that sildenafil ... The finding can propel a search for compounds related to sildenafil that are ... FOXNews

Viagra may lift effects of jet lag and shift work  -  May 22, 2007
The drug, known as sildenafil, has so far been used by more than 27 million men ... Sildenafil, which was originally developed by the company Pfizer for the ... Telegraph.co.uk

Viagra Works for (Some) Women, Too  -  Jul 22, 2008
Technically, sildenafil is a phosphodiesterase type 5 inhibitor that has been shown to combat ... Journal Citation: “Sildenafil Treatment of Women with ... Wired News

Sildenafil-associated vascular CASUALTIES  -  Dec 22, 2006
Correspondence: H Oguz, Department of Ophthalmology, Harran University School of Medicine, Arastirma ve Uygulama Hastanesi, TR-63100 Sanliurfa, Turkey. ... Nature.com

Viagra the New Oyster? Pill Also an Aphrodisiac, Study Shows  -  Aug 24, 2007
In both places, sildenafil works by blocking this enzyme, essentially releasing ... When the pituitaries were treated with sildenafil, they responded to the ... FOXNews

Sildenafil improves quality of life in men with heart failure and...  -  Apr 15, 2005
Correspondence: Dr D Freitas, Ambulatório de Miocardiopatias e Insuficiência Cardíaca, Hospital Universitário Prof. Edgard Santos, Rua João das Botas, s/n, ... Nature.com

Viagra may help heart in muscular dystrophy: study  -  May 12, 2008
Canadian researchers gave sildenafil, the active ingredient in drug maker ... "If you don't give the sildenafil, the heart of these mice doesn't function as ... Reuters

Sildenafil puts a 'brake' on chemical stimulation of heart  -  Oct 27, 2005
By Johns Hopkins Medicine, Sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, reduces the stimulatory effects ... RxPG NEWS

Reply to 'Sildenafil-associated vascular casualties' by Halit Oguz  -  Dec 22, 2006
Correspondence: S Gedik, Assistant Professor of Ophthalmology, Baskent University Faculty of Medicine, Fevzi Cakmak Caddesi, Bahceli, Ankara 06490, Turkey. ... Nature.com

The impact of formulary replacement of sildenafil by vardenafil at a...  -  Jun 21, 2007
Correspondence: Dr M Singh, Department of Urology, Case Western Reserve University School of Medicine, 11100 Euclid Avenue, Cleveland, OH 44112, USA. ... Nature.com

Compliance of sildenafil treatment for erectile dysfunction and...  -  Jun 11, 2005
Correspondence: Dr BP Jiann, Division of Urology, Department of Surgery, Kaohsiung Veterans General Hospital, 386 Ta-chung 1st Road, Kaohsiung, Taiwan 813, ... Nature.com

Early sildenafil dose optimization and personalized instruction...  -  Jan 27, 2006
Correspondence: Dr CP Steidle, Northeast Indiana Urology, 2512 East DuPont Road, Suite 100, Fort Wayne, IN 46825, USA. ... Nature.com

Perhaps Viagra Can Soften Jet Lag's Impact  -  May 21, 2007
Sildenafil is the active ingredient in the erectile dysfunction drug Viagra. ... Sildenafil works by sustaining a molecule that increases blood flow. ... ABC News

Outcome analysis of sildenafil citrate for erectile dysfunction of...  -  Jun 22, 2005
Correspondence: Dr K Kobayashi, Department of Urology, Sapporo Medical University School of Medicine, S1W16, Chou-ku, Sapporo, Japan. E-mail: kou@sapmed.ac. ... Nature.com

Does Viagra gives athletes an advantage?  -  Nov 23, 2008
Viagra, or sildenafil citrate, was devised to treat pulmonary hypertension, or high blood pressure in arteries of the lungs. The drug works by suppressing ... New York Times

FDA warns consumers to avoid 'natural' impotence pills sold on Web  -  Jul 12, 2006
The list includes a product called Zimaxx, which FDA testing showed contains sildenafil, the same active ingredient in Viagra. Viagra, made by Pfizer Inc., ... USA Today

Original heart hope of Viagra realised  -  Feb 16, 2007
The drug, also known as sildenafil, does not directly give a man an erection. ... "What sildenafil does is open up the blood vessels so they can capture the ... BBC News

… and sildenafil for hypogonadal patients unresponsive to sildenafil...  -  Sep 21, 2005
Correspondence: Dr TI-S Hwang, Division of Urology, Department of Surgery, Shin Kong Wu Ho-Su Memorial Hospital, No. 95 Wen Chang Road, Taipei, Taiwan 111, ... Nature.com

Sildenafil reduces bother associated with erectile dysfunction:...  -  Aug 28, 2006
Correspondence: Dr AD Seftel, Department of Urology, Case Western Reserve University, University Hospital of Cleveland, 11100 Euclid Ave, Cleveland, ... Nature.com

What happens when sildenafil fails?  -  Mar 4, 2007
The drugs used to treat erectile dysfunction may be marvellous, but there are various factors that can affect whether they're effective or otherwise. ... Malaysia Star

Wada to consider banning Viagra  -  Jun 23, 2008
Wada believes sildenafil (Viagra) enhances athletic performance, ... Sildenafil citrate drugs such as Viagra are intended to alleviate erectile dysfunction ... BBC News

Short-term use of sildenafil in the treatment of unconsumated...  -  Apr 13, 2005
Correspondence: Dr AE Guindi, Department of Andrology, Cairo University Hospitals, El Manial, Cairo 1111, Egypt. E-mail: mceze2002@yahoo.com ... Nature.com

Erectile dysfunction treatments: FDA warns of risky supplements  -  Jul 17, 2006
An FDA chemical analysis showed that Zimaxx contains sildenafil, ... People who unknowingly take either sildenafil or vardenafil risk serious interactions ... CNN

FDA Warns About Supplements Marketed to Treat Impotence  -  Dec 29, 2007
Shangai Regular, also marketed as Shangai Chaojimengnan, contains an unapproved substance with a chemical structure akin to sildenafil that may cause ... Washington Post

Chinese aphrodisiac may outperform Viagra  -  Sep 28, 2008
But, "sildenafil (Viagra) shows a lot of side effects including headache, facial flushing and visual disturbances," says lead author Mario Dell-Agli, ... National Post

… Factors Determine Erectile and Arterial Function Response to Silden...  -  Jun 17, 2005
Sildenafil is effective in treatment of erectile dysfunction but shows variable ... Chronic sildenafil therapy resulted in an increase of IIEF score of 13 ... Nature.com

Chinese firms appeal ruling over Viagra  -  Jun 20, 2006
Pfizer filed a patent application in May 1994 for the use of Sildenafil in erectile dysfunction treatment in China. SIPO granted the patent after seven ... 新�网

Erection problems Nitrates and drugs for erection problems  -  Sep 1, 2008
If you're taking nitrates, you cannot take sildenafil (brand name Viagra), ... Some men have died while taking sildenafil and nitrates together. ... guardian.co.uk

Learn about Sildenafil from Consumer Reports Health.  -  Jan 12, 2007
Sildenafil (Viagra) is used to treat erectile dysfunction (impotence; inability to get or keep an erection) in men. Sildenafil (Revatio) is used to improve ... consumerreports.org

… : intracavernosal injections and sildenafil following radical...  -  Aug 14, 2005
Sildenafil dose of 50 mg/day was started at the time of hospital discharge. ... Early combination therapy with sildenafil allowed a lower dose of ... Nature.com

Pfizer Wins Key China Court Ruling  -  Jun 3, 2006
...of the leading generic-drug makers in China against Pfizer's (nyse: PFE - news - people ) patent on sildenafil citrate, the main chemical in Viagra. ... Forbes

Poorly tot kept alive by VIAGRA  -  Mar 11, 2008
Oliver currently takes one tablet of Sildenafil - another name for Viagra - crushed up into four 5ml doses a day, plus heart channel blockers twice a day. ... The Sun

FDA: Chinese Dietary Supplements Contain Viagra  -  Dec 31, 2007
Product testing indicates that some of these so-called supplements contain Viagra's active ingredient, sildenafil, or a compound with a chemical structure ... FOXNews

The latest smoking cure: Viagra  -  Dec 14, 2006
When GPs tried to select Zyban, a drug that suppresses the part of the brain that experiences nicotine cravings, the computer instead selected sildenafil, ... Times Online

King of the pills  -  Mar 27, 2008
Early clinical trials found sildenafil didn't do much for angina, but it did have a ... Sildenafil works by blocking enzymes that degrade nitric oxide, ... San Diego Union - Tribune - San Diego Union Tribune

Circadian fix: Viagra may lessen effects of jet lag.(This Week)  -  May 26, 2007
Sildenafil, commonly known as Viagra, helps hamsters rebound from a 6-hour ... Hamsters receiving a large single dose of sildenafil resynchronized their ... Free with registration - Science News - AccessMyLibrary.com

Viagra chocolate-seller indicted  -  Apr 24, 2008
Tibor Liska pleaded guilty of selling by mail some 12000 packets a month of sildenafil - a drug used to treat erectile dysfunction sold under various names, ... NEWS.com.au

Oral sildenafil citrate lacks genotoxicity and cytotoxicity in a...  -  May 4, 2006
Correspondence: Dr ML Lemus-Varela, Departamento de Neonatología, Hospital de Pediatría, Unidad Médica de Alta Especialidad, Centro Médico Nacional de ... Nature.com

… in blood pressure during administration of sildenafil (Viagra ® )...  -  Oct 11, 2005
To determine the effect of sildenafil on blood pressure in patients with erectile ... A single dose of 50 mg of sildenafil was administered, and patients ... Nature.com

Sildenafil Produces Significant Haemodynamic Response in Patients …  -  Sep 6, 2007
By Chris Berrie. VIENNA, AUSTRIA -- September 6, 2007 -- A single oral dose of sildenafil has beneficial haemodynamic effects when added to bosentan in ... DG News

The Stakes in China's Viagra Wars  -  Mar 30, 2005
The revocation came three years after 12 Chinese pharmaceutical companies launched a petition to nullify Pfizer's patent for sildenafil citrate. ... Subscription - Wall Street Journal Online - Dow Jones & Company

Chilean mayor to offer free Viagra to older men to improve 'quality...  -  Apr 29, 2008
He did have some advice, however, for the Viagra seekers: "Sildenafil doesn't get you going without direct stimulation." New York Daily News

AUA 2006 - ABST [922] Influence of Sildenafil on Lower Urinary Tract ...  -  May 21, 2006
Hyuk Soo Chang*, Choal Hee Park, Chun Il Kim, Kwang Sae Kim, Tae Gyun Kwon, Duk Yoon Kim, Hee Chang Jung, Daegu, Republic of Korea. ... UroToday International Journal

Viagra in India @ Rs 594 a pill  -  Dec 21, 2005
The original blue pill will cost Rs 594 (Rs 463 for 50 mg) as against Rs 25 or less for the desi or generic version of the drug known as sildenafil citrate. ... Times of India

Sildenafil Improves Exercise Capacity in Pulmonary Fibrosis  -  Mar 12, 2007
By Michael Smith, Senior Staff Writer, MedPage Today. LOS ANGELES, March 12 -- There is more evidence that sildenafil (Viagra, Revatio) is beneficial to ... MedPage Today

Drug Attributes Influencing the Choice of Sildenafil Citrate and...  -  Feb 1, 2006
Drug Attributes Influencing the Choice of Sildenafil Citrate and Tadalafil for the Treatment of Erectile Dysfunction in an Open-Label, Crossover Study, ... Free with registration - Journal of Sex Research - AccessMyLibrary.com

Long-term Use of Sildenafil for Hypertension Has Positive Outcomes  -  Nov 4, 2005
Sildenafil was given to 14 unstable, patients with WHO Class IV pulmonary arterial hypertension (PAH) who were admitted to the hospital with severe right ... Medical News Today - Medical News Today (press release)

Health Canada warns of unauthorized erectile drug  -  Aug 7, 2008
Sildenafil can pose serious health risks and should only be used under the ... Use of sildenafil by people with heart disease can result in serious ... CTV.ca

Pfizer's Long March Through China's Courts  -  Jun 21, 2006
...that have challenged its claim to exclusive rights to make pills using sildenafil citrate and designed to improve sexual performance is far from over. ... BusinessWeek

Sildenafil Improves Lower Urinary Tract Symptoms in Men: Presented at...  -  May 25, 2007
By Laura Gater. ANAHEIM, CA -- May 25, 2007 -- Patients with concomitant erectile dysfunction (ED) and lower urinary tract symptoms (LUTS) reported ... DG News

Sildenafil effectively treats enlarged hearts, mouse study shows  -  Jan 19, 2005
Researchers at Johns Hopkins have found that sildenafil citrate (Viagra), a drug used to treat erectile dysfunction (ED) in millions of men, ... PsychCentral.com

Canadians warned about ED medication  -  Apr 28, 2008
Officials said the product might pose a health risk because it contains the drug sildenafil, which is not indicated on its label. ... United Press International

Sildenafil (Systemic).(Drug overview)  -  May 1, 2006
Sildenafil ( sil-DEN-a-fil) belongs to a group of medicines that delay the enzymes called phosphodiesterases from working too quickly. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… of certain II acceptors for spectrophotometric determination of...  -  Oct 1, 2007
The extensive use of sildenafil is exemplified by the fact that 6 million prescriptions ... Contrary to popular belief, sildenafil is not an aphrodisiac, ... Free with registration - American Journal of Applied Sciences - AccessMyLibrary.com

Sildenafil May Prevent Doxorubicin-Induced Cardiomyopathy  -  Apr 6, 2005
By Karla Gale. NEW YORK APR 06, 2005 (Reuters Health) - The phosphodiesterase-5 inhibitor sildenafil (Viagra) prevents cardiomyocyte apoptosis and left ... Cancerpage.com

Chinese medicine linked to health scare  -  Aug 15, 2008
..."Unsupervised use of sildenafil by patients with pre-existing heart ... "Sildenafil should not be used by individuals taking any type of nitrate drug, ... Sydney Morning Herald

Sildenafil for pulmonary arterial hypertension, repackaged as Revatio  -  Nov 22, 2005
Bologna, Italy - Sildenafil -- perhaps best known as the active ingredient in the impotence therapy Viagra (Pfizer) -- is now also available for use in the ... Medscape

Penile rehabilitation after radical prostatectomy  -  Feb 28, 2006
5, 6, 7 Montorsi et al. showed that when sildenafil 100 mg is taken at bedtime by ... 5 Moreover, early use of sildenafil at high doses after radical ... Nature.com

Health Canada issues health alert for Axcil, Desirin  -  Nov 29, 2007
Testing on the products has shown they contain sildenafil, ... For patients with heart disease, sildenafil can trigger serious adverse effects including ... CBC.ca

Published Study Shows Benefits of Revatio (Sildenafil Citrate) in...  -  Nov 16, 2005
NEW YORK, Nov. 16 /PRNewswire-FirstCall/ -- Pfizer Inc said today a study in the current issue of the New England Journal of Medicine shows Revatio(TM) ... Free with registration - PR Newswire - AccessMyLibrary.com

Viagra May Help Heart Patients  -  Oct 24, 2005
...“Until now, it was widely thought that drugs like sildenafil had no effects ... “Knowing more about the effects of sildenafil on heart function will allow ... Red Herring

Natural erectile dysfunction fixes may be unsafe  -  Nov 3, 2006
Zimaxx is adulterated with sildenafil, the active pharmaceutical ingredient found in ... Actra-Rx, 4Everon and Nasutra contain modified forms of sildenafil. ... CTV.ca

Consumers warned against taking illegal medicinal products  -  Mar 8, 2007
They may contain a potent drug called sildenafil which can cause serious side effects ... The Health Sciences Authority (HSA) said sildenafil should only be ... Channel News Asia

'Desi Viagra'is turn-on for women too  -  Aug 12, 2008
Unlike earlier tests which had used sildenafil citrate on women with sexual dysfunction, this test did not consider women who suffered from a dysfunction ... Times of India

Viagra keeps heart attack at bay  -  Mar 3, 2007
The research team reported that in an animal model, sildenafil and vardenafil reduce damage ... The team first investigated sildenafil, and then vardenafil, ... Rediff

Pharmacist charged for bootleg Viagra  -  Sep 28, 2005
In the most recent case, police allege the pharmacist made and dispensed capsules using sildenafil citrate, the active ingredient in Viagra, and also sold ... Pay-Per-View - The Record - ProQuest Archiver

Viagra, the original, is here  -  Dec 12, 2005
There is a huge market in India for sildenafil citrate tablets and we are keeping the original name, Viagra.'' The pricing, though, is still a closely ... Indian Express

Alert over bogus herbal helpers  -  Mar 2, 2006
Nasutra, sold for about $20 as a natural alternative to Viagra, was found to contain sildenafil, which is known to interfere with some heart medication and ... New Zealand Herald

US warning on Shanghai sex drugs  -  Jan 2, 2008
Tests have indicated some of the so-called supplements contain Viagra's active ingredient, sildenafil, or a compound with a chemical structure that mimics ... The Standard

FDA warns about dietary supplements  -  Mar 26, 2008
Sildenafil might interact with nitrates found in some prescription drugs and can lower blood pressure to dangerous levels, the agency said. ... United Press International

Sildenafil improves blood flow after heart attack in an animal model  -  Apr 13, 2006
Dogs treated with sildenafil, a drug most commonly used to treat erectile dysfunction, had better blood flow in coronary arteries than control animals, ... News-Medical.net

Sildenafil now treats pulmonary hypertension.(BREAKING NEWS ...)  -  Jun 20, 2005
Following a priority review, the FDA approved sildenafil (Revatio, Pfizer) for the treatment of pulmonary arterial hypertension (PAH) to improve exercise ... Free with registration - Drug Topics - AccessMyLibrary.com

Long-term results after addition of sildenafil in idiopathic PAH...  -  Aug 1, 2006
Abstract: Idiopathic pulmonary arterial hypertension is a disease involving small muscular pulmonary arteries and arterioles. ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

Cheapest Sildenafil Citrate  -  Jul 23, 2007
...outlay pharmaceutical Cheapest Sildenafil Citrate may do a number of things:[2] * Carefully research the demand for their potential new product Cheapest ... Sokwanele

Herbal sex drive capsules tainted by dose of Viagra  -  Apr 27, 2007
Advertisements recalling the products and warning sildenafil "could give rise to serious health consequences" ran in newspapers this week. ... The Age

Efficacy, Tolerability and Satisfaction With Sildenafil Citrate 100...  -  Sep 1, 2008
To evaluate the efficacy, tolerability, and treatment satisfaction after initiating treatment with sildenafil 50 mg and later titrating to 100 mg, ... UroToday International Journal

Sex drug victim felt 'constantly drunk'  -  Feb 22, 2008
But preliminary tests have shown it to contain drugs controlled under the Poisons Act - glibenclamide, a prescription drug for diabetes, and sildenafil, ... AsiaOne

Impotency drug banned  -  Jan 11, 2006
The product was deregistered after it was found to have been adulterated with tadalafil and sildenafil (viagra), drugs that can only be prescribed by ... Malaysia Star

FDA says two sexual supplements recalled  -  Jul 2, 2008
The FDA said both products contain thiomethisosildenafil, an analog of sildenafil, the active ingredient of a FDA-approved drug used for erectile ... United Press International

Half of sildenafil users stay on Rx 5 years post-RP: comorbidities,...  -  Aug 15, 2005
San Antonio -- Five years after radical prostatectomy, fewer than half of the men with erectile dysfunction who responded initially to sildenafil citrate ... Free with registration - Urology Times - AccessMyLibrary.com

Sildenafil Worsens Obstructive Sleep Apnea Events  -  Sep 28, 2006
September 28, 2006 — In men with severe obstructive sleep apnea, 50 mg of sildenafil worsens bedtime respiratory and desaturation events, according to the ... Medscape

SC: only licensed allopathic manufacturers can sell Viagra  -  Mar 28, 2008
...'Viagra' is actually Sildenafil Citrate, a prescription drug used to treat male sexual dysfunction. Setting aside a decision of the Andhra Pradesh High ... Indian Express

City dad boosts Viagra spin-off drug to treat rare lung illness  -  Jan 3, 2006
Pfizer undertook a six-year clinical development programme for Revatio because there was evidence that its constituent sildenafil citrate could be an ... Scotsman

Sildenafil Shows Promise for Treating Pulmonary Arterial Hypertension...  -  Nov 18, 2005
By Paula Moyer. SAN DIEGO, CA -- November 18, 2005 -- Sildenafil (Revatio) is effective in treating pulmonary arterial hypertension (PAH) as a complication ... DG News

Sildenafil May Be Effective for Raynaud's Phenomenon  -  Nov 8, 2005
Nov. 8, 2005 — Sildenafil is effective for Raynaud's phenomenon resistant to vasodilatory therapy, according to the results of a randomized trial reported ... Medscape

FDA Approves Revatio (Sildenafil Citrate) As Treatment for Pulmonary ...  -  Jun 6, 2005
NEW YORK, NY -- June 6, 2005 -- Pfizer Inc said today the US Food and Drug Administration has approved Revatioâ„¢ (sildenafil citrate) as a treatment for ... DG News

Recreational use of an erectile dysfunction drug can be risky for some  -  May 26, 2005
Although the drugs used to treat Erectile Dysfunction, Sildenafil ... Sildenafil users engaged in unprotected sex with partners of unknown HIV status from ... Medical News Today - Medical News Today (press release)

Sildenafil use may be linked to NAION in men: ophthalmologists should...  -  Oct 1, 2005
A recent paper in the Journal of Neuro-Ophthalmology authored by Pomeranz and Bhavsar (1) raises the question of a possible link between the use of ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

How to take Sildenafil from Consumer Reports Health.  -  Jan 12, 2007
...tell your doctor and pharmacist if you are allergic to sildenafil or any other medications. do not take sildenafil if you are taking or have recently taken ... consumerreports.org

Viagra improves high altitude exercise performance up to 45% for some  -  Jun 22, 2006
Sildenafil (Viagra) significantly improved the cardiovascular and exercise ... Ten cyclists who took sildenafil at altitude collectively lowered the time it ... eurekalert.org

Potent medicine: can Viagra and other lifestyle drugs save lives?  -  Aug 20, 2005
Named sildenafil citrate, it's better known as Viagra. The major use of sildenafil--and other drugs known as phosphodiesterase-5 (PDE-5) inhibitors, ... $4.95 - Science News - ECNext

… , E298A and IVF 23+10 G/T polymorphisms of ecNOS gene and sildenafil...  -  Mar 7, 2006
Sixty-seven patients received four consecutive doses of sildenafil from 25 to 100 mg ... Sildenafil citrate is the first phosphodiesterase type 5 (PDE-5) ... Nature.com

Sildenafil Well-Tolerated in Men on Multiple Antihypertensives  -  Jan 19, 2005
By Peggy Peck, Senior Editor, MedPage Today. The study, which was sponsored by Pfizer and published in the American Journal of Hypertension, included 568 ... MedPage Today

Sildenafil Citrate (Viagra) Increases Brain Blood Flow in MS Patients...  -  Oct 3, 2005
By Bruce Sylvester. THESSALONIKI, GREECE -- October 3, 2005 -- Sildenafil citrate (Viagra) appears to help cerebral blood perfusion and brain activation in ... DG News

Sildenafil Improves Depression in Men With Erectile Dysfunction: …  -  Nov 15, 2006
By Marvin Ross. TORONTO, CANADA -- November 15, 2006 -- Men with erectile dysfunction (ED) and depression reported an improvement in both their depression ... DG News

… Ischemic Optic Neuropathy In Men Using Sildenafil Citrate For...  -  Nov 4, 2006
No cases of NAION were observed in the sildenafil clinical trials or in the IMHS. ... This study strongly suggests that sildenafil is not a risk for NAION. ... Medical News Today - Medical News Today (press release)

Interim data suggest sildenafil may benefit some HF patients.(heart...  -  Nov 1, 2006
SEATTLE -- A 12-week study of sildenafil therapy in patients with heart failure due to left ventricular dysfunction and secondary pulmonary hypertension is ... Free with registration - Family Practice News - AccessMyLibrary.com

Selling fake Viagra brings jail  -  Jul 18, 2008
...tested the pills and found that while they were the same size, shape and color as real Viagra, they lacked a key ingredient, sildenafil citrate. ... Baltimore Sun

Sildenafil Does Not Interact with Alcohol  -  Feb 1, 2005
Synopsis: Eight healthy college students participated in this crossover trial. On separate occasions, each participant received, in a randomized manner, ... AAFP News Now

Sildenafil Equal to Bosentan in Pulmonary Hypertension Therapy  -  Oct 1, 2005
Clinical Question: Is sildenafil (Viagra) more effective than bosentan (Tracleer) in the treatment of patients with class III pulmonary hypertension? ... AAFP News Now

Brand Names/Synonyms:
Sildenafil is also known by the following brand names and/or synonymsSildenafil; Sildenafil Viagra; Viagra

Drug Category:
Sildenafil is categorized under the following by the FDA: Vasodilator Agents; Phosphodiesterase Inhibitors; ATC:G04BE03

Dosage Forms:
TABLET

Absorption:
~40%

Interactions:
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Chemical IUPAC Name:
3-[2-ethoxy-5-(4-methylpiperazin-1-yl)sulfonyl-phenyl]-7-methyl-9-propyl-2,4,7,8-tetrazabicyclo[4.3.0]nona-3,8,10-trien-5-one





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