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SimvastatinThis page contains recent news articles, when available, and an overview of Simvastatin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Simvastatin (when available) Simvastatin, the methylated form of lovastatin, is an oral antilipemic agent which inhibits HMG-CoA reductase. Simvastatin is used in the treatment of primary hypercholesterolemia and is effective in reducing total and LDL-cholesterol as well as plasma triglycerides and apolipoprotein B. For the treatment of hypercholesterolemia Mechanism Of Action: The 6-membered lactone ring of Simvastatin is hydrolyzed in vivo to generate mevinolinic acid, an active metabolite structurally similar to HMG-CoA (hydroxymethylglutaryl CoA). Once hydrolyzed, Simvastatin competes with HMG-CoA for HMG-CoA reductase, a hepatic microsomal enzyme. Interference with the activity of this enzyme reduces the quantity of mevalonic acid, a precursor of cholesterol. News Articles on Simvastatin Intradiscal injection of simvastatin retards progression of intervertebral ... - 14 Nov 2009 IntroductionEarlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) ... 7thSpace Interactive (press release) The Next Vytorin Study: Why Is Everybody So Worked Up? - Nov 13, 2009 Vytorin is actually a combination of two cholesterol drugs — the generic simvastatin and the patent-protected Zetia. Zetia and Vytorin are a huge franchise, ... Wall Street Journal (blog) Is Red Yeast Rice Effective in Lowering Lipid Levels? - Nov 12, 2009 Simvastatin was compared with red yeast rice used in conjunction with fish oil and lifestyle modification in a 12-week, open-label, randomized trial. ... Medscape Generic Name: Ezetimibe/Simvastatin, Inegy - Nov 11, 2009 Vytorin (generic name: Ezetimibe / Simvastatin; brand name: Inegy) is a combination of two cholesterol medicines, Ezetimibe (a medicine that reduces the ... Pattaya Daily News Cholesterol-lowering drug could prevent Parkinson's - Oct 29, 2009 A commonly used cholesterol-lowering drug, called simvastatin, can prevent progression of Parkinson's disease, according to a study by neurological ... Times of India Zetia Plus Lipitor? For Now, FDA Won't Consider It - Nov 2, 2009 The other half of Vytorin is simvastatin — a generic drug that Merck sold under the brand name Zocor. Lipitor and simvastatin are both in a class of ... Wall Street Journal (blog) Merck Cholesterol Pill Sales May Drop 20% After Study - Nov 10, 2009 The first trial, dubbed Enhance, found Vytorin didn't help artery health more than Merck's Zocor, sold generically as simvastatin for 77 percent less. ... Bloomberg EU Committee To Size Up Abbott, Solvay Cholesterol Drugs - Oct 26, 2009 Simvastatin, which was a blockbuster seller for Merck & Co. (MRK) under the brand Zocor before it lost patent protection in 2006, has been proven to reduce ... Wall Street Journal Study Demonstrates LIVALO(R) Is an Efficacious Treatment for Achieving Lipid Goals - Oct 22, 2009 With respect to LDL-C goal attainment, treatment with LIVALO was comparable to simvastatin according to the National Cholesterol Education Program (NCEP) ... Reuters ISLAND COMMENTARY Switch to generic drugs a blow to patients - Nov 11, 2009 For example, if a patient decides to switch from Lipitor to the generic drug, Simvastatin, the doctor will typically order several lab tests be conducted ... Honolulu Star-Bulletin Simvastatin, metformin had similar effect on ovarian volume in women with PCOS - Oct 21, 2009 Women with polycystic ovary syndrome assigned to treatment with simvastatin and/or metformin experienced comparable reductions in ovarian volume that ... Endocrine Today $41.5 Million Settlement Okayed in Ezetimibe Suit - Oct 23, 2009 The ENHANCE trial compared ezetimibe/simvastatin to simvastatin alone in a population with familial hypercholesterolemia. The trial found no significant ... MedPage Today Statins Protect Against Parkinson's Progression in Mice - Nov 2, 2009 Mice given the equivalent of standard simvastatin (Zocor) or pravastatin (Pravachol) doses lost fewer dopaminergic neurons and neurotransmitters, ... MedPage Today Anatomy of a CareFirst Blue Cross Blue Shield lie - Oct 28, 2009 Here's what I found for my recent purchase of Simvastatin from Costco (for cholesterol): What the above data is telling me is that I bought 90 pills of ... AMERICAblog (blog) Low cholesterol is really good for you - Nov 4, 2009 The bottom line here is more good news for statins like simvastatin, which were originally developed against heart disease. Keeping total cholesterol low ... SmartPlanet.com Stanols Squelch Cholesterol - Oct 23, 2009 Simvastatin, sold under the brand name Zocor, is from the HMG-CoA reductase inhibitor drug family, sometimes referred to as “statins. ... Medfinds The Medical Minute: Talk about prescriptions - Oct 28, 2009 If the person with the medication list above were admitted to a hospital, she might be given simvastatin instead of Lipitor, and upon discharge she might be ... PhysOrg.com Low dose Vytorin listed on PBS - Nov 1, 2009 Two low doses of Vytorin (ezetimibe/simvastatin) have been listed on the PBS at the start of this month, aimed at helping patients with statin intolerance. ... Pharmacy News Dose dependent effect of statins on postoperative atrial fibrillation after ... - Nov 4, 2009 However, in a subgroup analysis, the patients treated with Simvastatin >20 mg daily had a 36% reduction in the risk of postoperative AF (OR 0.64, ... 7thSpace Interactive (press release) Generics Makers Line Up To Sell Copies Of Pfizer's Lipitor - Nov 6, 2009 Sales have been declining due to the availability of cheaper generic versions of other cholesterol drugs such as simvastatin. ... CNNMoney.com Red Yeast Rice and Hyperlipidemia: How Strong Is the Evidence? - Oct 28, 2009 A small randomized, placebo-controlled trial of CoQ10 failed to demonstrate an improvement in myalgia symptoms or tolerability of simvastatin, ... Medscape What Risks Are Associated With High-Dose Rosuvastatin? - Oct 22, 2009 ...[1] Rosuvastatin is a potent statin, about twice as potent as atorvastatin, 4 times as potent as simvastatin, and at least 8 times as potent as pravastatin ... Medscape Smart Rx: Drugs that work and won't break the bank - Nov 4, 2009 ...with Merck's cholesterol-lowering pill Zocor, but they might not realize the drug is now available for a portion of its original cost as simvastatin. ... The Associated Press Aortic stenosis and statins - Oct 19, 2009 The recent publication of the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study 2 prompted us to do a meta-analysis on the same question to see ... The Journal of Thoracic and Cardiovascular Surgery Police: Homeless couple found with stolen guns - Nov 9, 2009 A prescription for Simvastatin, which is used to control high cholesterol, an old Concord police badge and tie tack, as well as the tent and two lanterns at ... Concord Monitor No benefits of aspirin for primary prevention in diabetics, meta-analysis suggests - Nov 10, 2009 Events in Diabetes (ASCEND) and the Aspirin and Simvastatin Combination for Cardiovascular Events Prevention Trial in Diabetes (ACCEPT-D). ... TheHeart.Org UPI NewsTrack Health and Science News - Nov 2, 2009 For example, the scientists said simvastatin reduced the expression of the cholesterol transporter ABCA1 by approximately 80 percent in astrocytes while ... United Press International US: “Health benefits and risks of grapefruit and grapefruit juiceâ€? - Nov 12, 2009 ...cyclosporine, ethinyl, estradiol, felodipine, lovastatin, nifedipine, nimodipine, saquinavir, simvastatin, tacrolimus, testosterone, triazolam. ... FreshPlaza IDSA: Statins May Lower Risk of Flu Death - Oct 30, 2009 ...including atorvastatin (Lipitor), fluvastatin (Lescol), lovastatin (Mevacor), pravastatin (Pravachol), rosuvastatin (Crestor), and simvastatin (Zocor). ... MedPage Today FDA Approves Labeling Update for REYATAZ® (atazanavir sulfate) Capsules to ... - Nov 5, 2009 ...ergonovine, methylergonovine, cisapride, St. John's wort (Hypericum perforatum)-containing products, lovastatin, simvastatin, pimozide, or indinavir. ... WELT ONLINE Cholesterol drug sales set to double - Nov 6, 2009 An official from an Indian drugmaker, which makes generic simvastatin, (one of the several statin variants) said, "though statins are positioned only as ... Daily News & Analysis Pfizer earnings up 26% despite lower sales of many drugs - Oct 21, 2009 ...notably the generic version of Merck & Co's Zocor (simvastatin). Generic competition also hurt the colorectal cancer drug Camptosar (irinotecan), ... Pharma Times Traumatic memories can be erased after all - Nov 10, 2009 Oct 30 (ANI): A commonly used cholesterol-lowering drug, called simvastatin, can prevent progression of Parkinson's disease, according to a study by ... India Business Blog (blog) New Data: Cholesterol Management Analysis of Upsher-Smith's Slo-Niacin(R ... - Oct 27, 2009 Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. 2001;345:1583-92. ... Reuters Heart valve changes don't always warrant treatment - Nov 3, 2009 Ezetimibe is combined with simvastatin (Zocor), which is a statin drug, the class of drugs that lower cholesterol by interfering with the liver's production ... Herald & Review Merck Announces Third-Quarter 2009 Financial Results - Oct 22, 2009 Combined global sales of ZETIA (ezetimibe) and VYTORIN (ezetimibe/simvastatin), as reported by the Merck/Schering-Plough partnership, were $1.0 billion for ... Reuters Management of Hyperlipidemia in Patients With Abdominal Aortic Aneurysm - Nov 2, 2009 However, in 2002, the manufacturer of simvastatin declined to provide placebo tablets for a randomized trial intended to test this effect, citing the ATP ... Annals of Internal Medicine US FDA slammed over post-marketing studies - Oct 28, 2009 ...likeâ€? Schering-Plough/Merck & Co's cholesterol-lowerer Vytorin (ezetimibe and simvastatin) and GlaxoSmithKline's diabetes drug Avandia (rosiglitazone). ... Pharma Times Pfizer sues Unilab for patent infringement in Avamax sale - Oct 23, 2009 Unilab accounts for 25 percent of the entire anti-cholasterol drug market locally Simvastatin and Atorvastatin . It is selling the generic drug Vidastat for ... Manila Bulletin Open enrollment: Time for your own health care debate - Oct 24, 2009 But it does have therapeutic equivalents -- simvastatin, lovastatin, pravastatin, according to health insurer AmeriHealth. Most insurance plans will have ... Hillsboro Argus - OregonLive.com PBS listings in effect - Nov 2, 2009 Further additions to the PBS include Vytorin, which allows patients to have a combination of Ezetimibe with simvastatin in the one product; ... Pharmacy News Health professionals' role in brand changes - Oct 29, 2009 Three of the medicine brand changes involved commonly-prescribed medicines – paracetamol for pain relief, omeprazole for gastric problems, and simvastatin ... New Zealand Doctor Online Merck & Co earnings climb as Januvia and Isentress impress - Oct 23, 2009 On the negative side, combined sales of Vytorin (ezetimibe plus simvastatin) and Zetia (ezetimibe), sold with Schering-Plough, fell 7% to $1.03 billion, ... Pharma Times Well positioned to realise long term growth potential with doubled production ... - Nov 2, 2009 The fixed-dose combination product, consisting of 1 g of Pronova BioPharma's API and 20 mg simvastatin, has been tested in bioequivalence studies with ... PR-Inside.com (Pressemitteilung) é™?胆固醇è?¯ç‰©è¾›ä¼?他汀或能治疗帕金森症 - Nov 10, 2009 ...美国拉什大å¦åŒ»å¦ä¸å¿ƒçš„神ç»?å¦ç ”究人员å?‘现，将一ç§?常用于é™?胆固醇的è?¯ç‰©â€”—辛ä¼?ä»–æ±€(Simvastatin)应用到患帕金森症的å°?é¼ ä¸Šï¼Œè¿™ç§?è?¯ç‰©èƒ½å¤Ÿæˆ?功地使病情å?‘生好转。 ... 中国生物技术信息网 Parkinson: Cholesterinsenker stoppt Krankheit - Nov 2, 2009 Der Wirkstoff Simvastatin machte die biochemischen und zellulären Veränderungen der Nervenkrankheit im Gehirn von Mäusen rückgängig. ... NetDoktor.de Allt fler fÃ¥r kolesterolsänkande medel i Dalarna - Oct 21, 2009 Det vanligaste kolesterol- och blodfettssänkande läkemedlet i Dalarna är Simvastatin. Det är ocksÃ¥ det tredje mest sÃ¥lda läkemedlet i hela länet. ... Dalarnas Tidningar Statin berpotensi sebabkan sakit otot - Oct 25, 2009 Pasien pengguna simvastatin melaporkan efek samping paling banyak sedang pengguna pravastatin mengalami sakit otot paling ringan. ... Waspada Online 米・08年処方薬トップ50 処方ã?›ã‚“枚数トップ５ã?¯GE - Oct 29, 2009 ...処方ã?›ã‚“数（対人å?£100万人）ã?®å¤šã?„é †ã?«50ä½?ã?¾ã?§æŽ²ã?’ã?Ÿãƒªã‚¹ãƒˆã?®ãƒˆãƒƒãƒ—ã?¯éŽ®ç—›å‰¤ã?®Hydrocodoneã€?2ä½?ã?¯é™?圧剤ã?®Lisinoprilã€?3ä½?ã?¯æŠ—コレステãƒãƒ¼ãƒ«è–¬ã?®Simvastatinã€?4ä½? ... ミクスOnline La terapia con statine nei pazienti con stenosi aortica è associata a una più ... - Nov 3, 2009 Lo studio SEAS ( Simvastatin and Ezetimibe in Aortic Stenosis ), non solo ha trovato che le statine non hanno un significativo effetto sulla progressione ... XagenaSalute Pfizer says Lipitor more effective than simvastatin for 2nd heart... - Sep 6, 2006 LONDON (AFX) - Pfizer Inc said its Lipitor drug is more effective than simvastatin for cutting the risk of additional heart attacks in patients who have ... Forbes … says Lipitor significantly reduces risk of cardio events vs Simvast... - Mar 2, 2007 Lipitor patients achieved a significant additional 14 pct reduction in the risk of cardiovascular events compared with patients taking simvastatin, ... Forbes 'Surrogate goals' may mislead patients - Jan 16, 2008 They were randomly assigned to take Vytorin or simvastatin for two years. ... Vytorin combines simvastatin, also sold as Zocor, and ezetimibe, ... USA Today … to cholesterol drug Zocor arrives - Generic simvastatin going on... - Jun 23, 2006 Humana's most popular policy will charge $30 to fill a prescription for simvastatin, compared to $50 for Zocor. "It makes economic sense for Humana to offer ... $2.95 - Detroit News - NewsBank Is simvastatin cost-effective for reducing the risk of vascular... - Jul 15, 2005 Mihaylova B et al. (2005) Cost-effectiveness of simvastatin in people at different levels of vascular disease risk: economic analysis of a randomised trial ... Nature.com Maker of Lipitor Digs in to Fight Generic Rival - Nov 3, 2007 The generic version of Zocor, simvastatin, is now much cheaper than ... Many doctors have come to see simvastatin as a viable substitute for Lipitor. ... New York Times Pfizer: Study shows patients more likely to stay on Lipitor vs simvast... - Jul 7, 2008 ...the company's cholesterol-reducing drug Lipitor were 'significantly' more likely to stay on their medication compared with those who took simvastatin. ... Forbes USFDA nod for Simvastatin by Indian firms - Dec 21, 2006 Ranbaxy Pharmaceuticals Inc. (RPI), a wholly-owned subsidiary of Ranbaxy Labs, has received US Food and Drug Administration (FDA) approval to manufacture ... Business Standard US warns of muscle damage when heart drugs combined - Aug 8, 2008 All drugs in the statin class of medicines, which include simvastatin, ... The risk increased with simvastatin doses greater than 20 milligrams per day. ... Reuters Sleepless Nights Tied to Popular Cholesterol-Lowering Drug, Study Says - Nov 8, 2007 Because simvastatin is fat soluble,it can more readily penetrate cell membranes and ... “A significantly greater number of individuals taking simvastatin ... FOXNews Ranbaxy Wins Simvastatin Ruling - Nov 14, 2006 ...by staff. Ranbaxy Laboratories said Wednesday that the United States Court of Appeals for the District of Columbia Circuit has affirmed an earlier District ... Red Herring US warns of muscle damage when heart drugs combined - Aug 11, 2008 All drugs in the statin class of medicines, which include simvastatin, ... The risk increased with simvastatin doses greater than 20 milligrams per day. ... Reuters Simvastatin tablets: Is it safe to eat grapefruit? - Jan 29, 2008 By Dr Fred Kavalier. Since I had a stroke I have taken simvastatin tablets and I have been told not to eat grapefruit. Is the warning really for people who ... Independent … Niacin/Laropiprant (CORDAPTIVE(TM)) Coadministered with Simvastatin... - Nov 5, 2007 In the study, 2 g (two 1-gram tablets) of CORDAPTIVE coadministered with simvastatin (pooled across 20 mg or 40 mg doses) reduced LDL-C by 48 percent, ... Genetic Engineering News - Genetic Engineering News (press release) Cadila gets tentative USFDA nod for Simvastatin - Nov 7, 2006 Cadila Healthcare has received tentative approval from the USFDA to market Simvastatin Tablets of 5 mg, 10 mg, 20 mg, 40 mg and 80mg, in the US market. ... Business Standard `Allow simvastatin drug sales over the counter' - Jan 21, 2005 INDIA should follow the UK in allowing the sale of Simvastatin, a natural cholesterol-lowering drug, over the counter (OTC), dispensing with the practice of ... Hindu Business Line Lipitor to Face Pressure From Insurers - Mar 19, 2007 Lipitor isn't just under attack from simvastatin. AstraZeneca's Crestor and Vytorin, made by Merck and Schering-Plough Corp., have been gaining market share ... FOXNews Bloomberg Printer-Friendly Page - Jul 21, 2008 Compared with placebo, the combination of simvastatin and ezetimibe reduced ... The use of simvastatin and ezetimibe in such patients was generally well ... Bloomberg Cholesterol: cheaper statin is just as effective - Oct 3, 2006 The two main statin drugs prescribed - simvastatin and atorvastatin - account for much of this. ... The usual simvastatin dose is either 20mg or 40mg a day; ... Independent Simvastatin Improves Endocrine Parameters, Clinical Signs of PCOS - Oct 19, 2005 Oct. 19, 2005 (Montreal) — The cholesterol-lowering agent simvastatin may help improve both endocrine abnormalities and some clinical signs and symptoms of ... Medscape Walgreen 4th-quarter net falls, shares drop - Oct 1, 2007 But simvastatin has been on the market since June 2006, the company said. Higher expenses for salaries, advertising and store operations also pressured ... Reuters UK Aurobindo gets Dutch board nod for Simvastatin - Dec 11, 2006 HYDERABAD: Aurobindo Pharma has received the marketing authorisation approval for a lipid-lowering agent, Simvastatin, from Medicines Evaluation Board (MEB) ... Economic Times Is Vytorin a Failure? - Jan 15, 2008 ENHANCE compared the effect of Vytorin to simvastatin alone, ... Simvastatin came off patent in 2006, and these results suggest that the generic form of ... TIME Ezetimibe/simvastatin (vytorin) for hypercholesterolemia. - Nov 15, 2005 Ezetimibe/simvastatin (vytorin) is a combination of ezetimibe (Zetia), which inhibits the absorption of cholesterol by the small intestine, and simvastatin ... Free with registration - American Family Physician - AccessMyLibrary.com India's Dr. Reddy's gets FDA nod for simvastatin - Aug 22, 2007 MUMBAI, Aug 22 (Reuters) - Indian drug maker Dr. Reddy's Laboratories Ltd. (REDY.BO) (RDY.N) has received approval from the US Food and Drug Administration ... Reuters Vitamin D can aid fertility - Nov 11, 2008 Simvastatin appears to be at least equivalent to metformin in improving clinical and ... Furthermore, simvastatin is superior to metformin in reducing ... Telegraph.co.uk Amiodarone Interacts with Simvastatin but not with Pravastatin... - Nov 9, 2006 The aim of this study was to determine the influence of amiodarone on the pharmacokinetics of simvastatin and pravastatin in humans. This was a prospective, ... Nature.com … of Combining Psyllium Fiber With Simvastatin in Lowering Cholestero... - May 23, 2005 Background Soluble fiber supplements are recommended to reduce levels of low-density lipoprotein cholesterol (LDL-C). We evaluated the LDL-C–lowering effect ... Archives of Internal Medicine Switch to cheap statins 'raises risk of heart attack or stroke' - Sep 6, 2007 Patients in Britain who have been prescribed branded statins such as Lipitor or Crestor are being switched by their GPs to a cheaper drug, simvastatin, ... Times Online … Receives FDA Approval To Market Simvastatin 80mg Tablets With 180-... - Jun 24, 2006 Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today that the company has received approval ... Medical News Today - Medical News Today (press release) ACC: ENHANCE Data on Ezetimibe/Simvastatin (Vytorin) Reveal Wavy … - Mar 30, 2008 By Peggy Peck, Executive Editor, MedPage Today. CHICAGO, March 30 -- The take home message from the ENHANCE trial reported here today is a simple one: it's ... MedPage Today … Submits New Drug Application for Combination Niaspan(R)/Simvastatin... - Apr 20, 2007 Niaspan and simvastatin are two widely prescribed medications for treating ... Niaspan is used to raise HDL "good" cholesterol levels, and simvastatin is ... Free with registration - PR Newswire - AccessMyLibrary.com Study Showed VYTORIN-TM- -ezetimibe/simvastatin- Superior to Lipitor ... - Mar 8, 2005 ORLANDO, Fla. -- Greater LDL Cholesterol Reduction with VYTORIN(TM) Compared to Lipitor Resulted in Greater Goal Attainment At Most Common Doses ... Free with registration - Business Wire - AccessMyLibrary.com Statin drug no aid for a learning disability: study - Jul 16, 2008 Studies involving mice with a condition called neurofibromatosis 1 had suggested that simvastatin helped correct the learning and attention deficits ... Reuters India NHS urged to 'reduce drugs bill' - Dec 28, 2006 It found a quarter of trusts used generic versions of statins called pravastatin and simvastatin in over two thirds of cases and it called for others to ... BBC News 2008 approval seen for Abbott cholesterol drug - Nov 5, 2007 Niacin raises levels of "good" HDL cholesterol, while simvastatin lowers "bad" LDL cholesterol. "Data from the Simcor pivotal trials should support ... Reuters UK … Exclusivities Relating to Pravastatin 80 mg and Simvastatin 80 mg... - Oct 31, 2005 ...petition requesting the relisting of two patents that had been delisted for Simvastatin tablets, ... and will now make our case regarding Simvastatin." ... Free with registration - PR Newswire - AccessMyLibrary.com King of generics having hot 2006 but faces slump next year - Aug. 10,... - Aug 10, 2006 Teva managed to secure the rights to produce simvastatin with only limited ... While Teva is approved to produce simvastatin in three of the drug's most ... CNNMoney.com No Definitive Link Seen Between Vytorin and Cancer - Sep 2, 2008 ..."Simvastatin and ezetimibe did not reduce the composite outcome of combined aortic-valve events and ischemic events in patients with aortic stenosis. ... Washington Post Lipitor Provides Greater Benefit Compared to simvastatin in Patients... - Nov 6, 2007 ORLANDO, Fla. -- Pfizer announced today that Lipitor([R]) (atorvastatin calcium) Tablets (80 mg) was more effective than simvastatin (20 mg-40 mg) in ... Free with registration - Business Wire - AccessMyLibrary.com FDA Approves Abbott's Simcor Cholesterol Med - Feb 15, 2008 Simcor, by the way, actually combines simvastatin, the generic name for Zocor, ... In data given to the FDA, 640 patients were started on simvastatin, ... Pharmalot Ranbaxy, Reddy's vie for US cholesterol drug mart - May 3, 2006 The patent on Simvastatin was delisted last year from the US book of patents, called the Orange Book. This had created a furore and was viewed as a way to ... Rediff Walgreen Miss Dunks Druggists - Oct 1, 2007 But with prices for simvastatin falling, Walgreen explained, the company's actual gross profits for that drug remained virtually unchanged. TheStreet.com - TheStreet.com (subscription) Rhabdomyolysis from simvastatin triggered by infection and muscle … - Aug 1, 2005 Abstract: A 42-year-old woman received a 6-month course of simvastatin (20 mg/d) for hypercholesterolemia. Despite an infection with fever, fatigue, ... $4.95 - Southern Medical Journal - ECNext Study of new cholesterol drug - Mar 31, 2008 The patients all took a statin drug called simvastatin. ... Simvastatin with or without ezetimibe in familial hypercholesterolemia. ... guardian.co.uk High-Dose Statins in Acute Coronary Syndromes - Jan 5, 2005 Merck attempted to develop a 160-mg dose of simvastatin in an alternate ... MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20536 ... Journal of American Medical Association - Journal of American Medical Association... Kmart adds generic Zocor, other drugs to $15 plan - Jul 11, 2007 It also added simvastatin, or the generic form of Merck's Zocor, ... Sertraline and simvastatin are not on the list of drugs available for $4 at Wal-Mart, ... Reuters Cholesterol drug: Ranbaxy wins at US appeals court - Nov 16, 2006 The US Court of Appeals for the District of Columbia Circuit reaffirmed an earlier order by a District Court on Simvastatin, which had directed the Food and ... Hindu Business Line AstraZeneca's Crestor 'to benefit most' from ENHANCE statin study - … - Apr 9, 2008 It adds that the data, produced by market research organisation ImpactRx, also suggest that there will also be an increase in sales of generic simvastatin, ... Forbes Early Intensive Simvastatin and Coronary Outcomes - Jan 1, 2005 Clinical Question: Can early initiation of an intensive regimen with simvastatin improve clinical outcomes after an acute coronary syndrome event? ... AAFP News Now NHS 'wasting over £500m on drugs' - Apr 20, 2006 Mr Hemming used official figures on anti-cholesterol drug simvastatin, ... He calculated that government overspend on simvastatin alone was by £382m from ... BBC News US lawmakers probing Merck, Schering-Plough trial - Dec 11, 2007 ...attempting to show that Vytorin is superior to Zocor, also known as simvastatin, in a bid to fend off competition from makers of generic simvastatin. ... Reuters Ezetimibe and Simvastatin ( Systemic). - Oct 27, 2005 Ezetimibe and Simvastatin(e-ZET-e-mibe and SIM-va-stat-in ) is used to lower cholesterol and triglyceride (fat-like substances) levels in the blood. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Merck, Schering-Plough Pharmaceuticals Enhance Study Misses … - Jan 14, 2008 Simvastatin Alone on the Atherosclerotic Process in Patients with Heterozygous Familial Hypercholesterolemia) trial. Merck/Schering-Plough has submitted an ... FierceBiotech Cholesterol-Lowering Drug Aids Memory in Alzheimer's-Like Mice - Apr 30, 2007 This new study found that mice treated with simvastatin had significantly higher levels of nNOS (neuronal nitric oxide synthase) in two brain regions, ... Washington Post Little Benefit Seen With High-Dose Simvastatin Therapy or Folic Acid... - Nov 10, 2008 By Ed Susman. NEW ORLEANS -- November 10, 2008 -- Researchers across the United Kingdom found no benefit to using folic acid supplementation for prevention ... DG News Ezetimibe/Simvastatin Better Than a Statin Alone - Mar 20, 2006 March 20, 2006 (Atlanta) — A combination of the cholesterol-lowering drugs ezetimibe and simvastatin is more effective at lowering C-reactive protein (CRP) ... Medscape Dubious Drugs, Tainted Foods Top 2008's Health Stories - Dec 31, 2008 Earlier in the year, another major trial found that the widely used cholesterol medication Vytorin, which combines simvastatin with a second drug, ... Washington Post Merck, Schering Call on Doctors to Boost Vytorin Use - Mar 27, 2008 Statins, such as simvastatin, Lipitor, and AstraZeneca Plc's Crestor work by blocking an enzyme in the liver needed to make cholesterol. ... Bloomberg Say goodbye to blood pressure? - Apr 15, 2008 The group was divided in three equal parts, with one given 20 milligrammes of simvastatin, another 40 milligrammes of pravastatin and the third placebo, ... Independent Online Patients advised to keep taking Inegy cholesterol therapy despite... - Sep 3, 2008 Inegy, a therapy that combines simvastatin with another drug called ezetimibe, was linked to slightly raised levels of a variety of cancers in an ... Times Online Simvastatin linked to protection against endothelial dysfunction in... - Apr 3, 2005 Almost two years ago, the diabetes arm of the Heart Protection Study, the largest-ever study using a cholesterol-lowering medication, found that diabetics ... News-Medical.net Patients taking statins for cholesterol may also find benefits for... - Apr 14, 2008 For six months at a time, one-third of the volunteers took simvastatin, one third took pravastatin and one-third was assigned to placebo, says a report in ... Daily Mail Coadministration of Ezetimibe-Simvastatin and Fenofibrate - Jul 28, 2006 Target lipid values are difficult to achieve in mixed hyperlipidemia -- a metabolic disorder characterized by the constellation of elevated low-density ... Medscape Pfizer sees Lipitor sales toward lower end of view - Sep 10, 2007 Although Zocor isn't identical to Lipitor, administrators of drug-benefit plans have tried to encourage members to switch to generic Zocor, or simvastatin, ... MarketWatch … Approval For SIMCOR® (Niaspan® / Simvastatin), A Novel Combination... - Feb 18, 2008 SIMCOR is used when treatment with simvastatin monotherapy or niacin extended-release monotherapy is considered inadequate, and when diet and other non-drug ... Medical News Today - Medical News Today (press release) Diabetic patients in SL study see big drop using drug combo - Apr 2, 2007 Simvastatin is typically used to treat high LDL or "bad" cholesterol levels, ... For the study, they used a 20 milligram-dose of simvastatin (Zocor) for ... Deseret News Merck's Zocor price cut a mixed bag for drug cos - Jun 29, 2006 ...affected as it had entered into an agreement with Merck in January this year to launch the authorised generic versions of Zocor tablets (Simvastatin). ... Times of India Euronext - Van genoteerde ondernemingen > Persberichten - Oct 22, 2007 Simvastatin is a prescription tablet and isn't right for everyone, ... Simvastatin may interact with certain foods or other medicines including ... euronext.com Combination ezetimibe and simvastatin lowers LDL cholesterol to a … - Jan 1, 2007 Combination therapy with ezetimibe and simvastatin for 6 weeks provides greater reductions in low-density lipoprotein cholesterol (LDL-C) compared with ... Free with registration - Formulary - AccessMyLibrary.com Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) - Aug 22, 2008 Some preliminary data suggest that statin therapy may have a beneficial effect on calcific aortic stenosis (AS). Accordingly, the goal of SEAS, ... Medscape Article: Ranbaxy's Simvastatin to go Down Under by August. - Economic... - Jul 21, 2007 Ranbaxy's Simvastatin to go Down Under by August. ... find Economic Times (New Delhi, India) articles. Byline: Khomba Singh Jul. 21--NEW DELHI -- Drug major ... Pay-Per-View - Economic Times - HighBeam Research Merck postpones filing of global marketing application for MK-0524B … - Sep 29, 2006 LONDON (AFX) - Merck & Co Inc has postponed the filing of a global marketing application for its MK-0524B combination of MK-0524A and simvastatin while ... Forbes Intensive Lipid Lowering With Simvastatin and Ezetimibe in Aortic … - Sep 9, 2008 Author(s): Rossebø AB, Pedersen TR, Boman K, et al., on behalf of the SEAS Investigators. Study Question: Does intensive lipid-lowering therapy with the ... Cardiosource Combination of Simvastatin and Fenofibrate Reduces Cholesterol and … - Mar 28, 2007 By Ed Susman. NEW ORLEANS, LA -- March 28, 2007 -- The combination of cholesterol-lowering agents simvastatin and fenofibrate enhances the ability to reduce ... DG News Euphoria over cholesterol drug Zocor misplaced, say analysts - May 5, 2006 Subsequently, a host of generic companies can make Simvastatin, ... It has authorised Dr Reddy's to make and sell Simvastatin, and will get a share of the ... Hindu Business Line … AUROBINDO PHARMA GETS UDFDA APPROVAL FOR SIMVASTATIN. - Apr 25, 2006 MUMBAI, April 25 Asia Pulse - India's Aurobindo Pharma Ltd (BSE:524804) has received tentative approval from US Food and Drug Administration for its ... $4.95 - AsiaPulse News - ECNext … Receives FDA Approval to Market Simvastatin 80mg Tablets With 180-... - Jun 23, 2006 PRINCETON, NJ, June 23 /PRNewswire/ -- Ranbaxy Pharmaceuticals Inc. (RPI), a wholly owned subsidiary of Ranbaxy Laboratories Limited (RLL), announced today ... RedOrbit Dr Reddy's to sell 2 Merck generics - Feb 2, 2006 Simvastatin, which raked in $5.2 billion in global sales in 2004, ... In June last year, Merck had delisted its simvastatin patent from the "Orange book" in ... Rediff Lipitor More Effective Than Simvastatin in Cutting Risk of Additional... - Jun 9, 2006 ...- Investigator: 'These data suggest the benefit of intensive treatment with Lipitor 80mg in very high-risk heart attack patients.' ... presseportal.de Statin switch ordered.(general practitioners to use simvastatin in... - Oct 26, 2006 By Gareth Iacobucci. GPs are being told to contact all their patients on statins and switch them en masse to generic simvastatin as part of swingeing ... Free with registration - Pulse - AccessMyLibrary.com Pfizer Continues Battle Against Simvastatin - Jul 10, 2008 Patients taking Pfizer's market-leading statin Lipitor who have experienced a previous cardiovascular (CV) event are 22 percent less likely to discontinue ... FDA news - FDA news (subscription) Lupin receives USFDA approval for Simvastatin tablets - May 15, 2007 Mumbai, May 15 (PTI) Pharma company Lupin today said it has received final approval from the US Food and Drug Administration (FDA) for its cholesterol drug ... Free with registration - PTI - The Press Trust of India Ltd - AccessMyLibrary.com Simvastatin Linked To Reduced Incidence Of Dementia - Jul 19, 2007 Statins are not all equal when it comes to their potential to guard against dementia, according to a study published in the online open access journal BMC ... Medical News Today - Medical News Today (press release) Cholesterol drug OK opens cash artery for Genepharm - Feb 2, 2006 As well as competing with the labelled brand of Simvastatin, there are several ... Almost 6 million prescriptions of Simvastatin were issued last year to ... The Age INDIA'S LUPIN GETS USFDA APPROVAL FOR SIMVASTATIN TABLETS. - May 16, 2007 MUMBAI, May 16 Asia Pulse - Indian pharmaceutical company Lupin (BSE:500257) on Tuesday said it has received final approval from the US Food and Drug ... $4.95 - AsiaPulse News - ECNext Statin simvastatin linked to protection against endothelial dysfunctio... - Apr 4, 2005 Almost two years ago, the diabetes arm of the Heart Protection Study, the largest-ever study using a cholesterol-lowering medication, found that diabetics ... i-newswire.com Ranbaxy wins 180-day exclusivity for simvastatin. | Article from... - Nov 16, 2006 Ranbaxy wins 180-day exclusivity for simvastatin. ... find Economic Times (New Delhi, India) articles. Nov. 16--NEW DELHI -- The US Court of Appeals has ... Pay-Per-View - Economic Times - HighBeam Research Vytorin is safe to take - Mar 18, 2008 Vytorin is a combination product containing simvastatin and ezetimibe. Zocor contains simvastatin alone. (Ezetimibe alone is available as Zetia.) ... Albany Times Union SWOPPING STATINS WOULD SAVE NHS £2BN IN FIVE YEARS - Jun 9, 2006 Most take one of two brands - simvastatin and atorvastatin, ... But experts say simvastatin costs six times less than its rival since its patent expired in ... Pay-Per-View - Daily Mail - Factiva, from Dow Jones … Possible Link Between Ezetimibe/Simvastatin and Increased Cancer … - Aug 21, 2008 ROCKVILLE, Md -- August 21, 2008 -- The US Food and Drug Administration (FDA) is informing healthcare professionals that it is investigating a report from ... DG News Article: Pfizer moves to protect Lipitor from cheaper drug.(Front) -... - Nov 3, 2007 Article: Lipitor More Effective Than Simvastatin in Cutting ... ... Developed by US ... difference between Lipitor and simvastatin users was similar ... ... Pay-Per-View - Virginian-Pilot - HighBeam Research SIMCOR Significantly Raises HDL, Lowers Triglycerides In Phase III … - Nov 6, 2007 Patients receiving a SIMCOR combination with 40 mg simvastatin experienced reductions in non-HDL comparable to 80 mg simvastatin alone, and significantly ... emaxhealth.com … Aurobindo gets Dutch board nod for Simvastatin. - Economic Times... - Dec 12, 2006 Aurobindo gets Dutch board nod for Simvastatin. ... find Economic Times (New Delhi, India) articles. Byline: Srividhya Ramkumar Dec. Pay-Per-View - Economic Times - HighBeam Research … study showed Vytorin (ezetimibe/simvastatin) significantly more... - Jun 19, 2006 Results from a new clinical study which included 2855 patients with high cholesterol showed that Vytorin (ezetimibe/simvastatin) was significantly more ... Pay-Per-View - Company Reports - Factiva, from Dow Jones Teva Announces Tentative Approval of Simvastatin Tablets - Jan 1, 2006 JERUSALEM--(BUSINESS WIRE)--Jan. 1, 2006--Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today that the US Food and Drug Administration has ... biotech-intelligence.com Genotyping identifies statin myopathy risk - Jul 24, 2008 And while the study concentrated on simvastatin, researchers believe the findings are more broadly applicable, as the genetic variants affect the blood ... 6minutes INEGYT Is Superior To Simvastatin In Reducing Key Risk Markers Of … - Sep 11, 2006 Results from new analyses of two clinical studies presented today at the 2006 World Cardiology Congress show that INEGYâ„¢ (ezetimibe/simvastatin) is ... Medical News Today - Medical News Today (press release) … Reduces C-Reactive Protein Better Than Simvastatin Alone: Presented... - Mar 15, 2006 By Ed Susman. ATLANTA, GA -- March 15, 2006 -- A combination of the anticholesterol drugs simvastatin (Zocor) and ezetimibe (Zetia) work together to reduce ... DG News Experts call for increased use of statins. - Nov 10, 2006 The authors said: "At current UK prices for generic simvastatin, 40mg of simvastatin is likely to be cost saving, or would cost less than GBP2,500 per life ... Free with registration - Europe Intelligence Wire - AccessMyLibrary.com Brand Names/Synonyms: Simvastatin is also known by the following brand names and/or synonymsCCRIS 7558; Cholestat; Coledis; Colemin; Corolin; DRG-0320; Denan; Labistatin; Lipex; Liponorm; Lodales; MK-0733; MK-733; Medipo; Nivelipol; Pantok; Rendapid; Simovil; Simvastatin; Simvastatin [Usan:Ban:Inn]; Simvastatina [Spanish]; Simvastatine [French]; Simvastatinum [Latin]; Sinvacor; Sivastin; Synvinolin; Vasotenal; Vytorin; Zocor; Zocord Drug Category: Simvastatin is categorized under the following by the FDA: Antilipemic Agents; Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA01 Dosage Forms: Oral tablets Absorption: Absorption of simvastatin, estimated relative to an intravenous reference dose, in each of two animal species tested, averaged about 85% of an oral dose. In animal studies, after oral dosing, simvastatin achieved substantially higher concentrations in the liver than in non-target tissues Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: [8-[2-(4-hydroxy-6-oxo-tetrahydropyran-2-yl)ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl]2,2-dimethylbutanoate |
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