Sorbitrate

This page contains recent news articles, when available, and an overview of Sorbitrate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Sorbitrate
(when available)

Pharmacology and use:
Isosorbide Dinitrate is a moderate- to long-acting oral organic nitrate used for the relief and prophylactic management of angina pectoris. It relaxes the vascular smooth muscle and consequent dilatation of peripheral arteries and veins, especially the latter. Dilatation of the veins promotes peripheral pooling of blood and decreases venous return to the heart, thereby reducing left ventricular end- diastolic pressure and pulmonary capillary wedge pressure (preload). Arteriolar relaxation reduces systemic vascular resistance, systolic arterial pressure, and mean arterial pressure. For the prevention of angina pectoris due to coronary artery disease

Mechanism Of Action:
Similar to other nitrites and organic nitrates, Isosorbide Dinitrate is converted to nitric oxide (NO), an active intermediate compound which activates the enzyme guanylate cyclase (Atrial natriuretic peptide receptor A). This stimulates the synthesis of cyclic guanosine 3',5'-monophosphate (cGMP) which then activates a series of protein kinase-dependent phosphorylations in the smooth muscle cells, eventually resulting in the dephosphorylation of the myosin light chain of the smooth muscle fiber. The subsequent release of calcium ions results in the relaxation of the smooth muscle cells and vasodilation.

News Articles on Isosorbide Dinitrate

Order Sorbitrate Overnight Delivery  -  Jul 12, 2007
...is the study of chemicals requires intimate knowledge of cell biology and biochemistry increasing, the field of pharmacology is typically offered as an ... Sokwanele

Take heart, Sorbitrate may come under price control.  -  Jan 14, 2006
Jan. 14--NEW DELHI -- Here's a bit of good news for heart patients. Clot-busting pill Sorbitrate may become cheaper soon. The government is looking at ... Free with registration - Economic Times - AccessMyLibrary.com

Article: Take heart, Sorbitrate may come under price control. -...  -  Jan 14, 2006
Take heart, Sorbitrate may come under price control. ... find Economic Times (New Delhi, India) articles. Byline: Gireesh Chandra Prasad Jan. Pay-Per-View - Economic Times - HighBeam Research

Sorbitrate 60 Pills X 10 Mg  -  Sep 30, 2007
...demand for their potential new medicines typically only one will ever reach the open market, this is an Sorbitrate 60 Pills X 10 Mg way Sorbitrate 60 Pills ... Sokwanele

Order Sorbitrate COD  -  Dec 15, 2007
...the beneficial effects. This development phase can take up to 6 years the new medicine preventing other companies from producing that medicine for a certain ... Sokwanele

Govt to force drug cos to cut prices  -  Sep 8, 2006
Also, the price of 50 tablets of Sorbitrate 10 mg rose by 29% from Rs 25 to Rs 32.44 during the same period. , while the cost of the Phenargan injection 25 ... Economic Times

Discount Sorbitrate COD  -  Jul 11, 2007
...main body that regulates pharmaceuticals is the study of pharmacology Discount Sorbitrate COD also changed Discount Sorbitrate COD It has become possible, ... Sokwanele

Sorbitrate No Rx  -  Jul 11, 2007
The Molecular Sorbitrate No Rx Behavior study of chemicals requires intimate knowledge of the drug. The dosage of any drug approved for use is intended to ... Sokwanele

Discount Sorbitrate Overnight Delivery  -  Sep 23, 2007
...offered as an advanced degree program. The following is a Discount Sorbitrate Overnight Delivery list of North American universities that offer a degree in ... Sokwanele

Buy Sorbitrate COD  -  Oct 8, 2007
...act Buy Sorbitrate COD specific cellular signalling pathways controlling cellular function). A chemical has, Buy Sorbitrate COD the pharmacological ... Sokwanele

Discount Sorbitrate  -  Jun 11, 2007
...is not identical with pharmacy, though in common usage Discount Sorbitrate two are at times confused. Contents [hide] * 1 Medicine development Discount ... Sokwanele

Satguru Partap Singh Apollo Heart Centre inaugurated  -  Sep 30, 2007
The patient should also take one Sorbitrate (5mg) bilingual to relieve the chest pain. Research shows that getting Disprin and Sorbitrate early in the ... Expressindia.com

Cardiac trouble  -  Feb 20, 2005
My cardiologist advises me not to take sorbitrate too much. Before taking sorbitrate my BP was 140/90 and at times more. Now it is between 120/80 and 130/80 ... The Hindu

A Nagpur Doctor Starts A Movement For A Healthier India  -  Jul 30, 2007
From handing out Sorbitrate lockets to a fitness movement, Dr Jichkar's driving force is a desire to teach people "to live for a 100 years". ... Outlook

Mumbai, India-based Ipca Labs buys cardiovascular brand Isordil from ...  -  Jan 8, 2005
Isordil is a well-known brand in the cardiovascular segment, though the market leader for nitrates is Nicholas Piramal's brand Sorbitrate. ... Free with registration - Economic Times - AccessMyLibrary.com

'Healthy Heart' expo begins at SPS Apollo hospital  -  Sep 27, 2008
The kit will have Sorbitrate (5mg), Disprin (325mg), Emergency Ambulance Numbers, a CD illustrating CPR, various educative and informative materials. ... Indian Express

The Doctor is in  -  May 3, 2008
My prescription includes Dilzem 90 mg sr BD, Sorbitrate 10 md tid, Coversyl 2 mg. Please advise. MN Satvekar. Your sugar control is excellent, ... Indian Express

THE BIG STORY  -  Jun 7, 2005
Swallow two Disprin tablets or keep a Sorbitrate under your tongue. IN a city that never seems to sleep, that runs eight days a week, 25 hours a day, ... Expressindia.com

Pain in the back  -  Apr 30, 2006
I take Sorbitrate 10 mg and Ecosprin 150 mg. I was operated for hip joint ball fracture replacement in the right side six years ago. ... The Hindu

Ipca, Chinese co in malaria drug JV. | Article from Economic Times...  -  May 1, 2005
Piramal's brand Sorbitrate. Ipca has plans to launch line extensions ... Jain said. The Rs 750-crore Ipca Laboratories is a backward integrated . ... Pay-Per-View - Economic Times - HighBeam Research

Perlecan begins clinical trail of anti-diabetic drug. | Article from...  -  Dec 27, 2006
Economic Times (New Delhi, India); February 19, 2007 ; 700+ words ... ... tablet, chest pain reliever Sorbitrate 10 mg, anti-allergy drug Phenargan ... Pay-Per-View - Economic Times - HighBeam Research

JVC's Everio camcorder & HD-ILA TV. | Article from Economic Times...  -  Jan 29, 2006
The medicines are Nicholas Piramal's anti-anxiety drug Stemetil 5 mg tablet, chest pain reliever Sorbitrate 10 mg, anti-allergy drug Phenargan injection 25 ... Pay-Per-View - Economic Times - HighBeam Research

Apan Vayu Mudra for Cardiac Emergencies  -  Feb 21, 2008
We all are aware of the seemingly important Nitroglycerine (Sorbitrate) tablet which is placed underneath one's tongue as a first-aid measure for severe ... HealthJockey.com

Buy Levitra Levitra Online Viagra  -  Nov 30, 2008
This includes nitroglycerin Nitrostat, Nitrolingual, Nitro Dur also, Nitro--Offered and other one, Isosorbiddinitrat Dilatrate SR, Isordil, Sorbitrate and ... College Sports Media

Nitroglycerin.(Drug overview)  -  Dec 1, 2005
Take particular care with calcium channel blockers such as Calan and Procardia XL, as well as isosorbide dinitrate (Sorbitrate, Isordil, others), ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

How to take Rosiglitazone from Consumer Reports Health.  -  Jan 3, 2008
...tell your doctor if you are taking insulin or nitrates such as isosorbide dinitrate (Isordril, Sorbitrate), isosorbide mononitrate (Imdur, ISMO), ... consumerreports.org

Levitra.(drug overview)(Drug overview)  -  Dec 1, 2005
...and isosorbide pills (Dilatrate-SR, Isordil, Sorbitrate). This also includes street drugs known as "poppers," including amyl nitrate and butyl nitrate. ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Compare Viagra To Cialis  -  Nov 30, 2008
Dilatrate-SR of dinitrate d' compare viagra to cialis isosorbure, Isordil, Sorbitrate, and mononitrate Imdur, ISMO, Monoket d' isosorbure. ... College Sports Media

Cialis- Are you ready for it  -  Sep 2, 2006
This includes nitroglycerin (Nitrostat, Nitrolingual, Nitro-Dur, Nitro-Bid, and others), isosorbide dinitrate (Dilatrate-SR, Isordil, Sorbitrate), ... Buzzle

- Lawyer died without proper medical aid, cry colleagues  -  Mar 5, 2005
...?There was neither oxygen nor Sorbitrate in the medical unit. There is also no ambulance, so the patient could not be taken to hospital,? he alleged. ... Calcutta Telegraph

Companies slash prices of popular medicines. | Article from Economic ...  -  Feb 19, 2007
The medicines are Nicholas Piramal's anti-anxiety drug Stemetil 5 mg tablet, chest pain reliever Sorbitrate 10 mg, anti-allergy drug Phenargan injection 25 ... Pay-Per-View - Economic Times - HighBeam Research

Residents of Payamanti Housing Co-operative Society in Kasba at the …  -  Jan 3, 2006
During the 20 minutes of chest pain, it is advisable to take a Sorbitrate kind of medicine, which should be kept under the tongue for five minutes. ... Calcutta Telegraph

Generic name: Sildenafil citrate  -  Dec 1, 2005
...nitroglycerin ointment (Nitro-Bid, Nitrol), nitroglycerin pills (Nitro-Bid, Nitrostat), and isosorbide pills (Dilatrate-SR, Isordil, Sorbitrate). ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Avoid After-Meal Workouts If Susceptible to Cramps  -  Jun 27, 2005
Finally, sugarless candy -- a favorite of Atkins and low-carb diets -- contains sorbitrate. It tastes sweet but can give you gas. Sorbitol is also found in ... RedOrbit

INDIAN HEALTH MINISTRY DEFERS NPPA'S PRICE-REGULATION …  -  Mar 8, 2006
...rights were three top-selling medications manufactured by drugmaker Nicholas Piramal -- Sorbitrate, which dilates blood vessels to relieve chest pain; ... Pay-Per-View - Daily International Pharma Alert - Factiva, from Dow Jones

Viagra and health: Beyond ED.(erectile dysfunction)(Drug overview)  -  Aug 1, 2007
...under-the-tongue tablets or sprays); long-acting nitrates (isosorbide dinitrate, or Isordil, Sorbitrate, and others, and isosorbide mononitrate, Imdur, ... Free with registration - Harvard Men's Health Watch - AccessMyLibrary.com

Drugs a double-edged sword - Consumers must take active role in …  -  Mar 11, 2005
Viagra or other drugs used for erectile dysfunction should never be taken with nitrates such as nitroglycerin, Isordil or Sorbitrate. ... Pay-Per-View - Dayton Daily News - NewsBank

Update on outpatient treatment of systolic heart failure.(Letters to...  -  Oct 1, 2005
...in patients given a combination of hydralazine (Sorbitrate) plus isosorbide (Apresoline) dinitrate compared with those treated with enalapril (Vasotec). ... $4.95 - American Family Physician - ECNext

Blood in sputum  -  Jan 29, 2007
My father (49) occasionally suffers from chest pain which lasts for 30 minutes on an average and subsides on taking rest, sorbitrate or antacids. ... Calcutta Telegraph

Những Ä‘iá»?u cần tránh khi uống thuốc viên  -  Dec 29, 2006
...giữ nguyên vẹn để đặt dưới lưỡi và ngậm cho tan, nếu bẻ nh� và nghi�n nát sẽ phá vỡ và làm h�ng dạng thuốc như thuốc sorbitrate sublingual, ergomar... ... Báo Khoa h�c

Exercise regulary. Half an hour walk at least five days a week  -  Oct 28, 2007
As: Help the person into a sleeping position , place an aspirin tablet under the tongue with a sorbitrate tablet if available, and rush him to a coronary ... The Island - The Island (subscription)

Nitroglycerin.(Drug overview)  -  Jan 22, 2007
Take particular care with calcium channel blockers such as Calan and Procardia XL, as well as isosorbide dinitrate (Sorbitrate, Isordil, others), ... Free with registration - PDR Family Guide to Prescription Drugs - AccessMyLibrary.com

Escan de adquisicion multiproposito.  -  Feb 1, 2007
...y el dinitrato de isosorbida (Isordil(r), Sorbitrate(r)). Si está embarazada o piensa que puede estarlo, infórmele a su médico antes del examen. ... Free with registration - CareNotes - AccessMyLibrary.com

Article: Chem ministry plans to pop price control pill. - Economic...  -  Mar 2, 2006
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... looking at imposing price ... Pay-Per-View - Economic Times - HighBeam Research

Govt-controlled drugs vanish from shelves. | Article from Economic...  -  Jul 18, 2006
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... Chandra Prasad Jan. ... Pay-Per-View - Economic Times - HighBeam Research

Govt may give a breather to overcharging drug companies. | Article...  -  Mar 31, 2005
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... The government is looking ... Pay-Per-View - Economic Times - HighBeam Research

Drugs under price control to cost more after government lifts expense...  -  Nov 21, 2005
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... The government is looking ... Pay-Per-View - Economic Times - HighBeam Research

Govt have more say in drug sales with new law. | Article from...  -  Jun 9, 2006
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... The government is looking ... Pay-Per-View - Economic Times - HighBeam Research

Article: 'Patented drugs to cost the same here as overseas'. -...  -  Feb 2, 2005
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... looking at imposing price ... Pay-Per-View - Economic Times - HighBeam Research

Vaccines, biologicals may be left out of price control. | Article...  -  Jun 6, 2006
Article: Take heart, Sorbitrate may come under price ... Economic Times (New Delhi, India); January 14, 2006 ; 614 words ... ... The government is looking ... Pay-Per-View - Economic Times - HighBeam Research

Brand Names/Synonyms:
Sorbitrate is also known by the following brand names and/or synonymsDilatrate; Isochron; Isordil; Titradose; Sorbitrate; Dinitrosorbide; Corosorbide; Carvanil; Carvasin; Cedocard; Claodical; Cornilat; Difutrat; Coronex; Flindix; 1,4:3, 6-Dianhydro-D-glucitol dinitrate; 1,4:3,6-Dianhydrosorbitol 2, 5-dinitrate; 87-33-2; AIDS-125686; AIDS125686; Cardio 10; Cardis; Carvanil; Carvasin; D-Glucitol, 1,4:3,6-dianhydro-, dinitrate; Dianhydrosorbitol 2,5-dinitrate; Dilatrate-SR; Dinitrosorbide; Emoper; Flindix; Glucitol, 1,4:3, 6-dianhydro-, dinitrate, D-; Harrical; IBD 20; ISD; ISDN; Ismotic; Iso-Bid; Isoket; Isorbid;; Isordil Tembids; Isosorbide Dinitrate; Isosorbide dinitrate(USAN); Isostat; Isotrate; Korodil; Lomilan; Maycor; Myorexon; Nitrosorbid; Nitrosorbide; Nitrosorbon; Nosim; Resoidan; Rifloc Retard; Rigedal; Sorbangil; Sorbide T.D.; Sorbide nitrate; Sorbide, dinitrate; Sorbidilat; Sorbidnitrate; Sorbislo; Sorbonit; Sorquad; Tinidil; Vascardin; Vasodilat; Vasorbate; Xanyl

Drug Category:
Sorbitrate is categorized under the following by the FDA: Vasodilator Agents; Nitrates and Nitrites; ATC:C01DA08; ATC:D03AX08

Dosage Forms:
Oral tablet

Absorption:
Absorption of isosorbide dinitrate after oral dosing is nearly complete, but bioavailability is highly variable (10% to 90%), with extensive first-pass metabolism in the liver.The average bioavailability of isosorbide dinitrate is about 25%

Interactions:
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Chemical IUPAC Name:
4,8-dinitrooxy-2,6-dioxabicyclo[3.3.0]octane





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