Sulfasalazine

This page contains recent news articles, when available, and an overview of Sulfasalazine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Sulfasalazine
(when available)

Pharmacology and use:
Sulfasalazine is an anti-inflammatory indicated for the treatment of ulcerative colitis and rheumatoid arthritis. For the treatment of Crohn's Disease and Rheumatoid Arthritis as a second-line agent

Mechanism Of Action:
The mode of action of Sulfasalazine or its metabolites, 5-aminosalicylic acid (5-ASA) and sulfapyridine (SP), is still under investigation, but may be related to the anti-inflammatory and/or immunomodulatory properties that have been observed in animal and in vitro models, to its affinity for connective tissue, and/or to the relatively high concentration it reaches in serous fluids, the liver and intestinal walls, as demonstrated in autoradiographic studies in animals. In ulcerative colitis, clinical studies utilizing rectal administration of Sulfasalazine, SP and 5-ASA have indicated that the major therapeutic action may reside in the 5-ASA moiety. The relative contribution of the parent drug and the major metabolites in rheumatoid arthritis is unknown.

News Articles on Sulfasalazine

25 Years in Arthritis: New Treatments, New Hope  -  ‎Jan 2, 2010‎
At that time, recalled Dr. Nortin Hadler of the University of North Carolina at Chapel Hill, "gold salts were in favor ... drugs like sulfasalazine and ... ABC News

Biologics Transform RA Outlook  -  ‎Dec 31, 2009‎
At that time, recalled Nortin Hadler, MD, of the University of North Carolina in Chapel Hill, NC, "gold salts were in favor . . . drugs like sulfasalazine ... MedPage Today

New and Upcoming Biologic Agents for Rheumatoid Arthritis  -  ‎Dec 29, 2009‎
As the disease progresses therapy can move to the use of non-biological disease modifying antirheumatic drugs (DMARDs) (eg, sulfasalazine, ... Ortho SuperSite

Two predictors of early arthritis identified  -  ‎Dec 19, 2009‎
Another 9 percent used sulfasalazine, 28 percent took a combination of DMARDs or more than one DMARD during the year (including 13 patients who received ... Philippine Star

Cross-breeding leading to native livestock decline in Orissa  -  ‎Dec 13, 2009‎
Oxytetracycline, Pergolide, Piroxicam, Pravastatin, Prochlorperazine, Spironolactone, Sulfasalazine, Sumatriptan, Terbinafine, Trifluoperazine. ... TopNews

Kenapa Bisa Kena Penyakit Lichen Planus?  -  ‎Jan 3, 2010‎
Untuk saat ini saya mengkonsumsi obat Cravit Levofloxacin 500 mg (antibiotik), Sulcolon Sulfasalazine 500 mg,Galflux Domperidone 10 mg, ... Detikcom

Surgery not first approach to foot pain  -  14 Nov 2009
Since seeing a rheumatologist for eight years, I am on all kinds of medications, including steroids, antimalarials, sulfasalazine, ... Telegraph-Journal

Study: No Benefit to Costly Arthritis Meds  -  ‎Oct 23, 2009‎
Two groups began with immediate combination therapy: either methotrexate combined with sulfasalazine and hydroxychloroquine (the traditional DMARDs) or ... CBS News

Early termination of ISRCTN45828668, a phase 1/2 prospective, randomized study ...  -  ‎Oct 19, 2009‎
Sulfasalazine, a NF-kappaB and x(c)-cystine/glutamate antiport inhibitor, has demonstrated a strong antitumoral potential in preclinical models of malignant ... 7thSpace Interactive (press release)

I'm a virtuoso violinist but when arthritis hit me, I couldn't even squeeze ...  -  ‎Oct 24, 2009‎
...cancer but which some think is far more effective than the immunosuppressive drug Sulfasalazine, which is commonly prescribed in the UK to treat RA. ... Daily Mail

Interaction of Topical Sulfacetamide and Topical Dapsone With Benzoyl Peroxide  -  ‎Oct 19, 2009‎
This phenomenon had previously been observed by one of us (ABF) when sulfasalazine was combined with benzoyl peroxide. To investigate these interaction ... Archives of Dermatology

FAQ: Psoriatic Arthritis  -  ‎Nov 9, 2009‎
...disease-modifiying medications, such as sulfasalazine and hydroxychloroquine. These medications help to slow down the joint destruction associated with the ... 24 Medica

Shire Presents Results of Five Lialda(R) (mesalamine) Analyses at ACG 2009 ...  -  ‎Oct 26, 2009‎
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Reuters

New SIMPONI(TM) Data Show Long-Term Efficacy in Treatment of Rheumatoid Arthritis  -  ‎Oct 19, 2009‎
At baseline, 66 percent of patients were receiving methotrexate; five percent and eight percent of patients were receiving sulfasalazine and ... Reuters

ACR: No Special Benefit Seen with Biologic RA Drugs  -  ‎Oct 20, 2009‎
Two groups were treated with a combination of drugs from the start: either methotrexate combined with sulfasalazine and hydroxychloroquine (the traditional ... MedPage Today

Study: No Benefit to Costly Arthritis Drugs  -  ‎Oct 21, 2009‎
Two groups began with immediate combination therapy: either methotrexate combined with sulfasalazine and hydroxychloroquine (the traditional DMARDs) or ... WebMD

Triple DMARD Therapy Effective for Aggressive Treatment of Early Rheumatoid ...  -  ‎Oct 21, 2009‎
PHILADELPHIA -- October 21, 2009 -- Initial use of methotrexate monotherapy with the addition of sulfasalazine/hydroxychloroquine or ... DG News

What is the appropriate use of chronic medications in the perioperative setting?  -  ‎Nov 5, 2009‎
The patient's home medications include aspirin, carbidopa/levodopa, celecoxib, clonidine, estradiol, ginkgo, lisinopril, NPH insulin, sulfasalazine, ... The Hospitalist Online

Rheumatoid Arthritis  -  ‎Nov 3, 2009‎
...leflunomide, sulfasalazine, and hydroxychlorquine) as well as less commonly used (minocycline) or rarely used (cyclosporine, gold) agents and those of ... Journal of American Medical Association (subscription)

Rectal mucosal prolapse syndrome as an unusual gastrointestinal manifestation ...  -  ‎Oct 30, 2009‎
Prohibition on straining during defecation and sulfasalazine suppository were effective. Conclusions: This case highlights the importance of defecation ... 7thSpace Interactive (press release)

Infliximab Bests DMARDs in Controlling Radiological Progression in Patients ...  -  ‎Oct 21, 2009‎
...methotrexate were randomised to receive either sulfasalazine 2000 mg/day plus hydroxychloroquine 400 mg/day (n = 130) or infliximab 3 mg/kg (n = 128). ... DG News

Pharmaceutical Journal - Avoid folic acid antagonists in first trimester of ...  -  ‎Oct 20, 2009‎
In the study, 349 women were exposed to dihydrofolate reductase inhibitors such as trimethoprim/sulfamethoxazole, methotrexate and sulfasalazine, ... DeHavilland (press release) (subscription)

New SIMPONI(TM) Data Show Long-Term Efficacy in Treatment of Rheumatoid Arthritis  -  ‎Oct 19, 2009‎
At baseline, 66 percent of patients were receiving methotrexate; five percent and eight percent of patients were receiving sulfasalazine and ... Genetic Engineering News (press release)

Etanercept plus sulfasalazine: added value in rheumatoid arthritis?  -  Oct 31, 2006
Combe B et al. (2006) Etanercept and sulfasalazine, alone and combined, in patients with active rheumatoid arthritis despite receiving sulfasalazine: a ... Nature.com

Does early sulfasalazine treatment provide long-term benefits to...  -  Feb 6, 2008
...van Rossum MA et al. (2007) Long-term outcome of juvenile idiopathic arthritis following a placebo-controlled trial: sustained benefits of early ... Nature.com

Sulfasalazine for rheumatoid arthritis  -  Aug 18, 2008
Sulfasalazine is a medicine formed from salicylic acid (the active ingredient in aspirin) and an antibiotic, sulfapyridine. It is given by mouth (orally) ... WebMD

Sulfasalazine for juvenile rheumatoid arthritis  -  Jun 25, 2008
Sulfasalazine is a combination of salicylic acid (the active ingredient in aspirin) and an antibiotic, sulfapyridine. Sulfasalazine may reduce joint ... WebMD

Are excellent systematic reviews of clinical trials useful for...  -  Feb 14, 2008
1 The authors' conclusion that the efficacy of sulfasalazine, ... Methotrexate has replaced sulfasalazine as the primary DMARD in Europe over the last ... Nature.com

A woman with rheumatoid arthritis whose condition did not improve …  -  Jul 20, 2005
Previous combination therapy, which included sulfasalazine had failed to control ... Sulfasalazine was discontinued and infliximab plus methotrexate were ... Nature.com

Hi ton here is some info on Sulfasalazine, which my son takes for...  -  Jan 3, 2006
Could you figure out what the generic name (rather than the brand name) is from the portuguese website? That might give you something to work on. ... Daily Mail

SULFASALAZINE (Oral route, Rectal route) - sul-fa-SAL-a-zeen.(Drug …  -  May 1, 2007
Sulfasalazine , a sulfa medicine, is used to prevent and treat inflammatory bowel disease, such as ulcerative colitis. It works inside the bowel by helping ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Australian research offers hope to chikungunya patients  -  May 7, 2008
..."The good news is that we have been able to determine through research that there is a drug, Sulfasalazine, which is currently available commercially that ... सिफी - सिफी

How Do The Older DMARDs Differ From The Newer DMARDs And Is …  -  Jan 3, 2008
Some of the medicines in this class are methotrexate, sulfasalazine, hydroxychloroquine -- and these are very very helpful for patients with rheumatoid ... ABC News

Sulfasalazine, dapsone: good alternative options, for treatment of...  -  Jan 1, 2007
Philadelphia -- In patients with chronic urticaria who do not respond to standard antihistamine treatment, the older drugs sulfasalazine and dapsone ... $4.95 - Dermatology Times - ECNext

How to recognize and treat IBD: recognizing, diagnosing, and managing...  -  Dec 1, 2005
Sulfasalazine (Azulfidine) was the first drug of this class to show a benefit for IBD and is ... Sulfasalazine competes with the uptake of folic acid in the ... Free with registration - Patient Care for the Nurse Practitioner - AccessMyLibrary.com

Phytomedics' Novel Oral Disease Modifying Drug Candidate PMI-001 …  -  Nov 28, 2006
These scores increased in subjects treated with sulfasalazine. Both treatment groups showed similar overall adverse events rates, which were mild in nature. ... Free with registration - PR Newswire - AccessMyLibrary.com

… Administrative Code - 77 Ill. Adm. Code 790.8620 SULFASALAZINE ( …  -  Aug 10, 2005
77 Ill. Adm. Code 790.8620 SULFASALAZINE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

… urticaria may respond to sulfasalazine.(Dermatologic Therapy) -...  -  Jul 1, 2006
Recalcitrant chronic urticaria may respond to sulfasalazine. ... MIAMI BEACH -- Oral sulfasalazine appears to be a good steroid-sparing alternative for ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Sulfasalazine an option for recalcitrant alopecia areata  -  Aug 1, 2008
By Samantha Crofskey. MedWire News: Sulfasalazine can be used as an alternative treatment for alopecia areata in patients who do not respond to standard ... Medwire (subscription)

… Tx response.(Methotrexate and sulfasalazine)(Clinical report) |...  -  Jul 1, 2006
Methotrexate and sulfasalazine)(Clinical report) ... find Family Practice News articles. PHILADELPHIA -- Patients with psoriasis who drink coffee frequently ... Pay-Per-View - Family Practice News - HighBeam Research

sulfasalazine | Definition of sulfasalazine | HighBeam.com: Online …  -  Jul 12, 2006
Find out what sulfasalazine means: The Oxford American College Dictionary has the definition of sulfasalazine. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

The Range of Treatments For Crohn's Disease  -  Jan 17, 2006
Anti-inflammatory medications, such as Sulfasalazine, Mesalamine, ... Sulfasalazine is very effective; however, it has severe side effects, such as nausea, ... Buzzle

A 36 year-old male with ulcerative colitis and renal failure <!-...  -  Nov 11, 2007
More recently he was treated with Asacol (mesalamine) that was stopped 5 months prior and sulfasalazine. Sulfasalazine was discontinued at presentation with ... Nature.com

Does treatment with DMARDs decrease the risk of cardiovascular...  -  Feb 16, 2007
Patients were separated into groups according to DMARD use: sulfasalazine, hydroxychloroquine, methotrexate monotherapy, combination therapy with two or ... Nature.com

Are DMARDs effective for rheumatologic diseases besides rheumatoid …  -  Nov 1, 2007
...(3) Sulfasalazine appeared to be clinically beneficial for peripheral psoriatic ... Sulfasalazine demonstrated some benefit in reducing erythrocyte ... $4.95 - Journal of Family Practice - ECNext

What is the optimal treatment for patients with RA who fail to...  -  Feb 16, 2008
During follow-up, 69 methotrexate failures proceeded to sulfasalazine monotherapy (group 1) and 69 added sulfasalazine to methotrexate (group 2); ... Nature.com

Aminosalicylates for inflammatory bowel disease  -  Oct 9, 2008
Sulfasalazine works 40% to 80% of the time to make ulcerative colitis symptoms ... About 80% of people who can't take sulfasalazine can use mesalamine ... WebMD

Chronic recurrent multifocal osteomyelitis: what is it and how should...  -  Apr 6, 2007
Treatment was switched to sulfasalazine, accompanied by 3 weeks of therapy ... Sulfasalazine therapy was initially accompanied by a 3-week course of oral ... Nature.com

Department of Veterans Affairs New Mexico Health Care System  -  Jun 28, 2005
Description: Sulfasalazine enteric coated tablets-500 mg with no markings or ... The estimated requirement is for approximately 500000 Sulfasalazine enteric ... Pay-Per-View - FedBizOpps - Factiva, from Dow Jones

Granulomatous ileitis in a patient with ankylosing spondylitis  -  Oct 24, 2006
Management Sulfasalazine and elemental diet, steroids, physiotherapy and bilateral hip ... 15 Treatment with sulfasalazine was appropriate because 46% of ... Nature.com

Drug Combos Effective Against Rheumatoid Arthritis  -  Nov 26, 2007
Donahue's team also found that prednisone, along with hydroxychloroquine, methotrexate or sulfasalazine worked better in reducing joint swelling and ... Washington Post

More on peripheral neuropathy and leflunomide  -  May 6, 2005
A case of peripheral neuropathy associated with sulfasalazine used for ... When sulfasalazine was discontinued, the neuropathy improved with time. ... Medscape

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...an NMDA antagonist and antioxidant derived from aspirin and sulfasalazine)' �는 제목으로 최근 뇌졸중 권위지� 미국� '국제 대뇌혈류 � 대사'(Journal of ... 머니투��

American College of Rheumatology Updates Rheumatoid Arthritis …  -  Jun 5, 2008
Sulfasalazine monotherapy is recommended for patients with all disease durations and ... Methotrexate plus sulfasalazine is recommended in patients with all ... Medscape

Therapy Insight: the use of antirheumatic drugs during nursing  -  Nov 8, 2006
Sulfasalazine is a combination of sulfapyridine and 5-aminosalicylic acid; ... In 26 women treated with 1.0–2.6 g of sulfasalazine daily, undetectable or ... Nature.com

Combination Drug Therapy Retards Early RA Damage  -  Mar 20, 2007
Methotrexate, followed by methotrexate with sulfasalazine, methotrexate with ... Combination of methotrexate and infliximab, followed by sulfasalazine, ... MedPage Today

Practice Guidelines  -  Feb 1, 2005
Patients with mild or moderate distal colitis may be treated with: oral aminosalicylate (ASA) (4 to 6 g per day of sulfasalazine in four divided doses; ... AAFP News Now

BeSt study in RA  -  Jun 20, 2005
Group 2 followed a step-up regimen, beginning on methotrexate, but with more drugs added on as necessary (sulfasalazine, then hydroxychloroquine, ... Medscape

Levofloxacin treatment in patients with rheumatoid arthritis receiving...  -  Feb 1, 2007
Background: Sulfasalazine and tetracyclines are effective against rheumatoid arthritis ... The study patients discontinued therapy with sulfasalazine and ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

Adverse effects of low-dose glucocorticoids and DMARD therapy in …  -  Jun 30, 2008
In the 2-year study by Capell and colleagues, patients who had active RA, with disease duration <3 years, took sulfasalazine at up to 40 mg/kg body weight ... Nature.com

Ulcerative colitis  -  Oct 4, 2005
Sulfasalazine (Azulfidine). Doctors have used this drug for many years to ... These medications tend to have fewer side effects than sulfasalazine has. ... cnn.com

Drug 'may reverse liver disease'  -  Sep 26, 2006
Sulfasalazine is currently used to treat arthritis and inflammatory bowel disease. ... The Newcastle team showed that sulfasalazine could aid recovery by ... BBC News

Cancer Therapy; Recent findings illuminate research in cancer therapy  -  Jun 21, 2005
Study 3: The nuclear factor-kappa B inhibitor sulfasalazine overwhelms ... "Sulfasalazine, an anti-inflammatory drug that specifically inhibits the ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

The pharmacologic management of Crohn's disease.  -  Mar 1, 2008
The first aminosalicylate to be used for IBD was sulfasalazine, ... Once sulfasalazine reaches the colon, colonic bacterial azo-reductase cleaves the ... $9.94 - Formulary - Alacra Store

Curcumin helps maintain remission in patient with ulcerative colitis.(...  -  Jun 1, 2007
Other than sulfasalazine or mesalamine, patients were required to stop all other ... Considering the high rate of side effects with sulfasalazine or ... $4.95 - Original Internist - ECNext

Cancer Therapy; Recent findings illuminate research in cancer therapy  -  Jun 24, 2005
Study 3: The nuclear factor-kappa B inhibitor sulfasalazine overwhelms ... "Sulfasalazine, an anti-inflammatory drug that specifically inhibits the ... Pay-Per-View - Genomics & Genetics Weekly - Factiva, from Dow Jones

Curcumin helps maintain remission in patient with ulcerative colitis.(...  -  Jun 1, 2007
Other than sulfasalazine or mesalamine, patients were required to stop all other ... Considering the high rate of side effects with sulfasalazine or ... Pay-Per-View - Original Internist - HighBeam Research

Will a 5-ASA a Day Keep the Cancer (and Dysplasia) Away?  -  Feb 9, 2005
Since sulfasalazine, unlike other 5-ASA agents, is a competitive inhibitor of folic acid absorption and folic acid may itself be chemopreventive, ... Nature.com

Press Release: Phytomedics' Novel Oral Disease Modifying Drug …  -  Nov 28, 2006
These scores increased in subjects treated with sulfasalazine. Both treatment groups showed similar overall adverse events rates, which were mild in nature. ... Pay-Per-View - PR Newswire - HighBeam Research

Curcumin helps maintain remission in patient with ulcerative colitis.(...  -  Sep 1, 2007
Study Medication & Dosage: All patients were given either sulfasalazine ... Other than sulfasalazine or mesalamine, patients were required to stop all other ... $4.95 - Original Internist - ECNext

A case of childhood-onset ankylosing spondylitis: diagnosis and …  -  Jul 7, 2008
Management Treatment with NSAIDs, sulfasalazine and methotrexate did not ... Sulfasalazine 5 and methotrexate do not exert any significant effect on the ... Nature.com

Bovine Glycomacropeptide Is Anti-Inflammatory in Rats With Hapten- …  -  May 24, 2005
Two sulfasalazine groups were administered 500 mg/ (kg . d) of that drug starting 2 ... An esophageal catheter was used to deliver all GMP and sulfasalazine ... RedOrbit

Cost-Effectiveness of 5-Aminosalicylic Acid Therapy for Maintenance...  -  Oct 23, 2006
If sulfasalazine can be tolerated and yields comparable benefits, sulfasalazine maintenance therapy is likely to be cost-effective. ... Nature.com

Combining Medications Often Best Strategy To Battle Rheumatoid …  -  Nov 21, 2007
Combining prednisone with the synthetic DMARD hydroxychloroquine, methotrexate or sulfasalazine works better than using only a synthetic DMARD to reduce ... emaxhealth.com

Is a step-down regimen more effective than a step-up regimen in the …  -  Feb 26, 2008
Patients in this group were later randomized to receive sulfasalazine or ... Patients in the step-up group received monotherapy with sulfasalazine, ... Nature.com

Combining Medications Often Best Strategy to Battle Rheumatoid...  -  Dec 17, 2007
Combining prednisone with the synthetic DMARD hydroxychloroquine, methotrexate or sulfasalazine works better than using only a synthetic DMARD to reduce ... newswise.com

Clinical News: DMARDs no substitute for methotrexate.(Brief article)  -  Nov 17, 2007
One group was randomised to treatment with sulfasalazine and then leflunomide, while the other had sulfasalazine with methotrexate followed by ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

Infliximab Monotherapy Effective for Long-Term Treatment of …  -  Jun 15, 2008
..."Concomitant treatment with methotrexate or sulfasalazine is not necessary," ... Methotrexate or sulfasalazine treatment was not significant in infusion ... DG News

Severe uveitis in an HLA-B27-positive patient with ankylosing...  -  Dec 19, 2005
Before TNF inhibitors became available, sulfasalazine had been suggested as ... (2000) Sulfasalazine in the prevention of anterior uveitis associated with ... Nature.com

Methotrexate side effect profiles differ among PsA, RA patients.(Psori...  -  Mar 1, 2008
The second most often prescribed first-line therapy was sulfasalazine in PsA and corticosteroids in RA (J. Rheum 2008 Jan. 15 [Epub before print]). ... Pay-Per-View - Skin & Allergy News - HighBeam Research

What are the pulmonary manifestations of inflammatory bowel disease? ...  -  Jun 1, 2007
Patients who have IBD are often treated with sulfasalazine and 5-ASA, ... Sulfasalazine pulmonary toxicity in ulcerative colitis mimicking clinical features ... $4.95 - Journal of Respiratory Diseases - ECNext

First international recommendations for ankylosing spondylitis  -  Mar 3, 2006
Although the evidence for the efficacy of sulfasalazine in AS is inconclusive, long-term trials generally support an effect on peripheral joints but not ... Medscape

Golimumab Phase 3 Data Show Significant Improvement In Physical …  -  Oct 27, 2008
Patients continued to receive stable doses of methotrexate, sulfasalazine and/or hydroxychloroquine if they were receiving them at baseline. ... RedOrbit

阿州科學家發ç?¾å¸¸è¦?腹痛藥å?¯æ²»æƒ¡æ€§è…¦ç˜¤  -  Jul 27, 2005
...他們在動物實驗中發�Sulfasalazine�以使被稱之為glioblastoma的一�致命腦腫瘤癌 ... 由于Sulfasalazine是常�藥物�已經�得美國食�和藥物管�局的批准�所以這一 ... epochtimes.com

Early Sustained RA Remissions Possible Without the Big Guns  -  Jun 13, 2008
If there is still no remission by week 12, 2 g/day of sulfasalazine is added. If by week 20 the patient has not had a remission, the dose of sulfasalazine ... Medscape

Juvenile rheumatoid arthritis  -  Oct 19, 2007
Side effects of sulfasalazine may include gastrointestinal problems, such as nausea, vomiting and diarrhea, as well as headache and sore throat. ... CNN International

Combining Medications Often Best Strategy to Battle Rheumatoid...  -  Nov 20, 2007
Combining the synthetic DMARDs methotrexate and sulfasalazine is no more effective than using just one of the medications for patients with early rheumatoid ... DG News

GI Agents: Part II.(Drugs, Pregnancy, And Lactation)  -  Mar 1, 2006
A third agent, sulfasalazine (Azulfidine), is metabolized to 5-ASA pius ... Although the human experience is limited, sulfasalazine appears to be compatible ... Free with registration - Family Practice News - AccessMyLibrary.com

Combining Medications Often Best Strategy to Battle Rheumatoid...  -  Nov 16, 2007
Combining the synthetic DMARDs methotrexate and sulfasalazine is no more effective than using just one of the medications for patients with early rheumatoid ... newswise.com

Golimumab: Uitkomsten nieuw reumageneesmiddel Golimumab  -  Nov 10, 2008
Patients continued to receive stable doses of methotrexate, sulfasalazine and/or hydrochloroquine if they were receiving them at baseline. ... apothekersnieuws.nl

Rheumatoid Arthritis Treatment: New 2008 Guidelines from the American...  -  Jul 5, 2008
Sulfasalazine monotherapy is recommended for all patients with all disease ... Methotrexate plus sulfasalazine is recommended for patients of all disease ... HealthCentral.com

Ann Intern Med -- Rapid Responses for Donahue et al., 148 (2) 124-134  -  Jan 25, 2008
Methotrexate appears considerably more effective than leflunomide or sulfasalazine in clinical care, despite apparent similarities in clinical trials. ... Annals of Internal Medicine

Several Crohn's drugs safe during pregnancy, lactation.(Women's...  -  Aug 15, 2006
Los ANGELES -- Mesalamine, sulfasalazine, and prednisone are safe to use in ... The panelists rated mesalamine, sulfasalazine, and prednisone as safe to use ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Rheumatoid arthritis  -  Sep 18, 2008
The ACR recommends hydroxychloroquine or minocycline for people with mild rheumatoid arthritis that has been present for less than two years, sulfasalazine ... CNN International

Abnormal Hepatic Biochemistries in Patients With Inflammatory Bowel …  -  Jun 5, 2006
The use of oral and topical 5-ASA compounds, sulfasalazine, and topical ... The use of other medications, such as sulfasalazine, corticosteroids, ... Nature.com

5-ASA, '국한ë?œ 궤양성 대장염-궤양성 ì§?장염'ì—? 효과  -  Jan 2, 2008
...▲5-aminosalicylic acid(5-ASA)= 중등� �하� 궤양성 대장염� 치료하는� 가장 기본� �는 약제는 sulfasalazine과 다른 5-ASA �다. Sulfasalazine� sulfapy ... 디지틀보사

Treatment of ankylosing spondylitis with moxifloxacin.(Clinical...  -  Apr 1, 2007
Sulfasalazine is effective against this disease. (2-4) Alteration of bowel flora has been a proposed mechanism of action for sulfasalazine, and it has been ... $4.95 - Southern Medical Journal - ECNext

Treatment of ankylosing spondylitis with moxifloxacin.(Clinical...  -  Apr 1, 2007
Sulfasalazine is effective against this disease. (2-4) Alteration of bowel flora has been a proposed mechanism of action for sulfasalazine, and it has been ... Pay-Per-View - Southern Medical Journal - HighBeam Research

Juvenile Rheumatoid Arthritis - Medications  -  Jun 25, 2008
Combination therapy-such as using methotrexate with sulfasalazine, hydroxychloroquine, or etanercept-has been used on a limited basis to treat JRA. ... WebMD

Mode of action of hydroxychloroquine in RA—evidence of an inhibitory ...  -  Jun 30, 2006
1 Hydroxychloroquine combined with methotrexate and sulfasalazine has also been shown to be significantly more effective than methotrexate monotherapy. ... Nature.com

A call for pragmatic treatment trials in rheumatoid arthritis  -  Feb 6, 2008
I saw the introduction of gold, cortisone, D-penicillamine, chloroquine and sulfasalazine. However, my chief, Professor Cats, threatened to fire anyone ... Nature.com

Safe adalimumab therapy for rheumatoid arthritis in a patient with...  -  Jul 29, 2007
Management RA was originally treated with gold, sulfasalazine, azathioprin and ... Following diagnosis, the patient was treated with gold and sulfasalazine, ... Nature.com

Is once-daily dosing of mesalazine effective for maintenance of...  -  Jun 4, 2008
Mesalazine therapy arose from attempts to make sulfasalazine treatment safer. The adverse effects of sulfasalazine treatment are often attributed to the ... Nature.com

Crohn's disease  -  Aug 10, 2005
Sulfasalazine (Azulfidine). Doctors have used this drug for many years to treat ... This medication tends to have fewer side effects than sulfasalazine has. ... cnn.com

MC 33/34 - Fatale sepsis bij niet gemelde leukopenie  -  Aug 15, 2007
Een 48-jarige reumapatiënte krijgt in 2003 sulfasalazine voorgeschreven onder ... Op 16 september 2003 werd gestart met sulfasalazine (SASP) volgens een ... Medisch Contact

Diagnosis and management of rheumatoid arthritis.  -  Sep 15, 2005
...(2) Sulfasalazine or hydroxychloroquine often are started first, but in more severe cases, methotrexate or combination therapy may be first-line treatment. ... $4.95 - American Family Physician - ECNext

Calcium.(dosage and administration)  -  Jun 1, 2006
Sulfasalazine: Concomitant sulfasalazine and calcium gluconate therapy has been reported to result in delayed absorption of sulfasalazine. ... Free with registration - PDR for Herbal Medicines - AccessMyLibrary.com

THERE ARE NO EASY ANSWERS  -  Jul 19, 2005
It used to be controlled with steroids and sulfasalazine. ... Sulfasalazine and mesalamine are effective in 50 percent to 75 percent of people with this ... $2.95 - Buffalo News - NewsBank

Golimumab Effective for RA in Patients Who Discontinue Prior Anti-TNF...  -  Jun 13, 2008
Subjects continued to receive stable doses of methotrexate and/or sulfasalazine if they were being treated with them at baseline. Eligible subjects had been ... DG News

Shire and TAP Agree to Co-promote LIALDA  -  Mar 26, 2008
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... prnewswire.co.uk

Adherence to Ulcerative Colitis Medications Not Affected by Drug …  -  Oct 24, 2006
The remaining patients were on the following 5-ASA treatments and median daily doses: sulfasalazine 2.0 grams (17.5 percent), Colazal (Salix ... EndoNurse

Experts Say Many Allergic Skin Disorders Are Treatable  -  Nov 13, 2006
..."A recent case series from Johns Hopkins suggests that sulfasalazine treatment is an effective therapy for approximately 75 percent of adult subjects with ... Medical News Today - Medical News Today (press release)

Analysis of Ulcerative Colitis (UC) Remission Rates from Long-term …  -  May 22, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Free with registration - PR Newswire - AccessMyLibrary.com

New Analyses of Long-Term LIALDA(TM) (mesalamine) Data Presented …  -  Oct 15, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Free with registration - PR Newswire - AccessMyLibrary.com

LIALDA(TM) (Mesalamine) With MMX(TM) Technology - the First Oral …  -  Mar 19, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... RedOrbit

Analysis of UC time to symptom resolution data from study of Lialda …  -  May 20, 2008
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... eurekalert.org

Long-Term Safety Study Of LIALDA Shows Ulcerative Colitis Remission …  -  May 28, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Medical News Today - Medical News Today (press release)

New Analyses Of Long-Term LIALDA(TM) (mesalamine) Data Presented …  -  Oct 16, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Medical News Today - Medical News Today (press release)

Long-term safety data on Lialda published in leading GI journal  -  Jun 17, 2008
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... eurekalert.org

LIALDA(TM) (Mesalamine) With MMX(TM) Technology The First Oral …  -  Mar 20, 2007
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Medical News Today - Medical News Today (press release)

Results From A Multidisciplinary Analysis LIALDA(R) (mesalamine) And ...  -  Oct 7, 2008
Caution should be exercised when treating patients with pyloric stenosis or those allergic to sulfasalazine. Mesalamine has been associated with an acute ... Medical News Today - Medical News Today (press release)

Clinical: Ulcerative colitis and Crohn's disease.  -  May 26, 2006
Sulfasalazine is often poorly tolerated, with side-effects of nausea, gastric pain and diarrhoea being dose-dependent. As mesalazine acts topically, ... Free with registration - GP - AccessMyLibrary.com

Initiating Anti-TNF Therapy in a Patient With RA  -  Apr 2, 2007
In the United States, methotrexate is the most commonly used first-line DMARD; however, in Europe, sulfasalazine is most commonly used as the first-line ... Medscape

Brand Names/Synonyms:
Sulfasalazine is also known by the following brand names and/or synonymsAccucol; Alti-Sulfasalazine; Asulfidine; Azlufidine En-Tabs; Azopyrin; Azopyrine; Azulfidine; Azulfidine En-Tabs; Benzosulfa; Colo-Pleon; Pms-Sulfasalazine; Pms-Sulfasalazine E.C.; Reupirin; Rorasul; S.A.S. 500; S.A.S. Enteric-500; S.A.S.-500; Salazopiridazin; Salazopyridin; Salazopyrin; Salazopyrin En-Tabs; Salazosulfapyridin; Salazosulfapyridine; Salicylazosulfapyridine; Salisulf; Sulcolon; Sulfasalazin; Sulfasalazine; Sulphasalazine; W-T Sasp Oral

Drug Category:
Sulfasalazine is categorized under the following by the FDA: Antirheumatic Agents; Gastrointestinal Agents; Anti-inflammatory Agents; Anti-Infectives; Sulfonamides; ATC:A07EC01

Dosage Forms:
TABLET

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
2-hydroxy-5-[4-(pyridin-2-ylsulfamoyl)phenyl]azo-benzoicacid





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