Sulfoxone

This page contains recent news articles, when available, and an overview of Sulfoxone but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Sulfoxone (when available)

Pharmacology and use:
Sulfoxone is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. For the treatment of leprosy and dermatitis herpetiformis

Mechanism Of Action:
Sulfoxone is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid.

News Articles on Sulfoxone

Brand Names/Synonyms:
Sulfoxone is also known by the following brand names and/or synonyms:
Adesulfone Sodium; Aldapsone; Aldesulfone Sodium; DDF; Diamidin; Diason; Diasone; Diasone Sodium; Diasone Sodium Enterab; Diazon; Novotrone; SULFOXONE; Sodium Aldesulphone; Sodium Sulfoxone; Sulfoxone Sodium

Drug Category:
Sulfoxone is categorized under the following by the FDA: Anti-Infectives; Anti-bacterial Agents

Dosage Forms:
TABLET

Absorption:
Rapidly absorbed.

Interactions:
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Chemical IUPAC Name:
[4-[4-(sulfinomethylamino)phenyl]sulfonylphenyl]aminomethanesulfinicacid

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