Tacrine

This page contains recent news articles, when available, and an overview of Tacrine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Tacrine (when available)

Pharmacology and use:
Tacrine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. Tacrine is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. Tacrine is postulated to exert its therapeutic effect by enhancing cholinergic function. This is accomplished by increasing the concentration of acetylcholine through reversible inhibition of its hydrolysis by acetylcholinesterase. If this proposed mechanism of action is correct, tacrine's effect may lessen as the disease process advances and fewer cholinergic neurons remain functionally intact. There is no evidence that tacrine alters the course of the underlying dementing process. For the treatment of mild to moderate dementia of the Alzheimer's type

Mechanism Of Action:
Tacrine acts by elevating acetylcholine concentrations in the cerebral cortex by slowing the degradation of acetylcholine released by still intact cholinergic neurons. It does so by reversibly binding acetylcholinesterase.

News Articles on Tacrine

�?�大研中西藥治�?人癡呆  -  ‎Oct 22, 2009‎
...新藥是�?�?�中�?西藥化學分�?的「新型二�?�體抑制劑�?，包括從中�?�藥「�?�層塔�?�??煉出石�?�鹼甲（Huperzine A），以�?�固有治療�?人癡呆症的西藥他克林（Tacrine）。 ... 大公報

Tacrine (Systemic).  -  Jul 28, 2005
Tacrine (TAK-reen) is used to treat the symptoms of mild to moderate Alzheimer's disease. Tacrine will not cure Alzheimer's disease, and it will not stop ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

tacrine | Definition of tacrine | HighBeam.com: Online Dictionary  -  Jul 12, 2006
Find out what tacrine means: The Oxford American College Dictionary has the definition of tacrine. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Alzheimer Disease Therapy; Tacrine distribution in rat brain character...  -  Apr 25, 2005
2005 APR 25 - (NewsRx.com) -- The distribution of the anti-Alzheimer agent tacrine in the rat brain has been characterized. In a study from South Korea, ... Pay-Per-View - Proteomics Weekly - Factiva, from Dow Jones

Alzheimer Disease Therapy; Tacrine distribution in rat brain character...  -  Apr 29, 2005
2005 APR 29 - (NewsRx.com) -- The distribution of the anti-Alzheimer agent tacrine in the rat brain has been characterized. In a study from South Korea, ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

… B Not Only Protects Against Liver Damage Caused by Tacrine, But  -  May 22, 2007
In the research paper entitled "SCHISANDRIN B PROTECTS AGAINST TACRINE- AND ... Tacrine, a drug used for ameliorating the symptoms associated with ... Genetic Engineering News - Genetic Engineering News (press release)

Investor Focus: Companies Of Interest.  -  May 23, 2007
In the research paper entitled "SCHISANDRIN B PROTECTS AGAINST TACRINE- AND ... Tacrine, a drug used for ameliorating the symptoms associated with ... Free with registration - M2 Presswire - AccessMyLibrary.com

Revue : la tacrine induit certains effets bénéfiques et de nombreux...  -  Nov 25, 2006
López Arrieta J, Rodriguez Artalejo F. Methodology, results and quality of clinical trials of tacrine in the treatment of Alzheimer's disease: a systematic ... EBM Journal (Abonnement)

Mathematics for Understanding Disease  -  Jan 9, 2008
25,26,27 This approach identified that tacrine exerts a symptomatic effect on the disease. That is, as soon as the drug is discontinued, the patient returns ... Nature.com

Prevent Alzheimer's disease by changing your shampoo. | Article from ...  -  Aug 1, 2008
Back in 1993, the FDA approved a drug called Cognex (tacrine) to treat Alzheimer's disease. Tacrine works by blocking the breakdown of acetylcholine. ... Pay-Per-View - Women's Health Letter - HighBeam Research

Cognitive dysfunctions in schizophrenia: potential benefits of …  -  Nov 1, 2006
Tacrine, donepezil, rivastigmine and galantamine have been used in clinical trials ... Tacrine, the first available ChEI, is a reversible AChE inhibitor, ... Free with registration - Journal of Psychiatry and Neuroscience - AccessMyLibrary.com

Leon J. Thal, Neurologist Who Led Study for Alzheimer's Drugs, Dies...  -  Feb 8, 2007
In the 1980s, Dr. Thal, a neurologist, helped lead successful clinical trials of tacrine, a cholinesterase inhibitor drug that was approved by the Food and ... New York Times

Study of Alzheimer's Drug Revives Questions on Risk  -  Mar 17, 2006
Dr. Schneider said some patients might conclude from the results of the latest study that Aricept and similar drugs like Reminyl, Exelon and Tacrine were ... New York Times

Pharmacologic management of Alzheimer disease.(Pharmacology …  -  Feb 1, 2008
The drugs in the acetylcholinesterase class are tacrine (Cognex), donepezil (Aricept) ... Tacrine, the first drug in this class, caused alterations in liver ... Free with registration - Journal of Neuroscience Nursing - AccessMyLibrary.com

Cholinesterase Inhibitor Use in Dementia: Introduction  -  May 18, 2005
Hepatotoxic effects of tacrine administration in patients with Alzheimer's disease. JAMA. ... Tacrine (drug evaluation). In: Klasco RK, ed. DRUGDEX system. ... Medscape

Alzheimer's drugs: Real benefits despite limitations  -  Jul 27, 2006
Tacrine (Cognex). Tacrine has been on the market since 1993. However, it's rarely prescribed because of serious side effects, including possible liver ... cnn.com

Me and my metabolism: personalized medicine takes new direction.(This...  -  Apr 22, 2006
Users of Tacrine, however, can suffer liver damage. ... Article: Tacrine: reversal of fortune? (users of the drug may suffer side ... ... Pay-Per-View - Science News - HighBeam Research

Press Release: Takata Acquires Lane Departure Warning Technology …  -  Jul 3, 2008
Committee today recommended approval of Cognex (tacrine or THA), ... 3 /PRNewswire ... of the company's Alzheimer's drug Cognex (tacrine or THA): We're ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Alzheimer's disease.(DRUG UPDATE) - Family Practice News | …  -  Jul 1, 2005
Tacrine, the first drug available in this class, is rarely used today because of its serious ... The efficacy of four cholinesterase inhibitors (tacrine, ... Pay-Per-View - Family Practice News - HighBeam Research

Article: Alzheimer's disease.(Drug Update) - Skin & Allergy News | …  -  Jul 1, 2005
Tacrine, the first drug available in this class, is rarely used today because of its serious ... The efficacy of four cholinesterase inhibitors (tacrine, ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: Alzheimer drug fight court bid.(News) - The Mirror (London, ...  -  Mar 27, 2007
...(tacrine) Science News; December 14, 1991 ; 630 words ...The maker of the experimental Alzheimer drug tacrine (THA) won the Food and Drug Administration's ... Pay-Per-View - The Mirror - HighBeam Research

Mexico's former anti-drug chief accused of taking traffickers'...  -  Nov 22, 2008
No one has directly compared Aricept to tacrine, ``but it has a modest effect like tacrine does ... The Virginian Pilot. Article: HEART MEDICATION POSICOR ... Pay-Per-View - Virginian-Pilot - HighBeam Research

Alzheimer's Disease - Treatments and Controls  -  Dec 28, 2007
These are: tacrine (Cognex), donepezil (Aricept) and rivostigmine (Exelon). ... Tacrine, first medicine of this type approved, also produces an elevation of ... Buzzle

Primary Care Panel Finds Dementia Drugs to be Peas in a Pod  -  Mar 4, 2008
Tacrine. The evidence did not substantiate a beneficial effect on cognition or behavior, except for a global assessment in two studies. ... MedPage Today

Alzheimer's Disease Genetic Testing Basics  -  Dec 7, 2007
Cognex (Tacrine) was the first such drug but these others are used now because Tacrine can cause liver damage. Memantine, a different type of drug that ... Intelihealth.com

Antipsychotics and dementia: the good and bad news  -  Jan 31, 2006
Drugs designed to help Alzheimer's patients, such as donepezil (sold as Aricept) and tacrine (sold as Cognex), work by boosting levels of messenger ... WTOP

The Cognitive Effects of Cholinesterase Inhibitor Treatment in Every-...  -  Jul 13, 2005
The release of cholinesterase inhibitors (ChEIs), namely tacrine, donepezil, ... One patient switched from tacrine to donepezil, due to hepatic intolerance ... RedOrbit

Huperzine A for Alzheimer's disease.(Alternative Medicine: AN …  -  Sep 15, 2006
In vitro studies have shown that huperzine A's acetyl-cholinesterase-inhibiting activity exceeds that of tacrine and galantamine, and animal studies have ... Free with registration - Family Practice News - AccessMyLibrary.com

Try to remember: more targeted treatments and better disease …  -  Jan 22, 2007
Use of tacrine, however, is not recommended due to its risk for hepatotoxicity and its complex titration. Donepezil received approval in October 2006 for ... $4.95 - Drug Topics - ECNext

Factiva Search  -  Apr 26, 2005
Alzheimer Disease Therapy; Tacrine distribution in rat brain characterized. 26 April, 2005 Science Letter. 2005 APR 26 - (NewsRx.com) -- The distribution of ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Article: Acetylcholinesterase inhibitors from plants.  -  Apr 1, 2007
There are a few synthetic medicines, eg tacrine, donepezil, and the natural product-based rivastigmine for treatment of cognitive dysfunction and memory ... Pay-Per-View - Phytomedicine: International Journal of... - HighBeam Research

Article: Huperzine A for Alzheimer's disease.(Alternative Medicine:...  -  Sep 15, 2006
In vitro studies have shown that huperzine A's acetyl-cholinesterase-inhibiting activity exceeds that of tacrine and galantamine, and animal studies have ... Pay-Per-View - Family Practice News - HighBeam Research

Brain teasers: popping pills for better memory.(SUPPLEMENT WATCH)  -  May 1, 2007
Drugs called cholinesterase inhibitors--Tacrine and Aricept--delay the breakdown of ... But Tacrine and Aricept are available only by prescription. ... $4.95 - Nutrition Action Healthletter - ECNext

Drug Side-Effect Complaints at New High | Article from AP Online | …  -  Mar 14, 2005
...``It's a crapshoot,'' George Poste, chief science ... helped by the drug tacrine. Tacrine can cause debilitating side effects, so ruling out those patients ... Pay-Per-View - AP Online - HighBeam Research

Common Medications Could Cause Physical Impairment in the Elderly  -  May 3, 2008
These include donepezil (brand name Aricept), galantamine (Razadyne), rivastigmine (Exelon) and tacrine (Cognex). About 10 percent of those studied were ... Washington Post

Huperzine a for Alzheimer's disease.(ALTERNATIVE MEDICINE) | Article ...  -  Sep 1, 2006
In vitro studies have shown that huperzine A's acetyl-cholinesterase-inhibiting activity exceeds that of tacrine and galantamine, and animal studies have ... Pay-Per-View - Internal Medicine News - HighBeam Research

Alzheimer's disease.(DRUG UPDATE) | Article from Internal Medicine …  -  Jul 1, 2005
Tacrine, the first drug available in this class, is rarely used today because of its ... Management * Cholinesterase inhibitors (tacrine, donepezil . ... Pay-Per-View - Internal Medicine News - HighBeam Research

Huperzine a for Alzheimer's disease.(ALTERNATIVE MEDICINE)  -  Sep 1, 2006
In vitro studies have shown that huperzine A's acetyl-cholinesterase-inhibiting activity exceeds that of tacrine and galantamine, and animal studies have ... $4.95 - Internal Medicine News - ECNext

Drug Side-Effect Complaints at New High | Article from AP Online | …  -  Mar 15, 2005
...``It's a crapshoot,'' George Poste, chief science ... helped by the drug tacrine. Tacrine can cause debilitating side effects, so ruling out those patients ... Pay-Per-View - AP Online - HighBeam Research

�?ови фармакологични препоръки за лечение на деменци�? ::: …  -  Mar 11, 2008
В�?е пак авторите отбел�?зват, че поради тежките �?и �?транични ефекти употребата на tacrine не е препоръчителна. ► �?еобходими �?а допълнителни из�?ледвани�? ... DoctorBG.com

Study: Some Preschoolers Can Use Ritalin | Article from AP Online | …  -  Oct 20, 2006
...``It's a crapshoot,'' George ... tacrine. Tacrine can cause debilitating side effects, so ruling out those patients could ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Maladie Alzheimer et apparentées : définition, étapes, analyses  -  Feb 16, 2008
Enfin, une étude évaluant l'effet d'un médicament anticholinestérasique (la tacrine) dans la maladie d'Alzheimer, suggère une synergie avec les oestrogènes. ... Agevillage

Injections cut need for HIV drugs.(Therapeutic Vaccine)(Brief...  -  Mar 12, 2005
Article: Tacrine: reversal of fortune? (users of the drug may suffer ... Science News; December 5, 1992 ; 700+ words ... ... be an early warning of liver ... Pay-Per-View - Science News - HighBeam Research

Pros, Cons of Ritalin in Preschoolers | Article from AP Online |...  -  Oct 19, 2006
...``It's a crapshoot,'' George ... tacrine. Tacrine can cause debilitating side effects, so ruling out those patients could ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Alzheimer, démences et autres maladies du système nerveux  -  Jan 11, 2007
Enfin, une étude évaluant l'effet d'un médicament anticholinestérasique (la tacrine) dans la maladie d'Alzheimer, suggère une synergie avec les oestrogènes. ... Age Village Pro

Review finds no good drugs for dementia  -  Mar 3, 2008
...rivastigmine, sold by Novartis AG under the brand name Exelone; and tacrine, marketed to combat Alzheimer's disease under the brand name Cognex. ... Reuters UK

Pros, Cons From Ritalin in Preschoolers | Article from AP Online | …  -  Oct 19, 2006
...``It's a crapshoot,'' George ... tacrine. Tacrine can cause debilitating side effects, so ruling out those patients could ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Alzheimer's drug's impact hailed  -  May 14, 2007
Post-mortem examinations were done on 12 patients who took part in UK trials of the drugs - donepezil, rivastigmine, tacrine and galantamine. ... BBC News

Groups Issue New Dementia Drug Guidelines  -  Mar 4, 2008
These include four acetylcholinesterase inhibitors -- donepezil (Aricept), galantamine (Razadyne, Reminyl, Nivalin), rivastigmine (Exelon), and tacrine ... Washington Post

Article: Congress lambastes FDA over risks related to diabetes drug -...  -  Jun 7, 2007
Article: WARNER-LAMBERT ISSUES STATEMENT ON TACRINE STUDY IN NEW . ... TACRINE STUDY IN NEW ENGLAND JOURNAL /ADVANCE/ MORRIS ... in Thursday's New England ... Pay-Per-View - Oakland Tribune - HighBeam Research

Bladder and dementia therapy may be incompatible  -  Jun 5, 2008
Examples of cholinesterase inhibitors include donepezil (Aricept), galantamine (Razadyne), rivastigmine (Exelon), and tacrine (Cognex). ... Reuters India

Bladder and dementia therapy may be incompatible  -  Jun 4, 2008
Examples of cholinesterase inhibitors include donepezil (Aricept), galantamine (Razadyne), rivastigmine (Exelon), and tacrine (Cognex). ... Reuters

Marijuana's Key Ingredient May Fight Alzheimer's Disease  -  Oct 5, 2006
THC could completely prevent AChE from forming amyloid plaques, while two drugs approved for use against Alzheimer's, donepezil and tacrine, ... FOXNews

Article: Democrats Target FDA Over Glaxo Concerns - AP Online | …  -  Jun 6, 2007
Article: WARNER-LAMBERT ISSUES STATEMENT ON TACRINE STUDY IN NEW . ... TACRINE STUDY IN NEW ENGLAND JOURNAL /ADVANCE/ MORRIS ... in Thursday's New England ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Paying tribute to UCSD's Leon Thal  -  Mar 5, 2007
Dr. Thal initiated and later completed clinical trials that yielded the first approved drug for the treatment of Alzheimer's disease, Tacrine. ... San Diego Union - Tribune - San Diego Union Tribune

Little Benefit Seen in Antipsychotics Used in Alzheimer's | Article...  -  Oct 12, 2006
The Washington Post; April 6, 1994 ; 627 words ... ... debilitating effects of Alzheimer's disease can be helped by a newly approved drug called tacrine, ... Pay-Per-View - Washington Post - HighBeam Research

FINDINGS | Article from The Washington Post | HighBeam Research  -  Feb 8, 2006
The Washington Post; September 26, 1995 ; 700+ words ... ... tacrine must be closely monitored because the drug can cause liver problems. ... Pay-Per-View - Washington Post - HighBeam Research

갈대뿌리 추출물 치매 치료�? '�?월'  -  Jan 8, 2008
...최 �?수는 "�?를 대�?으로 한 실험�?서 MPC가 현재 시�?중�?� 치매 치료제 니세틸(Nicetyl : acetyl L-carnitine)과 코그넥스(Cognex : tacrine-HCl), �?�본 �?�?�?�제약 ... 한국�?�보

St. Paul Pioneer Press : LIVER TESTS MANDATED TO AVOID SUDDEN …  -  Apr 13, 2005
...rosiglitazone (Avandia), rosuvastatin (Crestor), ritonavir (Norvir), simvastatin (Zocor), sulindac (Clinoril), tacrine (Cognex), tamoxifen (Nolvadex), ... $2.95 - St. Paul Pioneer Press - NewsBank

Science Journal: Alzheimer's research makes dramatic shift  -  Nov 17, 2006
Five drugs have been approved in the US One (tacrine) causes liver toxicity, so is rarely prescribed anymore. None of the other four treat what anyone ... Pittsburgh Post-Gazette - Pittsburgh Post Gazette

We're dopes not to OK marijuana  -  Dec 2, 2006
Alzheimer's disease -- in a manner "considerably superior" to government-approved Alzheimer's drugs such as donepezil and tacrine. And guess what again? ... Seattle Post-Intelligencer - Seattle Post Intelligencer

Article: Families say they're eager to try risky treatments for...  -  Nov 22, 2005
NEW YORK--A Food and Drug Administration advisory committee recommendation ... tacrine), a treatment for Alzheimer's disease that was developed ... and ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Don't hold your breath for pending cure for Alzheimer's, even if it...  -  Jun 24, 2007
For example, I remember when people believed aluminum pots were a powerful risk factor, and when a "miracle" drug -- tacrine, or THA -- was sold on the ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver

An Alzheimer's Christmas - Old fools are babes again,  -  Dec 18, 2005
Some of these are: Tacrine, donezepil, rivastigmine, and galantamine. All of them prevent symptoms from becoming worse. Treatment is also not just about ... Pay-Per-View - Manila Bulletin - Factiva, from Dow Jones

Strict moms raise fatter kids: study | Article from Chicago Sun-Times...  -  Jun 5, 2006
...doctors and the ... position," said Growdon, in response to the new study's results. "The new study confirms that tacrine has some beneficial effects . ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Article: Alzheimer's drugs found ineffective - Deseret News (Salt...  -  Oct 12, 2006
The drug, which has been developed ... as Tacrine (an earlier Alzheimer drug that never got a licence ... PR Newswire. Article: FDA-APPROVED ALZHEIMER DRUG ... Pay-Per-View - Deseret News - HighBeam Research

Article: How to spot a baby conservative: Whiny children, claims a...  -  Mar 26, 2006
...doctors and the ... position," said Growdon, in response to the new study's results. "The new study confirms that tacrine has some beneficial effects . ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Article: Panel's recommendation - Deseret News (Salt Lake City) | …  -  Jan 24, 2006
NEW YORK--A Food and Drug Administration advisory committee recommendation against approval of Cognex (tacrine ... executives and senior FDA officials ... Pay-Per-View - Deseret News - HighBeam Research

Exercise your mind to build neurons, help keep brain sharp  -  Sep 17, 2006
...many doctors argue the risk plus the expense outweigh the modest benefits of this medication and others like it, including Reminyl, Exelon and Tacrine. ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver

Drugs, therapy help kids kick depression | Article from Chicago Sun- …  -  Oct 7, 2007
...doctors and the ... position," said Growdon, in response to the new study's results. "The new study confirms that tacrine has some beneficial effects . ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

NO COMPROMISE.(News) | Article from The Cincinnati Post (Cincinnati, ...  -  Dec 14, 2005
Five drugs have been approved by the Food and Drug Administration for the treatment of Alzheimer's disease: tacrine ... ... Pay-Per-View - Cincinnati Post - HighBeam Research

4 out of 5 doctors agree that studies can be bad for you | Article...  -  May 29, 2005
...doctors and the ... position," said Growdon, in response to the new study's results. "The new study confirms that tacrine has some beneficial effects . ... Pay-Per-View - Chicago Sun-Times - HighBeam Research

Neurochem Slides 43 Percent On Alzhemed Phase III Failure  -  Aug 28, 2007
These drugs include Aricept (donepezil, Pfizer Inc.), Exelon (rivastigmine, Novartis AG), Cognex (tacrine, First Horizon Pharmaceutical Corp. ... BioWorld Online - BioWorld Online

Les principales maladies du cerveau  -  Dec 8, 2008
Il existe des médicaments symptomatiques (comme la tacrine) qui ralentissent la perte de mémoire. La maladie de Parkinson, qui peut survenir à partir de 45 ... La Croix

The reason for those liver tests.  -  Mar 25, 2005
...rosiglitazone (Avandia), rosuvastatin (Crestor), ritonavir (Norvir), simvastatin (Zocor), sulindac (Clinoril), tacrine (Cognex), tamoxifen (Nolvadex), ... Free with registration - Sun Herald - AccessMyLibrary.com

Restricted treatment; How Congress slows down innovative medicines.( …  -  Mar 29, 2007
The safety factor for BZ is enormously ... injection of the drug tacrine (approved by the FDA for treatment of Alzheimer's) will bring the person back to ... Pay-Per-View - Washington Times - HighBeam Research

No answers, no cure for Alzheimer's  -  May 24, 2006
Tacrine (Cognex®), the first cholinesterase inhibitor, was approved in 1993 but is rarely prescribed today because of side effects, including possible liver ... $2.95 - The JournalNews - NewsBank

ALZHEIMER'S RESEARCH TO BE SUBJECT OF TALK  -  Jul 17, 2007
Do prescription drugs such as Donepezil and Tacrine really help with Alzheimer's symptoms? What about estrogen, nonsteroidal anti-inflammatory drugs or ... $2.95 - Beacon Journal - NewsBank

Tormentos da idade, a doença de Alzheimer  -  Sep 17, 2006
O FDA (Food and Drug Administration), nos USA, aprovou 5 drogas para o alívio de sintomas e impedimento do progressividade: Cognex (tacrine), ... Paraná-Online - Paraná-Online (Assinatura)

Message: Trying to get property of non-object  -  Jan 23, 2008
Jenis yang memengaruhi neurotransmitter otak diperankan oleh golongan linopirdine, physostigmin, sabeluzole, tacrine, vasopressine, amantadine, ... KOMPAS.com

Marijuana's Active Ingredient May Slow Progression Of Alzheimer's …  -  Oct 10, 2006
Existing medications for AD, including donepezil and tacrine, also relieve AD symptoms by inhibiting the enzyme, acetylcholinesterase, which breaks down ... Medical News Today - Medical News Today (press release)

Cholinesterase Inhibitors Similarly Effective for Alzheimer's Disease  -  Jul 19, 2006
Tacrine was the first FDA-approved ChEI for Alzheimer's disease, but it is no longer recommended because of its complex titration schedule, risk of hepatic ... Medscape

Aricept (donepezil) Wins Indication for Severe Alzheimer's  -  Oct 13, 2006
They are Exelon (rivastigmine), Razadyne (galantamine) and Cognex (tacrine), all approved for mild to moderate disease. The fifth drug, Nameda (memantine), ... Psychiatric Times

Marijuana's Active Ingredient May Slow Progression Of Alzheimer's …  -  Oct 9, 2006
Existing medications for AD, including donepezil and tacrine, also relieve AD symptoms by inhibiting the enzyme, acetylcholinesterase, which breaks down ... sciencedaily.com

Alzheimer's Drug Moving Ahead Positively, Boosting Elan's Stock  -  May 22, 2007
Drugs currently indicated for Alzheimer's include Aricept (donepezil, from Pfizer Inc.), Exelon (rivastigmine, from Novartis AG), Cognex (tacrine, ... BioWorld Online - BioWorld Online

Dual treatment of incontinence and dementia associated with functional...  -  Apr 30, 2008
Examples include donepezil (Aricept), galantamine (Razadyne), rivastigmine (Exelon), and tacrine (Cognex). These drugs are designed to increase levels of ... Genetic Engineering News - Genetic Engineering News (press release)

Aricept, Zantac, Detrol, other Anticholinergic Drugs Lined to Mental ...  -  May 6, 2008
...treat dementia by increasing levels of acetylcholine—that include donepezil (Aricept), glantamine (Razdyne), rivatigmine (Exelon), and tacrine (Cognex). ... Newsinferno.com

Biogen, Neurimmune Entering Alzheimer's Deal: Up To $360M  -  Nov 21, 2007
Approved compounds include Aricept (donepezil, Pfizer Inc.), Exelon (rivastigmine, Novartis AG), Cognex (tacrine, First Horizon Pharmaceutical Corp. ... BioWorld Online - BioWorld Online

The Role of Estrogen in the Development of Age-Related Cognitive …  -  Apr 1, 2006
In one study with AD patients, estrogen administration appeared to enhance the effect of the anticholinesterase tacrine (Cognex) in AD. ... Psychiatric Times

Body of Information: Antipsychotics and dementia: the good and bad …  -  Dec 20, 2005
Drugs designed to help Alzheimer's patients, such as donepezil (sold as Aricept) and tacrine (sold as Cognex), work by boosting levels of messenger ... sptimes.com

Physical Activity May Slow the Progress of Alzheimer Disease  -  Jul 21, 2008
Donepezil, tacrine, rivastigmine, memantine and galantamine are some of the drugs used for managing the symptoms of Alzheimer. ... MediNEWS.Direct!

Pakistan's elderly fuel Alzheimer's relentless march  -  Sep 21, 2008
Examples include the medicines Tacrine, Donepezil, and Rivastigmine. But these are not enough. “The disease is progressive, so medication will eventually ... News International - The News International

GSK Pays Affiris $28M Up Front in Alzheimer's Vaccine Deal  -  Oct 27, 2008
Currently available drugs - Aricept (donepezil, Pfizer), Exelon (rivastigmine, Novartis AG), Cognex (tacrine, First Horizon Pharmaceutical Corp. ... BioWorld Online - BioWorld Online

Alzheimer's disease.(DRUG UPDATE)  -  Jul 1, 2005
Tacrine, the first drug available in this class, is rarely used today because of its serious side effects. Most physicians had favored donepezil because of ... Free with registration - Internal Medicine News - AccessMyLibrary.com

EPIX Pharmaceuticals Appoints Margaret Uprichard, Pharm.D. as Senior ...  -  Aug 21, 2007
Dr. Uprichard was involved in the development and approval of tacrine (Cognex(R)), the first approved agent for Alzheimer's disease. ... Genetic Engineering News - Genetic Engineering News (press release)

Focus on the World Alzheimer's and Parkinson's Disease Market  -  Sep 15, 2008
...(ChEIs) II-27 Donepezil (Aricept) II-27 Rivastigmine (Exelon) II-27 Galantamine Hydrobromide (Razadyne) II-28 Tacrine (Cognex) II-28 Other Alternatives ... marketwire.com

Drug Therapy for Patients with Alzheimer's Disease  -  May 15, 2005
Tacrine is used rarely because of hepatoxicity. The other three agents (ie, donepezil, galantamine, and rivastigmine) appear to be largely equivalent in ... AAFP News Now

Lindane (Topical).  -  Feb 1, 2006
Reminyl], rivastigmine [eg, Exelon], and tacrine [eg, Cognex]) or Choloroquine (eg, Aralen) or Cyclosporine (eg, Sandimmune) or Imipenem (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Lindane (Topical).(Drug overview)  -  May 1, 2006
Reminyl], rivastigmine [eg, Exelon], and tacrine [eg, Cognex]) or Choloroquine (eg, Aralen) or Cyclosporine (eg, Sandimmune) or Imipenem (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

New study investigates donepezil for severe Alzheimer's disease.( …  -  Jun 1, 2006
Although the ChEI tacrine is approved for treating AD, it is rarely prescribed due to associated hepatotoxicity. According to the American Academy of ... Free with registration - Brown University Geriatric Psychopharmac... - AccessMyLibrary.com

The Truth Behind Alzheimer's Disease  -  Jul 17, 2008
Despite the absence of cure or treatment for Alzheimer's, every patient should be given a good multivitamin, Ginkgo biloba, tacrine and donepezil. ... Buzzle

Brand Names/Synonyms:
Tacrine is also known by the following brand names and/or synonymsCS 12602; Cognex; Romotal; THA; Tacrine; Tetrahydroaminacrine; Tetrahydroaminoacridine; Tetrahydroaminocrin; Tetrahydroaminocrine

Drug Category:
Tacrine is categorized under the following by the FDA: Cholinesterase Inhibitors; Nootropic Agents; Parasympathomimetics; ATC:N06AA18; ATC:N06DA01

Dosage Forms:
Not Available

Absorption:
Tacrine is rapidly absorbed. Absolute bioavailability of tacrine is approximately 17 ± 13%.

Interactions:
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Chemical IUPAC Name:
1,2,3,4-tetrahydroacridin-9-amine

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