Targretin

This page contains recent news articles, when available, and an overview of Targretin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Targretin
(when available)

Pharmacology and use:
Bexarotene is a member of a subclass of retinoids that selectively activate retinoid X receptors (RXRs). These retinoid receptors have biologic activity distinct from that of retinoic acid receptors (RARs). Bexarotene is indicated for the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy. Bexarotene selectively binds and activates retinoid X receptor subtypes (RXRa, RXRb, RXRg). RXRs can form heterodimers with various receptor partners such as retinoic acid receptors (RARs), vitamin Dy receptor, thyroid receptor, and peroxisome proliferator activator receptors (PPARs). Once activated, these receptors function as transcription factors that regulate the expression of genes that control cellular differentiation and proliferation. Bexarotene inhibits the growth in vitro of some tumor cell lines of hematopoietic and squamous cell origin. It also induces tumor regression in vivo in some animal models. For the treatment of cutaneous manifestations of cutaneous T-cell lymphoma in patients who are refractory to at least one prior systemic therapy

Mechanism Of Action:
The exact mechanism of action of bexarotene in the treatment of cutaneous T-cell lymphoma (CTCL) is unknown.

News Articles on Bexarotene

Local biotech firm wins OK on cancer drug  -  ‎Nov 6, 2009‎
There are already three drugs on the market to treat CTCL, a form of non-Hodgkin's lymphoma: Ontak and Targretin, made by Eisai Inc. of Woodcliff Lake, NJ, ... Boston Globe

Allos Therapeutics, Inc., Q3 2009 Earnings Call Transcript  -  ‎Nov 3, 2009‎
The second trial is a randomized trial comparing FOLOTYN in combination with systemic Bexarotene, or Targretin, versus systemic Targretin alone in patients ... Seeking Alpha (blog)

FDA Approves Drug Treatment for Rare Cancer  -  ‎Nov 9, 2009‎
Previous approvals for CTCL included Zolinza (vorinostat), Ontak (denileukin difitox), and Targretin (bexarotene). Istodax was evaluated based on two ... FDA.gov

Transcript Of Live Chat With Doctors  -  ‎Oct 28, 2009‎
I am being treated with a gel called targretin. I was wondering if I should have a biopsy of my lymphnodes or some blood tests to see if this cancer has ... WFSB

FDA Approves New Drug For Rare Cancer Cutaneous T-Cell Lymphoma  -  ‎Nov 12, 2009‎
The other three are Zolinza (vorinostat), Ontak (denileukin difitox), and Targretin (bexarotene). The approval was granted on the evidence of two clinical ... Medical News Today

New Management Hires for Burnham Aimed at Accelerating Commercialization Efforts  -  ‎Oct 22, 2009‎
Burnham's pipeline includes three drugs that have already won FDA approval — heart attack medicines Integrilin and Aggrastat, and the cancer drug Targretin. ... GenomeWeb Daily News

US FDA approves Istodax to treat rare form of cancer  -  ‎Nov 11, 2009‎
Previous approvals for CTCL included Zolinza (vorinostat), Ontak (denileukin difitox), and Targretin (bexarotene). Istodax is marketed by Cambridge, ... pharmabiz.com

Ligand Says Targretin Didn't Meet Endpoints in Phase II Studies  -  Mar 28, 2005
By Jeff Ward. March 28 (Bloomberg) -- Ligand Pharmaceuticals Inc. said Targretin, a lung cancer drug, didn't meet endpoints of improved overall survival and ... Bloomberg

Targretin Fails to Meet Primary or Secondary Endpoints in Pivotal...  -  Mar 28, 2005
SAN DIEGO -- Ligand Pharmaceuticals Incorporated (Nasdaq:LGND) announced today that its two pivotal Phase III studies of Targretin(R) (bexarotene) capsules ... Free with registration - Business Wire - AccessMyLibrary.com

Eisai Pays $205 Million for Four Ligand Cancer Drugs  -  Sep 8, 2006
It gives Eisai global rights to ONTAK and Targretin capsules, both of which are used to ... The agreement also covers rights to a gel version of Targretin, ... Bloomberg

Ligand's Targretin Fails To Improve Survival In NSCLC  -  Mar 29, 2005
By Jennifer Boggs. Ligand Pharmaceuticals Inc.'s cancer drug Targretin missed its primary endpoints in two pivotal trials evaluating the drug in front-line ... BioWorld Online - BioWorld Online

Cephalon Buys Drug Firm Zeneus  -  Dec 6, 2005
Through the takeover, Cephalon will get Myocet, a chemotherapy agent used for late-stage breast cancer, Targretin, a treatment for cutaneous T-cell lymphoma ... TheStreet.com - TheStreet.com (subscription)

… REPLACING Investigators Present Detailed Targretin Lung Cancer...  -  May 16, 2005
Detailed reports of the results of Ligand Pharmaceuticals Incorporated (Nasdaq:LGNDE) two pivotal Phase III studies of Targretin(R) (bexarotene) capsules in ... RedOrbit

New Data on Lung Cancer Trials with Targretin(R) is Presented at...  -  Jun 5, 2006
Ligand Pharmaceuticals Incorporated (Pink Sheets:LGND) (the "Company" or "Ligand") -- Results of retrospective analysis in large trials in first line NSCLC ... Genetic Engineering News - Genetic Engineering News (press release)

Investigators Present Targretin(R) Data at World Lung Cancer …  -  Jul 5, 2005
Results of Ligand Pharmaceuticals Incorporated (Nasdaq:LGNDE) two pivotal Phase III studies (SPIRIT I & SPIRIT II) of Targretin(R) (bexarotene) capsules in ... RedOrbit

Article: T-Cell activation key to targretin gel efficacy: the...  -  Apr 1, 2006
T-Cell activation key to targretin gel efficacy: the rexinoid is showing positive data in early-phase studies in several hard-to-manage dermatoses. Pay-Per-View - Skin & Allergy News - HighBeam Research

… to settle patent interference on Targretin; Ligand strengthens...  -  Mar 14, 2005
The company believes the settlement strengthens Ligand's intellectual property position for bexarotene, the active ingredient in the Targretin products. ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Ligand Pharmaceuticals and the SALK Institute Enter Settlement …  -  Sep 5, 2008
...the parties have resolved all disputes that have arisen between them including SALK's primary claim in arbitration relating to the sale of Targretin(R) ... Genetic Engineering News - Genetic Engineering News (press release)

Ligand Pharmaceuticals, Inc., San Diego, Oct. 23 (DDMAC).(HUMAN …  -  Nov 1, 2006
The promotional piece also included claims for Ligand's Targretin (bexarotene). ... Targretin at a dose of 300 mg/m2/day is likely to increase her ... $4.95 - Warning Letter Bulletin - ECNext

Targretin: endpoints missed in NSCLC trials.(non-small cell lung...  -  Apr 4, 2005
USA-based drugmaker Ligand Pharmaceuticals saw its shares plunge 28.5% to close at $5.88 on March 28, as investors' confidence waned on the news that two ... $4.95 - Pharma Marketletter - ECNext

Eisai Announces Completion of Acquisition of Four Oncology-Related …  -  Oct 26, 2006
In the agreement, Eisai Co., Ltd. and Eisai Inc. obtained exclusive global rights to ONTAK(R) (denileukin diftitox), Targretin(R) (bexarotene) capsules, ... Free with registration - PR Newswire - AccessMyLibrary.com

Targretin May Breathe Life into Ligand  -  Jan 17, 2005
Shares of Ligand may rise after results are released for Phase III trials of its lung cancer drug – Targretin, writes First Albany Capital. ... Subscription - Barron's Online - Dow Jones & Company

INVESTIGATORS PRESENT TARGRETIN DATA AT WORLD LUNG …  -  Jul 7, 2005
Results of Ligand Pharmaceuticals' two pivotal Phase III studies (SPIRIT I & SPIRIT II) of Targretin (bexarotene) capsules in front-line combination therapy ... Pay-Per-View - FDAnews Drug Pipeline Alert - Factiva, from Dow Jones

Phase II randomized bilateral comparison of topical targretin gel 1%...  -  Jan 1, 2005
The rationale for the use of bexarotene in alopecia areata comes from the drugs' immunomodulatory effects. It has been shown to be effective in inflammatory ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

RECENTE INFORMATIE NOVEMBER 2007  -  Nov 8, 2007
Bexaroteen (Targretin®) is een antitumoraal middel van de familie van de retinoïden (beschikbaar sinds november 2007). Bexaroteen wordt langs orale weg ... Belgisch centrum voor farmacotherapeutis...

Cancer Therapy; New lung cancer research presented at ASCO  -  Jun 21, 2005
This is the first study to evaluate Targretin monotherapy in this patient population. The study completed accrual with 153 patients enrolled at 36 sites of ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Competitors by Product Report  -  Jun 16, 2007
Eisai Co., Ltd (ADR) (ESALY) Products:. Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere Reports - Revere

Competitors by Product Report  -  Dec 13, 2008
Eisai Co., Ltd (ADR) (ESALY) Products:. Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere - Alacra Store

Competitors by Product Report  -  Aug 2, 2008
Eisai Co., Ltd (ADR) (ESALY) Products:. Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere - Alacra Store

Ligand Announces Financial Results for First Quarter of Fiscal 2006.  -  May 15, 2006
Sales of Targretin capsules increased to $5.0 million for the three months ended March 31, 2006 compared to $4.0 million for the same 2005 period. ... Free with registration - Business Wire - AccessMyLibrary.com

Gesundheits-Forum - Community - Gesundheit - FOCUS Online  -  Sep 8, 2007
...in der klinik wurde ich dann mit targretin und puva behandelt. ... das targretin macht die ersten tage kopfschmerzen. gibt sich aber. ... focus.de

Novel Targeted Agents Under Investigation for Non-Small Cell Lung …  -  May 13, 2005
Targretin is a novel, multi-targeted synthetic retinoid analogue, which selectively ... Targretin has demonstrated promising activity in advanced NSCLC when ... Cancer Consultants

Merger and Acquisition Scenario  -  Apr 28, 2007
E5555; Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin ... $250.00 - Revere Reports - Revere

Ligand Pharmaceuticals Inc. - Company Snapshot - AlacraStore.com  -  Nov 4, 2008
The major trademarks of the Group's are Ligand(R), ONTAK, Panretin, Targretin, and AVINZA. The four oncology products marketed in the United States are ... Pay-Per-View - co - Alacra Store

Annales de Biologie Clinique  -  Jan 13, 2006
Le Targretin ® est maintenu avec une prise en charge des effets indésirables : fénofibrate ... Le médicament responsable est le Targretin ® (bexarotène). ... john-libbey-eurotext.fr

Merger and Acquisition Scenario  -  May 19, 2007
E5555; Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  May 19, 2007
E5555; Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin ... $250.00 - Revere Reports - Revere

Morning Updates for Monday, August 14,2006 - While One Company …  -  Aug 14, 2006
Ligand Pharmaceuticals also markets Panretin gel and Targretin capsules in Europe. The company also has various products in clinical development, ... Free with registration - M2 Presswire - AccessMyLibrary.com

Patents; Pharmaceutical company agrees to settle patent interference ...  -  Apr 11, 2005
The European Commission granted marketing authorization for Targretin capsules in ... Targretin is in continuing clinical trials in front-line, second-line, ... Pay-Per-View - Cancer Gene Therapy Week - Factiva, from Dow Jones

Merger and Acquisition Scenario  -  Jun 16, 2007
E5555; Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin ... $250.00 - Revere Reports - Revere

Morning Updates for Friday, August 11,2006 - As One Company …  -  Aug 11, 2006
Ligand Pharmaceuticals also markets Panretin gel and Targretin capsules in Europe. The company also has various products in clinical development, ... Free with registration - M2 Presswire - AccessMyLibrary.com

Patents; Pharmaceutical company agrees to settle patent interference ...  -  Apr 14, 2005
The European Commission granted marketing authorization for Targretin capsules in ... Targretin is in continuing clinical trials in front-line, second-line, ... Pay-Per-View - Gene Therapy Weekly - Factiva, from Dow Jones

Merger and Acquisition Scenario  -  Apr 7, 2007
E5555; Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin ... $250.00 - Revere Reports - Revere

GIGM, TARO, VEGF, IGII, LGND, PPTI have been added to naked short …  -  Mar 21, 2006
Ligand Pharmaceuticals also markets Panretin gel and Targretin capsules in Europe. Further, the company has various products in clinical development, ... $4.95 - M2 Presswire - ECNext

Press Release: Morning Updates for Friday, August 11,2006 - As One …  -  Aug 11, 2006
Ligand Pharmaceuticals also markets Panretin gel and Targretin capsules in Europe. The company also has various products in clinical development, ... Pay-Per-View - M2 Presswire - HighBeam Research

Article: This lotion relieved; SEVERE DERMATITIS.(News) - Coventry …  -  Oct 6, 2007
Article: Ligand's Targretin Gel Shows Promise for Chronic Severe Hand ... ... Three patients in the Targretin gel monotherapy arm had a moderate-to-severe ... Pay-Per-View - Coventry Evening Telegraph - HighBeam Research

Press Release: Bellwether Report.com is Scouting Ligand …  -  Sep 11, 2006
The sale includes Ligand's four marketed oncology drugs -- Ontak, Targretin capsules, Targretin gel and Panretin gel. Read all of this article with a FREE ... Pay-Per-View - M2 Presswire - HighBeam Research

Competitors by Product Report  -  Dec 13, 2008
Eisai Co., Ltd (ADR) (ESALY) Products:. E6201 (Multikinase Inhibitor); Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... $75.00 - Revere Reports - Revere

Highlights of rising and falling US stocks - MarketWatch  -  Jan 14, 2005
The results of trials for Ligand's lung cancer drug Targretin are expected in late March. Should the drug be approved the stock would be expected to rise ... MarketWatch

High Clinical Response Rate with Multimodality Immunomodulatory …  -  Aug 1, 2007
Article: Targretin[R] gel achieves 86% response rate in ... Dermatology Nursing; August 1, 2002 ; 579 words ...More than 85% of patients with early-stage ... Pay-Per-View - Dermatology Nursing - HighBeam Research

Stockioi watch list for: Tuesday, May 16, 2006 IPRE, XTHN, XOHO,...  -  May 17, 2006
The major trademarks, trade names and service marks of the Group include Ligand(R), ONTAK, Panretin, Targretin, and AVINZA. The four oncology products ... $4.95 - M2 Presswire - ECNext

Merger and Acquisition Scenario  -  Jan 26, 2008
Buyer (Total: 23). Fragmin (Dalteparin Sodium); E5555 (Thrombin Receptor Agonist); Targretin Gel (Bexarotene); Targretin Capsules (Bexarotene) ... $250.00 - Revere Reports - Revere

Eisai buys 4 cancer drugs from Ligand Pharma.  -  Sep 18, 2006
...for $205 M. Ontak (denileukin diftitox), Targretin capsules and Targretin gel (bexarotene) are designed for the treatment of cutaneous T lymphomas. ... Pay-Per-View - Chimie Pharma Hebdo - Factiva, from Dow Jones

Eisai gains recognition as 'human health care company'.  -  Apr 28, 2008
Eisai obtained exclusive rights for Ontak, Targretin capsules, Targretin gel and Panretin from Ligand. Eisai also enjoys success by following what the ... $9.94 - Chain Drug Review - Alacra Store

Competitors by Product Report  -  Apr 12, 2008
Eisai Co., Ltd (ADR) (ESALY) Products:. Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere Reports - Revere

Ligand says restatement of earnings is possible  -  Mar 18, 2005
The First Albany analyst noted that results from Ligand's Phase 3 study of its drug Targretin to treat lung cancer are expected soon, and good news there ... San Diego Union - Tribune - San Diego Union Tribune

Rates climb on short-term bills  -  Mar 15, 2005
Targretin is approved by the US Food and Drug Administration to treat cutaneous t-cell lymphoma. The drug is being tested in clinical trials as a treatment ... San Diego Union - Tribune - San Diego Union Tribune

Merger and Acquisition Scenario  -  Jan 26, 2008
Buyer (Total: 23). Fragmin (Dalteparin Sodium); E5555 (Thrombin Receptor Agonist); Targretin Gel (Bexarotene); Targretin Capsules (Bexarotene) ... $250.00 - Revere Reports - Revere

试验è?¯ç‰©ç–—效欠佳Ligandé‡?è·Œ24%  -  Mar 29, 2005
Ligand表示,虽然对上述试验的结果感到失望,但自己将继续从事将Targretin�为混� 化疗的第二�和第三��物的试验,治疗那些将Targretin�为主�的混�化疗未�得良好 ... 新浪网

Competitors by Product Report  -  Mar 29, 2008
E2007 (AMPA Receptor Antagonist); MGi Pharma AKR-501 (Thrombopoietin Mimetic); Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel ... $75.00 - Revere Reports - Revere

Article: Unigen Pharmaceuticals hires Director of Clinical Research.(...  -  Mar 1, 2006
Article: Ligand Presents at AACR: Targretin Causes Regression of . ... Targretin in Human Clinical Trials In November 1998, Ligand launched Phase II human ... Pay-Per-View - Pharmaceutical Processing - HighBeam Research

Competitors by Product Report  -  Aug 4, 2007
E2007 (AMPA Receptor Antagonist); Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere Reports - Revere

Competitors by Product Report  -  Aug 2, 2008
Eisai Co., Ltd (ADR) (ESALY) Products:. E6201 (Multikinase Inhibitor); Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene) ... $75.00 - Revere Reports - Revere

Press Release: Interim HIV Vaccine Trial Results to be Presented at...  -  Aug 30, 2005
Article: Clinical Trial Results of Targretin(R) Gel in ... Business Wire; May 9, 2000 ; 700+ words ... ... of Medicine, Northwestern University Medical ... Pay-Per-View - PR Newswire - HighBeam Research

Competitors by Product Report  -  Oct 27, 2007
E2007 (AMPA Receptor Antagonist); Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere Reports - Revere

Centron: organic growth continued to fuel revenue for this relatively...  -  Jul 1, 2008
New wins included Eisai (Ontak, Targretin Capsules and Targretin Gel, plus corporate work assigned in 2008); Velcade from Millennium Pharmaceuticals; ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Article: John Higgins.(Newsmakers)(Ligand Pharmaceuticals Inc....  -  Feb 19, 2007
An FDA panel agrees that Targretin should be used for treating patients with cutaneous T-cell lymphoma. Ligand Pharmaceuticals Inc. is the developer of the ... Pay-Per-View - Chain Drug Review - HighBeam Research

Ligand Announces Financial Results for Second Quarter of Fiscal 2006;...  -  Aug 9, 2006
Sales of Targretin capsules increased to $5.0 million (up 6%) and $10.0 million (up ... Targretin capsules sales for the three and six months ended June 30, ... $4.95 - Business Wire - ECNext

Minimizing Side-Effects of Oral Bexarotene in Cutaneous T-cell …  -  Aug 8, 2006
Bexarotene (Targretin®; Ligand Pharmaceuticals Inc., San Diego, CA, ... Phase 2 and 3 clinical trial of oral bexarotene (Targretin capsules) for the ... Medscape

Ligand's 1st-qtr 2006 revenues up 38%.(Brief article)  -  May 29, 2006
The firm added that this decline was in line with its spending plan for Phase III trials of Targretin as a treatment for non-small cell lung cancer. Free with registration - Pharma Marketletter - AccessMyLibrary.com

Eisai Acquires Four Oncology-Related Products from Ligand.  -  Sep 8, 2006
ONTAK (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... Free with registration - JCNN News Summaries - AccessMyLibrary.com

Ligand Sells More Products: $205M For Cancer Portfolio  -  Sep 11, 2006
The agreement with Eisai involves Ontak (denileukin diftitox), for cutaneous T-cell lymphoma; Targretin (bexarotene) gel and capsules, also for CTCL; ... BioWorld Online - BioWorld Online

Event Brief of Ligand Pharmaceuticals Earnings and Business Update - ...  -  Nov 18, 2005
PK saw a nice growth of ONTAK and consistent growth with Targretin capsules. 3. Product GM: 1. The product GMs are somewhat of an anomaly. 1. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Eisai to Acquire Global Rights to Four Oncology-Related Products from...  -  Sep 8, 2006
...(Nasdaq: LGND) for exclusive global rights for their four oncology-related products, ONTAK, Targretin capsules, Targretin gel 1% and Panretin gel 0.1%. ... StreetInsider.com - StreetInsider.com (subscription)

Avinza acquisition.(RXs)(Brief article) | Article from Chain Drug...  -  Mar 19, 2007
An FDA panel agrees that Targretin should be used for treating patients with cutaneous T-cell lymphoma. Ligand Pharmaceuticals Inc. is the developer of the ... Pay-Per-View - Chain Drug Review - HighBeam Research

Merger and Acquisition Scenario  -  Jan 27, 2007
Pharmaceuticals: ONTAK (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... $250.00 - Revere Reports - Revere

Ligand Pharmaceuticals Receives Leadership Award from Frost & …  -  Jan 3, 2005
To date, this has led to five products: Ligand markets four oncology and dermatology products in the United States - ONTAK(R), Targretin(R) capsules, ... $4.95 - Business Wire - ECNext

FDA COMMITTEE TO CONSIDER NAVY'S RESUS TRAUMA TRIAL. | …  -  Jul 1, 2006
..."We are extremely pleased with the FDA decision to rapidly approve Targretin capsules ... the approval of Targretin capsules by the FDA, ... Pay-Per-View - Biotech Business - HighBeam Research

Press Release: Eisai Announces Completion of Acquisition of Four …  -  Oct 26, 2006
In the agreement, Eisai Co., Ltd. and Eisai Inc. obtained exclusive global rights to ONTAK(R) (denileukin diftitox), Targretin(R) (bexarotene) capsules, ... Pay-Per-View - PR Newswire - HighBeam Research

Eisai Acquires Four Oncology-Related Products From Ligand.  -  Sep 7, 2006
...rights for ONTAK(R) (denileukin diftitox), Targretin(R) (bexarotene) capsules, Targretin(R) (bexarotene) gel 1% and Panretin(R) (alitretinoin) gel 0.1%. ... $4.95 - PR Newswire - ECNext

Competitors by Product Report  -  Sep 30, 2006
Ligand Pharmaceuticals Inc. (LGND) Products:. Ontak (Denileukin Diftitox); Targretin Capsules (Bexarotene); Targretin Gel (Bexarotene) ... $75.00 - Revere Reports - Revere

Article: Data collected on CTCL in children.(Clinical Rounds) - Skin...  -  Nov 1, 2006
Article: Targretin Capsules Benefit Patients in Treating Refractory ... ... Article: Targretin Gel Achieved 86% Response Rate in Early-Stage ... ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Merger and Acquisition Scenario  -  Dec 16, 2006
Pharmaceuticals: ONTAK (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... $250.00 - Revere Reports - Revere

Factiva Search  -  Mar 29, 2005
LIGAND'S TARGRETIN FAILS TO IMPROVE SURVIVAL IN NSCLC.(non-small- cell lung cancer). 29 March, 2005 BIOWORLD Today. Boggs, Jennifer ... Pay-Per-View - BIOWORLD Today - Factiva, from Dow Jones

Press Release: Eisai Acquires Four Oncology-Related Products From …  -  Sep 7, 2006
...rights for ONTAK(R) (denileukin diftitox), Targretin(R) (bexarotene) capsules, Targretin(R) (bexarotene) gel 1% and Panretin(R) (alitretinoin) gel 0.1%. ... Pay-Per-View - PR Newswire - HighBeam Research

Merger and Acquisition Scenario  -  Dec 16, 2006
Pharmaceuticals: ONTAK (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... $250.00 - Revere Reports - Revere

Merger and Acquisition Scenario  -  Nov 25, 2006
Pharmaceuticals: ONTAK (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... $250.00 - Revere Reports - Revere

The Biotechnology Industry Organizations (BIO): Carl Feldbaum, …  -  Jan 3, 2005
Targretin, initially approved for cutaneous T-cell lymphoma, has achieved clinical results that support combination use with Iressa in non-small-cell lung ... $9.94 - Chain Drug Review - Alacra Store

O/E Learning Inc acquires FamilyCare from CareGuide - Deal Snapshot -...  -  Jan 31, 2006
Its product portfolio includes…results and results from tw o studies of Targretin gel and…first of two pivotal Phas e III studies of Targretin (bexarotene… ... Pay-Per-View - deals - Alacra Store

Eisai; Recent developments announced by Eisai  -  Dec 5, 2006
...global rights for Ontak (denileukin diftitox), Targretin (bexarotene) capsules, Targretin (bexarotene) gel 1% and Panretin (alitretinoin) gel 0.1%. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Deep cuts at Ligand.(Ligand Pharmaceuticals Inc. Job cuts and …  -  Feb 5, 2007
In June, Ligand filed for a new drug application for Targretin . ... Provided the FDA approves Targretin gel, Ligand will have four approved treatments for ... Pay-Per-View - San Diego Business Journal - HighBeam Research

Seven Big Investors to Buy Sungard  -  Mar 28, 2005
Ligand Pharmaceuticals (LGND ) says its two pivotal Phase III studies of Targretin capsules in front-line combination therapy with standard chemotherapy to ... BusinessWeek

A brief primer on treatments of cutaneous T cell lymphoma, newly …  -  Jul 1, 2007
Bexarotene (Targretin[R], Ligand Pharmaceuticals Inc) is a synthetic retinoid analog with a specific affinity for the retinoid X receptor and belongs to a ... $4.95 - Journal of Drugs in Dermatology - ECNext

Article: Vic: New drugs could stop fat cell growth, scientists say -...  -  Oct 29, 2008
Article: Ligand Presents at ENDO '99: Targretin Causes Complete Regression ... Business Wire; June 14, 1999 ; 700+ words ... ... demonstrate that Targretin ... Pay-Per-View - AAP General News - HighBeam Research

Ligand Pharma: Günstiges "Lotterieticket"  -  Jan 14, 2005
Die Ergebnisse einer laufenden klinischen Studie des Lungenkrebsmedikaments Targretin seien im März zu erwarten, so die Analysten. ... FinanzNachrichten.de

Health Stocks in Motion  -  Mar 28, 2005
Ligand Pharmaceuticals (LGND - commentary - Cramer's Take) fell 28.6% after the company said its lung cancer drug, Targretin, failed to significantly extend ... TheStreet.com - TheStreet.com (subscription)

Press Release: FDA Approves ASMANEX(R) a New Option for the 20 …  -  Mar 31, 2005
Article: Ligand's Targretin(TM) (LGD1069) Published in 'Cancer Research' ... PR Newswire; December 16, 1996 ; 700+ words ...RXR-selective compound equally ... Pay-Per-View - PR Newswire - HighBeam Research

Pediatric alopecia areata severity should guide Tx; physician...  -  Jun 1, 2005
Article: T-Cell activation key to targretin gel efficacy: the rexinoid is ... Skin & Allergy News; April 1, 2006 ; 700+ words . ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Derm Dx.(Skin Disorders)(B-cell lymphoma) | Article from Family...  -  Apr 1, 2006
Article: FDA Approves Targretin for Treatment of CTCL. ... Oral Targretin (bexarotene) was approved by the Food ... for use in early- as well as late-stage ... Pay-Per-View - Family Practice News - HighBeam Research

Article: Taxol Doesn't Treat Common Breast Cancer - AP Online | …  -  Oct 10, 2007
Article: Ligand's Targretin Combined With Taxol Prevents and ... ... In this study ... the Targretin / Taxol combination resulted ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Taxol Doesn't Treat Common Breast Cancer - AP Online | …  -  Oct 10, 2007
Article: Ligand's Targretin Combined With Taxol Prevents and ... ... In this study ... the Targretin / Taxol combination resulted ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Article: Tool Theft Protection System.(NEW PRODUCTS) - Electrical …  -  Mar 1, 2006
Article: T-Cell activation key to targretin gel efficacy: . ... And all four appear to respond to bexarotene gel (Targretin), Dr. Marie-France Demierre said ... Pay-Per-View - Electrical Contracting Products - HighBeam Research

second-generation | Definition of second-generation | HighBeam.com: …  -  Jul 12, 2006
Article: FDA Approves Ligand's Targretin Capsules for Early and ... Business Wire; December 29, 1999 ; 700+ words ... ... the treatment of these early- and ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Article: Taxol Doesn't Treat Common Breast Cancer - AP Online | …  -  Oct 10, 2007
Article: Ligand's Targretin Combined With Taxol Prevents and ... ... In this study ... the Targretin / Taxol combination resulted ... ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Pharmaceutical firms mix and match to hone pipelines  -  Mar 3, 2006
Among the 12 products marketed by Zeneus in Europe are Myocet, a cardio-protective chemotherapy agent used to treat late-stage breast cancer, and Targretin, ... Bizjournals.com

Lessons from the lung for targeted anticancer drugs  -  Aug 2, 2007
...trials (erlotinib, sorafenib [Nexavar; Onyx/Bayer], vandetanib [Zactima; AstraZeneca] or a combination of erlotinib plus bexarotene [Targretin; Eisai]). ... Nature.com

St. Paul Pioneer Press : MANY MEDS DON'T MIX WITH THE SUN  -  Sep 21, 2005
Anti-cancer agents: Bexaro-tene (Targretin), capecitabine (Xeloda), dacarbazine (DTIC), epirubicin (Ellence), fluorou-racil (5-FU), interferon alfa (Intron ... $2.95 - St. Paul Pioneer Press - NewsBank

Brand Names/Synonyms:
Targretin is also known by the following brand names and/or synonymsBexarotene; Bexarotene [Usan]; LG 1069; LG 69; LGD 1069; LGD1096; Targret; Targretin; Targretyn; Targrexin

Drug Category:
Targretin is categorized under the following by the FDA: Anticarcinogenic Agents; ATC:L01XX25

Dosage Forms:
Not Available

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
4-[1-(3,5,5,8,8-pentamethyltetralin-2-yl)ethenyl]benzoicacid





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