Terfenadine

This page contains recent news articles, when available, and an overview of Terfenadine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

Terfenadine (when available)

Pharmacology and use:
Terfenadine, an H1-receptor antagonist antihistamine, is similar in structure to astemizole and haloperidol, a butyrophenone antipsychotic. The active metabolite of terfenadine is fexofenadine. For the treatment of allergic rhinitis; hay fever and allergic skin disorders

Mechanism Of Action:
Terfenadine competes with histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. This reversible binding of terfenadine to H1-receptors suppresses the formation of edema, flare, and pruritus resulting from histaminic activity. As the drug does not readily cross the blood-brain barrier, CNS depression is minimal.

News Articles on Terfenadine

치명�? 병용 금기약품 6개월간 4천건 처방  -  Sep 15, 2005
...�?�뇨제�?� 히드로�?�로르치아지드(hydrochlorthiazide)와 테르페나딘(terfenadine)�?� 치명�?�?� 부정맥�?� 유발할 수 있으나 244건�?� 함께 처방�??다. ... 한겨레

Drug-induced QT prolongation.(Editorial)  -  Jan 1, 2006
...grepafloxacin (Raxar), terfenadine (Seldane), cisapride (Propulsid), and astemizole ... As an example, when the nonsedating antihistamine terfenadine was ... $4.95 - Southern Medical Journal - ECNext

Heart Rhythm Disturbances Associated With Rupatadine: A Case Series …  -  Oct 2, 2008
3,4 Astemizole and terfenadine were removed from the market for this reason. ... The proarrhythmic antihistaminic drug terfenadine increases spontaneous ... Nature.com

Literature-based evaluation of four 'hard endpoint' models for...  -  Jul 7, 2008
The dose dependence of TdP biomarker effects of cisapride, terfenadine and ... Therefore, the mechanism of TdP liability of terfenadine may differ from that ... Nature.com

Drug-induced QT prolongation.(Editorial) | Article from Southern...  -  Jan 1, 2006
Editorial) ... find Southern Medical Journal articles. What do the following drugs all have in common?--grepafloxacin (Raxar), terfenadine (Seldane), ... Pay-Per-View - Southern Medical Journal - HighBeam Research

Ritonavir Oral : Uses, Side Effects, Interactions, Pictures, Warnings...  -  Sep 30, 2008
Seldane (terfenadine) US prescribing information. Hoechst-Marion Roussel September, 1997. 11.Allegra (fexofenadine hydrochloride) US prescribing information ... WebMD

Minus itch and irregular hear beats  -  Jun 6, 2007
Terfenadine is an effective antihistamine. But unlike most antihistamines, it has no sedative effect. However, it is associated with irregular heart beats ... Sun.Star

Severe arrhythmia as a result of the interaction of cetirizine and …  -  Oct 23, 2005
Cetirizine is a new histamine H 1 blocker and has a smaller effect to prolong the QT interval than do other traditional H 1 blockers such as terfenadine. ... Nature.com

Second Non-Medical use in Patent Claims  -  Nov 9, 2007
Here, the chemical reaction in the body produced by the ingestion of terfenadine had an anti-histamine effect. The invention was being worked before the ... Lawdit Commercial Solicitors

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
...(9,10) For example, in 1 clinical trial, terfenadine was associated with mean increases in ... (9) Yet terfenadine was withdrawn from the market because of ... Pay-Per-View - Journal of Family Practice - Factiva, from Dow Jones

A lingering mistake.(Letter to the editor)  -  Feb 28, 2006
Rangno R. Terfenadine therapy: Can we justify the risks? [editorial] CMAJ1997;157(1):37-8. (2.) Woosley RL. Cardiac actions of antihistamines. ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

Pharmacologic agents associated with QT interval prolongation.  -  Jun 1, 2005
...(9,10) For example, in 1 clinical trial, terfenadine was associated with mean increases in ... (9) Yet terfenadine was withdrawn from the market because of ... $4.95 - Journal of Family Practice - ECNext

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
Astemizole (eg, Hismanal) or Terfenadine (eg, Seldane) -- These medicines should not be taken with fluconazole, itraconazole, or ketoconazole; ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

�?�사CEO 지·�?·�?�·탈 - OD지�?醫  -  Feb 14, 2005
...한편 �?�들 고시 항목 유형 가운�?� 'terfenadine'�?� 현재 허가 금지 목�?�? �?�함�?�어 있으며, �?�외�? 'Aspirin', 'Amiodarone HCl', 'Diazepam' 등 약제�?� 경우 �?�료계 ... 오픈닥터스

Erythromycin and Sulfisoxazole (Systemic).(Drug overview)  -  May 1, 2006
...the side effects of these medicines Astemizole (eg, Hismanal) or Terfenadine (eg, Seldane) -- Use of astemizole or terfenadine with erythromycin and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

FDA Safety Labeling Changes: Fluvoxamine Maleate, Norvir, Tev-Tropin  -  May 25, 2005
May 25, 2005 — The US Food and Drug Administration approved in March revisions to safety labeling to advise that use of thioridazine, terfenadine, ... Medscape

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
Astemizole (eg, Hismanal) or Terfenadine (eg, Seldane) -- These medicines should not be taken with fluconazole, itraconazole, or ketoconazole; ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Erythromycin and Sulfisoxazole (Systemic).  -  Oct 27, 2005
...the side effects of these medicines Astemizole (eg, Hismanal) or Terfenadine (eg, Seldane) -- Use of astemizole or terfenadine with erythromycin and ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

United States Code of Federal Regulations - 21 CFR § 216.24 Drug …  -  Jul 11, 2006
Terfenadine: All drug products containing terfenadine. 3,3′,4′,5-tetrachlorosalicylanilide: All drug products containing 3,3′,4′,5-tetrachlorosalicylanilide ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Concise Guide to Drug Interaction Principles of Medical Practice: …  -  Jun 1, 2005
...result in pregnancy; inhibition of metabolism of terfenadine (a pro-drug) by the antimicrobial agent erythromycin can cause accumulation of terfenadine, ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

New Abbott Aluvia® Tablet for Treatment of HIV Available in South...  -  Jun 2, 2008
Do not take Aluvia with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, methylergonovine, ... AllAfrica.com

抗�?��?�与�?些�?�物相冲�?  -  Jul 6, 2007
...常用的�?�物。8�?�?�物包括抗心律失常�?�Flecainide�?�Propafenone，这些�?�物通常用作治疗心律�?整病人；抗组织胺�?�Terfenadine，�?少人用作治疗鼻�?感或皮肤�?感等。 ... 新�?�网河�?�频�?�

Depression (PDQ®)  -  Dec 19, 2008
Its use is, therefore, relatively contraindicated in patients who are receiving methadone and absolutely contraindicated in those receiving terfenadine or ... WebMD

Abbott Agrees With World Health Organization (WHO) Director-General...  -  Apr 10, 2007
Kaletra is contraindicated with astemizole, terfenadine, midazolam, triazolam, cisapride, pimozide, amiodarone, ergot alkaloids (eg, ergotamine, ... Free with registration - PR Newswire - AccessMyLibrary.com

Aventis Pharmaceuticals, Inc. v. Barr Laboratories, Inc., No. 01-3627...  -  Jan 30, 2006
...[103], [T]he Carr terfenadine metabolite patents use a substantially different ... More particularly, the Carr terfenadine metabolite patents' product is ... $2.95 - U.S. District Court, District of New... - VersusLaw

BOOK REVIEWED-Starting With Serotonin: How a High-Rolling Father of …  -  Aug 14, 2008
The biggest was terfenadine (Seldane), the first antihistamine that did not cause drowsiness. Developed in the 1970s, it was a blockbuster drug until heart ... Nature.com

Indications for Merck's SINGULAIR(R) Expand with FDA Approval for …  -  Aug 18, 2005
...did not change the plasma concentration profile of terfenadine (a substrate of CYP 3A4) or fexofenadine, its carboxylated metabolite, and did not prolong ... $4.95 - Business Wire - ECNext

Nicole Kidman Terima "Order of Australia"  -  Apr 10, 2007
Kaletra berkontraindikasi dengan astemizole, terfenadine, midazolam, triazolam, cisapride, pimozide, amiodarone, ergot alkaloids (contohnya, ergotamine, ... ANTARA

Looking for solid ground along the Critical Path  -  Aug 3, 2006
...whose research discovered the mechanism of the toxicity of the antihistamine Seldane (terfenadine) that contributed to its removal from the market. ... Nature.com

Article: Allegra-D approval.(Sanofi-Aventis SA's allergy drug)(Brief...  -  Aug 29, 2005
...(terfenadine, ... Science News; July 18, 1992 ; 663 words ...The Food and Drug Administration (FDA) last week asked the manufacturer of the popular ... Pay-Per-View - Chain Drug Review - HighBeam Research

Cough Medicines Dogged by Efficacy Concerns for Adults, Too  -  Jan 23, 2008
Among the antihistamines, terfenadine did not significantly improve cough in two adult studies and a third study showed no benefit with thonzylamine. ... MedPage Today

Abbott Submits EU and US Regulatory Filings for New Lower-Strength …  -  Jul 20, 2007
Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine ... Free with registration - PR Newswire - AccessMyLibrary.com

Seven saintly fruit juices  -  Oct 11, 2005
...by grapefruit juice include cyclosporin drugs, certain calcium channel blockers (excluding amlodipine and diltiazem) and terfenadine (an antihistamine). ... Daily Mail

Boehringer Ingelheim Initiates SPRING Study of Aptivus(R) (tipranavir)...  -  Jun 14, 2007
APTIVUS/ritonavir is contraindicated with amiodarone, bepridil, flecainide, propafenone, quinidine, astemizole, terfenadine, dihydroergotamine, ergonovine, ... Free with registration - PR Newswire - AccessMyLibrary.com

葡�?�柚�?�?藥大忌  -  Apr 25, 2006
...部分抗組織胺藥物如Terfenadine�?Astemizole，有產生心臟毒性副作用的�?�險。部分痛風治療藥物如Colchicine�?Carbamazepine�?�併使用�?�能產生嚴�?惡心�?嘔�??�?下痢�?� ... �?��?�新�?�網

FDA 2005 guidelines on the submission of pharmacogenomic data  -  Jun 28, 2005
For example, of the five drugs with the largest prewithdrawal sales (cisapride, rofecoxib, terfenadine, troglitazone and valdecoxib), two are thought to be ... Nature.com

The New England Journal Of Medicine Publishes Two Landmark Studies …  -  Jan 25, 2007
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine, is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott Study Shows Investigational Heat-Stable Norvir(R) Tablet...  -  Aug 8, 2008
Quinidine(R), also known as Quinaglute(R); Cardioquin(R); Quinidex(R); Rythmol(R) (propafenone); Seldane(R) (terfenadine); Tambocor(R); (flecainide); ... presseportal.de

PREZISTA Receives US FDA Approval as Part of HIV Combination …  -  Jun 23, 2006
PREZISTA/rtv is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, ... Free with registration - PR Newswire - AccessMyLibrary.com

Supplemental New Drug Application For PREZISTA™ Submitted To US …  -  Dec 25, 2007
...astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which ... Medical News Today - Medical News Today (press release)

Tibotec Therapeutics Launches New Dosage Strength for PREZISTA(TM)  -  May 19, 2008
...astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which ... RedOrbit

Abbott Statement on Agreement With Brazilian Government for Kaletra(R)...  -  Jul 11, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... Medical News Today - Medical News Today (press release)

Final Gemini Study Results Confirm Boosted Invirase Was as Effective...  -  Oct 25, 2007
INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. ... Free with registration - Business Wire - AccessMyLibrary.com

FDA Approves Intravenous form of Merck and Co., Inc. (MRK) Nausea …  -  Jan 30, 2008
Patients should not take EMEND for Injection or oral EMEND with Orap (pimozide), Seldane (terfenadine), Hismanal (astemizole) or Propulsid (cisapride) as ... Lifescience-online

Running, jumping increase back pain.(SPORTS)(WEEKEND ATHLETE: …  -  Dec 24, 2006
...the anti-AIDS drug, saquinavir; the immune suppressant, cyclosporin; the tranquilizers, midazolam and triazolam; and the antihistamine, terfenadine. ... $4.95 - Washington Times - ECNext

Article: DRUG CAPSULE WHAT YOU SHOULD KNOW - The Milwaukee …  -  Sep 26, 2005
Interactions: Do not take Prozac with drugs such as astemizole (Hismanal); cisapride (Propulsid); pimozide (Orap); terfenadine (Seldane); ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

African-American Women Who Have Received HIV Treatment Are Sought …  -  Feb 7, 2007
...astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which ... Medical News Today - Medical News Today (press release)

What is the name of the allery medicine made by Merck and banned by …  -  Apr 28, 2008
The only allergy drug that came up in my research was and antihistamine called Seldane (the generic name is terfenadine). The FDA wanted to pull the drug ... HealthCentral.com

Abbott在�?��?��??出抗HIV新�?�片剂注册申请  -  Apr 5, 2006
Lopinavir/ritonavir�?应与astemizole�?cisapride�?dihydroergotamine�?ergonovine �?ergotamine�?methylergonovine�?midazolam�?pimozide�?terfenadine或triazolam一�?� ... �?��?

Milwaukee Journal Sentinel : DRUG CAPSULE WHAT YOU SHOULD …  -  Jul 4, 2005
It also should not be used with pimozide, weight loss drugs, tryptophan, terfenadine, astemizole, dihydroergotamine. More info: www.zoloft.com; ... $2.95 - Milwaukee Journal Sentinel - NewsBank

New Cancer Practice Guidelines Recommend NOXAFIL(R) ( …  -  Mar 20, 2007
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine, is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

ChanTest Launches New Business to Provide Validated Ion Channel …  -  Aug 6, 2008
ChanTest scientists were the first to prove hERG as the target for adverse cardiac events linked to non-cardiac drugs: Seldane (terfenadine), ... Genetic Engineering News - Genetic Engineering News (press release)

Article: OMNICARE TO REPAY MEDICAID $5.75M.(Business) - The …  -  Apr 29, 2005
Synthroid levothyroxin Ceclor cefaclor Seldane terfenadine Procardia nifedipine Vasotec enalapril Source: American Druggist and The Complete Drug ... Pay-Per-View - Cincinnati Post - HighBeam Research

Milwaukee Journal Sentinel : DRUG CAPSULE WHAT YOU SHOULD …  -  Sep 26, 2005
Interactions: Do not take Prozac with drugs such as astemizole (Hismanal); cisapride (Propulsid); pimozide (Orap); terfenadine (Seldane); ... $2.95 - Milwaukee Journal Sentinel - NewsBank

DRUG CAPSULE WHAT YOU SHOULD KNOW | Article from The …  -  Jul 4, 2005
It also should not be used with pimozide, weight loss drugs, tryptophan, terfenadine, astemizole, dihydroergotamine. More info: www.zoloft.com; ... Pay-Per-View - Milwaukee Journal Sentinel - HighBeam Research

Abbott's New Tablet Formulation of Kaletra(R) (lopinavir/ritonavir) …  -  Jul 3, 2006
...astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or triazolam. ... Free with registration - PR Newswire - AccessMyLibrary.com

New Data Suggest Boosted Invirase(R) has Similar Efficacy to Boosted ...  -  Jul 20, 2007
INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. ... Free with registration - PR Newswire - AccessMyLibrary.com

How to take Fluvoxamine from Consumer Reports Health.  -  Jan 2, 2008
...terfenadine (Seldane) (not available in the US); tizanidine (Zanaflex) or thioridazine. Your doctor will probably tell you not to take fluvoxamine. ... consumerreports.org

Tibotec Therapeutics Announces Initiation of the Largest US Clinical ...  -  Sep 28, 2006
...astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, or triazolam) and for which ... Free with registration - PR Newswire - AccessMyLibrary.com

Ugandan Children Are Among the First to Receive Abbott's Lower- …  -  Dec 1, 2007
Do not take Kaletra with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, and methylergonovine ... Free with registration - PR Newswire - AccessMyLibrary.com

Tyche Industries board recommends 5% dividend  -  Aug 19, 2008
The company manufactures drug intermediates like sertraline, donepezil, sumatriptan, ibandronate sodium, terfenadine, and others. ... Myiris.com

Schering-Plough Announces FDA Approval of NOXAFIL(R) ( …  -  Oct 23, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may ... Free with registration - PR Newswire - AccessMyLibrary.com

Abbott's New Tablet Formulation Of Kaletra(R) (Lopinavir/Ritonavir) …  -  Apr 30, 2006
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... Medical News Today - Medical News Today (press release)

Abbott Statement on Agreement With Brazilian Government for Kaletra(R)...  -  Jul 12, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... i-newswire.com

European Union's CHMP Adopts Positive Opinion for Noxafil(R) ( …  -  Sep 22, 2006
Co-administration with the CYP3A4 substrates terfenadine, astemizole, cisapride, pimozide, halofantrine or quinidine is contraindicated since this may ... DG News

Interim Analysis of New Study Suggests Boosted INVIRASE(R) May …  -  Nov 13, 2006
INVIRASE/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. ... Free with registration - PR Newswire - AccessMyLibrary.com

New Abbott Aluvia(R) Tablet for Treatment of HIV Available in South …  -  Mar 6, 2008
Do not take Aluvia with astemizole, terfenadine, midazolam, triazolam, pimozide, cisapride, ergotamine, dihydroergotamine, ergonovine, methylergonovine, ... ITNews

How to take Nefazodone from Consumer Reports Health.  -  Jan 8, 2007
...cisapride (Propulsid) (not available in the United States), pimozide (Orap), or terfenadine (Seldane),(not available in the United States) if you are ... consumerreports.org

Analysis Provides Additional Data For PREZISTA As Part Of HIV …  -  Aug 15, 2006
PREZISTA/rtv is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, midazolam, ... Medical News Today - Medical News Today (press release)

Antifungal Vfend(R) provides significant cost advantages when used as...  -  Jun 2, 2005
VFEND is contraindicated with terfenadine, astemizole, cisapride, pimozide, quinidine (since increased plasma concentrations for these drugs can lead to QT ... Medical News Today - Medical News Today (press release)

International Approvals: Byetta and Noxafil  -  Nov 28, 2006
Concomitant use of posaconazole with the cytochrome-P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine is ... Medscape

A press release distributed by PR Newswire Europe  -  Apr 4, 2006
...not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or triazolam. ... prnewswire.co.uk

New Data Show a Kaletra(R) (Lopinavir/Ritonavir)-Based Regimen …  -  Nov 18, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... biotech-intelligence.com

Study of Breast Cancer Patients Showed Regimen Including EMEND-R- - …  -  Apr 18, 2005
Patients should not take EMEND if they are taking any of the following medicines: ORAP(R) (pimozide), SELDANE(R) (terfenadine), HISMANAL(R) (astemizole) or ... RedOrbit

Pfizer's Vfend equals two-drug candidemia regimen, with fewer serious...  -  Nov 7, 2005
Vfend is contraindicated with terfenadine, astemizole, cisapride, pimozide, quinidine (since increased plasma concentrations for these drugs can lead to QT ... Medical News Today - Medical News Today (press release)

Noxafil wins approval for the prevention of invasive Aspergillus,...  -  Nov 1, 2006
Coadministration is contraindicated for ergot alkaloids, terfenadine, astemizole, cisapride, pimozide, halofantrine, and quinidine. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Roche to Focus Resources on Availability of Invirase, Now Preferred …  -  Feb 6, 2006
Invirase/ritonavir should not be administered concurrently with terfenadine, cisapride, astemizole, pimozide, triazolam, midazolam or ergot derivatives. ... DG News

Drug-induced Prolongation of the QT Interval  -  Jan 1, 2005
Terfenadine was removed from the market because of associated episodes of torsades de pointes, yet therapeutic dosages only extended the QT interval by 6 ... AAFP News Now

FDA Approves EMEND® (aprepitant), in Combination with Other …  -  Jan 11, 2006
Patients should not take EMEND with ORAP® (pimozide), SELDANE® (terfenadine), HISMANAL® (astemizole) or PROPULSID® (cisapride) as EMEND may cause serious or ... biotech-intelligence.com

EMEND® (aprepitant) Helps Prevent Nausea/Vomiting for Breast Cancer …  -  Apr 21, 2005
Patients should not take EMEND if they are taking any of the following medicines: ORAP® ( pimozide ), SELDANE® ( terfenadine ), HISMANAL® ( astemizole ) or ... i-newswire.com

=> Abbott Statement on Agreement With Brazilian Government for...  -  Sep 7, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... FinanzNachrichten.de

Meeting analytical challenges with UPLC[TM]-MS.  -  Dec 1, 2005
In Figure 3, excellent linearity of response for Terfenadine is demonstrated for the UPLC-MS method. The detectability of low amounts (pg) is also required. ... Free with registration - LC-GC North America - AccessMyLibrary.com

Does Sex Make a Difference?  -  Jul 19, 2005
In 1998, the allergy drug Seldane (terfenadine) was removed from the market, when a safer alternative was approved. It had been discovered that Seldane ... RedOrbit

Emend.(NEW & APPROVED)(Drug overview)  -  Oct 1, 2006
Special Considerations: Emend is a weak to moderate CYP3A4 inhibitor, so it should not be used with pimozide, terfenadine, astemizole, or cisapride. ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Voriconazole (Systemic).(Drug overview)  -  Aug 1, 2006
Astemizole (eg, Hismanal) or Cisapride or Pimozide (eg, Orap) or Quinidine or Terfenadine -- Voriconazole may cause these drugs to remain in your body ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

A practical approach to cardiac safety: implementing ICH E14 to...  -  Oct 1, 2005
Examples include astemizole, cisapride, grepafloxacin, levacetyimethadol, lidoflazine, prenylamine, sertindole, sparfloxacin, terfenadine, and terodiline. ... Free with registration - Applied Clinical Trials - AccessMyLibrary.com

Voriconazole (Systemic).  -  Oct 27, 2005
Astemizole (eg, Hismanal) or Cisapride or Pimozide (eg, Orap) or Quinidine or Terfenadine -- Voriconazole may cause these drugs to remain in your body ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Plavix, emend.(New & Approved)  -  Nov 1, 2006
Special Considerations: Emend is a weak to moderate CYP3A4 inhibitor, so it should not be used with pimozide, terfenadine, astemizole, or cisapride. ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

Boehringer Ingelheim Initiates SPRING Study Of Aptivus(R) (tipranavir)...  -  Jun 15, 2007
APTIVUS/ritonavir is contraindicated with amiodarone, bepridil, flecainide, propafenone, quinidine, astemizole, terfenadine, dihydroergotamine, ergonovine, ... Medical News Today - Medical News Today (press release)

Abbott's New Tablet Formulation of Kaletra'R', Lopinavir/Ritonavir, …  -  Sep 12, 2006
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... marketwire.com

Five-Day Telithromycin Once Daily Is As Effective As 10-Day …  -  Nov 11, 2005
...to have adverse interactions with either study drug (including ergot alkaloid derivatives, terfenadine, cisapride, astemizole, pimozide, and quinidine). ... RedOrbit

Abbott Submits Application To EMEA For A New, More Convenient …  -  Jul 31, 2005
Kaletra should not be taken with astemizole, cisapride, dihydroergotamine, ergonovine, ergotamine, methylergonovine, midazolam, pimozide, terfenadine or ... i-newswire.com

Clarithromycin (Systemic).(Drug overview)  -  May 1, 2006
...(astemizole, cisapride, pimozide, and terfenadine should not be taken with clarithromycin ) Dihydroergotamine (eg, Migranal) or Ergotamine (eg, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

QT Prolongation: Closing in on the Target of Meaningful Data  -  Jun 1, 2005
QT prolongation has become a significant concern for pharma and FDA since the early 1990s, when Seldane (terfenadine), a popular antihistamine headed for ... PharmExec.com

International Approvals: Accomplia and Noxafil  -  Nov 20, 2006
Coadministration of posaconazole with the cytochrome P450 3A4 (CYP3A4) substrates terfenadine, astemizole, cisapride, pimozide, halofantrine, or quinidine ... Medscape

New analysis supports starting with VFEND for life-threatening fungal...  -  Oct 30, 2005
VFEND is contraindicated with terfenadine, astemizole, cisapride, pimozide, quinidine (since increased plasma concentrations for these drugs can lead to QT ... Medical News Today - Medical News Today (press release)

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
Terfenadine * Thiethylperazine * Thioridazine * Tizanidine * Trifluoperazine * Triflupromazine * Trimeprazine * Trimipramine * Ziprasidone ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

This antiviral offers new option to HIV patients.(NEW DRUG)  -  Aug 7, 2006
Use of Prezista is contraindicated with astemizole, terfenadine, dihydroergotamine, ergonovine, ergotamine, methylergonovine, cisapride, pimozide, ... Free with registration - Drug Topics - AccessMyLibrary.com

This medicine is available only with your doctor's prescription, in...  -  Jul 28, 2005
An older adult should not receive both triazolam and nefazodone Astemizole (eg, Hismanal) or Cisapride (eg, Propulsid) or Pimozide (eg, ORAP) or Terfenadine ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Statement Before the Institute of Medicine Committee Assessing the US...  -  Jan 19, 2006
Seldane (terfenadine), Hismanal (astemizole) These two antihistamines as well as Propulsid (cisapride), a gastrointestinal drug, and Raxar (grepafloxicin) a ... Public Citizen - Auto Safety & Consumer...

Brand Names/Synonyms:
Terfenadine is also known by the following brand names and/or synonymsAldaban; Allerplus; Cyater; MDL-9918; Nebralin; RMI 9918; Seldane; Teldane; Teldanex; Terdin; Terfenadine; Terfex; Ternadin; Triludan

Drug Category:
Terfenadine is categorized under the following by the FDA: Antiarrhythmic Agents; Anti-allergic Agents; Antihistamines; ATC:R06AX12

Dosage Forms:
Oral tablets

Absorption:
On the basis of a mass balance study using 14C labeled terfenadine the oral absorption of terfenadine was estimated to be at least 70%

Interactions:
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Chemical IUPAC Name:
4-[4-(hydroxy-diphenyl-methyl)-1-piperidyl]-1-(4-tert-butylphenyl)-butan-1-ol

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