Timolol

This page contains recent news articles, when available, and an overview of Timolol but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Timolol
(when available)

Pharmacology and use:
Similar to propranolol and nadolol, timolol is a nonselective, beta-adrenergic receptor antagonist. Timolol does not demonstrate appreciable intrinsic sympathomimetic or membrane-stabilizing activities but possesses a relatively high degree of lipid solubility and is subject to first-pass metabolism by the liver. For the treatment of hypertension, angina pectoris, cardiac arrhythmias, migraine and for the reduction of mortality following myocardial infarction. Ophthalmic solutions of timolol are used in the treatment of glaucoma to reduce intraocular pressure.

Mechanism Of Action:
Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.

News Articles on Timolol

QLT Acquires Early-Stage Ophthalmic Asset For $7.5 Million  -  ‎Jan 4, 2010‎
Additionally, the results of that study suggested that OT-730 may have comparable efficacy to timolol, but without the cardiovascular side-effects often ... India Business Blog (blog)

Hi-Tech Pharmacal Posts Sales and Earnings Results for 2Q  -  ‎Dec 14, 2009‎
Sales of Dorzolamide with Timolol ophthalmic solution, launched in the previous year, totaled $7.2 million. Newly launched Hydrocortisone with Acetic Acid, ... Trading Markets (press release)

QLT acquires novel glaucoma therapy from Othera  -  ‎Dec 31, 2009‎
In addition, study data showed that the compound may demonstrate comparable efficacy to timolol maleate, with no cardiovascular side effects. ... OSN SuperSite

Transporters beyond transport. Focus on "Deregulation of apoptotic volume ...  -  ‎Dec 16, 2009‎
Timolol may inhibit aqueous humor secretion by cAMP-independent action on ciliary epithelial cells. Am J Physiol Cell Physiol 281: C865–C875, 2001. ... AJP - Cell Physiology (subscription)

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 4, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, Istalol® (timolol maleate ophthalmic ... CNNMoney.com (press release)

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 3, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, Istalol® (timolol maleate ophthalmic ... Reuters

Ista narrows net loss, reports 47% revenue spike for third quarter  -  ‎Nov 6, 2009‎
Revenue from sales of Istalol (timolol maleate ophthalmic solution 0.5%) rose 31% to $5.1 million, while revenue from sales of Vitrase (hyaluronidase) ... OSN SuperSite

ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data at the American ...  -  ‎Oct 21, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, and Istalol® (timolol maleate ophthalmic ... Reuters

HEALTH CARE AND MIGRAINES  -  ‎Oct 26, 2009‎
These include propranolol (Inderal®), timolol (Blocadren®), topiramate (Topamax®) and divalproex sodium (Depakote®). These have had many years of use and ... The Cypress Times

Alcon Inc Q3 2009 Earnings Conference Call  -  ‎Oct 28, 2009‎
We established share leadership in this segment with Azopt® globally and we are continuing to introduce Azarga®, the combination of Azopt® and Timolol, ... Seeking Alpha (blog)

ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data At The 2009 Annual ...  -  ‎Nov 10, 2009‎
Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, and Istalol® (timolol maleate ophthalmic solution) 0.5% are trademarks of ISTA Pharmaceuticals. Medical News Today (press release)

20+1 Medicamente contraindicate soferilor  -  ‎Nov 12, 2009‎
Betoxolol, carteol, timolol, pilocarpina, latanoprost, dorzolamid, brinzolamid – antiglaucomatoase. Trebuie sa acordati o atentie deosebita asocierii ... Healthy.ro

Prefeitura de Fernandópolis terá que custear medicamentos a residentes do Asilo  -  ‎Nov 9, 2009‎
...(para Tereza Lina de Silva), Celebrat 100 mg (para Milton Ribeiro); Orap 01 mg (Inez de Carvalho); colírio Maleato de Timolol (Ana Moitinho Domingos). ... Regiao Noroeste

Tratamiento del glaucoma en embarazadas  -  ‎Oct 26, 2009‎
77,5 por ciento) tratadas con gotas oftalmológicas para controlar el glaucoma recibieron betabloqueantes, como por ejemplo, timolol maleato (Timoptic). ... MedicosConsultores.com

… -four-hour efficacy of the brimonidine/timolol fixed combination...  -  Jun 15, 2007
Correspondence: WC Stewart, PRN Pharmaceutical Research Network, LLC, 1 Southpark Circle, Suite 110, Charleston, SC 29407, USA. Tel: +1 843 762 6500; ... Nature.com

… /timolol fixed combination vs latanoprost/timolol fixed combination...  -  Jun 6, 2008
Correspondence: A Martínez, Instituto Gallego de Oftalmología, C/Ramón Baltar Sn, Santiago de Compostela, La Coruña 15706, Spain. Tel: +34 646 17 81 04; ... Nature.com

… assessment of bimatoprost 0.03% vs timolol maleate 0.5%: hypotensiv...  -  Oct 28, 2005
Correspondence: Dr JG Feijoo, Hospital Clinico San Carlos, Martin Lagos sn, 28040 Madrid, Spain. Tel: +349 1330 3977; Fax: +349 1330 3961; ... Nature.com

… for GANFORT(R) (LUMIGAN(R)/Timolol Combination) from European …  -  May 25, 2006
A fixed combination of bimatoprost 0.03% and timolol maleate 0.5%, GANFORT(R) offers powerful IOP-lowering efficacy comparable to the free combination of ... Free with registration - Business Wire - AccessMyLibrary.com

Peyronie's disease following long-term use of topical timolol  -  Sep 9, 2005
Peyronie's disease (PD) is characterised by formation of a localised fibrous plaque of the tunica albuginea of the penis, which results in varying degrees ... Nature.com

… effects of dorzolamide 2% and dorzolamide/timolol fixed combination...  -  Jan 18, 2008
We have found errors within the Results heading of the abstract and in Table 2 and 3. Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol ... Nature.com

Cost-effectiveness of latanoprost and timolol maleate for the...  -  Aug 24, 2007
Correspondence: WC Stewart, 1 Southpark Circle, Suite 110, Charleston, SC 29407, USA. Tel: +843 762 6500; Fax: +843 762 7444. E-mail: info@prnorb.com ... Nature.com

Combigan Drops Approved for Glaucoma  -  Oct 31, 2007
The drug combines two medications -- Alphagan and timolol ophthalmic solution -- both previously approved to treat glaucoma. The new drug will be available ... Washington Post

… fixed-combination glaucoma drug: brimonidine/timolol dual product...  -  Feb 1, 2005
Masking was maintained by having patients in the timolol and fixed-combination ... Treatment-related adverse events were least common with use of timolol ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Hi-Tech Pharmacal posts Q2 profit, shares jump  -  Dec 9, 2008
Sales of newly launched dorzolamide with timolol ophthalmic solution, for which the company received final regulatory approval in October, were $5.4 million ... Reuters

… Issues Approvable Letter for COMBIGAN(TM) (brimonidine tartrate/tim...  -  Dec 21, 2006
COMBIGAN(TM) includes two agents known to reduce IOP - ALPHAGAN(R) (brimonidine tartrate ophthalmic solution 0.2%) and timolol ophthalmic solution 0.5%, ... Genetic Engineering News - Genetic Engineering News (press release)

India's FDC says gets US FDA approval for glaucoma treatment drug  -  May 9, 2008
...(FDA) approval for its Abbreviated New Drug Application (ANDA) Timolol Maleate Ophthalmic Solution, used as a primary line of treatment for glaucoma. ... Forbes

… IOP at all time points: dorzolamide/timolol shows greater decrease...  -  Sep 1, 2007
Compared with timolol alone, application of the combination treatment resulted in ... Two serious adverse events occurred in the dorzolamide/timolol group, ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Hi-Tech Pharmacal rises after FDA oks company's ANDA for generic …  -  Apr 10, 2008
...had granted tentative approval for the Abbreviated New Drug Application for its dorzolamide hydrochloride with timolol maleate ophthalmic solution. ... Forbes

… compliance benefits from once-daily timolol solution.(Glaucoma...  -  Aug 1, 2005
Philadelphia -- The recently approved topical formulation of timolol maleate ophthalmic solution 0.5% (Istalol, Ista Pharmaceuticals) is a noteworthy ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Travoprost/timolol fixed combination shows promising results in phase...  -  Jul 1, 2007
...by Philippe Denis, MD, PhD. In a series of phase-3 trials, a fixed combination of travoprost 0.004%/timolol 0.5% proved to be safe and well tolerated as a ... OSN SuperSite

… Of Sandoz Timolol Ophthalmic Solution 0.25% And Sandoz Timolol …  -  Jul 19, 2008
Health Canada is warning consumers not to use the prescription drug Sandoz Timolol Ophthalmic Solution in 0.25% and 0.5% strengths, because some bottles may ... Medical News Today - Medical News Today (press release)

Efficacy, once-daily convenience make drug good choice: formulation …  -  Jan 15, 2006
..."Compared with other medication choices, timolol provides a greater and more ... As a result, administration of a single drop of this timolol formulation in ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Health Canada issues warning about timolol ophthalmic solution in...  -  Jul 22, 2008
OTTAWA — Health Canada has warned patients with ocular hypertension and glaucoma to discontinue using Sandoz timolol ophthalmic solution in 0.25% and 0.5% ... OSN SuperSite

… Cosopt (dorzolamide hydrochloride/timolol maleate) Now Available...  -  Nov 3, 2005
Preservative-free dorzolamide hydrochloride/timolol maleate answers an important medical need. All other glaucoma treatments currently approved in Canada ... DG News

… for GANFORT(R) (LUMIGAN(R)/Timolol Combination) in European Union  -  Mar 24, 2006
...approve GANFORT(R), Allergan's LUMIGAN(R)/timolol combination product (bimatoprost/timolol ophthalmic solution) for the treatment of glaucoma. ... RedOrbit

Topical timolol reverses post-LASIK myopic regression  -  Apr 30, 2007
Treatment with timolol maleate 0.5% can partially reverse myopic regression after LASIK for high myopia, said Joseph Frucht-Perry, MD, Department of ... Ophthalmology Times

University of Cologne; Latanoprost and timolol combined are effective...  -  Mar 29, 2006
Researchers in Germany conducted a study "to compare the efficacy and tolerability of fixed-combination latanoprost and timolol applied in the evening with ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

FDC gets approval for Ciprofloxacin solution  -  Jul 2, 2008
The Company had recently received approval for Timolol Maleate Ophthalmic Solution. Another ANDA ofloxacin ophthalmic solution is in the final stages of ... Business Standard

Drug Delivery; Mucoadhesive niosomal system improves ocular timolol …  -  Apr 19, 2005
..."The in vitro release phase of timolol (91% release in 2 h) was extended ... Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Ocular Hypertension; Latanoprost and timolol combined are effective …  -  Mar 28, 2006
Researchers in Germany conducted a study "to compare the efficacy and tolerability of fixed-combination latanoprost and timolol applied in the evening with ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Drug Delivery; Efficient iontophoretic timolol transport achieved...  -  Mar 27, 2005
..."Anodal iontophoretic transport of timolol was measured as a function of its ... "The fluxes of timolol across the human stratum corneum were strongly ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

… shows better efficacy, similar tolerability to timolol for chronic...  -  Feb 6, 2008
18.8% in the timolol group at 6 weeks ( P < .001) and 28.3% in the ... 18.4% in the timolol group at 3 months ( P < .001), according to the study. ... OSN SuperSite

Drug Delivery; Mucoadhesive niosomal system improves ocular timolol …  -  Apr 24, 2005
..."The in vitro release phase of timolol (91% release in 2 h) was extended ... Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

… hemodynamics is affected by treatment with dorzolamide/timolol  -  Mar 28, 2006
In a recent report published in the journal Current Medical Research and Opinion, researchers assessed "the effects of dorzolamide/timolol fixed combination ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Bimatoprost/Timolol Fixed Combination Therapy Demonstrates …  -  Jun 3, 2008
Greater intra-ocular pressure (IOP) lowering benefit can be achieved for glaucoma patients treated with a fixed combination of bimatoprost and timolol ... Medical News Today - Medical News Today (press release)

… for Drug Research; Efficient iontophoretic timolol transport...  -  Mar 23, 2005
..."Anodal iontophoretic transport of timolol was measured as a function of its ... "The fluxes of timolol across the human stratum corneum were strongly ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

… Combigan (brimonidine tartrate/timolol maleate ophthalmic solution)...  -  Dec 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%.(Pipeline) ... find Medical Marketing & Media ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Drug Delivery; Mucoadhesive niosomal system improves ocular timolol …  -  Apr 18, 2005
..."The in vitro release phase of timolol (91% release in 2 h) was extended ... Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

Timolol Fixed Combination Therapy Demonstrates Significantly Better...  -  Feb 6, 2008
Greater intra-ocular pressure (IOP) lowering benefit can be achieved for glaucoma patients treated with a fixed combination of bimatoprost and timolol ... presseportal.de

timolol | Definition of timolol | HighBeam.com: Online Dictionary  -  Jul 12, 2006
Find out what timolol means: The Oxford American College Dictionary has the definition of timolol. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

… Drug Delivery; Efficient iontophoretic timolol transport achieved...  -  Mar 22, 2005
..."Anodal iontophoretic transport of timolol was measured as a function of its ... "The fluxes of timolol across the human stratum corneum were strongly ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

Timolol may reduce post-phaco IOP increases in patients with glaucoma,...  -  Jan 30, 2008
Patients who have medically controlled glaucoma or exfoliation syndrome can experience IOP elevations within the first 24 hours after cataract surgery, ... OSN SuperSite

Reducing IOP with fixed-combination regimen  -  Jul 1, 2007
Evening dosing of fixed-combination travoprost/timolol appears most efficacious in ... In early clinical testing, the travoprost/timolol fixed combination ... OSN SuperSite

bimatoprost + timolol Allergan registered, EU (glaucoma).  -  Jun 5, 2006
On 25 May 2006 Allergan announced that the European Commission has granted marketing authorization for GANFORT in the EU for the treatment of glaucoma. ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

timolol + brimonidine Allergan receives approvable letter from US FDA.  -  Jan 8, 2007
...reduction of elevated intraocular pressure (IOP) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy because of ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Travoprost Plus Timolol Offers Improved Lowering of Intraocular...  -  Apr 30, 2008
By Cameron Johnston. FORT LAUDERDALE, Fla -- April 30, 2008 -- European patients with glaucoma who are being treated with the fixed-dose combination of ... DG News

Diagnostics; Purity and absolute configuration of timolol determined  -  Mar 1, 2005
2005 MAR 1 - (NewsRx.com & NewsRx.net) -- Researchers have conducted nonequivalence behavior studies for the direct determination of enantiomeric purity and ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Dorzolamide Hydrochloride With Timolol Maleate Ophthalmic Solution  -  Apr 14, 2008
Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck's Cosopt® and is indicated for the treatment ... Medical News Today - Medical News Today (press release)

Increased mortality linked with timolol-treated OAG among black...  -  Mar 20, 2008
Cardiovascular mortality rates significantly increase among black individuals who are treated with timolol maleate for open-angle glaucoma or ocular ... OSN SuperSite

Diagnostics; Purity and absolute configuration of timolol determined  -  Mar 6, 2005
2005 MAR 6 - (NewsRx.com & NewsRx.net) -- Researchers have conducted nonequivalence behavior studies for the direct determination of enantiomeric purity and ... Pay-Per-View - Medical Letter on the CDC & FDA - Factiva, from Dow Jones

… Regarding Dorzolamide and Timolol Ophthalmic Solution Exclusivity  -  Dec 12, 2008
Hi-Tech launched Dorzolamide and Timolol on October 28, 2008 and continues to market the product. Hi-Tech is a specialty pharmaceutical company developing, ... Genetic Engineering News - Genetic Engineering News (press release)

… Forms of Dorzolamide Hydrochloride-Timolol Maleate and Dorzolamide  -  Oct 28, 2008
Prasco to Distribute Generic Forms of Dorzolamide Hydrochloride-Timolol Maleate and Dorzolamide Hydrochloride Ophthalmic Solutions (Comparable to Merck's ... Pay-Per-View - PR Newswire - HighBeam Research

Othera Files IND Application for OT-730 in Glaucoma  -  Jul 30, 2008
The study is a randomized, multi-center, investigator-masked, timolol- ... Subjects will be randomized to placebo or 0.5% timolol maleate or 0.75% OT-730. ... Genetic Engineering News - Genetic Engineering News (press release)

Allergan Receives Positive Opinions for COMBIGAN(TM) From 21 …  -  Sep 28, 2005
Allergan, Inc. (NYSE:AGN) today announced that it received positive opinions for COMBIGAN(TM), Allergan's ALPHAGAN(R)/timolol combination product for ... RedOrbit

FDC gets USFDA nod for timolol maleate eye drops  -  May 7, 2008
FDC has received the approval from US Food and Drug Administration (USFDA) for its timolol maleate eye solution. FDC is engaged in bulk drugs, ... Myiris.com

Press Release: Bimatoprost / Timolol Fixed Combination Therapy …  -  Jun 2, 2008
Bimatoprost / Timolol Fixed Combination Therapy Demonstrates Significantly Better IOP Control Over 12 Hours Compared to Latanoprost / Timolol Combination. Pay-Per-View - PR Newswire Europe - HighBeam Research

Othera Files IND Application for Glaucoma Drug  -  Aug 1, 2008
This study is a randomized, multi-center, investigator-masked, timolol- ... Subjects will be randomized to placebo or 0.5% timolol maleate or 0.75% OT-730. ... RedOrbit

Bronchial reactivity may increase in glaucoma patients using timolol  -  Jan 25, 2005
Glaucoma patients treated with a topical non-selective beta blocker over a long period may be at risk of developing increased bronchial reactivity, ... Pay-Per-View - Australian Doctor - Factiva, from Dow Jones

Glaucoma treatment undergoes sea change.  -  Apr 9, 2007
Recently the familiar category has been reinvigorated by the introduction of a next-generation beta-blocker, Istalol (timolol maleate ophthalmic solution) ... $9.94 - Chain Drug Review - Alacra Store

Othera Begins Phase I/II Trial for Ocular Hypertension, Glaucoma  -  Sep 17, 2008
The randomized, multicenter, investigator-masked, timolol- and placebo-controlled study will evaluate the safety and efficacy of the drug in reducing ... FDA news - FDA news (subscription)

Illinois Administrative Code - 77 Ill. Adm. Code 790.9048 TIMOLOL …  -  Aug 10, 2005
77 Ill. Adm. Code 790.9048 TIMOLOL MALEATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Fixed combination glaucoma medications await US approvals  -  Nov 1, 2005
Combination fixed formulations currently available in Europe include timolol with pilocarpine and timolol with dorzolamide, which has been around for a ... OSN SuperSite

Beta-adrenergic Blocking Agents (Systemic).  -  Feb 1, 2006
Timolol ( TYE-moe-lole)(***) (***)Generic name product may be available in the ... For timolol For (oral) dosage form (tablets): For high blood pressure: ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

The pregnant glaucoma patient: here, we demystify the safety of …  -  Sep 15, 2006
In one report, the 21-week-old fetus of a mother using topical timolol showed bradycardia and ... These effects were possibly due to the use of timolol. ... Free with registration - Review of Optometry - AccessMyLibrary.com

Treated Open-Angle Glaucoma Linked with CV-Related Death  -  Mar 13, 2008
Treatment with timolol maleate was particularly problematic, ... "While side effects of beta blockers such as timolol could contribute to early deaths, ... Medscape

Changes in visual function after intraocular pressure reduction using...  -  Aug 1, 2008
After inclusion, patients randomly received timolol maleate 0.5%, ... A week after starting the treatment, four patients (one using timolol and three using ... Nature.com

Glaucoma Linked to Cardiovascular Mortality in Black Patients  -  Mar 11, 2008
In addition to timolol, other drugs included pilocarpine and medications such as ... Among the glaucoma patients, timolol treatment alone or combined with ... MedPage Today

… por la UE la combinación de bimatoprost y timolol para el glaucoma  -  May 30, 2006
Una combinación de bimatoprost y timolol para tratar el glaucoma acaba de ser aprobada por la autoridades sanitarias de la Unión Europea. ... Intramed.net - Intramed.net (Suscripción)

Costs Rising to Make Intraocular Pressure Fall  -  Dec 28, 2007
Per-bottle increases ranged from 0.62% for the generic β-blocker timolol ... Generic timolol maleate 0.5% in the 15.0 mL bottle size at $150.81 a year with ... MedPage Today

Prasco Laboratories Pictures from October 28, 2008 | HighBeam …  -  Oct 28, 2008
Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution & Dorzolamide ... Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution ... Pay-Per-View - AP Images - HighBeam Research

Do Beta Blockers Prevent Varices in Cirrhosis?  -  Jun 15, 2006
Adverse events were more common in the group treated with timolol. The authors conclude that these findings do not support the use of nonselective beta ... AAFP News Now

LA TERAPIA CON LA COMBINACIÓN FIJA BIMATOPROST / TIMOLOL …  -  Jun 2, 2008
Berlín, Alemania.- Se puede lograr el beneficio de una gran disminución de la presión intraocular (IOP, por sus siglas en inglés) en pacientes con glaucoma ... acceso.com

… garde : Rappel du médicament Sandoz Timolol Ophthalmic Solution en...  -  Jul 18, 2008
OTTAWA, ONTARIO--(Marketwire - 18 juillet 2008) - Santé Canada avise le consommateur de ne pas utiliser le médicament d'ordonnance Sandoz Timolol Ophthalmic ... marketwire.com

… : Rappel du médicament Sandoz Timolol Ophthalmic Solution en …  -  Jul 21, 2008
Les gouttes ophtalmiques Sandoz Timolol Ophthalmic Solution en concentrations de 0,25 % et de 0,5 % sont utilisées traiter une pression intraoculaire élevée ... marketwire.com

Prescription eye drops recalled  -  Jul 25, 2008
Sandoz Timolol Ophthalmic Solution 0.25 per cent and 0.5 per cent are eye drops taken for treatment of increased intraocular pressure (high fluid pressure ... Toronto Star

Press Release: New Head to Head Data(1) Show Efficacy of Treatment …  -  Dec 11, 2007
European Commission to market GANFORT(R), Allergan's LUMIGAN(R)/timolol ... A fixed combination of bimatoprost 0.03% and timolol maleate 0.5%, GANFORT ... ... Pay-Per-View - PR Newswire Europe - HighBeam Research

Beta-blocker linked with increased risk of cardiovascular mortality,...  -  Aug 15, 2006
The researchers conclude that the link between timolol and cardiovascular ... Clinicians should also consider low-dose timolol gel preparations, they say, ... Free with registration - Review of Optometry - AccessMyLibrary.com

Federal Register 2008 - 73 FR 12182 Summaries of Medical and Clinical...  -  Mar 6, 2008
RISPERDAL (risperidone), and TIMOLOL (timolol). The summaries are being made available consistent with section 9 of the BPCA (Public Law 107-109). ... Pay-Per-View - Federal Register 2008 - Loislaw

Contamination of Glaucoma Drugs Due to Patient Error More Than …  -  Apr 29, 2008
Of the BAK-containing control drops (timolol, brinzolamide, and timolol/dorzolamide) ... The tips or contents were positive in 1 (13%) of 8 timolol bottles, ... Medscape

The clinical validity of the treatment satisfaction survey for...  -  Jun 3, 2005
Compliance with topical timolol treatment. Am J Ophthalmol 1997; 103: 188–193. ... Comparison of latanoprost and timolol in patients with ocular ... Nature.com

Allergan receives FDA nod for glaucoma drug Combigan  -  Nov 3, 2007
Allergan, Inc. announced that the US Food and Drug Administration has approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2 per ... pharmabiz.com

spinneret | Definition of spinneret | HighBeam.com: Online Dictionary  -  Jul 12, 2006
Article: Timolol maleate 0.5% versus timolol maleate in gel forming ... ... Timolol in gel-forming solution (GFS) is timolol maleate in combination ... ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

The Columbus Dispatch - Local/State | The Columbus Dispatch  -  Dec 5, 2005
Q: I take verapamil for high blood pressure and timolol eyedrops for glaucoma. ... A: The manufacturer says that caution should be used when timolol ... Columbus Dispatch

Panel weighs pros and cons of fixed combination therapy for glaucoma  -  Oct 17, 2005
That study compared Combigan, dorzolamide + timolol maleate (Cosopt, Merck) and latanoprost + timolol maleate (Xalcom, AMO) and found the drop size was ... Ophthalmology Times

Health Canada recalls prescription eye drops  -  Jul 28, 2008
Sandoz Timolol Ophthalmic Solution 0.25 per cent and 0.5 per cent are eye drops taken for treatment of increased intraocular pressure (high fluid pressure ... CTV British Columbia

Addressing new risk factors could improve patient management  -  Apr 15, 2006
Use of the beta-blocker timolol is consistent at suppressing flow during ... One such study analyzed patients who were coadministered topical timolol and ... OSN SuperSite

Cataract Surgery and Intraocular Pressure  -  Apr 24, 2008
The use of timolol (1 drop at the completion of surgery) significantly lowered IOP ... Timolol reduced the occurrence of markedly elevated IOP in both the ... Medscape

International Approvals: Takepron, Ganfort, Kaletra  -  Jul 5, 2006
On May 25, the European Commission approved bimatoprost/timolol 0.03%0.5% ophthalmic solution ( Ganfort [ Lumigan/timolol], made by Allergan, ... Medscape

Erie Times-News : Front Page<br>  -  Oct 27, 2006
Timoptic Timolol 0.25% 10ml drp. Timoptic Timolol 0.25% 15ml drp. Timoptic Timolol 0.5% 10ml drp. Timoptic Timolol 0.5% 15ml drp. Ultram Tramadol 50mg tab ... $2.95 - Erie Times-News - NewsBank

Glaucoma In-Depth Report  -  Sep 13, 2006
Timolol has been used for years, and these other drugs are also well tolerated. ... They have now been largely replaced by timolol and others, although they ... New York Times

Ottawa  -  Jul 26, 2008
Sandoz Timolol Ophthalmic Solution 0.25 per cent and 0.5 per cent are eye drops taken for treatment of glaucoma and high fluid pressure inside the eye. ... Pay-Per-View - Toronto Star - ProQuest Archiver

Loislaw Federal District Court Opinions - PERTEE v. DETELLA (WDKy. …  -  Oct 6, 2005
The Lyons Eye Clinic noted that Pertee had refused the Timolol 0.25% at the jail due to "stinging." The Lyons Eye Clinic prescribed Timoptic 0.5% ophthalmic ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

OT 730 Othera preclinical data Othera partnering opportunity,...  -  Feb 14, 2005
Treatment with timolol resulted in a significant drop in heart rate and an ... Results showed that OT 730 had almost identical potency to timolol and ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

PHARMACY UPDATE: Shingles and glaucoma.  -  Sep 17, 2005
Timolol is a beta-blocker used to treat primary and secondary glaucoma. ... However, topical application of timolol (and other topical beta- blockers) can ... $4.95 - Chemist & Druggist - ECNext

Glaucoma: drops or surgery? Which comes first? In the United States, ...  -  Jan 15, 2007
Timolol has been used as the standard medical treatment of comparison in all clinical trials of new drugs and laser treatments. ... Free with registration - Review of Optometry - AccessMyLibrary.com

Press Release: New Data Suggest Once-Daily Atomoxetine May Provide …  -  May 24, 2005
Article: Latanoprost, timolol IOP control compared in crossover trial Ophthalmology Times; August 1, 2005 ; 700+ words ... ... that involved morning dosing ... Pay-Per-View - PR Newswire - HighBeam Research

Medications for Preventing Migraine Attacks  -  Sep 9, 2008
Propanolol and timolol are beta-blocker drugs. ... Propranolol (Inderal) and timolol (Blocadren) have been approved specifically for prevention of migraine. ... New York Times

Getting started in therapeutics (C7947)  -  Nov 30, 2007
The non-selective beta blocker timolol remains the gold standard against which ... Several combination products are available commercially eg timolol with ... Optician Online

… paneuropea para GANFORT(R) (combinación de LUMIGAN(R)/Timolol)  -  May 25, 2006
GANFORT(R), una combinación fija de bimatoprost al 0,03% y de maleato de timolol maleate al 0,5%, ofrece una gran eficacia en la reducción de PIO en ... elEconomista.es

SANTEN RELEASES CLINICAL TRIAL RESULTS OF TWO GLAUCOMA …  -  Feb 15, 2006
Timolol is a beta-blocker drug for the reduction of intraocular pressure in open angle glaucoma and ocular hypertension. Note to Editors: If you would like ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Medications for migraine prophylaxis.  -  Jan 1, 2006
Timolol (Blocadren) has been compared with placebo in three trials; its effect size is comparable to propranolol. (6) The 2002 American Academy of Family ... Free with registration - American Family Physician - AccessMyLibrary.com

Early diagnosis, diurnal IOP control among hot topics in glaucoma  -  Sep 15, 2006
Because timolol is a once-a-day drug and brimonidine is a twice-a-day drug, this creates some systemic issues. But the efficacy results were impressive. ... OSN SuperSite

Santen Announces Preliminary Results of Overseas Clinical Trials of...  -  Feb 14, 2006
Timolol is a beta-blocker drug for the reduction of intraocular pressure in open angle glaucoma and ocular hypertension. Newswit.com

Dorzolamide May Be Effective, Well Tolerated for Pediatric Glaucoma  -  Sep 13, 2005
In this three-month, double-masked, multicenter trial, patients were randomized to receive 2% dorzolamide three times daily or timolol maleate gel-forming ... Medscape

Brand Names/Synonyms:
Timolol is also known by the following brand names and/or synonymsApo-Timol; Apo-Timop; Aquanil; Betim; Betimol; Blocadren; HSDB 6533; Istalol; Novo-Timol; Proflax; Temserin; Tenopt; Tim-Ak; Timacar; Timacor; Timolol; Timolol Base; Timolol Maleate; Timololum [Inn-Latin]; Timopic; Timoptic; Timoptic in Ocudose; Timoptic-Xe; Timoptol

Drug Category:
Timolol is categorized under the following by the FDA: Antihypertensive Agents; Antiarrhythmic Agents; EENT Drugs; ATC:C07AA06; ATC:S01ED01

Dosage Forms:
DROPS; LIQUID; SOLUTION; SOLUTION (LONG-ACTING); TABLET

Absorption:
Bioavailability is about 60%

Interactions:
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Chemical IUPAC Name:
1-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]-3-tert-butylamino-propan-2-ol





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