Timolol Maleate

This page contains recent news articles, when available, and an overview of Timolol Maleate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Timolol Maleate
(when available)

Pharmacology and use:
Similar to propranolol and nadolol, timolol is a nonselective, beta-adrenergic receptor antagonist. Timolol does not demonstrate appreciable intrinsic sympathomimetic or membrane-stabilizing activities but possesses a relatively high degree of lipid solubility and is subject to first-pass metabolism by the liver. For the treatment of hypertension, angina pectoris, cardiac arrhythmias, migraine and for the reduction of mortality following myocardial infarction. Ophthalmic solutions of timolol are used in the treatment of glaucoma to reduce intraocular pressure.

Mechanism Of Action:
Like propranolol and nadolol, timolol competes with adrenergic neurotransmitters such as catecholamines for binding at beta(1)-adrenergic receptors in the heart and vascular smooth muscle and beta(2)-receptors in the bronchial and vascular smooth muscle. Beta(1)-receptor blockade results in a decrease in resting and exercise heart rate and cardiac output, a decrease in both systolic and diastolic blood pressure, and, possibly, a reduction in reflex orthostatic hypotension. Beta(2)-blockade results in an increase in peripheral vascular resistance. The exact mechanism whereby timolol reduces ocular pressure is still not known. The most likely action is by decreasing the secretion of aqueous humor.

News Articles on Timolol

QLT acquires novel glaucoma therapy from Othera  -  ‎Dec 31, 2009‎
In addition, study data showed that the compound may demonstrate comparable efficacy to timolol maleate, with no cardiovascular side effects. ... OSN SuperSite

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 4, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, Istalol® (timolol maleate ophthalmic ... CNNMoney.com (press release)

ISTA Pharmaceuticals Reports Third Quarter 2009 Financial Results  -  ‎Nov 3, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, Istalol® (timolol maleate ophthalmic ... Reuters

Ista narrows net loss, reports 47% revenue spike for third quarter  -  ‎Nov 6, 2009‎
Revenue from sales of Istalol (timolol maleate ophthalmic solution 0.5%) rose 31% to $5.1 million, while revenue from sales of Vitrase (hyaluronidase) ... OSN SuperSite

ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data at the American ...  -  ‎Oct 21, 2009‎
Bepreve(TM) (bepotastine besilate ophthalmic solution) 1.5%, Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, and Istalol® (timolol maleate ophthalmic ... Reuters

ISTA Pharmaceuticals Highlights Bepreve(TM) Clinical Data At The 2009 Annual ...  -  ‎Nov 10, 2009‎
Xibrom(TM) (bromfenac ophthalmic solution) 0.09%, and Istalol® (timolol maleate ophthalmic solution) 0.5% are trademarks of ISTA Pharmaceuticals. Medical News Today (press release)

… of bimatoprost 0.03% vs timolol maleate 0.5%: hypotensive efficacy,...  -  Oct 28, 2005
Correspondence: Dr JG Feijoo, Hospital Clinico San Carlos, Martin Lagos sn, 28040 Madrid, Spain. Tel: +349 1330 3977; Fax: +349 1330 3961; ... Nature.com

… Tentative Approval for Dorzolamide Hydrochloride with Timolol...  -  Apr 10, 2008
Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck's Cosopt(R) and is indicated for the ... Genetic Engineering News - Genetic Engineering News (press release)

Cost-effectiveness of latanoprost and timolol maleate for the...  -  Aug 24, 2007
Correspondence: WC Stewart, 1 Southpark Circle, Suite 110, Charleston, SC 29407, USA. Tel: +843 762 6500; Fax: +843 762 7444. E-mail: info@prnorb.com ... Nature.com

FDC's Timolol Maleate receives nod from US FDA  -  May 11, 2008
FDC Ltd has announced that the Company has received approval from the US FDA for its Abbreviated New Drug Application (ANDA), Timolol Maleate Ophthalmic ... Equity Bulls

… FDA Approval for COMBIGAN(TM) (brimonidine tartrate/timolol...  -  Oct 31, 2007
Allergan, Inc. (NYSE:AGN) today announced that the US Food and Drug Administration has approved COMBIGAN([TM]) (brimonidine tartrate/timolol maleate ... $4.95 - Business Wire - ECNext

Efficacy, once-daily convenience make drug good choice: formulation …  -  Jan 15, 2006
Portland, OR -- The novel formulation of timolol maleate 0.5% ophthalmic ... Dr. Samples noted the novel, once-daily timolol maleate solution may be ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

… Cosopt (dorzolamide hydrochloride/timolol maleate) Now Available...  -  Nov 3, 2005
Preservative-free dorzolamide hydrochloride/timolol maleate answers an important medical need. All other glaucoma treatments currently approved in Canada ... DG News

Bimatoprost/timolol fixed combination vs latanoprost/timolol fixed …  -  Jun 6, 2008
Six 12-h IOP curves were recorded for each patient at baseline (under treatment with timolol maleate 0.5% BID), week 6 and 12 for each treatment period. ... Nature.com

… ; Mucoadhesive niosomal system improves ocular timolol maleate …  -  Apr 19, 2005
Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical & Drug ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

… - Tentative Approval For Dorzolamide Hydrochloride With Timolol...  -  Apr 14, 2008
Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck's Cosopt® and is indicated for the treatment ... Medical News Today - Medical News Today (press release)

… ; Mucoadhesive niosomal system improves ocular timolol maleate …  -  Apr 24, 2005
Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical & Drug ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

… Distribute Generic Forms of Dorzolamide Hydrochloride-Timolol...  -  Oct 28, 2008
Dorzolamide hydrochloride-timolol maleate and dorzolamide hydrochloride ophthalmic ... Application (ANDA) for dorzolamide hydrochloride with timolol maleate ... Pay-Per-View - PR Newswire - HighBeam Research

Costs Rising to Make Intraocular Pressure Fall  -  Dec 28, 2007
Generic timolol maleate 0.5% in the 15.0 mL bottle size at $150.81 a year with a twice-daily dosing regimen. Generic metipranolol 0.3% in the 10.0 mL bottle ... MedPage Today

… ; Mucoadhesive niosomal system improves ocular timolol maleate …  -  Apr 18, 2005
Keywords: Chandigarh, India, Timolol Maleate, Niosomal Formulation, Biotechnology, Drug Delivery, Medical Devices, Ophthalmology and Pharmaceutical & Drug ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

… Combigan (brimonidine tartrate/timolol maleate ophthalmic solution)...  -  Dec 1, 2007
Allergan said the FDA approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%.(Pipeline) ... find Medical Marketing & Media ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Treated Open-Angle Glaucoma Linked with CV-Related Death  -  Mar 13, 2008
Treatment with timolol maleate was particularly problematic, ... The relative risk for all-cause mortality for timolol maleate use vs no treatment of OAG ... Medscape

FDC gets USFDA nod for timolol maleate eye drops  -  May 7, 2008
FDC has received the approval from US Food and Drug Administration (USFDA) for its timolol maleate eye solution. FDC is engaged in bulk drugs, ... Myiris.com

… Administrative Code - 77 Ill. Adm. Code 790.9048 TIMOLOL MALEATE (...  -  Aug 10, 2005
77 Ill. Adm. Code 790.9048 TIMOLOL MALEATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Glaucoma raises risk of death in blacks: study  -  Mar 10, 2008
..."The excess mortality associated with timolol maleate treatment ... warrants further investigation," the team concludes. Reuters

Twenty-four-hour efficacy of the brimonidine/timolol fixed combination...  -  Jun 15, 2007
Brimonidine 0.2% given two or three times daily versus timolol maleate 0.5% in ... Safety and efficacy of switching timolol maleate 0.5% solution to timolol ... Nature.com

Patient compliance benefits from once-daily timolol solution.(Glaucoma...  -  Aug 1, 2005
Dr. Katz said that the efficacy of timolol maleate seems to be comparable with other formulations of timolol that were used previously. ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Study Demonstrates Benefits of Combination Treatment for Glaucoma  -  May 11, 2006
Cosopt® contains two active ingredients, dorzolamide hydrochloride and timolol maleate, that have been demonstrated to reduce pressure inside the eye caused ... DG News

Sandoz Eye Solutions Recalled in Canada  -  Jul 21, 2008
Exposure to excess timolol maleate could cause users to experience dry eye, eye irritation, inflammation of the eyelids and/or cornea, drooping of the upper ... Newsinferno.com

Multiple factors guide decisions for post-SLT management: medical …  -  Sep 1, 2006
One glaucoma specialist explains why his choice is bromfenac 0.09% (Xibrom, ISTA Pharmaceuticals) and his preference for timolol maleate 0.5% (Istalol, ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Fixed-combination solution reduces IOP at all time points: dorzolamide...  -  Sep 1, 2007
Fort Lauderdale, FL -- Application of the fixed combination 2% dorzolamide hydrochlotided 0.5% timolol maleate ophthalmic solution (Cosopt, Merck, ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Woman referred for pressure in left eye  -  Sep 15, 2006
Eye drops in the left eye included prednisolone acetate 1% four times a day (for post-laser inflammation), dorzolamide hydrochloride-timolol maleate twice a ... OSN SuperSite

Othera Files IND Application for OT-730 in Glaucoma  -  Jul 30, 2008
Subjects will be randomized to placebo or 0.5% timolol maleate or 0.75% OT-730. Glaucoma is a leading cause of blindness in the world today, affecting more ... Genetic Engineering News - Genetic Engineering News (press release)

Fixed combination glaucoma medications await US approvals  -  Nov 1, 2005
In the United States, Cosopt (dorzolamide HCL, timolol maleate, Merck) is the only fixed combination glaucoma ophthalmic solution on the market. ... OSN SuperSite

Othera files investigational new drug application for novel glaucoma ...  -  Aug 1, 2008
In preclinical animal studies, OT-730 was comparable to timolol maleate in terms of IOP-lowering efficacy and had better systemic safety, according to a ... OSN SuperSite

spinneret | Definition of spinneret | HighBeam.com: Online Dictionary  -  Jul 12, 2006
Article: Timolol maleate 0.5% versus timolol maleate in gel forming ... ... Timolol in gel-forming solution (GFS) is timolol maleate in combination ... ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Market Live from BSE - NSE, Latest Market Commentary | Economic …  -  May 9, 2008
1:40 pm: FDC Ltd has received approval from the US FDA for its Abbreviated New Drug Application, Timolol Maleate Ophthalmic Solution.Timolol Maleate is a ... Economic Times

Ophthalmologists face reimbursement cuts despite some gains in eye …  -  Dec 1, 2007
Combigan consists of two already-approved therapies, brimonidine tartrate 0.2% and timolol maleate 0.5%. It is expected to enter the US market by the end of ... OSN SuperSite

Allergan receives FDA nod for glaucoma drug Combigan  -  Nov 3, 2007
Allergan, Inc. announced that the US Food and Drug Administration has approved Combigan (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2 per ... pharmabiz.com

Prasco Laboratories Pictures from October 28, 2008 | HighBeam …  -  Oct 28, 2008
Dorzolamide Hydrochloride-Timolol Maleate Ophthalmic Solution & Dorzolamide ... Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution ... Pay-Per-View - AP Images - HighBeam Research

Loislaw Federal District Court Opinions - PERTEE v. DETELLA (WDKy. …  -  Oct 6, 2005
A Physician Order dated June 22, 2004, indicates the jail physician prescribed Pertee Timolol Maleate ophthalmic solution, 0.25%. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Panel weighs pros and cons of fixed combination therapy for glaucoma  -  Oct 17, 2005
That study compared Combigan, dorzolamide + timolol maleate (Cosopt, Merck) and latanoprost + timolol maleate (Xalcom, AMO) and found the drop size was ... Ophthalmology Times

Aging eye is focus of ARVO meeting in 2007: novel and existing...  -  Aug 1, 2007
Through a prospective study with a travoprost/timolol maleate fixed combination, evening doses were significantly more effective at reducing IOP fluctuation ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Changes in visual function after intraocular pressure reduction using...  -  Aug 1, 2008
After inclusion, patients randomly received timolol maleate 0.5%, brimonidine tartrate 0.2%, or travoprost 0.004% in one randomly selected eye. ... Nature.com

Top 200 generic drugs by units in 2006.(COMMUNITY PRACTICE)( …  -  Mar 5, 2007
189 Methadose 1555 -25.4 190 Timolol Maleate GFS 1481 -6.8 191 Polymyxin ... Hycoclear Tuss 1438 -26.5 194 Timolol Maleate Oph 1434 8.1 195 Penicilin V ... $4.95 - Drug Topics - ECNext

Increased mortality linked with timolol-treated OAG among black...  -  Mar 20, 2008
..."The excess mortality associated with timolol maleate treatment of [open-angle glaucoma], also found in a white population, warrants further investigation," ... OSN SuperSite

Transdermal Drug Delivery; Efficient iontophoretic timolol transport ...  -  Mar 27, 2005
..."An increase in flux with increasing timolol maleate concentration in donor phase was observed, but this increase was not linear." ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

Glaucoma treatment undergoes sea change.  -  Apr 9, 2007
Recently the familiar category has been reinvigorated by the introduction of a next-generation beta-blocker, Istalol (timolol maleate ophthalmic solution) ... $9.94 - Chain Drug Review - Alacra Store

Global top 200 generic drugs by retail sales in dollars and percent …  -  Feb 21, 2005
57953 1.8 121 Diltiazem 56086 73.7 122 Methocarbamol 54145 -19.7 123 Glipizide 52586 -9.1 124 Timolol Maleate GFS 52273 -13.5 125 Cefadroxil 51102 -10.1 ... $20.00 - Drug Topics - Alacra Store

Leiden/Amsterdam Center for Drug Research; Efficient iontophoretic …  -  Mar 23, 2005
..."An increase in flux with increasing timolol maleate concentration in donor phase was observed, but this increase was not linear." ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Timolol may reduce post-phaco IOP increases in patients with glaucoma,...  -  Jan 30, 2008
..."Timolol maleate 0.5% eliminated IOP elevation [greater than] 30 mm Hg and reduced the frequency of IOP [greater than] 25 mm Hg in both groups to 14% in the ... OSN SuperSite

Transdermal Drug Delivery; Efficient iontophoretic timolol transport ...  -  Mar 22, 2005
..."An increase in flux with increasing timolol maleate concentration in donor phase was observed, but this increase was not linear." ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

… Letter for COMBIGAN(TM) (brimonidine tartrate/timolol maleate …  -  Dec 21, 2006
Administration (FDA) issued an approvable letter for COMBIGAN(TM) (brimonidine tartrate/timolol maleate ophthalmic solution) 0.2%/0.5% for the reduction ... Genetic Engineering News - Genetic Engineering News (press release)

FDC Ltd intends a stock buyback - Deal Snapshot - AlacraStore.com  -  Nov 12, 2008
Eye Infections A Timolol maleate FDC Glaucoma A Ofloxacin FDC Eye Infections PA Nizi Inflammation…#/##/#### Akorn Inc. FDC Ltd. -- Akorn and FDC Limited ... Pay-Per-View - deals - Alacra Store

Hi-Tech Pharmacal Co.(RX/GENERIC DRUGS--Profiles)(Hi-Tech …  -  Sep 29, 2008
Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck & Co.'s Cosopt and is indicated for the ... Pay-Per-View - Chain Drug Review - HighBeam Research

Hi-Tech Pharmacal Co.  -  Sep 29, 2008
Hi-Tech's dorzolamide hydrochloride with timolol maleate ophthalmic solution is the generic equivalent of Merck & Co.'s Cosopt and is indicated for the ... $9.94 - Chain Drug Review - Alacra Store

Wal-Mart expands $4 Rx drug plan: Wal-Mart expands $4 Rx drug plan.  -  Sep 28, 2007
Among the prescriptions Wal-Mart has added are timolol maleate (glaucoma), antifungal drugs, cardiac drugs and three $9 women's medications. Free with registration - Newsday - AccessMyLibrary.com

FDC gets approval for Ciprofloxacin solution  -  Jul 2, 2008
The Company had recently received approval for Timolol Maleate Ophthalmic Solution. Another ANDA ofloxacin ophthalmic solution is in the final stages of ... Business Standard

Wal-Mart expands $4 generic drugs program  -  Sep 27, 2007
These include timolol maleate (to treat glaucoma), terbinafine (antifungal medication), carvedilol (cardiac medication), and generic birth control for Ortho ... CNNMoney.com

Allergan Receives Pan European License for GANFORT(R) (LUMIGAN(R …  -  May 25, 2006
A fixed combination of bimatoprost 0.03% and timolol maleate 0.5%, GANFORT(R) offers powerful IOP-lowering efficacy comparable to the free combination of ... Free with registration - Business Wire - AccessMyLibrary.com

SANTEN RELEASES CLINICAL TRIAL RESULTS OF TWO GLAUCOMA …  -  Feb 15, 2006
...of data from another comparison study versus timolol maleate ophthalmic solution 0.5% (timolol) which is currently ongoing in the US and Europe. ... Free with registration - AsiaPulse News - AccessMyLibrary.com

Cost of glaucoma medications may impact treatment  -  Dec 30, 2007
For all categories of drugs, calculated yearly cost ranged from $150.81 for generic timolol maleate 0.5% (ß-blocker), to $697.42 for Cosopt (combination ... The Hindu

Yale biomedical engineers receive prestigious Early Career Awards  -  Jul 14, 2006
Erin Lavik was granted the award for her project "Sustained delivery of timolol maleate for management of elevated IOP for glaucoma," in collaboration with ... eurekalert.org

The effects of dorzolamide 2% and dorzolamide/timolol fixed combinatio...  -  Jan 18, 2008
Purpose To compare the effect of dorzolamide hydrochloride 2%, timolol maleate 0.5%, and their fixed combination on intraocular pressure (IOP) and retinal ... Nature.com

Combigan receives 'positive opinions' from EU regulators  -  Sep 29, 2005
Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) is indicated for the reduction of IOP in patients with chronic open-angle glaucoma or ocular ... OSN SuperSite

Othera Initiates Dosing in Phase I/II Ocular Hypertension and...  -  Sep 16, 2008
Subjects will be randomized to one of 0.75% OT-730, 0.5% timolol maleate or placebo. According to Othera, OT-730 is a novel, internally developed next ... RedOrbit

Santen Announces Preliminary Results of Overseas Clinical Trials of...  -  Feb 14, 2006
...of data from another comparison study versus timolol maleate ophthalmic solution 0.5% (timolol) which is currently ongoing in the US and Europe. ... Newswit.com

Corporate developments  -  Jul 3, 2008
The company has also received approval for Timolol Maleate Ophthalmic Solution. Another ANDA Ofloxacin Ophthalmic Solution is in the final stages of ... Hindu Business Line

GANJA - Is it harmful or useful?  -  May 11, 2005
Cantimol is a combination of canasol, an alpha agonist and timolol maleate, a beta blocker. West and Lockhart have stated in previous interviews that their ... Jamaica Gleaner

Intravenous dexamethasone vs methylprednisolone pulse therapy in the ...  -  Feb 22, 2008
Supportive therapy in the form of topical chloramphenicol (0.3%) four times a day, homatropine hydrobromide (2%) three times a day, timolol maleate (0.5%) ... Nature.com

Prescription eye drops recalled  -  Jul 25, 2008
The active ingredient is timolol maleate. Potential adverse events may include red eye, eye irritation, inflammation of the eyelids and-or cornea, ... Toronto Star

Immunotherapy for allergies to insect stings  -  Jan 22, 2008
Are taking beta-blockers, such as propranolol (Inderal, for example) or timolol maleate (Timoptic or Blocadren, for example), which are often used to treat ... WebMD

Competitors by Product Report  -  Mar 29, 2008
Carvedilol; Metoprolol Tartrate; Nadolol; Pindolol; Propranolol Hydrochloride; Propranolol Hydrochloride Extended Release; Timolol Maleate ... $75.00 - Revere Reports - Revere

The end of the road: an elderly glaucoma patient has progressive...  -  Feb 15, 2006
At that time, we diagnosed her with normal-tension glaucoma, and prescribed Timoptic 0.5% (timolol maleate, Merck) bid OU Post-treatment IOPs averaged 12mm ... Free with registration - Review of Optometry - AccessMyLibrary.com

Generics makers keep new products coming.(RX/GENERICS)(Statistical …  -  Sep 17, 2007
Timolol Maleate $57534646.66 Eon Labs Gabapentin $57100455.44 Par/Astrazeneca Metoprolol Succinate $56850343.24 Mylan Carbidopa/Levodopa $56454162.84 Watson ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Yale Biomedical Engineers Receive Prestigious Early Career Awards  -  Jul 17, 2006
Erin Lavik was granted the award for her project "Sustained delivery of timolol maleate for management of elevated IOP for glaucoma," in collaboration with ... Medical News Today - Medical News Today (press release)

Ottawa  -  Jul 26, 2008
The active ingredient is timolol maleate. Patients taking either of the eye drops should discontinue use and consult their doctor immediately. ... Pay-Per-View - Toronto Star - ProQuest Archiver

Eye problems worsen a bad streak for Jenne  -  Jun 9, 2008
Hardy, the suit says, prescribed timolol maleate -- a beta-blocker used to treat migraine headaches. The suit says another doctor correctly diagnosed ... $2.95 - Miami Herald - NewsBank

Beta-blocker.  -  Oct 15, 2006
According to ISTA, Istalol is the only BT-rated ophthalmic beta-blocker (generics and other timolol maleate solutions are not bioequivalent, they say). ... Free with registration - Review of Optometry - AccessMyLibrary.com

Recall Of Sandoz Timolol Ophthalmic Solution 0.25% And Sandoz …  -  Jul 19, 2008
...because some bottles may contain more of the active ingredient (timolol maleate) than indicated on the label, exposing patients to an increased risk of ... Medical News Today - Medical News Today (press release)

CMPH - Initial Marketing Authorisation Applications,Europe, February  -  Feb 24, 2006
Duotrav (travoprost/timolol maleate), Alcon Laboratories. Duotrav is an eye-drops solution, intended for the decrease of intraocular pressure in patients ... Medical News Today - Medical News Today (press release)

Topical timolol reverses post-LASIK myopic regression  -  Apr 30, 2007
Treatment with timolol maleate 0.5% can partially reverse myopic regression after LASIK for high myopia, said Joseph Frucht-Perry, MD, Department of ... Ophthalmology Times

Bimatoprost/Timolol Fixed Combination Therapy Demonstrates …  -  Jun 3, 2008
...to receive Ganfort (R) or Xalacom(R) for a 12-week period after a 6-week run-in period on timolol maleate 0.5% (one drop in each eye twice each day). ... Medical News Today - Medical News Today (press release)

Timolol Fixed Combination Therapy Demonstrates Significantly Better...  -  Feb 6, 2008
...to receive Ganfort(R) or Xalacom(R) for a 12-week period after a 6-week run-in period on timolol maleate 0.5% (one drop in each eye twice each day). ... presseportal.de

United States top 250 generic pharmaceuticals by sales, and …  -  Feb 4, 2008
55782241 231 Caraco Tramadol HCl/ 55214683 acetaminophen 232 Falcon Timolol maleate 54989395 233 Mylan Hydrochlorothiazide 54819735 234 Watson Labs. ... $20.00 - Chain Drug Review - Alacra Store

Missouri Regulations - 13 CSR 70-20.040 Five Prescription Limit Per …  -  Aug 16, 2005
Tablets Thyroid Tablets Timolol Maleate Tocainide Tolazamide Tablets Tolbutamide Triamcinolone Acetonide Oral Inhaler Trichlormethiazide Trihexyphenidyl ... Pay-Per-View - Missouri Regulations - Loislaw

ISTA posts net loss of $38.4 million for 2006  -  Mar 7, 2007
Net sales increased more than 200% for Xibrom (bromfenac ophthalmic solution 0.09%) and Istalol (timolol maleate 0.5%), rising to $20.2 million and $8.3 ... OSN SuperSite

Allergan Reports Fourth Quarter Operating Results.(Financial report)  -  Jan 31, 2007
On December 21, 2006, Allergan announced that the FDA issued an approvable letter for COMBIGAN[TM] (brimonidine tartrate/timolol maleate ophthalmic ... Free with registration - Business Wire - AccessMyLibrary.com

Wal-Mart Launches Phase Two of Prescription Program With New $4 …  -  Sep 27, 2007
Wal-Mart has added 24 new $4 prescriptions -- including timolol maleate (glaucoma), terbinafine (antifungal), carvedilol (cardiac), and three $9 women's ... Free with registration - PR Newswire - AccessMyLibrary.com

ISTA reports 91% increase in first quarter revenue  -  Apr 26, 2007
Revenue from sales of Istalol (timolol maleate 0.5%) increased 29% to total $2.2 million, while revenue from Vitrase (hyaluronidase) sales increased 25% to ... OSN SuperSite

Allergan reports 23% rise in first-quarter total product net sales  -  May 8, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled $99.5 ... OSN SuperSite

SLT comparable with medical therapy for open-angle glaucoma: added …  -  Jan 15, 2007
In the second step, a beta blocker, timolol maleate (Timoptic, Merck) or betaxolol (Betoptic S, Alcon), was added. In the third step, brimonidine tartrate ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Wal-Mart ups ante on generics.(News)(generics program)(Wal-Mart …  -  Oct 22, 2007
The chain has added 24 new $4 prescriptions, including timolol maleate for glaucoma, the antifungal terbinafine, and the cardiac drug carvedilol. ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Allergan reports 20.1% rise in second-quarter product sales  -  Aug 1, 2008
Alphagan P (brimonidine tartrate 0.15%), Alphagan (brimonidine tartrate) and Combigan (0.2% brimonidine tartrate, 0.5% timolol maleate) sales totaled ... OSN SuperSite

Small number of combination drugs reaching the Japanese market.  -  Sep 24, 2007
...while US pharmaceutical behemoth Pfizer is conducting Phase II/III studies for a combination of latanoprost and timolol maleate for the treatment of ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Persistent traumatic mydriasis alleviated with cerclage pupilloplasty....  -  Dec 15, 2005
Ocular history was significant for angle recession related to the injury with transient elevation of IOP managed well with dorzolamide HCl-timolol maleate ... Free with registration - Ophthalmology Times - AccessMyLibrary.com

Sandoz Recalls Eye Drug in Canada  -  Jul 29, 2008
The eyedrops are the generic equivalent of Merck's Timoptic (timolol maleate) and are used to treat increased intraocular pressure and glaucoma. ... FDA news - FDA news (subscription)

Dorzolamide May Be Effective, Well Tolerated for Pediatric Glaucoma  -  Sep 13, 2005
In this three-month, double-masked, multicenter trial, patients were randomized to receive 2% dorzolamide three times daily or timolol maleate gel-forming ... Medscape

IP Think Tank Global Week In Review.(reports of intellectual property)  -  Dec 5, 2007
Cosopt (dorzolamide hydrochloride and timolol maleate) - Merck achieves dismissal of invalidity claims & thwarts Apotex's chance at 180 d exlusivity: ... Free with registration - Mondaq Business Briefing - AccessMyLibrary.com

Health Canada recalls prescription eye drops  -  Jul 28, 2008
The active ingredient is timolol maleate. Potential adverse events may include red eye, eye irritation, inflammation of the eyelids and-or cornea, ... CTV British Columbia

Allergan Reports Second Quarter Operating Results; Total Product Net ...  -  Aug 2, 2006
A fixed combination of bimatoprost 0.03% and timolol maleate 0.5%, GANFORT(R) offers powerful IOP-lowering efficacy comparable to the free combination of ... $4.95 - Business Wire - ECNext

Last-minute 2006 US FDA decisions end with mostly "approvable"...  -  Jan 8, 2007
California, USA-based pharmaceutical firm Allergan's drug Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development as ... $9.94 - Pharma Marketletter - Alacra Store

ISTA Pharmaceuticals Reports Fourth Quarter and Year End 2004 …  -  Mar 2, 2005
Istalol a BT-rating, which means that prescriptions of Istalol cannot be substituted legally at pharmacies with generic timolol maleate products. ... $4.95 - PR Newswire - ECNext

Last-minute 2006 US FDA decisions end with mostly "approvable" letters  -  Jan 4, 2007
California, USA-based pharmaceutical firm Allergan's drug Combigan (brimonidine tartrate/timolol maleate opthalmic solution) 0.2%/0.5%, under development as ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

More chains embrace discount generics plans.  -  Feb 4, 2008
The chain added 24 new $4 prescriptions, including timolol maleate for glaucoma, the antifungal terbinafine, and the cardiac drug carvedilol. ... $9.94 - Chain Drug Review - Alacra Store

Article: PediaMed has entered into a US co-promotion agreement for …  -  Apr 1, 2005
Business Wire; October 31, 2007 ; 700+ words ... ... tartrate/timolol maleate ophthalmic solution) 0.2%/0.5%, an ... R]) (bimatoprost ophthalmic solution) ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Brand Names/Synonyms:
Timolol Maleate is also known by the following brand names and/or synonymsApo-Timol; Apo-Timop; Aquanil; Betim; Betimol; Blocadren; HSDB 6533; Istalol; Novo-Timol; Proflax; Temserin; Tenopt; Tim-Ak; Timacar; Timacor; Timolol; Timolol Base; Timolol Maleate; Timololum [Inn-Latin]; Timopic; Timoptic; Timoptic in Ocudose; Timoptic-Xe; Timoptol

Drug Category:
Timolol Maleate is categorized under the following by the FDA: Antihypertensive Agents; Antiarrhythmic Agents; EENT Drugs; ATC:C07AA06; ATC:S01ED01

Dosage Forms:
DROPS; LIQUID; SOLUTION; SOLUTION (LONG-ACTING); TABLET

Absorption:
Bioavailability is about 60%

Interactions:
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Chemical IUPAC Name:
1-[(4-morpholin-4-yl-1,2,5-thiadiazol-3-yl)oxy]-3-tert-butylamino-propan-2-ol





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