Tobramycin

This page contains recent news articles, when available, and an overview of Tobramycin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Tobramycin
(when available)

Pharmacology and use:
Tobramycin, an aminoglycoside antibiotic obtained from cultures of Streptomyces tenebrarius, is used in combination with other antibiotics to treat urinary tract infections, gynecologic infections, peritonitis, endocarditis, pneumonia, bacteremia and sepsis, respiratory infections including those associated with cystic fibrosis, osteomyelitis, and diabetic foot and other soft-tissue infections. For the treatment of pseudomonas aeruginosa lung infections

Mechanism Of Action:
Tobramycin binds irreversibly to one of two aminoglycoside binding sites on the 30 S ribosomal subunit, inhibiting bacterial protein synthesis. Tobramycin may also destabilize bacterial memebrane by binding to 16 S 16 S r-RNA. An active transport mechanism for aminoglycoside uptake is necessary in the bacteria in order to attain a significant intracellular concentration of tobramycin.

News Articles on Tobramycin

Two-stage Shoulder Reconstruction for Active Glenohumeral Sepsis  -  ‎Dec 29, 2009‎
11 with the exception that cefazolin was used rather than penicillin G in addition to an aminoglycoside (gentamicin or tobramycin) and vancomycin. ... Ortho SuperSite

Carrier Screening, Incidence of Cystic Fibrosis, and Difficult Decisions  -  ‎Dec 15, 2009‎
Randomized, placebo-controlled trials demonstrated that recombinant human DNase, 8 inhaled tobramycin, 9 chronic oral azithromycin, 10 and inhaled ... Journal of American Medical Association (subscription)

Gilead Closer to FDA Approval for CF Drug  -  ‎Dec 12, 2009‎
...the efficacy and safety of Cayston compared to Novartis' (NVS) tobramycin inhalation solution (TOBI) in CF patients with pulmonary P. aeruginosa. ... Seeking Alpha (blog)

Court Report  -  ‎Dec 20, 2009‎
...a generic version of Novartis' TOBI® (tobramycin inhalation solution, used in the management of cystic fibrosis patients with Pseudomonas aeruginosa). ... Patent Docs (blog)

Novartis set to sustain its leading global position in oncology with portfolio ...  -  ‎Dec 12, 2009‎
TOBI-TIP (tobramycin-inhaled powder), a treatment indicated for the long-term management of Pseudomonas aeruginosa infections in patients with cystic ... PR-USA.net (press release)

Gilead Awaits Committee Outcome  -  ‎Nov 13, 2009‎
...and safety of Cayston compared to Novartis' (NVS - Snapshot Report) tobramycin inhalation solution (TOBI) in CF patients with pulmonary P. aeruginosa. ... Zacks.com

New reports on animals, food, MRSA ST398  -  ‎Oct 29, 2009‎
...infections in Spain and is resistant to ciprofloxacin (Cipro), erythromycin and a third antibiotic, tobramycin, in addition to the usual suspects. ... GlobalPost

PBS listings in effect  -  ‎Nov 2, 2009‎
...a hypertension treatment that is listed on a cost-minimisation basis; and Tobra-Day, a new strength of Tobramycin sulfate preservative-free injection, ... Pharmacy News

FDA to review Gilead cystic fibrosis drug  -  ‎Oct 26, 2009‎
Gilead last week said that a head-to-head study of the drug versus Novartis AG's tobramycin inhalation solution, or TOBI, will be fully enrolled by the end ... San Jose Business Journal

Hope for cystic fibrosis patients  -  Feb 11, 2005
Researchers, who are based at Nottingham City Hospital, looked at the antibiotic tobramycin during the study. It is used to treat chronic chest infections, ... BBC News

Strides Arcolab receives USFDA approval for Tobramycin, Tazo Pip  -  Mar 12, 2008
MUMBAI: Strides Arcolab has received second abbreviated new drug application approval for Tobramycin 40 mg/ml. The product is licensed to Akorn-Strides, ... Economic Times

Tobramycin (Ophthalmic).(Drug overview)  -  Aug 1, 2006
Ophthalmic tobramycin (toe-bra-MYE-sin) is used in the eye to treat bacterial infections of the eye. Tobramycin works by killing bacteria. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Completes Successful Clinical Trials for Tobramycin 100 & Investigat...  -  Oct 11, 2008
PARI Pharma GmbH has successfully completed Phase I and Phase II clinical trials comparing its proprietary PARI Tobramycin 100 (150mg/1.5mL) formulation ... ITNews

… of Phase III Clinical Program Evaluating Tobramycin Inhalation...  -  Oct 5, 2005
..."Delivering an anti-infective drug like tobramycin quickly and directly into an infected lung is a logical way to treat CF patients," said John Patton, ... RedOrbit

TOBRAMYCIN (Ophthalmic route) - toe-bra-MYE-sin.(Drug overview)  -  May 1, 2007
Ophthalmic tobramycin is used in the eye to treat bacterial infections of the eye. Tobramycin works by killing bacteria. Ophthalmic tobramycin may be used ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Safety of Meropenem and Tobramycin Vs Ceftazidime and Tobramycin...  -  Nov 15, 2005
Background: Cystic fibrosis (CF) is characterized by chronic pulmonary infection with acute pulmonary exacerbations (APEs) requiring IV antibiotic treatment ... RedOrbit

… Completes Successful Clinical Trials for Tobramycin 100 & Investigat...  -  Nov 10, 2008
PARI Tobramycin 100 isan investigational therapy for cystic fibrosis ... Maximum tobramycin serum levels werebelow recommended safety thresholds for ... International Business Times

Loteprednol and Tobramycin ( Ophthalmic).  -  Feb 1, 2006
Loteprednol (loe-te-PRED-nol ) and tobramycin (toe-bra-MYE-sin) is a combination of an antibiotic and a corticosteroid ( kor-ti-ko-STER-oid). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Pharmacies settle with Chiron in drug inhaler dispute  -  Mar 7, 2005
The Emeryville biotechnology company (NASDAQ: CHIR) sued the pharmacies over marketing a compounded version of its tobramycin with an inhaler to deliver it. ... Bizjournals.com

Composition and three-dimensional EM structure of double affinity- …  -  Mar 1, 2007
Complexes were purified by a combination of tobramycin and anti-SF3a66 affinity selection, and fractionated on a glycerol gradient. ... Nature.com

… -Strides, LLC Announces FDA Approval for Tobramycin Injection USP,...  -  Mar 11, 2008
Akorn-Strides, LLC today announced the approval of an ANDA for Tobramycin Injection USP, 80 mg/2mL and 1.2 grams/30mL. Akorn-Strides, LLC is a Joint Venture ... Lifescience-online

Inhaled Tobramycin: Not Just for Cystic Fibrosis Anymore?  -  Apr 27, 2005
The use of inhaled medications for the treatment of pulmonary diseases is an attractive concept. In theory, this mode allows for the delivery of a high ... RedOrbit

Tobramycin Once versus 3 Times Daily Equally Effective in Cancer …  -  Apr 5, 2006
By Chris Berrie. NICE, FRANCE -- April 5, 2006 -- There is no significant clinical difference between the use of penicillin G with tobramycin either once a ... DG News

FDA issues non-approvable letter for ISTA's T-Pred  -  May 5, 2007
In the fourth quarter of 2005, ISTA Pharmaceuticals completed its phase III clinical study of prednisolone acetate 1.0% and tobramycin 0.3% ophthalmic ... Ophthalmology Times

Tobramycin And Dexamethasone (Ophthalmic).(Drug overview)  -  Aug 1, 2006
Tobramycin (toe-bra-MYE-sin) and dexamethasone (dex-a-METH-a-sone) is a combination of an antibiotic and a corticosteroid ( kor-ti-ko-STER-oid). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Elder bags Eli Lilly antibiotic brand rights  -  Jan 13, 2005
Tobramycin, the injectable antibiotic belonging to aminoglycoside class, is prescribed for additional gram-negative bacterial cover and helps in reducing ... Business Standard

… Completes Successful Clinical Trials for Tobramycin 100 & Investigat...  -  Nov 10, 2008
PARI Pharma Completes Successful Clinical Trials for Tobramycin 100 & Investigational eFlow for CF. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Loislaw Federal District Court Opinions - CHIRON CORP. v. SOURCECF …  -  May 16, 2006
Tobramycin and nebulizers were known well before the invention in question. ... A drug-device combination using tobramycin with a particular nebulizer came ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

… Pilot Study of the Safety and Efficacy of Tobramycin Solution for...  -  Apr 27, 2005
Study objective: To evaluate the efficacy and safety of tobramycin solution for inhalation (TSI) in patients with severe bronchiectasis. ... RedOrbit

… Completes Successful Clinical Trials for Tobramycin 100 & Investigat...  -  Nov 10, 2008
PARI Pharma Completes Successful Clinical Trials for Tobramycin 100 & Investigational eFlow for CF. from PR Newswire Europe. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire Europe - HighBeam Research

… Positive Phase III Results for Tobramycin and Prednisolone Acetate...  -  Feb 2, 2006
ISTA expects that its tobramycin and prednisolone acetate combination product, if approved, will compete in the antibiotic steroid segment of the US topical ... $4.95 - PR Newswire - ECNext

Inhalation with Tobramycin ® to improve healing of tracheobronchial …  -  May 15, 2008
...* Corresponding author. Address: Lungenklinik Merheim, Kliniken der Stadt Köln gGmbH, Ostmerheimerstr. 200, 51058 Köln, Germany. Tel.: +49 221 89078640; ... European Journal of Cardio-Thoracic...

Inhaled tobramycin: not just for cystic fibrosis anymore?(editorials)  -  Apr 1, 2005
The use of inhaled medications for the treatment of pulmonary diseases is an attractive concept. In theory, this mode allows for the delivery of a high ... Pay-Per-View - Chest - Factiva, from Dow Jones

Tobramycin (Ophthalmic).  -  Jul 28, 2005
The bottle is only partially full to provide proper drop control. To use: First, wash your hands. Tilt the head back and with the index finger of one hand, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… States Code of Federal Regulations - 21 CFR § 862.3900 Tobramycin ...  -  Jul 11, 2006
21 C.F.R. § 862.3900 Tobramycin test system. (a) Identification. A tobramycin test system is a device intended to measure tobramycin, an aminoglycoside ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

… Positive Phase III Results for Tobramycin and Prednisolone Acetat  -  Feb 2, 2006
ISTA Pharmaceuticals Announces Positive Phase III Results for Tobramycin and Prednisolone Acetate Combination Product. from PR Newswire. Pay-Per-View - PR Newswire - HighBeam Research

Accuracy of tobramycin levels obtained from central venous access …  -  Nov 1, 2008
Accuracy of tobramycin levels obtained from central venous access devices in patients with cystic fibrosis is technique dependent. Pay-Per-View - Pediatric Nursing - HighBeam Research

Tobramycin and Prednisolone Combination for Inflammatory Ocular …  -  Apr 28, 2005
By ISTA Pharmaceuticals, Inc., [RxPG] ISTA Pharmaceuticals, Inc. (Nasdaq: ISTA - News) announced today that the Company has filed an Investigational New ... RxPG NEWS

Chiron settles with RDN over tobramycin.(Respiratory Disease Network)(...  -  Mar 14, 2005
Chiron Corp of the USA says it has reached a settlement agreement with the Respiratory Disease Network, a group of three compounding pharmacies established ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

tobramycin | Definition of tobramycin | HighBeam.com: Online Dictionar...  -  Jul 12, 2006
Find out what tobramycin means: The Oxford American College Dictionary has the definition of tobramycin. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

… US Phase III Studies for Tobramycin and Prednisolone Acetate …  -  Apr 27, 2005
The tobramycin and prednisolone acetate combination product, if approved, will compete in the antibiotic steroid segment of the US topical ophthalmic ... $4.95 - PR Newswire - ECNext

Press Release: Tobi.com Gives Fashion a Conscience. - PR Newswire | …  -  Jun 12, 2007
Food and Drug Administration (FDA) for TOBI(TM) (Tobramycin Solution for Inhalation ... Prescription sales of TOBI(R) (tobramycin solution for inhalation ... Pay-Per-View - PR Newswire - HighBeam Research

A pilot study of the safety and efficacy of tobramycin solution for...  -  Apr 1, 2005
Study objective: To evaluate the efficacy and safety of tobramycin solution for inhalation (TSI) in patients with severe bronchiectasis. ... Pay-Per-View - Chest - Factiva, from Dow Jones

Press Release: Zysolin(TM) Improves Survival in Pivotal Animal...  -  Jun 26, 2008
AlphaRx's inhaled Tobramycin nanoparticles demonstrated superior therapeutic ... Injectible Tobramycin is the drug of choice used in the initial empirical ... Pay-Per-View - PR Newswire - HighBeam Research

InSite Vision drug meets endpoint  -  Nov 30, 2005
InSite Vision Inc. said Wednesday that preliminary data from a Phase III trial shows that its AzaSite solution is equivalent to treatment with tobramycin, ... East Bay Business Times

Loislaw Federal District Court Opinions - BERNDT v. KRAMER (Kan. …  -  Jan 17, 2006
Dr. Peterie notes in his report that the "tobramycin was given three times a day at ... The plaintiff was not given any tobramycin after September 12, 2000. ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Zysolin(TM) Improves Survival in Pivotal Animal Studies  -  Jun 26, 2008
Injectible Tobramycin is the drug of choice used in the initial empirical ... Zysolin(TM) is intended to replace injectible Tobramycin in VAP therapy. ... RedOrbit

… Streptomycin Antibacterial, systemic Amikacin Gentamicin Kanamycin...  -  Jul 28, 2005
Some reports have shown that aminoglycosides, especially streptomycin and tobramycin, may cause damage to the infant's hearing, sense of balance, ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Chiron settles with tobramycin compounders.  -  Mar 21, 2005
Chiron settles with tobramycin compounders. Chiron Corp. reached a settlement agreement with the Respiratory Disease Network (RDN), a group of three ... $9.94 - Drug Topics - Alacra Store

drug delivery system, inhaled tobramycin, Chiron/Nektar Chiron,...  -  Oct 17, 2005
Chiron and Nektar announced on 5 October 2005 that they have initiated a multinational phase III program (consisting of two pivotal trials) of tobramycin ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Oakland Tribune, The : Business<br>  -  Mar 5, 2005
Chiron filed suit against Source CF in October charging that the company's pharmacies illegally promoted an inhaler with the cystic fibrosis drug tobramycin ... $2.95 - Oakland Tribune - NewsBank

Illinois Administrative Code - 77 Ill. Adm. Code 790.9050 TOBRAMYCIN ...  -  Aug 10, 2005
77 Ill. Adm. Code 790.9050 TOBRAMYCIN SULFATE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

loteprednol etabonate + tobramycin Pharmos milestone payment (eye …  -  Jan 31, 2005
Bausch & Lomb has launched ZyLET, a combination of the anti-inflammatory corticosteroid loteprednol etabonate with the aminoglycoside antibiotic tobramycin, ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

loteprednol etabonate + tobramycin Bausch & Lomb registered, USA (eye...  -  Jan 10, 2005
Bausch & Lomb announced on 15 December 2004 that the US FDA has approved its fixed combination ophthalmic suspension, ZyLET, comprising the ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

… .(Chiron Corp.)(Nektar Therapeutics)(tobramycin inhalation powder)(B...  -  Oct 10, 2005
US drugmakers Chiron and Nektar Therapeutics have initiated a Phase III program evaluating tobramycin inhalation powder, an investigational inhaled ... $4.95 - Pharma Marketletter - ECNext

Azithromycin is a quicker remedy for conjunctivitis.(Clinical Rounds)...  -  Jan 1, 2007
More of the patients in the azithromycin group had a clinical cure at day 3 than did those in the tobramycin group, and the twice-daffy dosing of ... Pay-Per-View - Skin & Allergy News - HighBeam Research

InSite Vision's AzaSite to Be Highlighted at ARVO Conference; Two …  -  May 2, 2006
Tobramycin in Adult Subjects With Bacterial Conjunctivitis. ... Prominent organisms eradicated by both tobramycin and AzaSite were Streptococcus pneumoniae, ... Genetic Engineering News - Genetic Engineering News (press release)

Loislaw Federal District Court Opinions - CHIRON CORPORATION v. …  -  Dec 1, 2005
As a result, defendants have agreed that certain tobramycin formulations infringe '907 patent and have voluntarily stopped using dosages between 60 to 200 ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Toba Inc intends a stock buyback - Deal Snapshot - AlacraStore.com  -  Jun 23, 2008
Toba Disease Hub Infections Description Toba contains tobramycin sulphate as an… SUN PHARMACEUTICAL INDUSTRIES LTD.-COMPANY INSIGHT · SUN PHARMACEUTICAL ... Pay-Per-View - deals - Alacra Store

Comparative bacteriology of acute and chronic dacryocystitis  -  Jun 29, 2007
24 All patients who received medical therapy prior presentation had instilled broad-spectrum antibiotics; gentamicin, tobramycin, ciprofloxacin, ... Nature.com

Article: For lesbian, transgender son brings pride and worry.(Commenta...  -  Feb 26, 2006
Article: Chiron Presents Positive TOBI(R) Tobramycin Solution for . ... Food and Drug Administration (FDA) for TOBI(TM) (Tobramycin Solution for Inhalation ... Pay-Per-View - Register-Guard - HighBeam Research

Förändrade beställningsrutiner för Tobramycin och Vancomycin  -  Apr 10, 2007
Detta innebär att vid beställning i LabRoS, ligger dessa analyser under Klinisk kemi, kategori Antibiotika. Svaren på analyserna ligger också under Klinisk ... Landstinget i Jönköpings län

… Files IND to Commence US Phase III Studies for Tobramycin and …  -  Apr 27, 2005
Tobramycin and Prednisolone Acetate Combination Product In the fourth ... tobramycin ... Phase III study of a combination product containing tobramycin and ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: Cystic Fibrosis Axentis Pharma Initiates Clinical...  -  Sep 4, 2008
The product ARB-CF0223 EeA also known as Fluidosome(R) tobramycin EeA is a liposomal ... Utilising synthetic liposomes containing tobramycin, a standard ... Pay-Per-View - PR Newswire - HighBeam Research

Verdicts &amp; Settlements April 17, 2006: Smoker given 10 times the ...  -  Apr 17, 2006
29, 2000, the decedent was given 10-times the ordered dose of the antibiotic Tobramycin, which resulted in Tobramycin toxicity, and an acute insult to her ... Free with registration - Massachusetts Lawyers Weekly - AccessMyLibrary.com

Chiron Announces Settlement Agreement With the Respiratory Disease …  -  Mar 4, 2005
Resolution of Lawsuit Over Marketing of Compounded Tobramycin Acknowledges Value of Chiron's TOBI(R) Tobramycin Inhalation Solution, USP ... $4.95 - Business Wire - ECNext

Nektar Receives Patent Covering Pulmonary Targeted Antibiotics  -  May 7, 2008
7368102, which covers compositions and methods for creating and delivering Tobramycin Inhalation Powder (TIP) and other aminoglycoside antibiotics delivered ... RedOrbit

Gilead Announces Presentation of Positive Phase III Data on Aztreonam...  -  Apr 19, 2007
All patients received an initial 28 days of treatment with tobramycin inhalation solution ... Participants had received more than five courses of tobramycin ... RedOrbit

… with US Food and Drug Administration for T-Pred(TM), a Tobramycin  -  Jul 6, 2006
ISTA expects its tobramycin and prednisolone acetate combination product, if approved, will compete in the antibiotic steroid segment of the US topical ... Free with registration - PR Newswire - AccessMyLibrary.com

Comparison of topical fixed-combination fortified vancomycin–amikacin...  -  Jan 11, 2008
Among these drugs, gentamycin or tobramycin and cefazolin are recommended ... Ciprofloxacin versus tobramycin for the treatment of staphylococcal keratitis. ... Nature.com

Are Double-Beta Lactam Combinations Appropriate in the NICU?  -  Dec 3, 2007
...intensive care units with empiric use of intravenous amoxicillin and cefotaxime vs penicillin G with tobramycin or flucloxacillin and tobramycin. ... Medscape

Bronchial Constriction and Inhaled Colistin in Cystic Fibrosis*  -  Feb 23, 2005
Therapy with inhaled tobramycin, in particular, has gained popularity among ... Some patients with advanced disease harbor tobramycin- resistant strains of ... RedOrbit

TobraDex in My Practice  -  Jun 24, 2005
Tobramycin is most effective against gram-negative bacteria, ... The other found that tobramycin/dexamethasone significantly decreased the clinical signs of ... RedOrbit

Press Release: Cystic Fibrosis: License Agreement Boosts Development ...  -  Dec 19, 2007
Utilising synthetic liposomes that contain Tobramycin, a proprietary nebulizer delivers the drug directly to the endobronchial sites of infection in Cystic ... Pay-Per-View - PR Newswire - HighBeam Research

Mukoviszidose: Phase-III für Tobramycin-Inhalationspulver in den USA  -  Oct 24, 2005
Ein neuartiges Inhalationspulver für Mukoviszidose-Patienten kommt in die Phase III der klinischen Prüfung. In der Phase III wird geprüft, wie sicher und ... journalmed.de

Press Release: PARI's eFlow Nebulizer used in Alnylam Clinical Trial...  -  Oct 16, 2006
PARI conducted a Phase I clinical trial as a randomized ... deposition study of PARI Tobramycin 100 in ... Phase II multicenter clinical trial (10 sites) ... Pay-Per-View - PR Newswire - HighBeam Research

FINAL TRANSCRIPT  -  May 21, 2008
...actually potentiate each other, so we can drop the dose of tobramycin to a third of ... becomes resistant to tobramycin over time, and also the toxicity of ... $54.00 - Thomson StreetEvents - Alacra Store

The clinical impact of antibacterial prophylaxis and cycling antibioti...  -  Feb 26, 2007
Extended interval tobramycin dose was 5 mg/kg iv every 24 h, and adjusted ... Ceftazidime compared to piperacillin and tobramycin for the empiric treatment ... Nature.com

Mpex Pharmaceuticals Presents New Data On MP-376 In Cystic Fibrosis  -  Oct 24, 2008
Potency: MIC90s for MP-376 against nearly 300 P. aeruginosa clinical isolates from CF patients were at least 4-fold lower than those obtained for tobramycin ... Medical News Today - Medical News Today (press release)

AlphaRx Appoints Leading Infectious Disease Specialist to Its...  -  Sep 17, 2008
Zysolin(TM) is a Tobramycin compound, encapsulated in AlphaRx's Nano Drug Delivery ... Zysolin(TM) improves the intracellular activity of Tobramycin - in ... RedOrbit

Mpex Pharmaceuticals Presents New Data on MP-376 in Cystic Fibrosis  -  Oct 23, 2008
Potency: MIC90s for MP-376 against nearly 300 P. aeruginosa clinical isolates from CF patients were at least 4-fold lower than those obtained for tobramycin ... International Business Times

Article: Local Focus.(Business) - Daily Herald (Arlington Heights,...  -  Mar 12, 2008
Tobramycin Injection is an antibiotic and is recommended in the treating of ... Article: Akorn-Strides, LLC Announces FDA Approval for Tobramycin ... ... Pay-Per-View - Daily Herald - HighBeam Research

Press Release: Zysolin Shows Promising Results in Animal Study. - PR ...  -  Jun 3, 2008
AlphaRx's specially-formulated Tobramycin nanoparticles increase survival ... 40% in the Tobramycin treatment group. An increase of survival by 50% or more, ... Pay-Per-View - PR Newswire - HighBeam Research

Enterobacter cloacae outbreak and emergence of quinolone resistance …  -  May 1, 2006
Of these, 83 tobramycin-resistant isolates obtained from 83 patients ... Five of these patients also carried a tobramycin-susceptible variant of the clonal ... $4.95 - Emerging Infectious Diseases - ECNext

Tear function and goblet cell density after pterygium excision  -  Dec 9, 2005
At the completion of surgery, 0.3% tobramycin and 0.1% dexamethasone ... All eyes were treated with 0.3% tobramycin and 0.05% dexamethasone eye drops four ... Nature.com

Heterogeneity of Treatment Response to Azithromycin in Patients With ...  -  Oct 28, 2005
Participants continued their ongoing use of inhaled tobramycin solution, ... The pattern of use of inhaled tobramycin and rhDNase both before and during the ... RedOrbit

InSite's pink eye drug proves positive.(Thursday, Dec. 1)  -  Dec 5, 2005
InSite Vision Inc. hit the primary endpoint--equivalence to tobramycin, ... Tobramycin-treated patients got their dose four times per day for five days. ... Free with registration - BioWorld Week - AccessMyLibrary.com

Impact of biofilms on the treatment of otitis.(Clinical report)  -  Nov 1, 2007
Evaluation of the in vivo efficacy of topical tobramycin against Pseudomonas ... Treatment of chronic suppurative otitis media with topical tobramycin and ... Free with registration - Ear, Nose and Throat Journal - AccessMyLibrary.com

Merger and Acquisition Scenario  -  Apr 15, 2006
Betaseron (Interferon Beta-1b); TOBI (Tobramycin); (Tobi) Inhalable Tobramycin ... TOBI (Tobramycin); (Tobi) Inhalable Tobramycin. Pneumonia. $250.00 - Revere Reports - Revere

What's your diagnosis?[R] Sharpen your diagnostic skills.  -  Jan 1, 2005
Topical tobramycin has also produced allergy when administered to the airways. (7). We felt that the patient's condition was not persistent bacterial ... $4.95 - Consultant - ECNext

EDITED BRIEF  -  May 7, 2008
Development partnership with Novartis for Tobramycin inhalation powder to treat ... Patent covers compositions of Tobramycin and other dry formulations of ... $54.00 - Thomson StreetEvents - Alacra Store

Drug/Medical Device  -  Apr 15, 2006
...(Tobi) Inhalable Tobramycin, Cystic Fibrosis Patients With Pseudomonas Aeruginosa ... TOBI (Tobramycin), Management Of Cystic Fibrosis In Patients With ... $70.00 - Revere Reports - Revere

Press Release: Court Rules in Favor of Alabama-Based CF Company, …  -  May 18, 2006
..."We find comfort in the fact that patients prescribed tobramycin for use in eFlow at these concentrations can continue to realize its benefits." ... Pay-Per-View - PR Newswire - HighBeam Research

ISTA Pharmaceuticals, Inc. Reports First Quarter 2006 Financial...  -  May 8, 2006
In February, ISTA announced positive Phase III results for tobramycin and prednisolone acetate combination product for the treatment of steroid-responsive ... $4.95 - PR Newswire - ECNext

armA and aminoglycoside resistance in Escherichia coli.(DISPATCHES)  -  Jun 1, 2005
Solna, Sweden) indicated that the strain was also highly resistant to the 4,6-disubstituted deoxystreptamines netilmicin and tobramycin (Table). ... $4.95 - Emerging Infectious Diseases - ECNext

Issues Updates for InSite Vision Incorporated.  -  May 15, 2006
The results of its phase 3 clinical trial show that the clinical resolution and bacterial eradication rates of AzaSite are equivalent to those of tobramycin ... $4.95 - M2 Presswire - ECNext

Guidelines Issued for Cystic Fibrosis  -  Nov 15, 2007
Long-term use of inhaled tobramycin to improve lung function and reduce exacerbations in patients who have moderate to severe lung disease with cultures of ... Medscape

Marginal keratitis.(CORNEA)(Disease/Disorder overview)  -  Mar 15, 2007
Another very acceptable option in MK associated with blepharitis is an antibiotic-steroid combination, such as TobraDex (tobramycin/dexamethasone, ... Free with registration - Review of Optometry - AccessMyLibrary.com

Gilead Announces Interim 12-Month Phase III Study Results for …  -  Jun 13, 2008
Gilead also recently initiated a European Phase III study (0110) comparing aztreonam lysine for inhalation to inhaled tobramycin. 0110 is an open-label, ... Lifescience-online

FINAL TRANSCRIPT  -  May 7, 2008
The development partnership with Novartis for Tobramycin ... Tobramycin but other dry formulations of amino glucoside antibiotics that could be delivered ... $54.00 - Thomson StreetEvents - Alacra Store

Press Release: Towing Troubles: Danger On America's Road. - PR …  -  Aug 25, 2005
Article: PARI Pharma Completes Successful Clinical Trials for Tobramycin . ... Maximum tobramycin serum levels were below recommended safety thresholds for ... Pay-Per-View - PR Newswire - HighBeam Research

Market Gainer issues profile for InSite Vision Incorporated.  -  Dec 2, 2005
AzaSite demonstrated a clinical resolution rate of 80 percent as compared to 78 percent for tobramycin. This result shows that the clinical resolution rate ... Free with registration - M2 Presswire - AccessMyLibrary.com

InSite Vision Reports 4th Quarter and Fiscal 2005 Financial Results; ...  -  Mar 30, 2006
In this trial, designed to show comparability with the marketed eye drop, tobramycin, with respect to the resolution of bacterial conjunctivitis, ... Free with registration - Business Wire - AccessMyLibrary.com

InSite Vision Completes Enrollment In First Phase 3 AzaSite(TM)...  -  Sep 29, 2005
The randomized patients were treated for five days with either AzaSite or tobramycin ophthalmic solution. The goal of the study was to show equivalent ... RedOrbit

Pharmacy has pilot program for cystic fibrosis treatment  -  Jun 20, 2008
Half-dosing Tobramycin and other drugs can save Medicaid up to $1600 a month, Carter said. The state is using $250 a month of the savings to lease the eFlow ... Florida Times-Union

Tracking Trends in Pharmacologic Therapy  -  Mar 31, 2006
Two combination agents, tobramycin 0.3%-loteprednol etabonate 0.5% suspension (Zylet) and tobramycin 0.3%-dexamethasone (TobraDex), offer similar coverage ... RedOrbit

Catheter-related bacteremia is common in hemodialysis.(Infectious …  -  Apr 1, 2005
Of the gram-negative infections, 22% were tobramycin resistant. ... Given the frequency of oxacillin--and tobramycin-resistant organisms seen in this study, ... Free with registration - Pediatric News - AccessMyLibrary.com

Inspire Provides Update on Cystic Fibrosis Program; Moving Forward to...  -  Jun 2, 2008
The interpretation of results for patients on inhaled tobramycin is complex, due to the small size of the trial and the logistics of intermittent inhaled ... businesswire.com

GlobeNewswire, Inc. - News Room  -  Jun 28, 2005
...and (2) tobramycin-resistant pseudomonas infections in clinical isolates from ... University of Washington) that are highly resistant to Tobramycin, ... primezone.com

Brand Names/Synonyms:
Tobramycin is also known by the following brand names and/or synonyms3'-Deoxykanamycin B; Aktob; CHEMBANK2411; Distobram; Gernebcin; NF 6; Nebcin; Nebramycin; Nebramycin 6; Nebramycin Factir 6; Nebramycin Factor 6; Nebramycin Vi; Obracin; Obramycin; T4014; TOBRAMYCIN; Tenebrimycin; Tenemycin; Tobi; Tobracin; Tobradex; Tobradistin; Tobramaxin; Tobramitsetin; Tobramycetin; Tobramycin 98%; Tobramycin Base; Tobramycin Sulfate; Tobrasone; Tobrex

Drug Category:
Tobramycin is categorized under the following by the FDA: Anti-bacterial Agents; Aminoglycosides; ATC:J01GB01; ATC:S01AA12

Dosage Forms:
Ophthalmic Ointment; POWDER FOR SOLUTION; Solution for oral inhalation; Ophthalmic Solution; Oral Solution; IV Solution

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
4-amino-2-[4,6-diamino-3-[3-amino-6-(aminomethyl)-5-hydroxy-tetrahydropyran-2-yl]oxy-2-hydroxy-cyclohexoxy]-6-(hydroxymethyl)tetrahydropyran-3,5-diol





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