Tolbutamide

This page contains recent news articles, when available, and an overview of Tolbutamide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Tolbutamide
(when available)

Pharmacology and use:
Tolbutamide, a second-generation sulfonylurea antidiabetic agent, is used with diet to lower blood glucose levels in patients with diabetes mellitus type II. Tolbutamide is twice as potent as the related second-generation agent glipizide. For the management of hyperglycemia in non-insulin-dependent diabetes mellitus (NIDDM)

Mechanism Of Action:
Sulfonylureas likely bind to ATP-sensitive potassium-channel receptors on the pancreatic cell surface, reducing potassium conductance and causing depolarization of the membrane. Depolarization stimulates calcium ion influx through voltage-sensitive calcium channels, raising intracellular concentrations of calcium ions, which induces the secretion, or exocytosis, of insulin.

News Articles on Tolbutamide

常用的糖尿病藥物與心衰竭有關  -  ‎Dec 10, 2009‎
...研究中探討的第1代磺醯尿素類藥物包括:acetohexamide (商å“?å??Dymelor)ã€?chlorpropamide (商å“?å??Diabinese)ã€?tolbutamide以å?Štolazamide (商å“?å??Tolinase)。 ... 臺灣新浪網

Learn about Tolbutamide from Consumer Reports Health.  -  Jan 5, 2007
Tolbutamide is used to treat type 2 diabetes (condition in which the body does not use insulin normally and therefore cannot control the amount of sugar in ... consumerreports.org

tolbutamide (drug) -- Britannica Online Encyclopedia  -  Jun 5, 2008
Britannica online encyclopedia article on tolbutamide (drug), drug used in the treatment of type II (non-insulin-dependent) diabetes. Subscription - Encyclopedia Britannica

tolbutamide | Definition of tolbutamide | HighBeam.com: Online...  -  Jul 12, 2006
Find out what tolbutamide means: The Oxford American College Dictionary has the definition of tolbutamide. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Diabetes drugs have a dark history .  -  Jun 21, 2007
Patients taking the oral diabetes medication tolbutamide had a higher rate of cardiovascular death than patients on placebo or insulin. ... Tuscaloosa News - Google News Archive

Illinois Administrative Code - 77 Ill. Adm. Code 790.9060 TOLBUTAMIDE...  -  Aug 10, 2005
77 Ill. Adm. Code 790.9060 TOLBUTAMIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Cytochrome P450 2C9 *2 and *3 Polymorphisms and the Dose and Effect …  -  Dec 31, 2006
In CYP2C9*3 allele carriers using tolbutamide, the prescribed dose was lower ... No differences in the prescribed dose were found in tolbutamide users with ... Nature.com

Box 2 : A real-time method of imaging glucose uptake in single,...  -  Mar 29, 2007
Prepare tolbutamide in KRB by dissolving 1 M stock solution of tolbutamide (in DMSO) into KRB containing 2.8 mM glucose in a manner similar to that depicted ... Nature.com

Diabetes; New findings from Belgium and the United States in the area...  -  May 17, 2006
Study 1: Glucose potentiation of arginine- or tolbutamide-induced insulin ... Between G7 and G15, the effect of tolbutamide on [Ca2+]i increased only ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

CYP2C9, but not CYP2C19, polymorphisms affect the pharmacokinetics …  -  Apr 4, 2005
The role of the CYP2C9-Leu359 allelic variant in the tolbutamide ... CYP2C19 participates in tolbutamide hydroxylation by human liver microsomes. ... Nature.com

Validation of incorporating flurbiprofen into the Pittsburgh cocktail...  -  Jan 26, 2006
A number of drugs including tolbutamide, phenytoin, warfarin, and losartan ... In addition, the use of tolbutamide requires glucose monitoring or a highly ... Nature.com

Sulfonylurea improves CNS function in a case of intermediate DEND …  -  Apr 16, 2007
Tolbutamide (0.5 mmol/l; dark blue bars) potently blocks mutant K ATP channels, ... When tolbutamide causes a block of this magnitude, patients carrying the ... Nature.com

United States Code of Federal Regulations - 21 CFR § 310.517 Labeling...  -  Jul 11, 2006
Although only one drug in the sulfonylurea class (tolbutamide) was included in this study, it is prudent from a safety standpoint to consider that this ... Pay-Per-View - United States Code of Federal Regulation... - Loislaw

Antidiabetic Agents, Sulfonylurea (Systemic).  -  Aug 1, 2006
Chlorpropamide and tolbutamide pass into human breast milk and glimepiride passes into the milk of rats. Chlorpropamide is not recommended in nursing ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Oral Agent Combination Therapy  -  Jun 14, 2005
...[4] Another early example of such an approach is seen with the additive effect of acarbose plus tolbutamide. [5] Other approaches that have been shown ... Medscape

Antidiabetic Agents, Sulfonylurea (Systemic).(Disease/Disorder...  -  May 1, 2006
Chlorpropamide and tolbutamide pass into human breast milk and glimepiride passes into the milk of rats. Chlorpropamide is not recommended in nursing ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Endocrinology; Some mutations of K-ATP are responsive to diazoxide …  -  Apr 11, 2005
This included positive AIR to both tolbutamide and leucine in diffuse HI cases or positive AIR to leucine in focal HI cases," the researchers wrote. ... Pay-Per-View - Obesity & Diabetes Week - Factiva, from Dow Jones

A Primer on New Drug Options.(Report)  -  Nov 1, 2007
Then, in the 1950s, the introduction of tolbutamide (a sulfonylurea) and phenformin (a biguanide) offered options for oral treatment of type 2 diabetes.1,2 ... $4.95 - Consultant - ECNext

Endocrinology; Some mutations of K-ATP are responsive to diazoxide …  -  Apr 16, 2005
This included positive AIR to both tolbutamide and leucine in diffuse HI cases or positive AIR to leucine in focal HI cases," the researchers wrote. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Kir6.2 mutations causing neonatal diabetes provide new insights into...  -  Jun 16, 2005
The bars indicate azide and tolbutamide (tolb) application. (B) Mean steady-state whole-cell currents evoked by a voltage step from -10 to -30 mV before ... Nature.com

Diabetes Therapy; Short-term sulfonylurea therapy is safe for...  -  Sep 19, 2006
The response of mutant KATP channels to the sulfonylurea tolbutamide was assayed ... Investigators observed, "The extent of the tolbutamide blockade of KATP ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Diabetes drugs have a dark history  -  Jun 18, 2007
Patients taking the oral diabetes medication tolbutamide (Orinase) had a higher rate of cardiovascular death than patients on placebo or insulin. ... $3.50 - Press Telegram - NewsBank

A novel leptin signalling pathway via PTEN inhibition in hypothalamic...  -  May 4, 2006
The action of leptin on -cell membrane potential was determined in the presence of (A) 100 M tolbutamide, (B) 100 nM jasplakinolide and (C) 100 nM ... Nature.com

Endocrine Function and Glucose Metabolism in Patients with Parkinson's...  -  Dec 1, 2005
Glucose decay constants and insulin secretion following the iv glucose and tolbutamide were not changed. The oral glucose tolerance was modified in that ... Journal of Clinical Endocrinology and...

Nonautonomous Function of a Pancreatic Insulinoma  -  Jul 1, 2007
The patient displayed exaggerated plasma insulin responses following oral glucose (peak response: 447 µxU/ml at 30 min) and following 1 gm of iv tolbutamide ... Journal of Clinical Endocrinology and...

Gymnema sylvestre for the treatment of diabetes--how sweet it isn't.  -  Mar 1, 2005
The diabetic patients in the tolbutamide treatment arm also showed significant reductions in both FBS and PPBS at day 7, but not at day 14. ... Free with registration - Alternative Medicine Alert - AccessMyLibrary.com

White flour contains diabetes-causing contaminant alloxan  -  Jun 2, 2005
When fed garlic, the rabbits' elevated blood sugar dropped almost as much as it did when they were given the antidiabetic drug tolbutamide. ... Natural News.com

Drug Restores Insulin Secretion for Rare Type 1 Cases  -  Aug 3, 2006
In addition, the in vitro studies showed that the sulfonylurea tolbutamide blocked the ATP-sensitive potassium channels in a manner similar to that seen in ... MedPage Today

Kinetics-Effect Relations of Insulin-Releasing Drugs in Patients With...  -  Jan 23, 2005
The first-generation sulfonylureas (left side) (eg, tolbutamide and chlorpropamide) have a straight aliphatic side- chain (butyl- and propyl-, ... RedOrbit

Impact of Infectious and Inflammatory Disease on Cytochrome P450– …  -  Nov 18, 2008
9 This may be an enzyme-selective regulation because, in a recent small study, cancer was found to have no effect on tolbutamide (CYP2C9) clearance. ... Nature.com

The Hormonal Phenotype of Nonclassic 3{beta}-Hydroxysteroid …  -  Jan 1, 2006
The insulin sensitivity index determined by the frequently sampled iv glucose-tolbutamide test (FSIVGTT) in all HF with HSD3B phenotype and in all HF with ... Journal of Clinical Endocrinology and...

Effects of Exenatide (Exendin-4) on Glycemic Control Over 30 Weeks in...  -  May 8, 2005
...or 1500 mg/day tolbutamide) or to minimum recommended dose (MIN group; ... mg/ day chlorpropamide, 100 mg/day tolazamide, or 250 mg/day tolbutamide). ... RedOrbit

Pruritus (PDQ®)  -  Aug 14, 2008
Drugs associated with secondary pruritus include opium derivatives (cocaine, morphine, butorphanol), phenothiazines, tolbutamide, erythromycin estolate, ... WebMD

Post-MI mortality dip bigger with new sulfonylureas.(myocardial...  -  Nov 1, 2006
For the individual older agents, mortality was 61.7% in the 877 glibenclamide patients, 61.5% of the 436 tolbutamide patients, and 60.9% of the 412 who had ... Free with registration - Family Practice News - AccessMyLibrary.com

Figure 2 : Dual role of proapoptotic BAD in insulin secretion and...  -  Jan 27, 2008
...(d) Insulin release in response to 10 mM -ketoisocaproic acid (KIC), 0.25 mM tolbutamide or 0.25 mM carbachol, as measured by static incubation method. ... Nature.com

Sciscapeæ–°è?ž[Mar 19, 2007]: å?ƒæˆ–ä¸?å?ƒï¼Ÿå¤§æœ‰å­¸å•?  -  Mar 19, 2007
...為了證明這個想法,他們進一步�注鉀離�通�抑制劑�tolbutamide到�鼠腦部後,當鉀 離�通��到阻斷後,這些Pten基因剔除�鼠的�度進食情形��發生,其體�也有 ... 科景网

Botanical options for diabetes: research points to the usefulness of...  -  Oct 1, 2007
In a double-blind, randomized study comparing Pterocarpus marsupium with the popular diabetes drug tolbutamide, 365 newly-diagnosed or untreated NIDDM ... Free with registration - Nutraceuticals World - AccessMyLibrary.com

The impact of early nutrition in premature infants on later childhood...  -  Nov 1, 2006
Glucose metabolic data were obtained using a modified intravenous glucose tolerance test with tolbutamide and Bergman's Minimal Model as described ... $4.95 - Pediatrics - ECNext

In the News; Heart failure risk prompts warning labels on diabetes...  -  Aug 1, 2007
Drugs in this class include glimepiride (Amaryl), glipizide (Glucotrol), glyburide (Diabeta, Glynase, Micronase), and tolbutamide (Orinase). ... Free with registration - Harvard Women's Health Watch - AccessMyLibrary.com

New research poses dilemma for treating diabetes  -  Jun 30, 2008
This study was the most ambitious diabetes trial at the time, but patients who received the oral diabetes medication tolbutamide (Orinase) had a higher rate ... $3.50 - Press Telegram - NewsBank

Botanical options for diabetes: research points to the usefulness of...  -  Oct 1, 2007
In a double-blind, randomized study comparing Pterocarpus marsupium with the popular diabetes drug tolbutamide, 365 newly-diagnosed or untreated NIDDM ... $4.95 - Nutraceuticals World - ECNext

Article - Bulletin d'information toxicologique - Centre de toxicologie...  -  Jun 19, 2006
...(1993) rapportent le cas d'un patient suicidaire ayant ingéré une grande quantité de tolbutamide, chez lequel le traitement initial avec du dextrose s'est ... INSPQ

Longitudinal Changes in Body Fat in African American and Caucasian …  -  Jul 1, 2008
...and acute insulin response (AIR) from the tolbutamide-modified frequent sampling iv glucose tolerance test and for determination of body composition by ... Journal of Clinical Endocrinology and...

Sweet, sweet herb  -  Jul 31, 2005
Potentaition of tolbutamide action by jasad bhasma and karela (Momordica charantia). Indian J Med. Res. 1962; 50:715-9. This article is courtesy of Himalaya ... Malaysia Star

Clinical characterisation of the multiple maternal hypomethylation …  -  Aug 17, 2007
At 4 years and 6 months of age, insulin was successfully substituted with an oral sulphonyl urea, which is still her medication (tolbutamide, 500 mg three ... Nature.com

How to take Chloramphenicol Injection from Consumer Reports Health.  -  Jan 2, 2008
...cyanocobalamin (vitamin B12); folic acid; iron supplements; certain oral medications for diabetes such as chlorpropamide (Diabinese) and tolbutamide; ... consumerreports.org

A gating mutation at the internal mouth of the Kir6.2 pore is...  -  Apr 29, 2005
...-30 mV before (white bars) and after application of 3 mM azide (black bars) and in the presence of 3 mM azide and 0.5 mM tolbutamide (tolb; grey bars). ... Nature.com

Cerasee cured my eczema (part II)  -  Jun 20, 2007
Alcohol-extracted charantin consists of mixed steroids and was found to be more potent than the oral hypoglycaemic agent tolbutamide in an animal study. ... Jamaica Gleaner

Changes in 24-h area-under-the-curve ghrelin values following diet- …  -  Mar 10, 2005
Blood was withdrawn for measurement of baseline blood samples, followed by a tolbutamide-modified frequently sampled intravenous glucose-tolerance test ... Nature.com

sulfonamide -- Britannica Online Encyclopedia  -  Jun 19, 2008
...and tolbutamide (qv), a hypoglycemic. Chlorothiazide and hydrochlorothiazide are effective both as diuretics and in reducing blood pressure. ... Subscription - Encyclopedia Britannica

In silico pharmacogenetics of warfarin metabolism  -  May 5, 2006
...(b) The effect of a Cyp2c isoform-specific inhibitor (tolbutamide) on the rate of formation of 7-hydroxywarfarin from R-warfarin (150 M) in mouse liver ... Nature.com

In silico pharmacogenetics of warfarin metabolism  -  May 5, 2006
...rate-limiting step in biotransformation of warfarin to its 7-hydroxylated metabolite was inhibited by tolbutamide, a Cyp2c isoform-specific substrate, ... Nature.com

Production of pancreatic hormone–expressing endocrine cells from …  -  Oct 19, 2006
TOL, tolbutamide; BAY, (–)-BAY K8644; MP, methylpyruvate; L+G, L-leucine plus L-glutamine. (c,d) The C-peptide release in response to KCl and methylpyruvate ... Nature.com

ICER induced by hyperglycemia represses the expression of genes …  -  Feb 23, 2006
...(B) The cells were cultured for 2 days at 2 mM glucose in the presence or absence of 100 M Tolbutamide (Tolbut) or at 20 mM glucose with or without 200 M ... Nature.com

Article: Deadly Incident On River Recounted. - Hartford Courant...  -  Jul 10, 2007
Tolbutamide and Insulin) and the second taking Life-Star(TM) only and a third group taking ... The Topeka Capital-Journal. Article: Life Star copter makes ... Pay-Per-View - Hartford Courant - HighBeam Research

Top 5 skin diagnoses vary by ethnicity in study.(Skin Disorders) |...  -  Jan 1, 2008
Family Practice News; February 15, 2001 ; 700+ words ... ... sulfonylurea drugs such as tolbutamide and chlorpropamide, said researchers Dr. Oded Langer of ... Pay-Per-View - Family Practice News - HighBeam Research

NU IN DE WINKEL  -  Dec 1, 2008
...volgende tekst: 'Bloedsuikerspiegelverlagende middelen: voorbeelden zijn Tolbutamide en Metformine. Je dient op te passen met lage bloedsuikerspiegels. ... Duiken

Tanner Staging of Secondary Sexual Characteristics and Body …  -  May 7, 2005
Goran and Gower (8), in a longitudinal study using the tolbutamide-modified intravenous glucose tolerance test and a combined staging of secondary sexual ... Nature.com

Meest gestelde vragen en antwoorden over het Preferentiebeleid  -  Jun 10, 2008
Mirtazapine, Ondansetron, Paroxetine, Perindopril, Quinapril, Ramipril, Ranitidine, Risperidon, Sertraline, Sumatriptan, Tamsulosine en Tolbutamide. ... Medical facts

H is for Hypo  -  May 31, 2007
The first-generation sulfonylureas include Dymelor (acetohexamide), Diabinese (chlorpropamide), Orinase (tolbutamide), Tolinase (tolazamide). ... HealthCentral.com

Widely Used Diabetes Drug May Not Work  -  Oct 20, 2006
...in combination with another class of drugs called sulfonylureas, which include medications such as tolbutamide, glipizide and glimepiride, among others. ... HealthCentral.com

Sulfonylureas :: Diabetes Self-Management  -  Jun 16, 2006
The first-generation sulfonylureas, which have been around for many years, are tolbutamide, tolazamide (brand name Tolinase), and chlorpropamide (Diabinese) ... Diabetes Self Management

Mortality risk increases with exposure to sulfonylurea  -  Jan 18, 2006
...were then divided according to the drug they were prescribed metformin, glyburide, or first-generation sulfonylureas (chlorpropamide or tolbutamide). ... Medscape

The Exon 1 Cys7Gly Polymorphism Within the Betacellulin Gene Is …  -  Apr 13, 2005
The activin A/betacellulin-treated cells also increase insulin secretion when stimulated with tolbutamide, potassium chloride, and glucagon-like peptide 1. ... RedOrbit

Do sulfonylurea drugs increase the risk of cardiac events?( …  -  Jan 17, 2006
...(10) Like glyburide, tolbutamide blocks increases in blood flow induced by diazoxide, a vasodilator whose effects are mediated through the opening of ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

Independent Nurse: Clinical - Prescribing - Oral therapy options for...  -  Sep 30, 2005
...if necessary) and tolbutamide, and newer generation sulphonylureas, such as glimepiride and glipizide, which are reputed to reduce hypoglycaemia risk. ... Free with registration - GP - AccessMyLibrary.com

Shin Nippon Biomedical Laboratories Obtains New Knowledge on Drug- …  -  May 9, 2006
...under the title "CYP2C76, a novel CYP in cynomolgus monkey, is a major CYP2C in liver, metabolizing tolbutamide and testosterone". ... japancorp.net

Side Effects. Side effects include:  -  Jul 15, 2006
A number of brands are available, including chlorpropamide (Diabinese), tolazamide (Tolinase), acetohexamide (Dymelor), glipizide (Glucotrol), tolbutamide ... HealthCentral.com

Diabetes Can Be Managed, Healthy Lifestyle Best Prescription  -  Dec 29, 2006
The first drug in this class was a drug manufactured by the Upjohn Company called Orinase (tolbutamide). Subsequently, newer drugs with a variety of ... Alameda Sun

How to take Zafirlukast from Consumer Reports Health.  -  Jan 1, 2007
...cyclosporine (Neoral, Sandimmune); erythromycin (EES, Erythrocin); phenytoin (Dilantin); theophylline (Theo-Dur, others); and tolbutamide. ... consumerreports.org

Chloramphenicol (Otic).  -  Jul 28, 2005
Chloramphenicol may increase the blood levels of these medications: alfentanil, chlorpropamide, phenobarbital, phenytoin, tolbutamide, and warfarin. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Oral Medicines for Type 2 Diabetes  -  Jul 18, 2006
...tolazamide (Tolinase), and tolbutamide (Orinase)—works most successfully in those who have recently been diagnosed with Type 2 diabetes. ... Diabetes Self Management

Sulfonylureas Linked to Heart Deaths  -  Jan 31, 2006
This study found a higher rate of cardiovascular death in patients taking Orinase (tolbutamide) compared with placebo. However, subsequent evidence has been ... Diabetes In Control

Outcome Studies in Type 2 Diabetes  -  May 11, 2005
Five groups of patients were studied: diet plus placebo, standard insulin doses, variable insulin doses, tolbutamide and phenformin. ... RedOrbit

Antiadrenal Ketoconazole Antifungal, systemic Fluconazole Itraconazole...  -  Aug 1, 2006
Diabinese], glipizide [eg, Glucotrol], glyburide [eg, DiaBeta, Micronase], tolbutamide [eg, Orinase]) -- May cause hypoglycemia (low blood sugar). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Sulfonylureas can replace insulin use in permanent neonatal diabetes.  -  Nov 1, 2006
...gliclazide [not available in the United States] in 2, tolbutamide in 1, and glimepiride in 1) with the goal of either achieving insulin independence or ... Free with registration - Pediatric News - AccessMyLibrary.com

St. John's Wort (Hypericum perforatum)  -  Jun 23, 2005
St. John's wort has been shown to decrease the blood concentrations of omeprazole and affect the levels of tolbutamide, caffeine, dextromethorphan, ... Intelihealth.com

FLUOROQUINOLONE (Oral route, Injection route, Intravenous route).( …  -  May 1, 2007
Tolbutamide * Trifluoperazine * Triflupromazine * Trimeprazine * Trimethoprim * Trimipramine * Troglitazone * Vasopressin * Warfarin * Ziprasidone ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Medical News: Alternative Medicine  -  Apr 5, 2006
...the cytochrome P450 probe drugs caffeine (CYP1A2), Orinase (tolbutamide, CYP2C9), dextromethorphan (CYP2D6), and Versed (hepatic and intestinal CYP3A). ... MedPage Today

Diabetes mellitus drugs in India  -  Nov 21, 2007
...a) First generation drugs like chlorpropamide and tolbutamide, which are not in use or preferred currently. b) Second generation drugs like Glibenclamide, ... pharmabiz.com

How to take Irbesartan from Consumer Reports Health.  -  Jan 5, 2007
Be sure to mention any of the following: diuretics ('water pills'), nifedipine (Adalat, Procardia), and tolbutamide (Orinase). ... consumerreports.org

Correlation of Hyperprolactinemia with Altered Plasma Insulin and …  -  Jun 1, 2007
Plasma glucose and insulin concentrations were measured during oral glucose and iv tolbutamide tolerance tests in nine women with hyperprolactinemia and the ... Journal of Clinical Endocrinology and...

Maintaining certification.(Readers React)(Letter to the editor)  -  Aug 3, 2007
Yet he may still be treating all diabetics with tolbutamide. If you really want to be legitimate, all diplomates must keep current with certification and no ... Free with registration - Medical Economics - AccessMyLibrary.com

Isopak announces spiral jet mill results  -  Aug 1, 2005
Drugs such as amphotericin, fluocinolone acetonide, medroxyprogesterone acetate, bishydroxycoumarin, nitrofurantoin, tolbutamide, and spironolactone have ... In-PharmaTechnologist.com

Progesterone, Pregnancy and the Augmented Plasma Insulin Response …  -  Jul 1, 2005
On days 5 and 6 plasma glucose concentrations during oral glucose and intravenous tolbutamide tolerance tests were unchanged, but plasma insulin responses ... Journal of Clinical Endocrinology and...

Independent Nurse: Support for reduction of sulphonylurea use.(Brief ...  -  Jan 27, 2006
...patients on sulphonylurea monotherapy, 120 patients on a first-generation drug (either chlorpropamide or tolbutamide) and 1537 patients on metformin. ... Free with registration - GP - AccessMyLibrary.com

Insulin secretion, insulin action and non-insulin-dependent glucose …  -  Jun 1, 2006
...an iv glucose tolerance test, with frequent blood sampling and tolbutamide administration to elicit a second insulin response was used to estimate ... Journal of Clinical Endocrinology and...

The -238 and -308 G->A Polymorphisms of the Tumor Necrosis Factor { …  -  Sep 1, 2007
All study participants underwent an iv glucose tolerance test with the addition of tolbutamide after 20 min. In addition, a number of biochemical and ... Journal of Clinical Endocrinology and...

Persistence of impaired insulin secretion in infant rhesus monkeys...  -  Oct 1, 2006
...was significantly reduced by approximately 50% in response to iv glucose, arginine, and tolbutamide when given at 3, 4, and 5 months of age. ... Journal of Clinical Endocrinology and...

University of Maryland obtains United States patent.(Brief article)  -  Oct 1, 2007
Ca-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. ... Free with registration - BIOTECH Patent News - AccessMyLibrary.com

Tyramine-Mediated Activation of Sympathetic Nerves Inhibits Insulin …  -  Aug 7, 2007
In that study, NE infusions impaired the insulin response to either glucose or tolbutamide (1). Later measurements of the plasma NE levels achieved during ... Journal of Clinical Endocrinology and...

New diabetic drug class shows promise  -  Mar 24, 2005
Commonly used sulfonylureas include short acting agent, Tolbutamide, intermediate acting agents, Gilpizide and Glicazide, and long acting agents, ... DrugResearcher.com

Antifungals, Azole (Systemic).(Drug overview)  -  May 1, 2006
Diabinese], glipizide [eg, Glucotrol], glyburide [eg, DiaBeta, Micronase], tolbutamide [eg, Orinase]) -- May cause hypoglycemia (low blood sugar). ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

In vitro evidences for glucosensing capacity and mechanisms in …  -  Jun 12, 2007
These agents were a competitor for glucose phosphorylation (15 mM mannose), SUR-1 effectors (500 µM tolbutamide or diazoxide), glycolytic intermediates (15 ... AJP-Regul Integr Comp Physiology...

Psychiatric Times. Sweet Sorrow: The Relationship Between Depression ...  -  Apr 1, 2005
...particularly if it includes insulin or sulfonylurea oral hypoglycemic medications (tolbutamide [Orinase], glipizide [Glucotrol], glyburide [Diabeta], ... Psychiatric Times

Risks of sulfonylurea drugs in the treatment of diabetes mellitus...  -  Aug 28, 2006
Patients who were prescribed a sulfonylurea drug (chlorpropamide, tolbutamide or glyburide) experienced higher mortality rates than those who received ... Natural News.com

Divalproex sodium, Depakote, Depakene valproic acid (generic) (brand)...  -  Jun 1, 2005
...meropenem, ethosuximide (Zarontin), primidone (Mysoline), tolbutamide, phenytoin, amitriptyline/nortriptyline, warfarin (Coumadin), and zidovudine. ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Sun Herald : Photosensitive medicines listed  -  Aug 23, 2007
...chlorpropamide (Diabinese); glimepiride (Amaryl); glipizide (Glucotrol); glyburide (DiaBeta, Micronase); tolazamide (Tolinase); tolbutamide (Orinase). ... $2.95 - Sun Herald - NewsBank

WHO expert committee on specifications for pharmaceutical preparations...  -  Aug 1, 2005
171046 9930196 4,4'-thiodianiline 50mg 183116 thyroxine sodium see levothyroxine sodium 9930431 tolbutamide 100mg 179086 9930432 tolnaftate 100mg 176074 ... Free with registration - Technical Report Series - AccessMyLibrary.com

Diabetes mellitus: type 2.(Disease/Disorder overview)  -  May 24, 2006
Examples of this type of medicine are tolbutamide (Orinase), tolazamide (Tolinase), glyburide (DiaBeta, Glynase, Micronase), glipizide (Glucotrol), ... $4.95 - Clinical Reference Systems - ECNext

Diabetes Surgery; Researchers' data advance diabetes surgery research  -  Apr 4, 2005
...concentration of potassium, tolbutamide and a high concentration of glucose, and insulin secretion increased by 2.5-, 2.3- and 1.6-fotd, respectively." ... Pay-Per-View - Gastroenterology Week - Factiva, from Dow Jones

Brand Names/Synonyms:
Tolbutamide is also known by the following brand names and/or synonymsAglicid; Apo-Tolbutamide; Arkozal; Artosin; Artozin; BZ 55; Butamid; Butamide; D 860; Diaben; Diabetamid; Diabetol; Diabuton; Diasulfon; Dirastan; Dolipol; Drabet; Glyconon; HLS 831; Ipoglicone; Mobenol; Novo-Butamide; Orabet; Oralin; Orezan; Orinase; Orinase Diagnostic; Orinaz; Oterben; Pramidex; Rastinon; Restinon; Sk-Tolbutamide; Tolbusal; Tolbutamid; Tolbutamide; Tolbutamide.; Toluina; Tolumid; Toluvan; Tolylsulfonylbutylurea; U-2043; Willbutamide

Drug Category:
Tolbutamide is categorized under the following by the FDA: Hypoglycemic Agents; Sulfonylureas; ATC:A10BB03; ATC:V04CA01

Dosage Forms:
TABLET

Absorption:
Well absorbed, not affected by food consumption

Interactions:
Not Available



Chemical IUPAC Name:
3-butyl-1-(4-methylphenyl)sulfonyl-urea





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