Topiramate

This page contains recent news articles, when available, and an overview of Topiramate but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Topiramate
(when available)

Pharmacology and use:
Topiramate is an anticonvulsant indicated in the treatment of epilepsy and migraine. The precise mechanisms by which Topiramate exerts its anticonvulsant and migraine prophylaxis effects are unknown; however, preclinical studies have revealed four properties that may contribute to Topiramate's efficacy for epilepsy and migraine prophylaxis. Electrophysiological and biochemical evidence suggests that Topiramate, at pharmacologically relevant concentrations, blocks voltage-dependent sodium channels, augments the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABAA receptor, antagonizes the AMPA/kainate subtype of the glutamate receptor, and inhibits the carbonic anhydrase enzyme, particularly isozymes II and IV. Used for the treatment of partial or primary generalized tonic-clonic seizures also used as a treatment for adults with partial-onset seizures. Also indicated for prophylaxis of migraine headaches

Mechanism Of Action:
Topiramate most likely exerts its actions by four mechanisms: (1) blockage of voltage-dependent sodium channels, (2) augmentation of the activity of the neurotransmitter gamma-aminobutyrate at some subtypes of the GABAA receptor, (3) antagonism of the AMPA/kainate subtype of the glutamate receptor, (4) inhibition of the carbonic anhydrase enzyme.

News Articles on Topiramate

Biotech's Race to Battle the Bulge  -  ‎Dec 28, 2009‎
But analysts worried that the topiramate component could cause central nervous system side effects and could limit the drug's potential for long-term use. ... Minyanville.com

Vigabatrin (Sabril®): A New Epilepsy Drug -- With Strings Attached  -  ‎Dec 31, 2009‎
...aware of each drug's idiosyncratic side effects, such as hyponatremia with oxcarbazepine, edema with pregabalin, and metabolic acidosis with topiramate. ... Medscape

Arena files for approval for weight loss drug  -  ‎Dec 22, 2009‎
Qnexa combines relatively low doses of the generic stimulant phentermine with the epilepsy drug topiramate, sold under the brand name Topamax. ... Reuters

Brittany Murphy: Why did she need all those prescription drugs?  -  ‎Dec 22, 2009‎
Topamax (topiramate: for treatment of seizures and occasionally for prevention of migraine), methylprednisolone (a corticosteroid: for suppressing ... Telegraph.co.uk (blog)

Pharmacotherapy for borderline personality disorder: Cochrane systematic ...  -  ‎Dec 31, 2009‎
Most beneficial effects were found for the mood stabilisers topiramate, lamotrigine and valproate semisodium, and the second-generation antipsychotics ... British Journal of Psychiatry

Teva UK launches generic co-beneldopa capsules  -  ‎Dec 22, 2009‎
It comes hot on the heels of diamorphine hydrochloride powder for injection, oxcarbazepine tablets and topiramate tablets which were added to our product ... Trading Markets (press release)

Pharmaceutical industry financial performance  -  ‎Dec 11, 2009‎
Lilly), montelukast (Singulair; Merck), clopidogrel (Plavix; Bristol–Myers Squibb/Sanofi–Aventis), valsartan (Diovan; Novartis) and topiramate (Topamax; ... Nature.com (subscription)

Antiepileptic Medications May Be Risk Factors for Premenstrual Dysphoria ...  -  ‎Dec 10, 2009‎
Of the patients, 14 were on carbamazepine, 20 on lamotrigine, 8 on levetiracetam, and 1 on topiramate; the researchers also examined 16 normal control ... DG News

Teva Launches Co-Beneldopa (Levodopa/Benserazide)  -  ‎Dec 18, 2009‎
It comes hot on the heels of diamorphine hydrochloride (HCL) powder for injection, oxcarbazepine tablets and topiramate tablets which were added to our ... PharmaLive.com (press release)

2010ë…„ 8ê°œ 블ë¡?버스터 신약 출시  -  ‎Dec 29, 2009‎
...비버스(Vivus)ì?˜ 항비만제 í??넥사(phentermine+topiramate)는 펜터민ì?„ 통해 ì‹?ìš•ì?„ 억제하고 복합 간질약 토피ë?¼ë©”ì?´íŠ¸ê°€ 만족ê°?ì?„ 줌으로ì?¨ 작용한다. ... 디지틀보사

Myopie, hypermétropie et troubles de l'accommodation d'origine médicamenteuse  -  ‎Dec 30, 2009‎
...semblent liées à des modifications de l'hydratation de diverses structures de l'œil (notamment avec les sulfamides, les diurétiques, le topiramate). Vie Femme

Le Qnexa et le Lorcaserin, médicaments pour la perte de poids, soumis à la FDA  -  ‎Dec 29, 2009‎
Ce médicament est une combinaison de phentermine (dérivé de l'amphétamine, utilisé pour réduire l'appétit) et de topiramate (Topamax, un antiépileptique). ... PsychoMédia

새로운 비만치료제, 美FDA 신약신청 제출  -  ‎Dec 23, 2009‎
...í??넥사는 간질약 토피ë?¼ë©”ì?´íЏ(topiramate)와 펜터민(phentermine) 복합제ì?´ê³  콘트ë?¼ë¸ŒëŠ” 항우울제ì?¸ '웰부트린(Wellbutrin)'ê³¼ 날트렉ì†?(naltrexone) 복합제ì?´ë‹¤. ... 데일리팜

Additional Data from the Qnexa Phase 3 Studies Presented at The Obesity ...  -  ‎Oct 29, 2009‎
This rate is considerably lower than the similar event rates reported in the Topamax® (topiramate) label. The label for Topamax for the prevention of ... Reuters

3 new prescription diet drugs may soon help obese  -  ‎Oct 21, 2009‎
It incorporates low doses of two previously approved prescription medications: the diet drug phentermine, and topiramate, which is used to treat epilepsy ... USA Today

Weighing In on a New Name  -  ‎Nov 10, 2009‎
The other drug in Qnexa is Johnson & Johnson's (JNJ:NYSE) topiramate, which is used to treat epilepsy and migraines. The true benefits in the resultant ... TheStreet.com (subscription)

Obesity drugs lumber toward marketplace  -  ‎Oct 28, 2009‎
Qnexa, made by Vivus Inc., is a combination of two drugs: phentermine and topiramate. In two Phase 3 studies of 3750 patients, the average weight loss was ... Los Angeles Times

Teen arrested after tagging stop sign  -  ‎Nov 3, 2009‎
Allison Powers of 61âÑ2 Hampshire Road was charged with tagging and illegal possession of a prescription drug (topiramate). Sgt. Michael Lahey said a ... Eagle Tribune

Cadila Healthcare gets USFDA nod for its Topiramate Capsules  -  ‎Oct 21, 2009‎
Topiramate drug is indicated as an initial monotherapy in patients 10 years old or older with partial onset or primary generalized tonic-clonic seizures. ... TopNews

Three new prescription diet drugs for the obese on FDA roadmap  -  ‎Oct 22, 2009‎
Qnexa from Vivus: Incorporates low doses of two previously approved prescription medications: phentermine, and topiramate. Phentermine reduces appetite ... ChattahBox

Three biotechs race for Holy Grail of drug development  -  ‎Oct 19, 2009‎
But Qnexa mixes phentermine and topiramate, a generic epilepsy drug which has been known to leave patients befuddled. And some doctors, writes Pollack, ... FierceBiotech

Two Old Drugs Make One New Diet Pill  -  ‎Oct 25, 2009‎
Patients taking a novel diet drug that combines the stimulant phentermine with the anticonvulsant topiramate lost an average of 37 pounds over a year with ... China dgshi News (blog)

Band-Aid Won't Stop Generic Bleeding at Johnson & Johnson  -  ‎Nov 11, 2009‎
...as demand for seizure medicine Topamax (topiramate) and Risperdal oral (risperidone), a treatment for schizophrenic and bipolar disorders, ... BNET

Sandoz introduces two new generic drugs  -  ‎Oct 20, 2009‎
According to the news source, the company has launched topiramate sprinkle capsules, a generic version of Johnson & Johnson's epilepsy drug Topamax Sprinkle ... Trading Markets (press release)

Personal Health The Many Ills of Peripheral Nerve Damage  -  ‎Oct 20, 2009‎
Many with neuropathic pain have benefited from drugs licensed for other uses, including antiseizure medications like gabapentin, topiramate (Topamax) and ... New York Times

New weight loss drugs on the horizon!  -  ‎Nov 7, 2009‎
Topiramate increases the sense of fullness. In two separate studies, the mean weight loss was 13.2% (30 pounds) and 14.7% (37 pounds) for patients who were ... Drumheller Mail

Anna Nicole Smith clown video released by LA Court  -  ‎Nov 3, 2009‎
...of prescription drugs in her body: topiramate, meprobamate, methocarbamol, clonazepam, diazepam (Valium), nordiazepam, lorazepam, and ciprofloxacin. ... Prime Writer News Network

Forecast Insight - Migraine - Generic incursion inhibits market growth ...  -  ‎Oct 23, 2009‎
Led by the seven triptan brands and Topamax´s (topiramate; Johnson & Johnson) continued uptake, seven major market migraine revenues grew strongly at an ... PR-Inside.com (Pressemitteilung)

No Clear Winner as Top Obesity Candidates Reveal Detailed Data  -  ‎Oct 26, 2009‎
Inc.'s Qnexa (phentermine/topiramate), while Orexigen Therapeutics Inc.'s Contrave (bupropion SR/naltrexone SR) came in at 4.2 percent to 5.2 percent. ... BioWorld Online

A Shopper's Guide To Use Of Generic Drugs  -  ‎Nov 2, 2009‎
The Medical Letter cites the following study: “Another retrospective cohort study found that generic substitution of topiramate (Topamax, and others) was ... Philadelphia Bulletin

HEALTH CARE AND MIGRAINES  -  ‎Oct 26, 2009‎
These include propranolol (Inderal®), timolol (Blocadren®), topiramate (Topamax®) and divalproex sodium (Depakote®). These have had many years of use and ... The Cypress Times

Cadila Healthcare extends gains on healthy Q2 numbers  -  ‎Oct 28, 2009‎
Cadila Healthcare had on 16 October 2009 received approval from US Food and Drug Administration (US FDA) for Topiramate capsules in multiple strengths. ... India Infoline.com

Glenmark Generics Europe announces the launch of its first Four Products for ...  -  ‎Oct 27, 2009‎
Of the four products Launched, Topiramate Tablets (25mg, 50mg, 100mg, 200mg) was Launched on September 24, 2009 which was Day 1 of patent expiry the UK ... Equity Bulls

Nieuw medicijn: Qnexa, belooft 15 % gewichtsverlies  -  ‎Nov 13, 2009‎
Qnexa bevat fentermine (phentermine), een eetlustremmer en topiramaat (topiramate) dat zorgt voor een voller gevoel. Vivus inc. gaat verder met de ... HotFrog (persbericht)

항비만제 개발 3파전…비버스 ì„ ë‘?  -  ‎Oct 20, 2009‎
...오렉시젠(Orexigen), 아레나(Arena) 등 3ê³³ì?´ ì ‘ì „ì?„ 벌ì?´ê³  있는 가운ë?°, 비버스ì?˜ 'í??넥사'(Qnexa, phentermine/ topiramate)ê°€ 가장 í?° 기대를 받고 있다. ... 디지틀보사

Warning over epilepsy drug topiramate linked to birth defects  -  Jul 21, 2008
The babies of women who take an epilepsy drug while pregnant are at increased risk of birth defects, scientists warn. By Rebecca Smith, Medical Editor ... Telegraph.co.uk

India's Cadila gets tentative FDA nod for anti-epileptic drug Topirama...  -  Jun 6, 2007
Cadila said the Topiramate tablets in the strengths of 25 mg, 50 mg, ... The permanent injunction keeps Mylan from selling Topiramate tablets and capsules ... Forbes

India's Lupin gets tentative FDA nod for topiramate  -  May 30, 2008
MUMBAI, May 30 (Reuters) - Indian drugmaker Lupin Ltd (LUPN.BO) said on Friday it had got tentative approval from the US Food and Drug Administration to ... Reuters

Efficacy and safety of topiramate in combination with metformin in...  -  Aug 3, 2005
To investigate the efficacy and safety of topiramate in obese subjects with type 2 diabetes treated with metformin. This was a multicenter, double-blind, ... Nature.com

Study: Migraine drug may help alcoholics  -  Oct 9, 2007
Unlike other drugs to treat alcoholism, topiramate, or Topamax, ... Researchers randomly assigned 183 to topiramate pills and 188 to placebo pills. ... USA Today

Topiramate | Life and style | BMJ Group  -  Nov 18, 2008
We don't know. There's only been one small study so far, which doesn't give us enough information to know for sure if topiramate works.[1] ... guardian.co.uk

Epilepsy Drug Holds Promise as Treatment for Alcoholism  -  Oct 10, 2007
The drug topiramate proved measurably better than a placebo at helping alcoholics ... The subjects, both male and female, received daily doses of topiramate ... Washington Post

What's the evidence for topiramate?  -  Dec 4, 2008
We don't know for certain which epilepsy drugs work best, or if they all work about the same. But there is reasonably good evidence that taking topiramate ... guardian.co.uk

Is the anticonvulsant topiramate beneficial in essential tremor?  -  Apr 5, 2006
Ondo WG et al. (2006) Topiramate in essential tremor: a double-blind, placebo-controlled trial. Neurology 66: 672–677 PubMed ... Nature.com

Topiramate—effective for chronic migraine?  -  Apr 23, 2007
Silberstein SD et al. (2007) Efficacy and safety of topiramate for the treatment of chronic migraine: a randomized, double-blind, placebo-controlled trial. ... Nature.com

Weight loss and metabolic effects of topiramate in overweight and...  -  Feb 10, 2006
Correspondence: Professor B Eliasson, Lundberg Laboratory for Diabetes Research, Sahlgrenska University Hospital, Göteborg University, SE-413 45 Göteborg, ... Nature.com

Alcohol craving reduced by drugs  -  Jun 9, 2008
US researchers say that epilepsy drug topiramate boosts general health as well as ... A UK specialist said the potential side-effects of topiramate still ... BBC News

Topiramate (Topamax): Dosage, Side Effects, and Interactions  -  Oct 29, 2007
Topiramate is taken several times each day. Topiramate comes in tablets and capsules, which can be opened and sprinkled on food. ... WebMD

Focus on Topiramate in Neuropathic Pain  -  Feb 26, 2005
Topiramate is a drug that has shown efficacy in the treatment of epilepsy. A survey of MEDLINE, EMBASE and the American Academy of Neurology Abstracts ... RedOrbit

… should patients with migraine continue to receive prophylactic...  -  Dec 11, 2007
To compare the effects of discontinuation of topiramate therapy after 6 months with ... The Prolonged Migraine Prevention with Topiramate (PROMPT) study was ... Nature.com

Mylan Laboratories (MYL) Receives Final FDA Approval for Topiramate …  -  Sep 12, 2006
Topiramate Tablets are the generic version of Ortho-McNeil's Topamax Tablets, which had US sales of approximately $1.37 billion for the three strengths ... StreetInsider.com - StreetInsider.com (subscription)

Ortho-McNeil Pharmaceutical, Inc. v. Mylan Laboratories, Inc., No....  -  Mar 31, 2008
The '006 patent claims the anticonvulsive drug topiramate. ... Topiramate is a reaction intermediate in the synthesis Dr. Maryanoff ran as part of his ... $2.95 - U.S. Court of Appeals, Federal Circuit - VersusLaw

Breaking the drug habit 1 therapeutic pill at a time: U.Va. researcher...  -  Mar 31, 2007
The drugs are topiramate and ondanse- tron. Johnson, whose specialty is ... Topiramate already is approved as a treatment for seizures and migraine ... Free with registration - Richmond Times - Dispatch - AccessMyLibrary.com

Topiramate Linked With Increased Risk for Nephrolithiasis  -  Nov 10, 2006
November 10, 2006 — Treatment with the antimigraine agent topiramate ( Topamax, Ortho-McNeil) caused metabolic changes favoring the formation of calcium ... Medscape

Topiramate for weight reduction in olanzapine-treated women.(What's …  -  Aug 1, 2005
Findings from a new study suggest that topiramate is safe and effective in treating weight gain in women during olanzapine therapy. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Inside Drugmakers' War on Fat  -  Mar 6, 2008
In 2003, after a scientist presented J&J's data on topiramate at the conference of the North American Association for the Study of Obesity, McAfee spoke up. ... BusinessWeek

Study finds Topamax/kidney-stone link  -  Oct 31, 2006
Known by the chemical name topiramate, the widely prescribed neurological ... "The wide-spread and escalating use of topiramate emphasizes the importance of ... United Press International

Topiramate (generic): Topamax (brand).(YOUR MEDICATION …  -  Oct 1, 2005
COMMON USAGE: Topiramate is indicated as adjunctive therapy for the treatment of adults and children ages 2 to 16 with partial onset seizures, ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Study: New Diet Drug Shows Promise  -  Dec 12, 2008
Qnexa is a combination of phentermine – half of the recalled fen-phen diet pill – and the epilepsy drug topiramate, which is marketed under Topamax. ... FOXNews

Topiramate (Systemic).(Drug overview)  -  Aug 1, 2006
Topiramate (toe-PYRE-a-mate) is used to help control some types of seizures in the treatment of epilepsy. This medicine cannot cure epilepsy and will only ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Topiramate Treatment in Alcohol-Dependent Patients  -  Aug 1, 2005
Topiramate (Topamax) has been shown to be effective in reducing alcohol cravings, decreasing heavy drinking, and improving abstinence rates in patients who ... AAFP News Now

Fears over child epilepsy drugs  -  Jun 10, 2007
Professor Wong and his colleagues found three drugs in particular - lamotrigine, topiramate and levetiracetam - had seen a "massive" rise in prescribing. ... BBC News

Article: Antiseizure drug topiramate may help reduce binge eating.(Rx)...  -  Mar 1, 2005
Antiseizure drug topiramate may help reduce binge eating.(Rx)(Brief Article) ... find Internal Medicine News articles. Topiramate, approved in 1996 for ... Pay-Per-View - Internal Medicine News - HighBeam Research

Topiramate Appears Effective and Safe for Prevention of Chronic …  -  Sep 8, 2006
By Chris Berrie. GLASGOW, UK -- September 8, 2006 -- The new anticonvulsant topiramate is effective for the treatment of chronic migraine, ... DG News

Age, antiepileptics influence topiramate plasma levels.(WHAT'S NEW IN...  -  May 1, 2005
Younger age and treatment with concomitant antiepileptic drug enzyme inducers significantly increased the clearance of topiramate in children with epilepsy, ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

What treatments work?  -  Nov 18, 2008
A drug called topiramate also seems to help people with bulimia, but there isn't enough research to be sure. Combining cognitive behaviour therapy and ... guardian.co.uk

India's Glenmark gets tentative FDA nod for anti-epileptic drug Topira...  -  Jul 2, 2007
Topiramate tablets are part of the group's central nervous system segment ... The permanent injunction prevents Mylan from selling Topiramate tablets and ... ABCmoney.co.uk

Topiramate for borderline personality disorder.(What's New in...  -  Apr 1, 2006
This was a double-blind, placebo-controlled study of topiramate (Topamax) for borderline personality disorder (BPD) in women. ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

Topiramate may reduce frequency of binge eating.(Psychosomatic …  -  Mar 1, 2005
Topiramate may reduce frequency of binge eating.(Psychosomatic Medicine)(Brief Article) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Topiramate May Help Alcoholics Stop Drinking, Says Study  -  Nov 1, 2007
By Barbara Bittner. A new study that assesses the effectiveness of an antimigraine medication in treating alcohol dependence reports the drug shows promise ... AAFP News Now

Topiramate as Treatment for Alcohol Dependence  -  Jan 30, 2008
To the Editor: Dr Johnson and colleagues 1 reported the results of a randomized controlled trial of topiramate for treating alcohol dependence. ... Journal of American Medical Association - Journal of American Medical Association...

… drug reduces days of chronic headache.(Neurology)(topiramate)  -  Aug 1, 2006
Los ANGELES -- The anticonvulsant drug topiramate significantly eased chronic daily ... With this multicenter study, topiramate has demonstrated "the best ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Mitigating cognitive side effects associated with topiramate.(The Art...  -  Apr 1, 2005
This column offers a question-and-answer forum to help nurses maintain their knowledge of advances in prescribing and psychopharmacology, and implications ... $4.95 - Perspectives in Psychiatric Care - ECNext

Topiramate Effective Headache Prophylaxis in Chronic Migraineurs: …  -  May 2, 2006
By Jill Stein. VALENCIA, SPAIN -- May 2, 2006 -- New data suggest that patients who experience chronic migraine headaches, defined as at least 15 headache ... DG News

Topiramate Prophylaxis Effectiveness for Migraines Maintained for Up...  -  Aug 30, 2007
By Chris Berrie. BRUSSELS, BELGIUM -- August 30, 2007 -- Topiramate, an anticonvulsant, provides prophylactic efficacy along with the expected safety ... DG News

Topiramate lowers weight and blood pressure  -  Jul 28, 2005
NEW YORK (Reuters Health) - The antiseizure drug topiramate, sold under the trade name Topamax, reduces body weight and blood pressure in obese patients ... RedOrbit

Article: Topiramate prevented migraines in adolescents.(News) -...  -  Aug 15, 2008
Topiramate prevented migraines in adolescents.(News) ... find Family Practice News articles. BOSTON -- Topiramate is an effective, well-tolerated, ... Pay-Per-View - Family Practice News - HighBeam Research

Effects of topiramate on essential tremor of the voice, jaw, and...  -  Mar 1, 2006
The effects of topiramate were evaluated in a study of 18 patients with essential tremor of the voice, tongue, jaw, and upper limb. ... Free with registration - Journal of Medical Speech - Language... - AccessMyLibrary.com

Topiramate Monotherapy Appears to Offer Substantial Seizure Reduction...  -  Aug 27, 2007
By Chris Berrie. BRUSSELS, BELGIUM -- August 27, 2007 -- Topiramate, a broad-spectrum anticonvulsant, was well tolerated and associated with a substantial ... DG News

Early Results Show Topiramate May Be Effective in Posttraumatic...  -  Mar 22, 2005
By Bonnie Darves. SEATTLE, WA -- March 22, 2005 -- Topiramate might emerge as a viable therapeutic option for patients with posttraumatic stress disorder ... DG News

… malformation risk rose with use of topiramate.(Women's Health) |...  -  Sep 1, 2008
Congenital malformation risk rose with use of topiramate.(Women's Health) ... find Family Practice News articles. Topiramate is associated with a ... Pay-Per-View - Family Practice News - HighBeam Research

Topiramate vs. Placebo for Essential Tremor  -  Jul 15, 2006
Synopsis: In this study, 223 patients with essential tremor were randomly assigned to receive topiramate or matching placebo. The topiramate was initiated ... AAFP News Now

Can antiepileptic drugs unmask a susceptibility to psychiatric...  -  Nov 18, 2008
These agents include barbiturates, topiramate, levetiracetam and zonisamide. ... In a study of 491 consecutive patients treated with topiramate, ... Nature.com

A pilot controlled trial of topiramate for mania in children and...  -  Jun 1, 2005
Objective: To assess the efficacy of topiramate monotherapy for acute mania in children and adolescents with bipolar disorder type 1. ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

Article: Topiramate reduces drinking, increases abstinence.(Addiction...  -  Nov 1, 2007
Topiramate reduces drinking, increases abstinence.(Addiction psychiatry) ... find Clinical Psychiatry News articles. Topiramate may be a promising treatment ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Topiramate May Help People With Alcohol Dependence Quit Smoking  -  Feb 21, 2006
Smoking and alcohol dependence cause poor health, frequently co-occur, and can be difficult to treat simultaneously. A drug that can effectively treat both ... JoinTogether.org

Topiramate helpful for bulimia  -  Dec 28, 2005
By Anne Harding. NEW YORK (Reuters Health) - The drug topiramate, usually used as an anti-seizure treatment, can reduce bingeing and purging in women with ... RedOrbit

Drug Choices for Different Seizures Get Clarification  -  Mar 23, 2007
..."We see no reasons to prefer gabapentin or topiramate to the standard drug ... Valproate, they concluded, is better tolerated than topiramate and more ... MedPage Today

Topiramate Safe, Effective for Migraine Prophylaxis in Adolescents  -  Jul 10, 2008
July 10, 2008 (Boston, Massachusetts) — The first successful randomized controlled trial of migraine prevention in adolescents the United States has shown ... Medscape

Topiramate for migraine improves quality of life  -  Oct 13, 2005
By Megan Rauscher. NEW YORK (Reuters Health) - The anti-epileptic drug topiramate (Topamax) improves health-related quality of life when used to prevent ... RedOrbit

… Announces Final FDA Approval for Topiramate Tablets. - PR Newswire...  -  Sep 12, 2006
Mylan Announces Final FDA Approval for Topiramate Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Topiramate Could Become First-Line Treatment for Chronic Migraine …  -  Jun 29, 2007
By Thomas S. May. STOCKHOLM, SWEDEN -- June 29, 2007 -- The anticonvulsant drug topiramate is more effective than flunarizine, a calcium channel blocker, ... DG News

Topiramate Therapy During Pregnancy Raises Concerns Pregnant …  -  Jul 22, 2008
TUESDAY, July 22 (HealthDay News) -- The use of topiramate as monotherapy or as an adjunct to other treatment for epilepsy during pregnancy raises some ... ModernMedicine

European survey underscores migraine burden  -  Sep 21, 2005
This [topiramate] is the only preventive drug that leads to loss of weight or to weight being unchanged. All other preventive therapies lead to weight gain, ... Medical News Today - Medical News Today (press release)

Topiramate Treatment Fails to Surpass Placebo for Restless Legs …  -  Oct 11, 2006
By Ed Susman. CHICAGO, IL -- October 11, 2006 -- The anticonvulsant drug topiramate failed to distinguish itself from placebo in a study of patients with ... DG News

Treatment To Prevent Migraines Boosts Work Productivity  -  Mar 17, 2007
Treatment with topiramate had only a small effect on work absenteeism. ... Use of topiramate resulted in an increase of 9.5 hours of work productivity from ... Medical News Today - Medical News Today (press release)

Topiramate Helps Some Patients With SUNCT: Presented at IHS  -  Jul 1, 2007
By Thomas S. May. STOCKHOLM, SWEDEN -- July 1, 2007 -- The anticonvulsant drug topiramate effectively reduces the symptoms of short-lasting unilateral ... DG News

Study of Topiramate for Prophylaxis of Basilar-Type Migraine in...  -  Feb 4, 2008
Background. Basilar-type migraine (BM) is the most common migraine "variant," representing 3-19% of migraine in children.BMis characterized by attacks of ... Medscape

Consider low-dose topiramate for newly diagnosed epilepsy.( …  -  Mar 1, 2005
BRECKENRIDGE, COLO. -- Topiramate monotherapy at a target dosage of 100 mg/day--substantially less than conventional dosing--is at least as effective as ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

… : Lupin Receives USFDA Approval for Topiramate Tablets. - PR...  -  May 30, 2008
Lupin Receives USFDA Approval for Topiramate Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Vivus Starts Phase III Effort With Obesity Combo Qnexa  -  Nov 12, 2007
Topiramate (Topamax, Johnson & Johnson) prevents epilepsy and migraine but ... The once-per-day controlled-release topiramate reduced the peak plasma ... BioWorld Online - BioWorld Online

Topiramate Shows Promise in Addiction Fight  -  Jun 8, 2005
Topiramate, a drug used to treat epilepsy under the brand name Topamax, is being studied as a possible treatment for alcoholism, nicotine addiction, ... JoinTogether.org

I want to try topiramate  -  May 20, 2008
Hi. After 6 years on olanzapine/zyprexia I've gone from about 100lbs to 300lbs. I am currently on lithium as a mood stabiliser, but I still have real ... HealthCentral.com

Topiramate Reduces Seizure Frequency in Elderly Patients with...  -  Jun 22, 2007
By Thomas S. May. RHODES, GREECE -- June 22, 2007 -- Topiramate is well tolerated and effective in elderly patients with epilepsy, results of a prospective, ... DG News

Topiramate: an effective add-on treatment in obese, drug-naive...  -  Sep 1, 2007
In a randomized, placebo-controlled trial published in the journal Diabetes, Obesity, and Metabolism, topiramate was demonstrated to be an effective add-on ... $4.95 - Formulary - ECNext

Lupin Receives USFDA Approval For Topiramate Tablets  -  Jun 2, 2008
Lupin Pharmaceuticals has received tentative approval for the Company's Abbreviated New Drug Application (ANDA) for Topiramate tablets, 25 mg, 50 mg, ... emaxhealth.com

New Medications May Offer Hope to Drinkers Battling Alcohol …  -  Jul 17, 2008
Notably, these combined effects suggest that topiramate may decrease the risk of ... By decreasing liver enzymes and cholesterol levels, topiramate also may ... newswise.com

Teva Announces Tentative Approval of Topiramate Tablets, 50 mg.  -  Mar 6, 2006
JERUSALEM -- Teva Pharmaceutical Industries Ltd. (Nasdaq: TEVA) announced today that the US Food and Drug Administration has granted tentative approval for ... Free with registration - Business Wire - AccessMyLibrary.com

… Tentative FDA Approval for Topiramate Capsules. - PR Newswire | …  -  Sep 10, 2007
Mylan Announces Tentative FDA Approval for Topiramate Capsules. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Article: Topiramate aids basilar migraine in small study.(Clinical...  -  Aug 1, 2007
Topiramate aids basilar migraine in small study.(Clinical Rounds)(Clinical report) ... find Pediatric News articles. CHICAGO -- Topiramate reduced the ... Pay-Per-View - Pediatric News - HighBeam Research

… Rapid Seizure Freedom Than Topiramate or Lamotrigine: Presented at...  -  Dec 4, 2007
...with patients on lamotrigine and 54% more compared with patients on topiramate, ... 85 received topiramate (TPM); and 85 received lamotrigine (LTG). ... DG News

JAMA -- Topiramate for Treating Alcohol Dependence: A Randomized …  -  Oct 10, 2007
You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you ... Journal of American Medical Association - Journal of American Medical Association...

Tentative FDA OK for Mylan's topiramate.(Mylan Pharmaceuticals)(Brief...  -  Sep 17, 2007
Mylan Pharmaceuticals has received tentative approval from the US Food and Drug Administration for its Abbreviated New Drug Application for Topiramate ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

Acute mental status changes with topiramate.(LETTERS TO THE EDITOR …  -  Aug 1, 2005
Topiramate is a PDA-approved anticonvulsant agent used for the adjunctive ... Pediatric patients ages 4-17 years clear topiramate more rapidly than adults, ... Pay-Per-View - Journal of the American Academy of... - Factiva, from Dow Jones

STEPS - October 15, 2005 - - American Family Physician  -  Oct 15, 2005
Topiramate (Topamax) is an antiepileptic drug recently approved by the US Food and ... Clinical trials and experience with topiramate have not identified ... AAFP News Now

Scottish Medicines Consortium (SMC) Approves Topamax(R) For …  -  Sep 14, 2006
Topiramate in Migraine Prevention: Results of a Large Controlled Trial. Arch Neurol. ... Topiramate for Migraine Prevention: A randomised Controlled Trial. ... Medical News Today - Medical News Today (press release)

JournalWatch: Topiramate keeps working.  -  Dec 12, 2007
Patients who take the migraine prophylaxis drug topiramate for six months carry on receiving benefit after they stop, suggests new data. ... Free with registration - Pulse - AccessMyLibrary.com

… Medication Errors Between TOPAMAX(R) (topiramate) and TOPROL-XL( …  -  Oct 2, 2005
...potential for medication errors between its product, TOPAMAX(R) (topiramate) tablets and TOPROL-XL(R)* (metroprolol succinate) extended-release tablets. ... Medical News Today - Medical News Today (press release)

Topiramate for trichotillomania.(News Notes)(Brief article)  -  Nov 1, 2006
In an open-label pilot study of topiramate (Topamax) for treating trichotillomania, an impulse control disorder characterized by chronic hair-pulling, ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

FDA approved topiramate tablets and sprinkle capsules (Topamax, Ortho...  -  Aug 1, 2005
FDA approved topiramate tablets and sprinkle capsules (Topamax, Ortho-McNeil) as initial monotherapy in patients aged 10 years and older with partial-onset ... Free with registration - Formulary - AccessMyLibrary.com

Pediatric migraine frequency cut by topiramate.(Clinical Rounds) |...  -  Mar 1, 2007
Pediatric migraine frequency cut by topiramate.(Clinical Rounds) ... find Family Practice News articles. PITTSBURGH -- Topiramate appears to be a good ... Pay-Per-View - Family Practice News - HighBeam Research

Topiramate tried in sleep-related eating disorders.  -  Oct 15, 2006
SALT LAKE CITY -- Patients with sleep-related eating disorder may benefit from treatment with topiramate, data from a small study suggest. ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

Article: Topiramate may cut basilar migraine frequency.(Child/Adolesce...  -  Feb 1, 2008
Topiramate may cut basilar migraine frequency.(Child/Adolescent Psychiatry) ... find Clinical Psychiatry News articles. CHICAGO -- Topiramate reduced the ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Topiramate aids basilar migraine in small study.(Clinical Rounds)(Clin...  -  Aug 1, 2007
CHICAGO -- Topiramate reduced the frequency of basilar migraine by up to 75% in almost 90% of children who took the drug for migraine prevention, ... $4.95 - Pediatric News - ECNext

Article: Caution urged with topiramate, bupropion for weight loss.( …  -  May 1, 2005
Caution urged with topiramate, bupropion for weight loss.(Endocrinology) ... find Internal Medicine News articles. COLORADO SPRINGS -- By far, ... Pay-Per-View - Internal Medicine News - HighBeam Research

… of chronic headache.(Neurology)(topiramate) - Internal Medicine...  -  Aug 1, 2006
Neurology)(topiramate) ... find Internal Medicine News articles. Los ANGELES -- The anticonvulsant drug topiramate significantly eased chronic daily ... Pay-Per-View - Internal Medicine News - HighBeam Research

Clinical News: Topiramate useful in alcoholism?  -  Oct 13, 2007
Clinical News: Topiramate useful in alcoholism? The epilepsy and migraine treatment topiramate has emerged as a promising possible treatment for alcoholism ... $9.94 - Chemist & Druggist - Alacra Store

Article: Consider low-dose topiramate for newly diagnosed epilepsy.( …  -  Mar 1, 2005
Consider low-dose topiramate for newly diagnosed epilepsy.(Neuropsychiatric Medicine)(Brief Article) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Antiepileptic drugs and birth defects  -  Jul 22, 2008
Research into the drug topiramate, which is also used for people with ... Topiramate is used to treat epilepsy, either alone or in combination with other ... NHS Choices

Topiramate may help smokers quit.  -  Aug 6, 2005
Topiramate may help smokers quit. The antiepileptic drug topiramate has shown potential as a smoking cessation aid. US researchers randomised nearly 100 ... $9.94 - Chemist & Druggist - Alacra Store

A Pill to Cure Alcoholism?  -  Jun 13, 2008
Topiramate is currently approved by the Food and Drug Administration to treat seizures and migraine headaches. But doctors can prescribe it "off label" for ... U.S. News & World Report

Article: Topiramate could reduce pediatric migraine frequency.(Pain …  -  Mar 1, 2007
Topiramate could reduce pediatric migraine frequency.(Pain Medicine)(Clinical report) ... find Clinical Psychiatry News articles. Pay-Per-View - Clinical Psychiatry News - HighBeam Research

The Telegraph - Calcutta (Kolkata) | KnowHOW | Drug dilemma  -  Jul 28, 2008
A widely used anti epilepsy drug called topiramate raises the risk of birth ... Three of those were in mothers who had taken only topiramate and 13 in those ... Calcutta Telegraph

Diabetes Control; Topiramate treatment effects are exerted through …  -  Apr 18, 2005
According to JJ Wilkes and associates at the University of California San Diego, "We have studied the in vivo and in vitro effects of Topiramate (TPM) in ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Tentative FDA OK for Mylan's topiramate.(Mylan Pharmaceuticals)(Brief...  -  Sep 17, 2007
Mylan Pharmaceuticals has received tentative approval from the US Food and Drug Administration for its Abbreviated New Drug Application for Topiramate ... $4.95 - Pharma Marketletter - ECNext

Brand Names/Synonyms:
Topiramate is also known by the following brand names and/or synonymsCHEMBANK1823; Mcn-4853; Tipiramate [French]; Tipiramato [Spanish]; Topamax; Topamax Sprinkle; Topiramate; Topiramate [Usan:Ban:Inn]; Topiramato [Inn-Spanish]; Topiramatum [Inn-Latin]; Topiramatum [Latin]

Drug Category:
Topiramate is categorized under the following by the FDA: Antiobesity Agents; Neuroprotective Agents; Anticonvulsants; ATC:N03AX11

Dosage Forms:
CAPSULE; TABLET

Absorption:
Rapid with pleak plasma concentrations occurring after 2 hours. Bioavailability is 80%

Interactions:
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Chemical IUPAC Name:
2,3:4,5-Bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate





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