|
 |
TopotecanThis page contains recent news articles, when available, and an overview of Topotecan but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Topotecan (when available) Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug. For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy. Mechanism Of Action: Topotecan has the same mechanism of action as irinotecan. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. The cytotoxicity of topotecan is thought to be due to double strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I and DNA. Mammalian cells cannot efficiently repair these double strand breaks. News Articles on Topotecan Featured Clinical Trial: Defining Optimal Therapy for Metastatic and Recurrent ... - Dec 15, 2009 Phase III Randomized Study of Paclitaxel in Combination with Cisplatin or Topotecan Hydrochloride with Versus without Bevacizumab in Patients with Stage IVB ... NCI Cancer Bulletin NICE recommends topotecan for cervical cancer - Oct 29, 2009 Cancer drug topotecan will now be available on the NHS for the treatment of advanced or recurring cervical cancer. The National Institute for Health and ... Cancer Research UK NICE Recommends Topotecan For Cervical Cancer - Nov 3, 2009 The National Institute for Health and Clinical Excellence (NICE) has today (28 October) published final guidance recommending the use of topotecan in ... Medical News Today (press release) Amrubicin® and Paraplatin® Active and Tolerable in Elderly Patients with SCLC - Oct 22, 2009 ...[2] The first study compared Amrubicin to topotecan in patients with platinum-sensitive SCLC. The ORR was 44% in patients treated with Amrubicin compared ... Cancer Consultants Partial victory for Hycamtin after final 'yes' from NICE - Oct 28, 2009 The National Institute for Clinical Health and Excellence has pushed ahead with its decision to allow a mix of Hycamtin (topotecan) and the chemotherapy ... Pharma Times A phase III trial of topotecan and whole brain radiation therapy for... - Nov 25, 2008 Brain metastases represent an important cause of morbidity in patients with lung cancer and are associated with a mean survival of less than 6 months. ... Nature.com Topotecan (Systemic). - Feb 1, 2006 Topotecan (toe-poe-TEE-kan ) belongs to the group of medicines known as antineoplastics. It is used to treat cancer of the ovaries and certain types of lung ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Drug combo zaps childhood cancer - Jul 12, 2007 Then the potent cancer killer topotecan (Hycamtin) was administered. When the researchers administered topotecan to the tumor-bearing mice three days after ... United Press International The feasibility of using topotecan, vinorelbine, thiotepa and... - Feb 28, 2008 The success of haematopoietic stem cell transplantation depends upon the pretransplant leukaemic burden. 1 In relapsed or refractory acute leukaemia and ... Nature.com Glaxo wins US approval for lung cancer capsules - Oct 15, 2007 The drug, Hycamtin, also known as topotecan, was approved to treat patients who responded fully or in part to previous treatment with chemotherapy. ... Reuters OnMedica - News: Hycamtim (topotecan powder) has received positive … - Nov 25, 2005 We hope you have enjoyed your visit so far. We notice that you're not currently an onmedica.com member. Would you like to join? Tell me more... ... OnMedica Hana will license three cancer drugs for $11.5M - Mar 17, 2006 Vincristine, vinorelbine and topotecan are all approved chemotherapy drugs. Hana will test them in trials using sphingosomal delivery. ... Bizjournals.com Once-feared Thalidomide may treat ovarian cancer - Feb 27, 2008 In the latest study, Downs and his colleagues gave thalidomide and a standard chemotherapy drug (topotecan) to one group of 30 ovarian cancer patients, ... Houston Chronicle Addition of topotecan to standard treatment is not recommended for … - Aug 1, 2006 The drug topotecan does not increase survival for ovarian cancer patients when used with standard chemotherapy in first-line treatment and is not ... eurekalert.org … For Oral Formulation Of HYCAMTIN(R) (topotecan) To Treat Relapsed ... - Jun 13, 2007 GlaxoSmithKline (GSK) announced today that its new drug application (NDA) for ORAL HYCAMTIN(R) (topotecan) capsules, a treatment for relapsed small cell ... Medical News Today - Medical News Today (press release) … Commission Approves IV Hycamtin (Topotecan Powder for Concentrate ... - Feb 1, 2006 By Jill Stein. LONDON, UK -- February 1, 2006 -- The European Commission has approved Hycamtin® (topotecan powder for concentrate for solution for infusion) ... DG News GSK Receives Approval For HYCAMTIN(R) (topotecan) Capsules For The … - Oct 16, 2007 GlaxoSmithKline (NYSE: GSK) announced approval by the US Food and Drug Administration (FDA) for oral HYCAMTIN(R) (topotecan) capsules for the treatment of ... Medical News Today - Medical News Today (press release) Cancer Therapy; PEGylated liposomal topotecan has enhanced safety … - Dec 27, 2005 2005 DEC 27 - (NewsRx.com) -- The use of PEGylated liposomes for delivery improves the safety and efficacy of topotecan treatment in murine cancer models. ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Topotecan (Systemic).(Used to treat cancer)(Drug overview) - Aug 1, 2006 Topotecan (toe-poe-TEE-kan ) belongs to the group of medicines known as antineoplastics. It is used to treat cancer of the ovaries and certain types of lung ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Hycamtin Capsules Topotecan - Dec 1, 2007 Topotecan is a semisynthetic derivative of camptothecin; this antitumor agent acts as a topoisomerase I inhibitor, thus causing double-strand DNA damage ... Free with registration - Formulary - AccessMyLibrary.com … ; Flavonoid BCRP inhibitors don't affect topotecan pharmacokinetics... - Apr 26, 2005 ..."However, neither chrysin nor BF significantly altered topotecan pharmacokinetics in rats or in mdr1a/1b (-/-) mice after oral coadministration of doses up ... Pay-Per-View - Science Letter - Factiva, from Dow Jones … produced superior overall response rate compared with topotecan - Dec 25, 2008 Only 43% of patients assigned to topotecan developed grade-4 neutropenia and 3% developed febrile neutropenia. The researchers observed one ... HemOncToday … Resistance; Transient hypoxia augments tumor sensitivity to topotec... - Nov 29, 2005 ..."We examined how the effect of topotecan is modulated by transient hypoxia ... "Topotecan + hypoxia resulted in significantly greater suppression of tumor ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Topotecan Tops Best Supportive Care for Relapsed Small Cell Lung … - Sep 27, 2006 By Jill Stein. TURIN, ITALY -- September 27, 2006 -- The addition of oral topotecan (Hycamtin®) to best supportive care (BSC) significantly increases ... DG News Topotecan Combo No Extra Help in Ovarian Cancer - Jul 28, 2008 By David Douglas. NEW YORK JUL 28, 2008 (Reuters Health) - In women with recurrent ovarian cancer, treatment with topotecan along with etoposide or ... Cancerpage.com Drug topotecan shows promise against Wilms tumor - Aug 17, 2007 St. Jude researchers have shown that the drug topotecan holds promise as a treatment for the recurrent form of a kidney cancer called Wilms tumor, ... News-Medical.net … ; Flavonoid BCRP inhibitors don't affect topotecan pharmacokinetics... - Apr 29, 2005 ..."However, neither chrysin nor BF significantly altered topotecan pharmacokinetics in rats or in mdr1a/1b (-/-) mice after oral coadministration of doses up ... Pay-Per-View - Drug Week - Factiva, from Dow Jones … ; Ovarian cancer treated by prolonged topotecan infusion with... - Mar 28, 2006 Toxicity was observed in the first 4 patients treated with topotecan (.4 mg/m2/day ... Further studies investigating topotecan in combination with platinum ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones … Cancer Treatment; Effects of gemcitabine and topotecan in human... - Apr 22, 2005 2005 APR 22 - (NewsRx.com) -- Scientists studied the effects of gemcitabine and topotecan in human non-small cell lung cancer cells (NSCLC). ... Pay-Per-View - Drug Week - Factiva, from Dow Jones Thalidomide | Birth Defects | Ovarian Cancer | Gynecologic Oncology - Nov 23, 2008 The study compared the effectiveness and safety of the combination of thalidomide and topotecan, a chemotherapy often used for ovarian cancer, ... Oneindia Article: Thalidomide aids topotecan efficacy in ovarian ca.(News) -... - May 15, 2006 Thalidomide aids topotecan efficacy in ovarian ca.(News) ... find OB GYN News articles. PALM SPRINGS, CALIF. -- Combining thalidomide with topotecan for the ... Pay-Per-View - OB GYN News - HighBeam Research … Cancer Treatment; Effects of gemcitabine and topotecan in human... - Apr 18, 2005 2005 APR 18 - (NewsRx.com) -- Scientists studied the effects of gemcitabine and topotecan in human non-small cell lung cancer cells (NSCLC). ... Pay-Per-View - Clinical Oncology Week - Factiva, from Dow Jones GSK Receives Approval For Hycamtin® (topotecan) Capsules For The … - Oct 21, 2007 GlaxoSmithKline [NYSE: GSK] announced approval by the US Food and Drug Administration (FDA) for oral Hycamtin ® (topotecan) capsules for the treatment of ... Medical News Today - Medical News Today (press release) Celgene's Thalomid plus topotecan superior to topotecan alone. - Nov 14, 2005 US drugmaker Celgene Corp says that a Phase II randomized, multicenter clinical study of Thalomid (thalidomide) in treatment-naive recurrent epithelial ... Free with registration - Pharma Marketletter - AccessMyLibrary.com Addition Of Topotecan To Standard Treatment Is Not Recommended For … - Aug 4, 2006 The drug topotecan does not increase survival for ovarian cancer patients when used with standard chemotherapy in first-line treatment and is not ... Medical News Today - Medical News Today (press release) … Tweezers and Yeast Help St. Jude Show How Cancer Drug TOPOTECAN … - Jul 16, 2007 Using both a type of nanotechnology called magnetic tweezers as well as yeast cells, investigators showed that a camptothecin drug called topotecan kills ... Cancer Focus US FDA grants full approval to Doxil following submission of Phase... - Feb 7, 2005 A total of 239 patients received Doxil; 235 patients received topotecan HCl. The primary endpoint, time to disease progression after starting therapy, ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com Topotecan/cisplatin for late-stage cervical cancer.(Regulatory Action... - Mar 22, 2006 United States of America -- The Food and Drug Administration (FDA) has approved a combination of topotecan hydrochloride (Hycamtin[R]) and cisplatin for use ... Free with registration - WHO Drug Information - AccessMyLibrary.com … for Oral Formulation of HYCAMTIN(R) (topotecan) to Treat Relapsed ... - Jun 15, 2007 GlaxoSmithKline (GSK) announced today that its new drug application (NDA) for ORAL HYCAMTIN(R) (topotecan) capsules, a treatment for relapsed small cell ... Cancer Focus Chemotherapy; Lower-dose topotecan tolerated in patients with … - Nov 7, 2005 This study evaluates the activity and tolerability of low-dose topotecan in our ... The researchers concluded, "Lower-dose topotecan is generally well ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones Hycamtin(R) (Topotecan HCl) Indication Expanded To Include Treatment ... - Dec 1, 2006 LONDON, UK -- December 1, 2006 -- GlaxoSmithKline plc announced today that the European Medicines Agency (EMEA) has granted Marketing Authorisation for ... DG News GlaxoSmithKline announces Hycamtin® receives positive opinion in … - Nov 28, 2005 28 Nov 2005 - GlaxoSmithKline (GSK) announced that HYCAMTIN® (topotecan powder for concentration for solution for infusion) received positive opinion from ... chemie.de Figure 1 : Antitumour drugs impede DNA uncoiling by topoisomerase I :... - Jul 12, 2007 ...a, In the absence of topotecan, uncoiling (red dots, at 100 s) proceeds ... Topotecan-mediated uncoiling of positive supercoils proceeds 20-fold more slowly ... Nature.com Thalidomide provide more hope to women diagnosed with Ovarian … - Apr 12, 2008 ..."We found that patients who received topotecan plus thalidomide showed an ... "In patients receiving topotecan plus thalidomide, 30 percent achieved a ... TopCancerNews.com Hana Biosciences Completes Licensing of Three Targeted Cancer Drug … - May 8, 2006 ...--Sphingosome encapsulated topotecan, based on a unique formulation which has ... Vincristine, vinorelbine and topotecan are approved cancer therapies which ... Free with registration - Business Wire - AccessMyLibrary.com … Therapy; [I-131]MIBG and topotecan combination therapy evaluated... - Dec 13, 2005 2005 DEC 13 - (NewsRx.com) -- [I-131]MIBG and topotecan combination therapy was evaluated for neuroblastoma. "MIBG is selectively concentrated in ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Tiny Tweezers And Yeast Help Explain How Cancer Drug Works - Jul 11, 2007 Topotecan exploits the binding of topoisomerase I to double-stranded DNA that occurs ... Researchers already knew that topotecan "poisons" topoisomerase by ... sciencedaily.com Hycamtin® (topotecan HCl) Indication Expanded To Include Treatment Of... - Dec 8, 2006 GlaxoSmithKline plc announced today that the European Medicines Agency (EMEA) has granted Marketing Authorisation for HYCAMTIN® (topotecan HCl) in ... Medical News Today - Medical News Today (press release) Fine Tuning Drug Levels in Neuroblastoma Patients is Effective - Jun 16, 2005 Monitoring and fine tuning the levels of the cancer drug topotecan in children ... Such differences mean that the standard drug of topotecan might help some ... RedOrbit Ovaio, buoni risultati da talidomide e topotecan. Corriere della Sera - Apr 3, 2008 Su Cancer i risultati di uno studio dell'università del Minnesota (Usa)Ovaio, buoni risultati da talidomide e topotecanEntrambi i farmaci svolgono un'azione ... Corriere della Sera Fine tuning drug levels in neuroblastoma patients is effective - Jun 19, 2005 Monitoring and fine tuning the levels of the cancer drug topotecan in children ... Such differences mean that the standard drug of topotecan might help some ... News-Medical.net Cancer Therapy; Hematologic safety and tolerability of topotecan … - Jan 10, 2006 2006 JAN 10 - (NewsRx.com) -- Researchers investigated the hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Cancer Therapy; Hematologic safety and tolerability of topotecan … - Jan 9, 2006 2006 JAN 9 - (NewsRx.com) -- Researchers investigated the hematologic safety and tolerability of topotecan in recurrent ovarian cancer and small cell lung ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones Pediatric Oncology; Topotecan arrests the manufacture of angiogenic … - Aug 5, 2005 2005 AUG 5 - (NewsRx.com) -- Topotecan arrests the manufacture of angiogenic protein in ... Topotecan blocked the IGF-I-stimulated increase in HIF-1 alpha, ... Pay-Per-View - Angiogenesis Weekly - Factiva, from Dow Jones topotecan GlaxoSmithKline clinical data (phase II) (NSCLC).(Brief... - Jul 18, 2005 A clinical trial of topotecan (HYCAMTIN) in the treatment of platinum and taxane refractory advanced nonsmall cell lung cancer (NSCLC) is under way in ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones Pharmion's Amrubicin Shows Encouraging Results Compared to … - Jun 4, 2007 The trial compares Amrubicin and topotecan in patients with ED-SCLC that initially ... None of the nine topotecan patients showed a response to the drug. ... Free with registration - PR Newswire - AccessMyLibrary.com Treatment Can Make Cancer Stronger - Jun 10, 2008 The most potent, Melillo says, is a rug called topotecan, marketed under the brand name ... And the timing is important, because when topotecan is used as ... CBS News Clinical Data on Thalidomide Reported in Recurrent Epithelial Ovarian... - Nov 3, 2005 Dr. Downs reported that patients in the topotecan plus thalidomide arm reported an overall response rate of 50% compared to 22% of patients in the topotecan ... biotech-intelligence.com Cancer Treatment; New findings from France, the People's Republic of ... - Sep 5, 2006 They found that, "compared with free topotecan or conventional liposome (H-Lip) ... "Moreover, H-PEG increased the accumulation of topotecan in tumors;" the ... Pay-Per-View - Science Letter - Factiva, from Dow Jones … Showed Oral Hycamtin(R) (Topotecan Hydrochloride) Clinically... - May 17, 2005 ORLANDO, Fla., May 17 /PRNewswire-FirstCall/ -- Results from two new, investigational Phase III clinical trials showed that oral Hycamtin(R) was clinically ... Pay-Per-View - PR Newswire - HighBeam Research Cancer Treatment; Recent studies from Belgium, Japan and the People's... - May 10, 2006 They found that, "compared with free topotecan or conventional liposome (H-Lip) ... "Moreover, H-PEG increased the accumulation of topotecan in tumors;" the ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Hana Bio to license chemo drugs from Inex.(Hana Biosciences, Inex … - Mar 27, 2006 The compounds in question are Marqibo (sphingosomal vincristine), sphingosomal vinorelbine and sphingosomal topotecan, the first of which has already ... $4.95 - Pharma Marketletter - ECNext EC OKs GSK's Hycamtin for relapsed SCLC.(European Commission)( … - Feb 6, 2006 UK drug major GlaxoSmithKline says that the European Commission has granted Marketing Authorization for Hycamtin (topotecan powder for concentrate for ... $4.95 - Pharma Marketletter - ECNext How It Works - Nov 26, 2008 Topotecan is an intravenous (IV) medication usually given in a dose based ... Topotecan is a topoisomerase inhibitor that stops the growth of cancer cells ... WebMD Temporary Improvement of Tumor Blood Flow Can Improve … - Jul 11, 2007 When the researchers administered topotecan to the tumor-bearing mice three days after bevacizumab, the size of the tumors was only 36% of the size of ... DG News thalidomide Celgene clinical data (phase II) (ovarian cancer). - Nov 14, 2005 Results showed that patients receiving the thalidomide/topotecan combination ... Preliminary analysis of the thalidomide/topotecan-treated group showed that ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones International Approvals: Rotarix, Hycamtin, Pulmicort HFA - Mar 6, 2006 According to a company news release, topotecan is the first drug to be ... Results of the first study showed topotecan to be similarly effective to a 3-drug ... Medscape The breast cancer resistance protein BCRP (ABCG2) concentrates drugs ... - Jan 30, 2005 We also found that active secretion of topotecan into the milk by Abcg2 could be effectively reversed by oral administration of the Abcg2 inhibitor GF120918 ... Nature.com Data from Studies of Amrubicin in Small-Cell Lung Cancer Presented at... - Jun 2, 2008 Results of the studies demonstrated improved overall response rates that compare favorably with topotecan, as well as no evidence of anthracycline-induced ... Genetic Engineering News - Genetic Engineering News (press release) Increased Response To Therapy With No Added Toxicity In Treatment Of ... - Mar 28, 2006 The study, "A Prospective Randomized Trial of Thalidomide with Topotecan Compared to Topotecan Alone in Women with Recurrent Epithelial Ovarian, ... Medical News Today - Medical News Today (press release) TU Delft brengt invloed kankerremmer op DNA-molecuul in beeld - Jun 25, 2007 Het onderzochte medicijn topotecan gaat een interactie aan met een ... Tot op heden werd verondersteld dat topotecan er alleen voor zorgde dat het ... Blik op Nieuws Netherlands Corporate News - Data van onderzoeken naar amrubicin in … - Feb 6, 2008 Results of the studies demonstrated improved overall response rates that compare favorably with topotecan, as well as no evidence of anthracycline-induced ... Netherlands Corporate News - Netherlands Corporate News (persbericht) Advantage for Women Treated With Pegylated Liposomal Doxorubicin: … - Jul 8, 2005 The study cohort consisted of 474 patients randomized to receive either pegylated liposomal doxorubicin, 50 mg/m 2 every 28 days (n = 239), or topotecan, ... Medscape New Study Reports Increased Response to Therapy With No Added … - Mar 24, 2006 The study, "A Prospective Randomized Trial of Thalidomide with Topotecan Compared to Topotecan Alone in Women with Recurrent Epithelial Ovarian, ... $4.95 - PR Newswire - ECNext Press Release: Pharmion's Amrubicin Shows Encouraging Results … - Jun 4, 2007 40% response rate for Amrubicin versus 0% response rate for topotecan ... The trial compares Amrubicin and topotecan in patients with ED-SCLC that initially ... Pay-Per-View - PR Newswire - HighBeam Research INX Inc intends a stock buyback - Deal Snapshot - AlacraStore.com - May 5, 2008 Its preclinical stage products include INX - #### (sphingosomal vinorelbine) and INX - #### (sphingosomal topotecan) for the…treatment of various cancers; ... Pay-Per-View - deals - Alacra Store WHO巨资介入医è?¯æ?¿å?— - Nov 14, 2005 ...ç›®å‰?抗肿瘤è?¯ç‰©å? 世界è?¯å“?市场总销售é¢?çš„4.2%å·¦å?³,畅销å“?ç§?除紫æ?‰é†‡å¤–,还有 å?‰è¥¿ä»–滨(gemcitabine)ã€?托泊替康(topotecan)ã€?多西他赛(docetaxel)和泰索å¸?(taxotere)。 ... 金èž?ç•Œ Tre studi promuovono Topotecan - Feb 1, 2006 Via libera dell'EMEA al topotecan di GlaxoSmithKline per il trattamento dei pazienti con recidiva di carcinoma polmonare a piccole cellule, ... Pharma Marketing Randomized Trial First to Demonstrate a Survival Benefit in Patients... - Aug 1, 2005 Randomized Phase III Trial of Cisplatin with or without Topotecan in Carcinoma of the Uterine Cervix. J Clin Oncol. 2005 Jun 6; [Epub ahead of print]. ... Pay-Per-View - Clinical Oncology Report - Factiva, from Dow Jones Pharmion Initiates Pivotal Phase 3 Study of Amrubicin in Small Cell... - Oct 20, 2007 The study compares amrubicin and topotecan in second-line treatment of SCLC patients ... None of the nine topotecan patients showed a response to the drug. ... Cancer Focus Combined therapies beneficial - Apr 19, 2006 The study, "A Prospective Randomized Trial of Thalidomide with Topotecan Compared to Topotecan Alone in Women with Recurrent Epithelial Ovarian, ... DentalPlans.com Tumore ovarico: l'aggiunta di Topotecan alla terapia standard non è … - Jan 30, 2007 Martedì 30 Gennaio 2007 - Il farmaco Topotecan ( Hycamtin ) non aumenta la sopravvivenza nelle donne con tumore ovarico, quando impiegato con la ... XagenaSalute Drugs get OK - Sep 25, 2006 Topotecan is already approved for treating ovarian and small-cell lung cancer. In clinical trials, 293 patients randomly received either topotecan plus ... Deseret News Topotecan: Mittel der Wahl bei SCLC-Rezidiv - May 2, 2006 Patienten mit kleinzelligem Bronchialkarzinom (SCLC) sollten nach Versagen der Erstlinientherapie eine weitere Chemotherapie erhalten, auch wenn ihr ... Ärzte Zeitung Genomic signatures to guide the use of chemotherapeutics - Oct 22, 2006 Bottom, the relationship between Src pathway deregulation and topotecan resistance ... Ovarian cell lines that are predicted to be topotecan resistant (a, ... Nature.com Brain Tumor - Adults Radiotherapy - Brain Tumor - Adults Health … - Jun 10, 2008 These drugs, such as topotecan, increase the effects of radiation. Topotecan combined with other drugs, such as thiotepa and carboplatin, may help children ... New York Times Nueva indicación del topotecan en España - Jul 16, 2007 Las autoridades sanitarias españolas han aprobado recientemente la administración de Hycamtin (topotecan) combinado con cisplatino para el cáncer de cuello ... doyma.es NUEVA INDICACIÓN DE HYCAMTIN® (TOPOTECAN HCL) PARA EL … - Dec 20, 2006 LONDRES, diciembre 2006 – GlaxoSmithKline anuncia que la Agencia Europea del Medicamento (European Medicines Agency, EMEA) ha concedido la Autorización de ... acceso.com Press Release: New Study Reports Increased Response to Therapy With … - Mar 24, 2006 The study, "A Prospective Randomized Trial of Thalidomide with Topotecan Compared to Topotecan Alone in Women with Recurrent Epithelial Ovarian, ... Pay-Per-View - PR Newswire - HighBeam Research Press Release: Pharmion Initiates Pivotal Phase 3 Study of Amrubicin... - Oct 17, 2007 The study compares amrubicin and topotecan in second-line treatment of SCLC patients ... None of the nine topotecan patients showed a response to the drug. ... Pay-Per-View - PR Newswire - HighBeam Research Press Release: GlaxoSmithKline Application Accepted by the FDA to … - Feb 17, 2006 SmithKline Beecham's (NYSE: SBH) Hycamtin(R) (topotecan HC for Injection . ... FDA) today recommended approval of Hycamtin(R) (topotecan hydrochloride for ... Pay-Per-View - PR Newswire - HighBeam Research Nanotweezers unlock anticancer drug secrets - Aug 22, 2007 But in the presence of topotecan, the rate of DNA uncoiling due to topoisomerase I was reduced twentyfold compared with uncoiling without topotecan. ... Nanowerk LLC Nanotweezers Unlock Anticancer Drug Secrets, Research, Delft … - Sep 3, 2007 But in the presence of topotecan, the rate of DNA uncoiling due to topoisomerase I was reduced twentyfold compared with uncoiling without topotecan. ... nanotechwire.com Nanotweezers Unlock Anticancer Drug Secrets - Aug 23, 2007 But in the presence of topotecan, the rate of DNA uncoiling due to topoisomerase I was reduced twentyfold compared with uncoiling without topotecan. ... AZoNano.com US FDA grants full approval to DOXIL(R) for ovarian cancer progression... - Feb 9, 2005 A total of 239 patients received DOXIL; 235 patients received topotecan HCl. The primary endpoint, time to disease progression after starting therapy, ... i-newswire.com Drugs get OK | Article from Deseret News (Salt Lake City) | HighBeam ... - Sep 25, 2006 Topotecan is already approved for treating ovarian and small-cell lung cancer. In clinical trials, 293 patients randomly received either topotecan plus ... Pay-Per-View - Deseret News - HighBeam Research INX Inc intends a stock buyback - Deal Snapshot - AlacraStore.com - Sep 10, 2008 Its preclinical stage products include INX - #### (sphingosomal vinorelbine) and INX - #### (sphingosomal topotecan) for the…treatment of various cancers; ... Pay-Per-View - deals - Alacra Store Telik Reports Results of TELCYTA(R) ASSIST-1 Trial - Jun 3, 2007 The performance of the drugs on the active control arm, PLD or topotecan, was unexpected based on reported data, and no known prognostic or predictive ... Genetic Engineering News - Genetic Engineering News (press release) Ovarian Cancer; US FDA grants approval to ovarian cancer treatment … - Mar 7, 2005 The median time to disease progression was 4.1 months for the Doxil group and 4.2 months for the topotecan HCl group; the p value, a statistical measurement ... Pay-Per-View - Clinical Trials Week - Factiva, from Dow Jones Ovarian Cancer; US FDA grants approval to ovarian cancer treatment … - Mar 13, 2005 The median time to disease progression was 4.1 months for the Doxil group and 4.2 months for the topotecan HCl group; the p value, a statistical measurement ... Pay-Per-View - Medical Letter on the CDC & FDA - Factiva, from Dow Jones Ovarian Cancer; US FDA grants approval to ovarian cancer treatment … - Mar 8, 2005 The median time to disease progression was 4.1 months for the Doxil group and 4.2 months for the topotecan HCl group; the p value, a statistical measurement ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones INX Inc intends a stock buyback - Deal Snapshot - AlacraStore.com - Dec 5, 2007 Its preclinical stage products include INX - #### (sphingosomal vinorelbine) and INX - #### (sphingosomal topotecan) for the…treatment of various cancers; ... Pay-Per-View - deals - Alacra Store Press Release: GlaxoSmithKline Announces Expanded Indication for … - Jun 15, 2006 SmithKline Beecham's (NYSE: SBH) Hycamtin(R) (topotecan HC for Injection . ... FDA) today recommended approval of Hycamtin(R) (topotecan hydrochloride for ... Pay-Per-View - PR Newswire - HighBeam Research Other News To Note. - Nov 4, 2005 Results showed that patients in the topotecan plus thalidomide arm reported ... 16 percent of those in the topotecan arm. These data were presented at the ... Pay-Per-View - BIOWORLD Today - Factiva, from Dow Jones Press Release: Pharmion's Amrubicin Shows Encouraging Results … - Nov 9, 2007 The trial presented today compares Amrubicin and topotecan in patients with ED-SCLC that initially responded to first-line platinum-based therapy but whose ... Pay-Per-View - PR Newswire - HighBeam Research Brand Names/Synonyms: Topotecan is also known by the following brand names and/or synonymsHycamptamine; Hycamptin; Hycamtin; TOPOTECAN, HYCAMTIN; TPT; TTC; Topotecan; Topotecan Hcl; Topotecan Hydrochloride; Topotecan Lactone; Topotecane [Inn-French]; Topotecanum [Inn-Latin] Drug Category: Topotecan is categorized under the following by the FDA: Antineoplastic Agents; Enzyme Inhibitors; ATC:L01XX17 Dosage Forms: POWDER FOR SOLUTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: (S)-10-[(dimethylamino) methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3', 4' |
|
Health Home | Conditions | Cancer | Medications | Surgery | Vaccines The Cancer News Network
COPYRIGHT 2009 CANCERNEWSNETWORK | Privacy |