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TositumomabThis page contains recent news articles, when available, and an overview of Tositumomab but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Tositumomab (when available) Bexxar binds to the CD20 antigen, which is predominantly expressed on mature B cells and on >90% of B-cell non-Hodgkin’s lympohomas. The antibody leads to selective killing of B-cells. For treatment of non-Hodgkin's lymphoma (CD20 positive, follicular) Mechanism Of Action: Binds to the CD20 antigen which is found on mature B lymphocytes. The antibody binding appears to induce apoptosis, complement-dependent cytotoxicity and cell death through ionizing radiation. News Articles on Tositumomab GLG News by this Author - Dec 17, 2009 Re-treatment with I-131 tositumomab radioimmunotherapy (RIT) following a previous response can produce second responses that can be durable. ... Gerson Lehrman Group Targeting B-Cell Surface Proteins to Fight Cancer - Nov 6, 2009 Current medications that target CD20 include rituximab (Rituxan or MabThera), Ibritumomab tiuxetan (Zevalin) and tositumomab (Bexxar). ... Mesothelioma Web One Week of 131-I Tositumomab May Induce Remission in Follicular … - Feb 2, 2005 Feb. 2, 2005 — A single one-week regimen of 131 I-tositumomab can induce remission for many with follicular lymphoma, according to the results of a ... Medscape … Name: Tositumomab and Iodine 131 (I131) tositumomab (toe-si-TOO- … - Mar 2, 2005 How is this drug used? Tositumomab and I131 is FDA approved for the treatment of patients with CD20 positive, follicular, non-Hodgkin's lymphoma, ... Cancer Consultants Tositumomab and Iodine I 131 Tositumomab (Systemic).(Drug overview) - May 1, 2006 Tositumomab ( tos-IT-too-moe-mab) and iodine (EYE-oh-din) I 131 tositumomab(tos-IT-too-moe-mab) is a protein called a monoclonal antibody. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Brand Names/Synonyms: Tositumomab is also known by the following brand names and/or synonymsIg gamma-1 chain C region; Bexxar (Corixa Corp) Drug Category: Tositumomab is categorized under the following by the FDA: Antineoplastic Agents Dosage Forms: Not Available Absorption: Not Available Interactions: Not Available Chemical IUPAC Name: Murine anti-CD20 antibody |
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