Trihexyphenidyl

This page contains recent news articles, when available, and an overview of Trihexyphenidyl but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Trihexyphenidyl
(when available)

Pharmacology and use:
Trihexyphenidyl is an anticholinergic used in the symptomatic treatment of all etiologic groups of parkinsonism and drug induced extrapyramidal reactions (except tardive dyskinesia). Trihexyphenidyl possesses both anticholinergic and antihistaminic effects, although only the former has been established as therapeutically significant in the management of parkinsonism. Indicated for the treatment of parkinson's disease and extrapyramidal reactions caused by drugs.

Mechanism Of Action:
Trihexyphenidyl is a selective M1 muscarinic acetylcholine receptor antagonist. It is able to discriminate between the M1 (cortical or neuronal) and the peripheral muscarinic subtypes (cardiac and glandular). Trihexyphenidyl partially blocks cholinergic activity in the CNS, which is responsible for the symptoms of Parkinson's disease. It is also thought to increase the availability of dopamine, a brain chemical that is critical in the initiation and smooth control of voluntary muscle movement.

News Articles on Trihexyphenidyl

Cross-breeding leading to native livestock decline in Orissa  -  ‎Dec 13, 2009‎
Company supplies generics to the European and UK markets like Amlodipine Maleate, Bendroflumethiazide, Benzhexol (Trihexyphenidyl), Bisacodyl 5mg Tablets, ... TopNews

Four Pharmaceutical Companies Pay $124 Million for Submission of False Claims ...  -  ‎Oct 19, 2009‎
Propox Naps & APAP, Flecainide Acetate, Trihexyphenidyl, Ranitidine HCL syrup, Sucralfate Suspension, Selegiline HCL and Bumetanide). ... Reuters

Polres Donggala Tangkap Pengedar Ribuan Pil Koplo  -  ‎Nov 7, 2009‎
Jajaran Polres Donggala di Sulawesi Tengah menangkap basah seorang warga Kota Palu saat sedang mengedarkan ribuan pil trihexyphenidyl atau biasa dikenal ... Harian SIB

Polres Donggala Tangkap Pengedar Ribuan Pil Koplo  -  ‎Nov 5, 2009‎
Palu (ANTARA News) - Jajaran Polres Donggala di Sulawesi Tengah menangkap basah seorang warga Kota Palu saat sedang mengedarkan ribuan pil trihexyphenidyl ... ANTARA

Trihexyphenidyl Oral : User Ratings covering uses, effectiveness, …  -  Jul 11, 2008
...my brother takes it for symptoms resulring from phych drugs and he has started to fall without warning several times a day. Went to primary care md today ... WebMD

… Administrative Code - 77 Ill. Adm. Code 790.9180 TRIHEXYPHENIDYL …  -  Aug 10, 2005
77 Ill. Adm. Code 790.9180 TRIHEXYPHENIDYL HYDROCHLORIDE (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

Survey of management of acquired nystagmus in the United Kingdom  -  May 26, 2006
A double-blind study of trihexyphenidyl and trihexethyl chloride. Neurology 1991; 41: 1737–1741. | PubMed | ISI | ChemPort |. Arnold DB. ... Nature.com

Quetiapine and EPS.(EVIDENCE-BASED PSYCHIATRIC MEDICINE)  -  Feb 1, 2008
How likely is it that this patient actually needs trihexyphenidyl, a medication wanted by inmates for its abuse potential? In other words, what is the ... Free with registration - Clinical Psychiatry News - AccessMyLibrary.com

Adjuvant levetiracetam for treating adolescent bipolar affective...  -  Jul 1, 2007
During the current episode she was given sodium valproate 800 mg, olanzapine 20 mg/day, and trihexyphenidyl 2 mg/day for 2 weeks, beginning one week prior ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Article: Seizures may present as subtle cognitive changes. - Clinical...  -  Jul 1, 2006
One study using trihexyphenidyl 6 mg/day for 2 weeks in patients with early ... Three studies using trihexyphenidyl 4-6 mg/day or benztropine 2 mg/day for 1 ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Quetiapine and EPS.(EVIDENCE-BASED PSYCHIATRIC MEDICINE) | …  -  Feb 1, 2008
How likely is it that this patient actually needs trihexyphenidyl, a medication wanted by inmates for its abuse potential? In other words, what is the ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

SUARA MERDEKA - SEMARANG  -  Aug 15, 2005
Polisi hanya menyita delapan butir pil koplo jenis trihexyphenidyl. Razia yang dimulai sekitar pukul 22.30 itu mengejutkan para penghuni maupun pengunjung ... Suara Merdeka CyberNews

「你留言他æ??款ã€?~ 「無屑宣言ã€?助罕病ï¼?  -  Feb 5, 2008
...其他藥物還有(3)抗膽鹼類Trihexyphenidyl (å?³Artane)或是採用(4)維生素B6(Pyridoxine)(5)L-DOPA 等。有些疾病的治療å??應有性別差異,雖有部分å?‡èªªå˜—試解釋,但尚未有 ... 公民新è?ž

Amyotrophic Lateral Sclerosis - Symptoms, Diagnosis, Treatment of …  -  Sep 11, 2008
Trihexyphenidyl or amitriptyline may be prescribed for people with problems swallowing their own saliva. Physical therapy, rehabilitation, use of braces or ... New York Times

Blepharospasm and Paget's cancer  -  Jan 3, 2007
Cogentin, Klonopin, Lioresal and trihexyphenidyl are examples. If neither Botox nor medicine is effective, surgical removal of some of the eyelid muscles is ... Sarasota Herald-Tribune

SINUSITIS TAKES MANY FORMS  -  Jan 27, 2006
Trihexyphenidyl and baclofen are two medicines that might alleviate your muscle cramping. Botox, the diluted poison of the botulism germ, can loosen the ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

War on drugs lacks a certain something  -  Feb 16, 2008
...glass syringes and bubble-packs of commercial pills including trihexyphenidyl and clonazepam, drugs for controlling Parkinson's disease and seizures. ... Sydney Morning Herald

Don't diagnose your own sinus problem  -  Jan 28, 2006
Trihexyphenidyl and baclo-fen might alleviate the cramping. Botox, the diluted poison of the botulism germ, can loosen the tight grip dystonia produces. ... Pay-Per-View - St. Paul Pioneer Press - Factiva, from Dow Jones

MEDICAL EDGE, L-dopa therapy, other Parkinsons options  -  Jan 10, 2006
And the anticholinergics such as trihexyphenidyl and benztropine may produce memory loss, confusion, severe constipation and difficulty urinating ... Pay-Per-View - Newsday - ProQuest Archiver

Amyotrophic Lateral Sclerosis (ALS) - Treatment Overview  -  Aug 14, 2008
Glycopyrrolate (Robinul), benztropine, transdermal hyoscine (Scopolamine), atropine, trihexyphenidyl hydrochloride, or amitriptyline for extra saliva or ... WebMD

FPIN's Clinical Inquiries  -  Aug 1, 2005
Anticholinergic agents (eg, benztropine [Cogentin] and trihexyphenidyl [Artane]) should be avoided because of neuropsychiatric and cognitive adverse ... AAFP News Now

How to take Clozapine from Consumer Reports Health.  -  Jan 4, 2007
...tranquilizers; and trihexyphenidyl (Artane). Your doctor may need to change the doses of your medications or monitor you carefully for side effects. ... consumerreports.org

Parkinson's disease.(development of Parkinson drug treatments )  -  Jan 1, 2005
Anticholinergic drugs, such as trihexyphenidyl (Artane) and benztropine (Cogentin), are mildly effective in controlling tremors, but their use is seriously ... Free with registration - New Medical Therapies -- Parkinson's... - AccessMyLibrary.com

Parkinson's Disease  -  Aug 27, 2007
For mild symptoms in early Parkinson's disease, amantadine (Symmetrel) or anticholinergic medications, such as trihexyphenidyl (Artane, Trihexane, ... HealthCentral.com

How to take Clomipramine from Consumer Reports Health.  -  Jan 8, 2007
...and trihexyphenidyl (Artane); and vitamins. Your doctor may need to change the doses of your medication or monitor you more carefully for side effects. ... consumerreports.org

BJP -- eLetters for Vieta et al., 187 (3) 235-242  -  Nov 18, 2005
Although anticholinergics were prohibited, 9.6% of patients received medications for EPS (protocol deviations, biperiden, n=23; trihexyphenidyl, n=6; ... British Journal of Psychiatry (subscript...

New laboratory approach to treat Parkinson's  -  Mar 27, 2006
Some people with Parkinson's disease take drugs called muscarinic antagonists, which include Artane (trihexyphenidyl) and Cogentin (benztropine). ... LabTechnologist.com

Familial Parkinsonism and Ophthalmoplegia From a Mutation in the …  -  Jan 6, 2007
Trihexyphenidyl hydrochloride improved her tremor. Magnetic resonance images of the brain were normal at age 42 years. On examination at age 45 years, ... Archives of Neurology

How to take Mesoridazine Oral from Consumer Reports Health.  -  Jan 10, 2005
...phenytoin (Dilantin), propranolol (Inderal), quinidine, sedatives, trihexyphenidyl (Artane), valproic acid (Depakane), and vitamins. ... consumerreports.org

Condeng Tertangkap Basah Bawa Ribuan Pil Koplo  -  Dec 2, 2008
PALU, SELASA - Satu lagi warga di Kota Palu, Sulawesi Tengah, tertangkap tangan oleh petugas karena mengedarkan ribuan pil Trihexyphenidyl (THD) atau biasa ... KOMPAS.com

Deep Brain Stimulation Helps Dystonia Patients  -  Nov 10, 2006
Many of the patients tried several different therapies in the past, like trihexyphenidyl (Artane) and botox injections, without satisfactory results. ... Ivanhoe Broadcast News

Modern antipsychotic drugs: a critical overview.(Synthese)  -  Jun 21, 2005
...procyclidine or trihexyphenidyl), as is often required with older antipsychotic agents to rebalance critical dopaminergic -cholinergic functions in the ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

WHO expert committee on specifications for pharmaceutical preparations...  -  Aug 1, 2005
...sulfamethoxypyridazine gallamine triethiodide tiabendazole glibenclamide trihexyphenidyl hydrochloride haloperidol trimethoprim hydrochlorothiazide ... Free with registration - Technical Report Series - AccessMyLibrary.com

Antidyskinetics (Systemic).(Drug overview)  -  Aug 1, 2006
The following information includes only the average doses of benztropine, biperiden, ethopropazine, procyclidine, and trihexyphenidyl. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

The effect of botulinum toxin type A on speech intelligibility in...  -  Jun 1, 2007
...of systemic pharmacologic agents including anticholinergics (trihexyphenidyl, benztropine), benzodiazepines (clonazepam, lorazepam, diazepam), baclofen, ... $4.95 - Journal of Medical Speech - Language... - ECNext

Treatment Modalities for Parkinson's Disease  -  Jun 9, 2008
In early PD, amantadine, anticholinergic agents (eg, benztropine, trihexyphenidyl), and selegiline are modestly effective. However, amantadine can be ... Medscape

Erie Times-News : Front Page<br>  -  Oct 27, 2006
Artane Trihexyphenidyl 2mg tab. N/A Ultra natal care tab. Calan Verapamil 80mg tab. Calan Verapamil 120mg tab. Coumadin Warfarin 5mg tab ... $2.95 - Erie Times-News - NewsBank

A bright red pruritic rash on the forearms.(PHOTO ROUNDS)(Case study)  -  Aug 1, 2007
She was taking a number of medications including trihexyphenidyl, fluphenazine, mirtazapine, ibuprofen, propranolol, acetaminophen, albuterol/ipratropium ... $4.95 - Journal of Family Practice - ECNext

Do Incontinence Drugs Affect Cognition in the Elderly?  -  Jun 10, 2008
These include the Parkinson/tardive dyskinesia drugs trihexyphenidyl and benztropine, antihistamines (diphenhydramine, chlorpheniramine, meclizine, etc), ... Medscape

Missouri Regulations - 13 CSR 70-20.040 Five Prescription Limit Per …  -  Aug 16, 2005
Maleate Tocainide Tolazamide Tablets Tolbutamide Triamcinolone Acetonide Oral Inhaler Trichlormethiazide Trihexyphenidyl Valproic Acid Valproic Acid, ... Pay-Per-View - Missouri Regulations - Loislaw

New York Codes, Rules and Regulations - 18 NYCRR 360-7.12. Co- …  -  May 18, 2007
...trazodone, triazolam, trifluoperazine, triflupromazine, trihexyphenidyl HC1, trimethadione, trimipramine, and valproic acid and its derivatives. ... Pay-Per-View - New York Codes, Rules and Regulations - Loislaw

Parkinson Disease: New Insights, New Treatment Options.  -  Oct 1, 2006
Anticholinergic medications, such as trihexyphenidyl. and benztropine, were the mainstays of therapy before levodopa became available. ... $4.95 - Consultant - ECNext

Drooling, excessive.(Pediatric Advisor 2007)  -  May 31, 2007
Artane (trihexyphenidyl hydrochloride) comes in either liquid or tablet form. ** Cogentin (benztropine mesylate) comes in tablet form. ... $4.95 - Clinical Reference Systems - ECNext

Cognitive side effects of anticholinergics.(EVIDENCE-BASED …  -  Aug 1, 2005
Our Medline search combined "anticholinergic, cholinergic antagonist, trihexyphenidyl, or benztropine" and "cognitive, cognition, or memory." The Evidence ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

New Jersey Administrative Code - 8:71-1.1 Precedence of lists  -  Aug 16, 2005
500 mg Tablet West-ward ARTANE Trihexyphenidyl HCl 2 mg/5 ml Elixir Pharm Assoc 2 mg, 5 mg Tablet Vintage, Watson, West-ward ASENDIN Amoxapine 25 mg, ... Pay-Per-View - New Jersey Administrative Code - Loislaw

Federal Register 2007 - 72 FR 28982 Determination That Protamine …  -  May 23, 2007
NDA 6-773 ARTANE (trihexyphenidyl Lederle, c/o Wyeth hydrochloride (HCl)) Pharmaceuticals, P.O. Box Tablets, 2 mg and 5 mg 8299, Philadelphia, ... Pay-Per-View - Federal Register 2007 - Loislaw

euphoriant | Definition of euphoriant | HighBeam.com: Online Dictionar...  -  Jul 12, 2006
Journal of Psychoactive Drugs; September 1, 2007 ; 700+ words ... ... increased her trihexyphenidyl to achieve antidepressant and euphoriant effects (Bolin ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

Parkinson's Disease Market analysis and forecasts, 2008- 2012, 2017 &...  -  Jan 8, 2008
Artane (Trihexyphenidyl) To Control Common. Symptoms. 3.9. Antihistamines And Antidepressants Can Aid. PD Symptoms? 3.10. Apomorphine as Additional Relief ... $4,422.00 - VISIONGAIN A - Alacra Store

Drooling, excessive.  -  May 24, 2006
Artane (trihexyphenidyl hydrochloride) comes in either liquid or tablet form. ** Cogentin (benztropine mesylate) comes in tablet form. ... $4.95 - Clinical Reference Systems - ECNext

Article: Bright market prospect of epoxy cyclohexane.(Organics) -...  -  Aug 6, 2008
Epoxy cyclohexane is an important raw material for the synthesis of trihexyphenidyl hydrochloride, cyhexatin, propargite, aliphatic polycarbonate ... Pay-Per-View - China Chemical Reporter - HighBeam Research

Parkinson's disease is a complex neurological dis-order with cardinal...  -  Jul 8, 2005
On occasions younger patients, particularly those with severe tremor, may be given anti-cholinergics, such as trihexyphenidyl (benzhexol) hydro-chloride as ... Pay-Per-View - Practice Nurse - Factiva, from Dow Jones

Drooling, excessive.(Pediatric Advisor 2006)(Disease/Disorder...  -  Nov 1, 2006
Artane (trihexyphenidyl hydrochloride) comes in either liquid or tablet form. ** Cogentin (benztropine mesylate) comes in tablet form. ... $4.95 - Clinical Reference Systems - ECNext

Management of Parkinson disease: current treatments, recent advances,...  -  Sep 1, 2007
Clinically, anticholinergics such as trihexyphenidyl and benztropine are used in younger patients with PD (eg, those aged <60 years) in whom resting tremor ... $4.95 - Formulary - ECNext

SUARA MERDEKA - SEMARANG  -  May 12, 2005
Polisi menyita 294 butir pil, masing-masing 275 butir Lexotan dan 19 butir pil Trihexyphenidyl atau biasa disebut trihex. Polisi terus mengembangkan kasus ... Suara Merdeka CyberNews

A Parkinson's disease primer.(CONTINUING EDUCATION: An ongoing …  -  Oct 22, 2007
Anticholinergic agents, such as benzttopine and trihexyphenidyl, are believed to work by attempting to balance dopamine and acetylcholine activity. ... $4.95 - Drug Topics - ECNext

Pemasok dan Pengguna Putaw Ditahan  -  Sep 21, 2006
...sebuah jarum suntik bekas, plastik air minum, tiga tutup jarum suntik, plastik bekas pembungkus putaw, serta lima tablet obat flu trihexyphenidyl . ... Suara Merdeka CyberNews

Pharmacotherapy for Parkinson's disease: current options, promising …  -  Aug 1, 2006
Four of the most common anticholinergics are benztropine, trihexyphenidyl, biperiden, and procyclidine. (11,42) In later stages of PD, anticholinergics may ... Free with registration - JAAPA-Journal of the American Academy... - AccessMyLibrary.com

Cognitive dysfunctions in schizophrenia: potential benefits of …  -  Nov 1, 2006
...biperiden, trihexyphenidyl), low-potency conventional antipsychotic drugs (86) (e.g., chlorpromazine), clozapine (86) and tricyclic antidepressants. ... Free with registration - Journal of Psychiatry and Neuroscience - AccessMyLibrary.com

When writing an Rx for therapy, think details.(Special Needs:...  -  Oct 1, 2008
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words . ... Pay-Per-View - Pediatric News - HighBeam Research

Article: Neuroimaging advances in cerebral palsy.(Special Needs: …  -  Oct 1, 2007
Article: Trihexyphenidyl deserves further study for dystonic ... Pediatric News; December 1, 2006 ; 700+ words ... ... potential benefit in dystonic ... Pay-Per-View - Pediatric News - HighBeam Research

Similarities arise in developmental syndromes.(Behavioral Pediatrics)...  -  Aug 1, 2008
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... Medicine. ... Pay-Per-View - Pediatric News - HighBeam Research

Intrauterine infection linked to cerebral palsy.(News) | Article from...  -  Mar 1, 2007
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... promising for the ... Pay-Per-View - Pediatric News - HighBeam Research

Cerebral palsy patients cite positive quality of life.(Behavioral...  -  Oct 1, 2006
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... promising for the ... Pay-Per-View - Pediatric News - HighBeam Research

Parents pleased with HBOT for cerebral palsy patients.(Clinical...  -  Dec 1, 2006
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... promising for the ... Pay-Per-View - Pediatric News - HighBeam Research

Headache, disturbed sleep often are comorbid.(Clinical Round) |...  -  Apr 1, 2006
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... placebo treatment. ... Pay-Per-View - Pediatric News - HighBeam Research

Treadmill training beneficial in children with CP: participants felt...  -  Feb 1, 2007
Article: Trihexyphenidyl deserves further study for dystonic CP.(Clinical ... Pediatric News; December 1, 2006 ; 700+ words ... ... promising for the ... Pay-Per-View - Pediatric News - HighBeam Research

Brand Names/Synonyms:
Trihexyphenidyl is also known by the following brand names and/or synonymsApo-Trihex; Artane; Artane Sequels; Benzhexol; Benzhexolum; CHEMBANK1005; HSDB 3196; Parkinane Retard; Pms Trihexyphenidyl; T125; Tremin; Trihexane; Trihexifenidilo [Inn-Spanish]; Trihexy; Trihexylphenidyl; Trihexylphenidyle; Trihexylphenizyl; Trihexyphenidyl; Trihexyphenidyl Hcl; Trihexyphenidyle; Trihexyphenidyle [Inn-French]; Trihexyphenidylum [Inn-Latin]; Triphenidyl

Drug Category:
Trihexyphenidyl is categorized under the following by the FDA: Antiparkinson Agents; Antidyskinetics; ATC:N04AA01

Dosage Forms:
TABLET,ORAL LIQUID

Absorption:
Trihexyphenidyl is rapidly absorbed from the gastrointestinal tract.

Interactions:
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Chemical IUPAC Name:
1-cyclohexyl-1-phenyl-3-(1-piperidyl)propan-1-ol





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