Triphasil

This page contains recent news articles, when available, and an overview of Triphasil but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Triphasil
(when available)

Pharmacology and use:
Norgestrel is used as a female contraceptive. Norgestrel is a progestin or a synthetic form of the naturally occurring female sex hormone, progesterone. In a woman's normal menstrual cycle, an egg matures and is released from the ovaries (ovulation). The ovary then produces progesterone, preventing the release of further eggs and priming the lining of the womb for a possible pregnancy. If pregnancy occurs, progesterone levels in the body remain high, maintaining the womb lining. If pregnancy does not occur, progesterone levels in the body fall, resulting in a menstrual period. Norgestrel tricks the body processes into thinking that ovulation has already occurred, by maintaining high levels of the synthetic progesterone. This prevents the release of eggs from the ovaries. Used as an oral contraceptive to prevent pregnancy

Mechanism Of Action:
Binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Norgestrel will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge.

News Articles on Norgestrel

Birth control pills in short supply  -  Nov 1, 2006
Women who use Alesse and Triphasil brands of birth control pills may find ... “We are working hard to make Alesse and Triphasil available to Canadian ... Globe and Mail

US federal agency warns drug firm over plant in Puerto Rico  -  May 31, 2006
However, last Friday Wyeth issued a voluntary recall of 20 lots of Triphasil from wholesale distributors. There has been no consumer recall. ... Jamaica Observer

FDA issues Wyeth warning letter over manufacturing plant in Puerto...  -  May 30, 2006
However, last Friday Wyeth issued a voluntary recall of 20 lots of Triphasil from wholesale distributors. There has not been a consumer recall. ... San Diego Union - Tribune - San Diego Union Tribune

Wyeth Provides Status Update On TRIPHASIL-28 And ALESSE Oral …  -  Aug 7, 2006
Wyeth (NYSE:WYE) announced that the company has designated both TRIPHASIL®-28 (levonorgestrel and ethinyl estradiol tablets-triphasic regimen) and ALESSE® ... Medical News Today - Medical News Today (press release)

Pill shortage leaves tempers short, too  -  Nov 2, 2006
..."For them, they stabilized on Triphasil or [Alesse] and now they are out of ... Hanna said to switch someone from Alesse or Triphasil to another brand means ... Pay-Per-View - The Record - ProQuest Archiver

Drug stocks slip, Merck falls on Vioxx data.  -  May 30, 2006
Wyeth said that it had voluntarily recalled Triphasil from drug wholesalers as a result of the letter. Earlier Tuesday, analysts at Merrill Lynch downgraded ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Wyeth Pharmaceuticals, Madison, NJ, May 8 (San Juan, PR).  -  Nov 7, 2005
On June 21, 2005, aliquots of the original sample from Triphasil 21 50/30 ... Also on June 21, 2005, two new samples of Triphasil-21 and Triphasil-28 were ... Entrepreneur

Hard times for Wyeth's manufacturing operations  -  Jul 19, 2006
..."In the mean time Triphasil has run out at wholesale level while Alesse will also run ... Triphasil played a prominent role in the FDA's grievances after a ... In-PharmaTechnologist.com

Birth control pill shortage almost over  -  Nov 29, 2006
Dr. Dara Maker said drugstores in Canada are still out of stock of Triphasil pills, but she has been told supplies should be replenished in three weeks. ... CBC.ca

Audio et Vidéo  -  Nov 1, 2006
Les pilules de marque Triphasil ne sont plus disponibles depuis déjà 6 à 8 ... La pénurie de Triphasil est moins grave que celle des pilules Alesse, ... Radio-Canada

FDA warns Wyeth over plant lapses | Article from The Record (Bergen …  -  May 31, 2006
The Triphasil contraception tablet, which generated $13.1 million in 2005 ... The company decided to recall the lots of Triphasil because "we felt it was ... Pay-Per-View - The Record - HighBeam Research

Wyeth boosts manufacturing in US plant as Puerto Rico site struggles  -  Nov 13, 2006
The GMP violations identified by the FDA affected several drugs including Effexor and the company's Triphasil oral contraceptive. ... In-PharmaTechnologist.com

Contraceptives: Must-knows about `The Pill'  -  Feb 19, 2007
However, 99 per cent of all contraceptive pills are combination pills (Marvelon, Ovral-L, Triquilar, Femilon, Triphasil, Diane-35), which contain both ... Rediff

Emergency contraception care: advise for recent changes in the...  -  Dec 1, 2006
...white pills Seasonale 120 0.60 4 pink pills Triphasil 120 0.50 4 yellow pills SECOND DOSE BRAND NAME (12 HOURS LATER) Progestin only Plan B none Ovrette ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Are periods obsolete?  -  Mar 11, 2005
However, in triphasic pills such as Triphasil and Tricyclen, hormone levels fluctuate during a cycle. Taking the triphasic variety continuously could cause ... Pay-Per-View - The Record - ProQuest Archiver

Probe delays second Wyeth drug | Article from The Record (Bergen …  -  Jan 24, 2007
Other problems prompted the recall of 20 lots of Triphasil, a contraceptive. "Any significant delays in clearing up issues in Puerto Rico is going to be ... Pay-Per-View - The Record - HighBeam Research

Wyeth steps up production in Rouses Point  -  Nov 7, 2006
Specifically noted were “unexplained discrepancies or out of specification results� in batches of the drugs Triphasil 21 and Triphasil 28. ... $2.95 - Press-Republican - NewsBank

ContracepÅ£ia de urgenţă  -  Apr 29, 2007
În cazul pilulelor progestative macrodozate (Triphasil, Triguilar, Tri-Norinyl), nu trebuie luate măsuri suplimentare dacă întârzierea nu a fost mai mare de ... Adevărul

FDA warns Wyeth about Puerto Rico plant.  -  Jun 5, 2006
However, on May 26, Wyeth recalled 20 lots of Triphasil from wholesale distributors. Copyright 2006 Marketletter Publications Ltd. $9.94 - Pharma Marketletter - Alacra Store

Press Release: Video: New Survey Shows Young Women Turn to …  -  Jan 28, 2008
The findings ... was more than 99 percent effective, which ... a once-daily birth control pill, Triphasil ... compliance was 88.7 percent for women wearing ... Pay-Per-View - PR Newswire - HighBeam Research

Hawaii Administrative Rules - EXHIBIT B  -  Aug 12, 2008
Tri-Levlen Berlex 4 yellow pills 120 0.50 Triphasil Wyeth-Ayerst 4 yellow pills 120 0.50 Trivora Watson 4 pink pills 120 0.50 Adapted from RA Hatcher, ... Pay-Per-View - Hawaii Administrative Rules - Loislaw

ILLINOIS FIRST LADY LAUNCHES NEW WEBSITE SO WOMEN CAN …  -  Jul 13, 2005
Prescription contraceptives, such as Ortho-Evra 20-150, Ortho Novum 7/7/7, Ortho-Cyclen, Ortho Tri-Cyclen, Alesse, Micronor and Triphasil are available from ... Pay-Per-View - US Fed News - Factiva, from Dow Jones

Wyeth pill change  -  Mar 3, 2005
On two other Wyeth products — Triphasil and Trifeme — the design will change but the content of the starting pills will remain the same. Pay-Per-View - Australian Doctor - Factiva, from Dow Jones

Press Release: Data Show Low Incidence of Breakthrough Bleeding With ...  -  May 9, 2007
An overall higher ... Ortho-Cyclen and Ortho-Tri-Cyclen. NGMN ... levonorgestrel/ethinyl estradiol (Triphasil) on ... ... Pay-Per-View - PR Newswire - HighBeam Research

Gesinsbeplanning: hulp is beskikbaar  -  Sep 15, 2008
Die vier gesinsbeplanningsmetodes wat Nappa volgens sy aanbieding voorstaan, is inspuitings (Wur-Esterate en Petogen), pille (Ovral 28, Triphasil, ... Die Republikein

California Code of Regulations - § 16:1746. Emergency Contraception.  -  Aug 16, 2005
100 0.50 Aviane Duramed 5 orange tablets 100 0.50 Triphasil Wyeth 4 yellow tablets 120 0.50 Levlen Berlex 4 light-orange tablets 120 0.60 Trivora Watson ... Pay-Per-View - California Code of Regulations - Loislaw

Article: Ohio U. female students divided on period-less birth control...  -  May 24, 2007
10 for a 28-day package of birth control pills. At Osco Drug, a patient can ... of the more common forms of birth control, Triphasil, or $23.99 for ... ... Pay-Per-View - University Wire - HighBeam Research

Press Release: Purchase of Additional Wyeth KK Equity by Wyeth from …  -  Apr 7, 2005
The Tridiol 21 regimen, which Wyeth-Ayerst markets as Triphasil ... marketing of oral contraceptives, Wyeth-Ayerst provides women all . ... Pay-Per-View - PR Newswire - HighBeam Research

Deficit Reduction Act's effect on birth control prices hits U....  -  Dec 4, 2007
10 for a 28-day package of birth control pills. At Osco Drug, a patient can ... of the more common forms of birth control, Triphasil, or $23.99 for ... ... Pay-Per-View - University Wire - HighBeam Research

“â€? el) will now start a new pack with an active pill on the first day...  -  Mar 9, 2005
...etk]><[stk 1]>On two other Wyeth products Triphasil and Trifeme the design will change but the content of the starting pills ... Pay-Per-View - Pharmacy News - Factiva, from Dow Jones

DEAR PHARMACIST, Stopping periods: convenience with risk  -  May 30, 2006
...including Alesse, Aviane, Enpresse, Lessina-28, Levlen, Levlite, Levora, Nordette, Portia, Seasonale, Tri-Levlen, Triphasil and Trivora-28. ... Pay-Per-View - Newsday - ProQuest Archiver

Birth control -- what's best for you?  -  Sep 8, 2006
The catch is that it can't be done with triphasic pills, such as Triphasil, because the hormone levels fluctuate during a cycle. ... Pay-Per-View - The Record - ProQuest Archiver

HORMONAL DRUG HAS RISKS  -  Jun 1, 2006
...including Alesse, Aviane, Enpresse, Lessina-28, Levlen, Levlite, Levora, Nordette, Portia, Seasonale, Tri-Levlen, Triphasil and Trivora-28. ... Pay-Per-View - South Florida Sun - Sentinel - ProQuest Archiver

Event Brief of Wyeth Mid-Year Business Update - Final.  -  Jul 12, 2006
Triphasil. 1. These contaminants were determined to be trace substances that migrated from the packaging material into the product. ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Engelhard backs BASF takeover  -  May 31, 2006
...including birth control pill Triphasil, hormone replacement Prempro, antidepressant Effexor and over-the-counter pain reliever Advil. ... $3.50 - Intelligencer, The - NewsBank

Bosentan (Systemic).(Drug overview)  -  Aug 1, 2006
Lunelle), oral (eg, Triphasil), or transdermal ("the patch" [eg, Ortho-Evra] -- Bosentan may prevent contraceptives from working properly and may result ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Press Release: VIDEO from Medialink and Warner Chilcott: First and...  -  Dec 9, 2006
Article: Wyeth Laboratories announces approval of Triphasil birth ... PR Newswire; November 8, 1984 ; 700+ words ... ... The first combination birth control ... Pay-Per-View - PR Newswire - HighBeam Research

Brand Names/Synonyms:
Triphasil is also known by the following brand names and/or synonymsAlesse; Alpha-Norgestrel; CCRIS 6525; Component of Lo/Ovral; Component of Ovral; Component of Stediril; D-Norgestrel; Dl-Norgestrel; Follistrel; HSDB 3595; HSDB 6483; Jadelle; Ld Norgestrel; Ld Norgestrel [French]; Levlen; Levlen Ed; Levonorgestrel; Levonorgestrel Implants; Levonorgestrel [Usan:Ban:Inn]; Levonorgestrelum [Inn-Latin]; Levonova; Levora-21; Levora-28; Lo/Ovral; Logynon; Logynon Ed; Methylnorethindrone; Microgest Ed; Microgyn; Microgynon; Microgynon 21; Microgynon 28; Microgynon 30 Ed; Microgynon Cd; Microlut; Microlution; Microval; Minivlar 30; Mirena; Monofeme 28; Monovar; NOG; Neogest; Neogynon 21; Nordet; Nordette; Nordette 21; Nordette 28; Norgeston; Norgestrel; Norgestrel [Progestins]; Norgestrel [Usan:Ban:Inn:Jan]; Norgestrelum [Inn-Latin]; Norplant; Norplant 2; Norplant Ii; Norplant System in Plastic Container; Ovral; Ovral-Lo; Ovran; Ovranette; Ovrette; Plan B; Postinor; Preven; Rigevidon 21+7; SH 850; Stediril; Stediril 30; Tetragynon; Tri-Levlen; Tri-Levlen 21; Triagynon; Triciclor; Trifeme 28; Trigoa; Trinordiol; Trinordiol 21; Trinordiol 28; Triphasil; Triphasil 21; Triphasil 28; Triquilar Ed; Trivora; Wy 3707; Wy-5104

Drug Category:
Triphasil is categorized under the following by the FDA: Contraceptives; ATC:G03AC03

Dosage Forms:
Tablets

Absorption:
65%

Interactions:
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Chemical IUPAC Name:
13-ethyl-17-ethynyl-17-hydroxy-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one





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