Ultram

This page contains recent news articles, when available, and an overview of Ultram but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Ultram
(when available)

Pharmacology and use:
Tramadol, a centrally-acting analgesic, exists as a racemic mixture of the trans isomer, with important differences in binding, activity, and metabolism associated with the two enantiomers. Although Tramadol is a synthetic analog of codeine, it has a significantly lower affinity for opioid receptors than codeine. Tramadol is used to treat postoperative, dental, cancer, and acute musculosketetal pain and as an adjuvant to NSAID therapy in patients with osteoarthritis. Indicated in the treatment of moderate to severe pain.

Mechanism Of Action:
Tramadol and its O-desmethyl metabolite (M1) are selective, weak OP3-receptor agonists. Opiate receptors are coupled with G-protein receptors and function as both positive and negative regulators of synaptic transmission via G-proteins that activate effector proteins. As the effector system is adenylate cyclase and cAMP located at the inner surface of the plasma membrane, opioids decrease intracellular cAMP by inhibiting adenylate cyclase. Subsequently, the release of nociceptive neurotransmitters such as substance P, GABA, dopamine, acetylcholine and noradrenaline is inhibited. The analgesic properties of Tramadol can be attributed to norepinephrine and serotonin reuptake blockade in the CNS, which inhibits pain transmission in the spinal cord. The (+) enantiomer has higher affinity for the OP3 receptor and preferentially inhibits serotonin uptake and enhances serotonin release. The (-) enantiomer preferentially inhibits norepinephrine reuptake by stimulating alpha(2)-adrenergic receptors.

News Articles on Tramadol

Cipher secures summary judgment in the company's favour in pending patent ...  -  ‎Jan 4, 2010‎
...in the FDA's "Orange Book" for Ultram(R) ER is invalid, unenforceable, and/or will not be infringed by the manufacture or sale of Cipher's drug product. ... PR Newswire (press release)

Bemidji woman pleads guilty to criminal vehicular homicide  -  ‎Dec 10, 2009‎
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Murder case critic arrested for drugs  -  14 Nov 2009
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J&J to cut 174 Montco jobs  -  ‎Nov 9, 2009‎
Development LLC employed 680 in Spring House, where the company said prescription medicines, including Topamax, Ultram and Ultracet, were developed. ... Philadelphia Inquirer

Par's Hanging Generic Tramadol Launch Fuels Settlement Talk  -  ‎Oct 28, 2009‎
...(PRX) takes to launch its generic version of once-daily painkiller tramadol, Ultram ER, the more reason the market has to believe a settlement is in the ... Wall Street Journal

FDA Safety Changes: Ultram, Ultracet, Sustiva, Kayexalate  -  ‎Oct 28, 2009‎
On September 9, the FDA approved safety labeling revisions for tramadol HCl (marketed alone and with acetaminophen as Ultram and Ultracet tablets by Ortho ... Medscape

Biovail 3Q profit falls 17 percent on costs  -  ‎Nov 5, 2009‎
Sales of the antiviral cream Zovirax fell 6 percent to $30.8 million, and sales of extended-release pain drug Ultram ER fell 42 percent to $12.1 million. ... Forbes

Brand and Generic TRAMADOL (Ultram). FDA approved. Fast Delivery. Ultram.  -  ‎Oct 31, 2009‎
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Pfizer to cut jobs at Wyeth's Montco site  -  ‎Nov 10, 2009‎
Development LLC employed 680 in Spring House, where the company said prescription medicines, including Topamax, Ultram, and Ultracet, were developed. ... Philadelphia Inquirer

Cipher receives complaint of patent infringement for CIP-TRAMADOL ER  -  ‎Nov 2, 2009‎
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Par Pharmaceutical Reports EPS of $0.76 for Third Quarter 2009  -  ‎Nov 6, 2009‎
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Tramadol & Other Prescription Drugs: Prices Dropped to New All-Time Low by ...  -  ‎Nov 3, 2009‎
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Tramadol online  -  ‎Oct 31, 2009‎
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Cipher reports Q3 2009 financial results  -  ‎Nov 4, 2009‎
In Q3 2009, the Company filed a Paragraph IV Certification with the FDA, which states that the relevant patent listed in the FDA's Orange Book for Ultram(R) ... CNW Telbec (Communiqué de presse)

Cipher reports Q3 2009 financial results  -  ‎Nov 4, 2009‎
In Q3 2009, the Company filed a Paragraph IV Certification with the FDA, which states that the relevant patent listed in the FDA's Orange Book for Ultram(R) ... PharmaLive.com (press release)

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Biovail voluntarily recalls some lots of Ultram tablets  -  Dec 30, 2008
Dec 30 (Reuters) - Biovail Corp (BVF.TO: Quote, Profile, Research) (BVF.N: Quote, Profile, Research) said it was voluntarily recalling certain lots of ... Reuters India

Biovail Faces Generic Competition  -  May 12, 2006
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I Dulled Her Pain, and My Judgment  -  Jul 30, 2006
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Biovail, Labopharm shares jump on US marketing deal  -  Nov 4, 2005
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Prescription Tramadol: New Preteen High  -  Sep 12, 2008
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Biovail profit rises, says understated 2006 income  -  May 10, 2007
TO) reported a higher first-quarter profit on Thursday helped by a 99 percent boost in sales of its Ultram pain treatment, but said it planned to restate ... Reuters

… Voluntary Recall of Certain Lots of Ultram® ER 100mg Tablets  -  Dec 30, 2008
Biovail Corporation today announced a voluntary recall of certain lots of Ultram® ER (extended-release tramadol hydrochloride) 100mg tablets from pharmacies ... International Business Times

Biovail Profit Rises 22-fold on Wellbutrin Sales  -  Aug 10, 2006
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Biovail contracts J&J to sell pain drug  -  Jan 2, 2008
...said Wednesday it partnered with Johnson & Johnson unit Janssen Pharmaceutica NV to market its extended-release pain drug Ultram ER in 86 countries. ... Boston Globe

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IMPAX Sued Based on ANDA for Generic Ultram(R) ER  -  Aug 12, 2008
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FDA Wants More Studies on Biovail's Generic Ultram  -  Mar 31, 2005
Biovail might have to delay the launch of its Tramadol ER product by up to 18 months after learning that the FDA wants more clinical studies performed on ... Pay-Per-View - Drug Industry Daily - Factiva, from Dow Jones

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Drug firm's quarterly profit soars 160 per cent  -  Mar 24, 2006
Squires said revenues are being enhanced by the recent launch of Ultram ER, a one-a-day pill for chronic pain distributed in the United States by Johnson ... Pay-Per-View - Toronto Star - ProQuest Archiver

Wise v. Kind & Knox Gelatin, Inc., 429 F.3d 1188 (8th Cir. 12/07/2005)  -  Dec 7, 2005
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Press Release: Once Daily ULTRAM(R) ER Extended-Release Tablets …  -  Feb 21, 2006
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For Chronic Pain Treatment, Ultram May Work Best  -  Apr 7, 2008
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Ultram Drug  -  Aug 4, 2007
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TheraQuest announces a safer, abuse deterrent, long-acting, once...  -  Feb 14, 2005
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Biovail Reports First-Quarter 2006 Financial Results; Company Records...  -  May 11, 2006
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How Do People Abuse Ultram  -  Sep 18, 2007
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TheraQuest Receives Orphan Drug Status for its Abuse Deterrent, Once-...  -  Feb 17, 2005
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Biovail, J&J Expand Ultram ER Supply Agreement  -  Jan 8, 2008
Johnson & Johnson (J&J) will sell Biovail's opioid Ultram ER in markets outside the US under an expanded 10-year supply agreement for the painkiller. ... FDA news - FDA news (subscription)

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Ultram[R]er: (tramadol HCl) extended-release tablets: an oral once...  -  Sep 1, 2006
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can ultram cause MOH?  -  May 5, 2008
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Say good-bye to all your pains  -  Nov 3, 2006
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Biovail, Ortho-McNeil Partnership Receives Hart-Scott-Rodino Regulator...  -  Dec 2, 2005
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Ultram Detoxification  -  May 25, 2007
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Ultram Pain Reliever  -  Jun 21, 2007
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Generics hurt Biovail sales, earnings  -  Aug 9, 2007
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TSX edges higher at midday  -  Dec 31, 2008
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Kidney and Liver Disease Do Not Appear to Significantly Affect …  -  Sep 22, 2006
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Ultram debuts.  -  Mar 27, 2006
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Ultram debuts.  -  Mar 27, 2006
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Ultram debuts.(Brief article) | Article from Chain Drug Review |...  -  Mar 27, 2006
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Ask The Doctor About Osteoarthritis Pain  -  Dec 20, 2007
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Loislaw Federal District Court Opinions - SUAREZ v. KEISER (WDNY 10- …  -  Oct 19, 2007
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New Once Daily Medicine Available For Treatment For Moderate To …  -  Jul 15, 2006
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Press Release: Chronic Pain Up Almost 40 Percent Among US Workers …  -  Jan 30, 2007
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WILLIAMS v. KOENIGSMANN, 03Civ.5267(SAS)(RLE). (SDNY 05/09/ …  -  May 9, 2005
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Article: Integrated Communications.(Update) - Medical Marketing &...  -  Jul 1, 2006
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What is the addiction risk associated with tramadol?(Clinical...  -  Jan 1, 2005
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En bref - Biovail rappelle l'Ultram  -  Dec 31, 2008
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Biovail in tramadol deal with J&J unit.(Johnson & Johnson)(Brief...  -  Nov 14, 2005
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Marketing; Hart-Scott-Rodino regulatory clearance granted for pain...  -  Jan 3, 2006
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Stocks Rally on GMAC Funding  -  Dec 30, 2008
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Loislaw Federal District Court Opinions - SUAREZ v. KEISER (WDNY …  -  Mar 2, 2006
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Movers: GM, Rohm & Haas, Dow Chemical, Biovail  -  Dec 30, 2008
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Dr. Eisner Answers Your Questions About Acid Reflux  -  Dec 31, 2008
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Chronic Pain Up Almost 40 Percent Among US Workers in Past Decade  -  Feb 2, 2007
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United States v. Ortho-McNeil Pharmaceutical, Inc., No. 03 C 8239...  -  Jul 20, 2007
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The Deadly Side Effects of Net Pharmacies  -  Dec 18, 2006
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C. Óscar Soria esq. Rosendo Gutiérrez Telf. 2117408  -  Jul 9, 2008
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Loislaw Federal District Court Opinions - ENCARNACION v. WRIGHT ( …  -  Sep 28, 2007
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Event Brief of Q1 2007 Biovail Corporation Earnings Conference Call -...  -  May 10, 2007
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Biovail Reports First-Quarter 2008 Financial Results  -  May 8, 2008
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Johnson и Johnson обьÑ?вила тендер на рекламу  -  Jul 22, 2008
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WPP и Interpublic Group получили креативный Ñ?ккаунт Johnson & …  -  Nov 7, 2008
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Loislaw Federal District Court Opinions - KROWIORZ v. BARNHART ( …  -  Mar 30, 2005
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Competitors by Product Report  -  Dec 27, 2008
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Loislaw Federal District Court Opinions - LYONS v. ASTRUE (NDOhio 6- …  -  Jun 16, 2008
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Loislaw Federal District Court Opinions - GARREN v. UNKNOWN …  -  Oct 24, 2008
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Loislaw Federal District Court Opinions - SOBERY v. ASTRUE (EDMo. 9- …  -  Sep 17, 2008
Dr. Farley, who had refilled Plaintiff's Ultram and Daypro prescriptions between her visits, noted that Plaintiff had been on Ultram "for quite a period of ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Encarnacion v. Wright, No. 04-CV-6064 CJS (WDNY 09/28/2007)  -  Sep 28, 2007
Ultram has also been discontinued at various times, based on Plaintiff's ... On June 25, 2004, a note indicates that Plaintiff's Ultram prescription was ... $2.95 - U.S. District Court, Western District... - VersusLaw

Biovail to Promote AstraZeneca's Zoladex(R) 3.6mg (Goserelin Acetate ...  -  May 2, 2006
Ultram(R) ER was launched in February; Biovail and OMI anticipate the launch of Ultram(R) ODT later in mid-2006. Zoladex 3.6mg is indicated for the ... Genetic Engineering News - Genetic Engineering News (press release)

Event Brief of Q4 2006 Biovail Corporation Earnings Conference Call -...  -  Mar 15, 2007
Terminated copromotion efforts for Ultram ER and Zoladex. ... In late February, launched Ultram ER. 1. First formulation of tramadol HCL to receive market ... Free with registration - Fair Disclosure Wire - AccessMyLibrary.com

Labopharm to present data at the 23rd Annual American Academy of Pain...  -  Sep 2, 2007
Following single-dose administration, the initial absorption of tramadol from Tramadol Contramid(R) OAD 200 mg is rapid and comparable to that of Ultram(R) ... FinanzNachrichten.de

Ir sÄ?cies jaunais mÄ?cÄ«bu gads  -  Sep 14, 2007
...>ultram</a> [url=http://www.networkingitalia.it/modules.php? name=Forums&file=viewtopic&p=26352&c-topic=ultram]ultram[/url] Waiting for you! ... Dzirkstele

TSX jumps more than 1 percent as oil spikes  -  Dec 31, 2008
...(Reuters) - Biovail Corp said it was voluntarily recalling certain lots of Ultram tablets, its treatment for chronic pain in adults, and expects the total ... ReportonBusiness.com

Loislaw Federal District Court Opinions - RAND v. SIMONDS (DNH 2006)  -  Mar 22, 2006
The next day, Simonds, a physician's assistant at the MCHC, added Ultram, an analgesic, to Rand's drug regimen. Rand asked for further medical attention on ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Loislaw Federal District Court Opinions - PURDUE PHARMA PRODUCTS …  -  Nov 4, 2008
Because the FDA lists ULTRAM ® ER as covered by the `887 patent, [fn7] Defendants also certified that the `887 patent is invalid or will not be infringed by ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Brand Names/Synonyms:
Ultram is also known by the following brand names and/or synonymsCrispin; Ralivia Er; Ralivia Flashtab; TRAMADOL/HCL; Tramadol; Tramadol Hcl; Tramadol Hcl Bp/Ep; Tramadol Hydrochloride; Tramadolum [Inn-Latin]; Tramal; Tramodol Hcl; Ultram; Zydol

Drug Category:
Ultram is categorized under the following by the FDA: Narcotics; Analgesics; ATC:N02AX02

Dosage Forms:
TABLET

Absorption:
Racemic tramadol is rapidly and almost completely absorbed after oral administration. The mean absolute bioavailability of a 100 mg oral dose is approximately 75%.The mean peak plasma concentration of racemic tramadol and M1 occurs at two and three hours, respectively, after administration in healthy adults.

Interactions:
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Chemical IUPAC Name:
2-(dimethylaminomethyl)-1-(3-methoxyphenyl)-cyclohexan-1-ol





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