Valacyclovir

This page contains recent news articles, when available, and an overview of Valacyclovir but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Valacyclovir
(when available)

Pharmacology and use:
Valacyclovir is a prodrug and synthetic purine nucleoside analogue with inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), varicella-zoster virus (VZV), Epstein-Barr virus (EBV), and cytomegalovirus (CMV). Valacyclovir is almost completely converted to acyclovir and L-valine. The inhibitory activity of valacyclovir is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts acyclovir into acyclovir monophosphate, which is then converted into acyclovir diphosphate and triphosphate by cellular enzymes. Acyclovir is selectively converted to the active triphosphate form by cells infected with herpes viruses. For the treatment or suppression of cold sores (herpes labialis), herpes zoster (shingles), genital herpes in immunocompetent individuals, and recurrent genital herpes in HIV-infected individuals.

Mechanism Of Action:
Valacyclovir is phosphorylated by viral thymidine kinase to acyclovir triphosphate (the active metabolite) which then inhibits herpes viral DNA replication by competitive inhibition of viral DNA polymerase, and by incorporation into and termination of the growing viral DNA chain. When used as a substrate for viral DNA polymerase, acyclovir triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where acyclovir triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand.

News Articles on Valacyclovir

Ranbaxy: Generic Version of Flomax to Be Launched in March  -  ‎Dec 10, 2009‎
...--launched valacyclovir hydrochloride with a 180-day marketing exclusivity in the US The drug is a generic version of GlaxoSmithKline's anti-herpes medicine ... Wall Street Journal

What could strike you after chicken pox  -  ‎Dec 21, 2009‎
Drugs that fight viruses (antivirals), such as acyclovir (Zovirax), valacyclovir (Valtrex), or famciclovir (Famvir), can reduce the severity and duration of ... Express Buzz

Niacin may be effective in lowering cholesterol  -  ‎Dec 18, 2009‎
There are three prescription medications used to fight the herpes virus: Famvir (famciclovir), Valtrex (valacyclovir) and Zovirax (acyclovir). ... Los Angeles Times

Ranbaxy sure of monetising Flomax, Lipitor, Nexium  -  ‎Dec 14, 2009‎
Valtrex (valacyclovir hydrochloride) is the $1.3 billion innovator drug of GlaxoSmithKline used in treatment of herpes. With the launch of its generic ... Daily News & Analysis

Genital herpes is a common and treatable ailment  -  ‎Dec 24, 2009‎
There are three medications used to fight the herpes virus: Famvir (famciclovir), Valtrex (valacyclovir) and Zovirax (acyclovir). For occasional outbreaks ... St. Louis Post-Dispatch

Mit Acyclovir kann bei Krebserkrankungen Infektionen mit Herpes simplex-Viren ...  -  ‎Dec 30, 2009‎
Als effektiv erwiesen sich der antivirale Wirkstoff Acyclovir und seine Vorstufe, das so genannte Valacyclovir, das im Körper in Acyclovir umgewandelt wird. ... DKG Krebsgesellschaft

Generic Name: Valaciclovir, Valacyclovir, Zelitrex  -  ‎Nov 11, 2009‎
Valtrex (generic name: Valaciclovir/Valacyclovir; brand name: Zelitrex) is an antiviral medicine that targets herpes infections, including herpes zoster ... Pattaya Daily News

Postherpetic Neuralgia in Herpes Zoster  -  ‎Nov 3, 2009‎
However, this is not accurate; our review did not include any trials of valacyclovir. In addition, Whitley stated that "[p]revention of PHN is a major ... Journal of American Medical Association (subscription)

Optimal guidelines needed for preventing neonatal herpes simplex virus  -  ‎Nov 5, 2009‎
Proposed regimens include a 400-mg dose of oral acyclovir (Zovirax, GlaxoSmithKline) three times daily or 500 mg of oral valacyclovir (Valtrex, ... Pediatric SuperSite

The kissing disease  -  ‎Oct 25, 2009‎
The antiviral drug valacyclovir (Valtrex) has been used to reduce the symptoms of infectious mononucleosis. The main side effects of Valtrex that affect ... Martinsburg Journal

Late valacyclovir for herpes yields greater response  -  Jun 8, 2007
By Martha Kerr. NEW YORK (Reuters Health) - Therapy with valacyclovir (Valtrex, GlaxoSmithKline), started within three months of infection with either ... Reuters UK

One-day valacyclovir effective for genital herpes  -  Apr 17, 2008
By Martha Kerr. NEW YORK (Reuters Health) - Recurrent outbreaks of herpes simplex virus 2 (HSV2), or "genital herpes," can be effectively treated with a ... Reuters India

Herpes treatment may help HIV patients - study  -  Feb 21, 2007
Valacyclovir, made and sold by GlaxoSmithKline (GSK.N) (GSK.L) under the brand name Valtrex, is one of several drugs that can treat herpes. ... Reuters

Herpes Study Put Pregnant Women at Risk  -  Dec 1, 2006
Acyclovir is widely available in generic form. Valacyclovir is sold as Valtrex by GlaxoSmithKline, which sponsored the 2006 study. FOXNews

Valacyclovir in pregnancy limits herpes recurrence.(News)  -  Jun 1, 2005
SAN FRANCISCO -- Women with a history of genital herpes or a primary herpes episode experienced a reduction in both subclinical and active disease ... Free with registration - OB GYN News - AccessMyLibrary.com

Ranbaxy settles Glaxo patent row, shares up  -  Jul 26, 2007
Ranbaxy received approval from the US Food and Drug Administration in February for valacyclovir hydrochloride, the active ingredient of Valtrex. ... Reuters India

Valacyclovir (Systemic).(Drug overview)  -  May 1, 2006
Valacyclovir (val-ay-SYE-kloe-veer) is used to treat the symptoms of herpes zoster (also known as shingles), a herpes virus infection of the skin; ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Is There Anything I Can Do To Prevent Pain Associated With Shingles?  -  Jan 2, 2008
They are acyclovir, famciclovir, and valacyclovir. These are the generic names. If for any reason, your doctor is out of office, or the person that sees you ... ABC News

Ranbaxy and GSK agree to settle Valacyclovir US patent case  -  Jul 27, 2007
Ranbaxy Laboratories Limited (RLL) has announced that the Company has reached an agreement with GlaxoSmithKline (GSK) resulting in a dismissal of their US ... News-Medical.net

… : MDs 'obligated' to tell patients daily valacyclovir decreases HSV...  -  Jul 1, 2005
Valacyclovir is indicated for the prevention of genital herpes outbreaks and ... Approved by the US Food and Drug Administration in 1995, valacyclovir is ... Free with registration - Dermatology Times - AccessMyLibrary.com

Valtrex (valacyclovir) - US Patent Litigation Update.  -  Feb 2, 2007
PHILADELPHIA and LONDON, Feb. 2 /PRNewswire-FirstCall/ -- GlaxoSmithKline today issued an update on US patent litigation regarding Valtrex (valacyclovir), ... Free with registration - PR Newswire - AccessMyLibrary.com

Herpes Simplex Virus; Valacyclovir reduces risk of HSV-2 transmission...  -  Jan 2, 2006
2006 JAN 2 - (NewsRx.com) -- Valacyclovir reduces the risk of herpes simplex virus-2 transmission between HSV-2 discordant couples. ... Pay-Per-View - Anti-Infectives Week - Factiva, from Dow Jones

Mylan gets tentative OK for generic version of Valtrex  -  Jan 31, 2007
N said on Wednesday it received tentative approval for its abbreviated new drug application for Valacyclovir Hydrochloride tablets in 500 milligrams and ... Reuters

Valacyclovir Dosage Recommendations for EHV Released  -  Aug 24, 2008
Oklahoma researchers interested in limiting equine herpesvirus (EHV) disease outbreaks have established specific dosing recommendations for the antiviral ... TheHorse.com

High-Dose Oral Valacyclovir Reduces Viral Shedding From Recurrent …  -  Feb 23, 2005
Feb. 23, 2005 (New Orleans) — One day of high-dose oral valacyclovir treatment significantly decreases the duration of virus shedding that occurs with ... Medscape

Valacyclovir cheapest way to prevent neonatal herpes.(Infectious …  -  Nov 1, 2005
CHARLESTON, SC -- Oral valacyclovir was the most economically favorable treatment choice for the prevention of intrapartum herpes transmission in a recent ... Free with registration - Family Practice News - AccessMyLibrary.com

Prednisolone—but not antiviral drugs—improves outcome in patients...  -  Nov 25, 2008
Treatment with valacyclovir, either alone or in combination with prednisolone ... Allen D and Dunn L. Aciclovir or valacyclovir for Bell's palsy (idiopathic ... Nature.com

Valacyclovir Reduces HIV-1 Levels in Men Coinfected With Herpes …  -  Oct 17, 2006
By Louise Gagnon. TORONTO, CANADA -- October 17, 2006 -- The use of therapy for herpes simplex virus type 2 (HSV-2) can help reduce plasma and rectal levels ... DG News

Valacyclovir proves safe for HSV-2 suppressive therapy of up to 20 …  -  Oct 1, 2005
CHARLESTON, SC -- Once-daily treatment with valacyclovir for the suppression of genital herpes caused by herpes simplex virus type-2 was well-tolerated for ... Free with registration - OB GYN News - AccessMyLibrary.com

One-day valacyclovir effective for recurrent genital herpes  -  Apr 18, 2008
NEW YORK -- Recurrent outbreaks of herpes simplex virus 2 (HSV2), or “genital herpes,� can be effectively treated with a one-day course of valacyclovir ... China Post

SCIENCE FILE; Science in Brief; Treating herpes may slow HIV  -  Feb 24, 2007
...herpes was being treated with 500 milligrams of the drug valacyclovir twice daily for three months, the women were less likely to spread the AIDS virus. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Valacyclovir clears EBV in mono, may also restrict spread.(News)(epste...  -  Feb 1, 2006
WASHINGTON -- Valacyclovir appears to be an effective treatment for infectious mononucleosis and might also reduce the risk of transmission, ... Free with registration - Pediatric News - AccessMyLibrary.com

Steroids or Valacyclovir for Vestibular Neuritis  -  May 1, 2005
After benign paroxysmal positional vertigo, vestibular neuritis is the next most common cause of peripheral vestibular vertigo. The typical presentation is ... AAFP News Now

Herpes drug helps control HIV  -  Feb 22, 2007
The herpes medication, valacyclovir, also appears to reduce levels of HIV in the ... The researchers behind the study suggest that valacyclovir, and other ... New Scientist

… gestational genital herpes outbreaks may be reduced with valacyclov...  -  May 1, 2006
..."The 112 enrolled women (57 valacyclovir, 55 placebo) had similar HSV ... "Administration of valacyclovir beginning at 36 weeks' gestation to women with a ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones

High-dose valacyclovir reduced shedding of oral herpes virus.(Infectio...  -  Jul 1, 2005
NEW ORLEANS -- Treatment with once-daily, high-dose valacyclovir significantly decreases the duration and quantity of oral herpes simplex virus-1 shedding ... Free with registration - Family Practice News - AccessMyLibrary.com

Valacyclovir clears EBV in mono, may also restrict spread.(News)(epste...  -  Feb 1, 2006
Valacyclovir clears EBV in mono, may also restrict spread.(News)(epstein-barr virus) ... find Pediatric News articles. WASHINGTON -- Valacyclovir appears to ... Pay-Per-View - Pediatric News - HighBeam Research

Valacyclovir prophylaxis best for neonatal herpes.(Dermatologic...  -  Nov 1, 2005
Valacyclovir prophylaxis best for neonatal herpes.(Dermatologic Therapy) ... find Skin & Allergy News articles. Charleston, SC -- Oral valacyclovir was the ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Press Release: Valtrex (valacyclovir) - US Patent Litigation Update. ...  -  Feb 2, 2007
Valtrex (valacyclovir) - US Patent Litigation Update. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Valacyclovir clears EBV in mono, may help prevent spread.(News)( …  -  Jan 15, 2006
Valacyclovir clears EBV in mono, may help prevent spread.(News)(Epstein-Barr virus) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Valacyclovir as good as Acyclovir for prevention of ocular herpes.( …  -  Oct 1, 2007
Once-daily oral valacyclovir is as good as twice-daily oral acyclovir for preventing the recurrence of eye disease caused by herpes simplex virus, ... $4.95 - Skin & Allergy News - ECNext

Article: High-dose valacyclovir reduced shedding of oral herpes...  -  Jul 1, 2005
High-dose valacyclovir reduced shedding of oral herpes virus.(Infectious Diseases) ... find Family Practice News articles. NEW ORLEANS -- Treatment with ... Pay-Per-View - Family Practice News - HighBeam Research

Leukemia; Oral valacyclovir may protect against herpes during high...  -  Jan 25, 2005
2005 JAN 25 - (NewsRx.com & NewsRx.net) -- Oral valacyclovir may protect against herpes during high-dose chemotherapy. "Reactivation of herpes simplex virus ... Pay-Per-View - Cancer Weekly - Factiva, from Dow Jones

… Enter Into an Agreement to Settle Valacyclovir US Patent Litigatio  -  Jul 26, 2007
Ranbaxy to Launch Valacyclovir Hydrochloride Tablets in Late 2009 With 180 Days ... 4957924, covering Valacyclovir Hydrochloride which is used in the ... Pay-Per-View - PR Newswire - HighBeam Research

Article: Valacyclovir clears Epstein-Barr in mononucleosis.(Clinical ...  -  Feb 1, 2006
Valacyclovir clears Epstein-Barr in mononucleosis.(Clinical Rounds) ... find Skin & Allergy News articles. WASHINGTON -- Valacyclovir appears to be an ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Antiviral Medications For Herpes Treatment  -  Aug 22, 2008
Valacyclovir provides a unique mechanism of enhancing the oral ... Valacyclovir is a prodrug converted to acyclovir in the intestine and liver. ... Buzzle

Leukemia; Oral valacyclovir may protect against herpes during high...  -  Jan 28, 2005
2005 JAN 28 - (NewsRx.com & NewsRx.net) -- Oral valacyclovir may protect against herpes during high-dose chemotherapy. "Reactivation of herpes simplex virus ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

… FDA Approval to Manufacture and Market Valacyclovir HCl Tablets. -...  -  Feb 1, 2007
Valacyclovir HCl has combined sales totaling $1.26 billion (IMS - MAT: September 2006). Valacyclovir HCl is indicated for the treatment of herpes zoster ... Pay-Per-View - PR Newswire - HighBeam Research

Leukemia; Oral valacyclovir may protect against herpes during high...  -  Jan 24, 2005
2005 JAN 24 - (NewsRx.com & NewsRx.net) -- Oral valacyclovir may protect against herpes during high-dose chemotherapy. "Reactivation of herpes simplex virus ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Genital herpes therapy effective if begun early  -  Jul 16, 2008
Valacyclovir was effective in preventing disease recurrences, Dr. Kenneth H. Fife, ... After 24 weeks, 71 percent of the valacyclovir-treated subjects were ... Reuters

… After Treatment With Intravenous Acyclovir Followed by Oral Valacyc...  -  May 8, 2006
Effect of intravenous acyclovir and oral valacyclovir in patients with ... The remaining 12 patients began receiving oral valacyclovir after 14 days of IV ... Archives of Neurology

Antiviral Therapy Following Dental Treatment May Inhibit Herpesviruses  -  May 15, 2005
In the study valacyclovir, an antiviral drug, was administered to ... Effect of prophylactic valacyclovir on the presence of human herpesvirus DNA in saliva ... Medical News Today - Medical News Today (press release)

GSK to oppose Ranbaxy`s launch of generic in US  -  Feb 3, 2007
Ranbaxy won US regulatory approval to market valacyclovir hydrochloride tablets on Feb. 1 but Glaxo has been fighting Ranbaxy`s plans since May 2003. ... Myiris.com

Article: Valacyclovir proves safe for the long-term suppression of...  -  Nov 1, 2005
Valacyclovir proves safe for the long-term suppression of HSV-2.(Infectious Diseases) ... find Family Practice News articles. CHARLESTON, SC -- Once-daily ... Pay-Per-View - Family Practice News - HighBeam Research

Ranbaxy gains final approval for generic valacyclovir.  -  Feb 12, 2007
Ranbaxy gains final approval for generic valacyclovir. Ranbaxy Pharmaceuticals, the wholly-owned US subsidiary of India's Ranbaxy Laboratories, has received ... $9.94 - Pharma Marketletter - Alacra Store

Article: Valacyclovir as good as Acyclovir for prevention of ocular...  -  Oct 1, 2007
Valacyclovir as good as Acyclovir for prevention of ocular herpes.(Infectious Diseases) ... find Skin & Allergy News articles. Once-daily oral valacyclovir ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: Valacyclovir cheapest way to prevent neonatal herpes.(Infecti...  -  Nov 1, 2005
Valacyclovir cheapest way to prevent neonatal herpes.(Infectious Diseases)(Brief Article) ... find Family Practice News articles. Pay-Per-View - Family Practice News - HighBeam Research

Post USFDA ban, Ranbaxy readies plan B for drugs  -  Sep 20, 2008
...“Since the launch of Valacyclovir is scheduled only in last quarter next calendar ... Also, the API of Valacyclovir is also in the list of the banned drug. ... Economic Times

… Tentative Approval for Valacyclovir Hydrochloride Tablets. - PR …  -  Jan 31, 2007
Mylan Announces Tentative Approval for Valacyclovir Hydrochloride Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Article: Valacyclovir reduces oral herpes shedding.(Dermatologic...  -  Jun 1, 2005
Valacyclovir reduces oral herpes shedding.(Dermatologic Therapy)(Brief Article) ... find Skin & Allergy News articles. New Orleans -- Treatment with ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: Valacyclovir in pregnancy limits herpes recurrence.(News) -...  -  Jun 1, 2005
Valacyclovir in pregnancy limits herpes recurrence.(News) ... find OB GYN News articles. SAN FRANCISCO -- Women with a history of genital herpes or a ... Pay-Per-View - OB GYN News - HighBeam Research

Treatment for Genital Herpes  -  Sep 19, 2008
...(Acyclovir and famiciclovir are taken twice a day, valacyclovir once a day. ... Valacyclovir may work especially well for preventing herpes transmission ... New York Times

Bell's Palsy: diagnosis and management.(Information from Your Family ...  -  Oct 1, 2007
Approximately 70 to 80 percent of patients will recover spontaneously; however, treatment with a seven-day course of acyclovir or valacyclovir and a ... Free with registration - American Family Physician - AccessMyLibrary.com

What are the best treatments for herpes labialis?(CLINICAL INQUIRIES:...  -  Jul 1, 2007
There are 3: valacyclovir, acyclovir, and topical penciclovir. Valacyclovir, 2 g twice in 1 day taken during the prodromal stage of herpes labialis, ... $4.95 - Journal of Family Practice - ECNext

Transplantation, May 2005  -  Jun 28, 2005
The authors concluded that valacyclovir and oral ganciclovir are equally ... However, valacyclovir was associated with a significantly reduced risk of acute ... Medscape

FPIN's Clinical Inquiries  -  Mar 1, 2006
Oral valacyclovir may be slightly superior to acyclovir for resolution of acute pain. ... Valacyclovir (Valtrex) 1000 mg three times daily for seven days is ... AAFP News Now

Herpes Drug Fights HIV Too  -  Nov 13, 2007
The anti-herpes drug Valtrex (valacyclovir) has been found to lower HIV ... The men were randomized to receive either 500mg of valacyclovir twice a day or a ... AIDSmeds.com HIV/AIDS Treatment News

For Bell's palsy, start steroids early; no need for an antiviral.(NEW...  -  Jan 1, 2008
Hato et al, (9) in a Japanese study, showed that valacyclovir reaches a level of ... The overall rate of recovery of those treated with valacyclovir and ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

葛兰素å?²å…‹ç”³è¯·ç¦?制令æ??å?«å¸‚场  -  Feb 6, 2007
...祸ä¸?å?•行的是在2007å¹´2月1日,å?—æ–°å…¬å?¸çš„valacyclovir获得美国FDA批准å?¯ä»¥å…¬å¼€é”€å”®ã€‚ 无奈之下,葛兰素å?²å…‹å†³å®šå?‘法院æ??出ç¦?制令,以阻止此è?¯å“?在美国上市。 ... 腾讯网

Article: Study: Herpes drug slows HIV - Oakland Tribune | HighBeam …  -  Feb 22, 2007
Medicine, women who took the herpes drug valacyclovir had less HIV in their blood and in their ... with acyclovir, the first herpes drug, can slow down HIV ... Pay-Per-View - Oakland Tribune - HighBeam Research

Article: Herpes Study Put Pregnant Women at Risk - AP Online | …  -  Dec 2, 2006
Valacyclovir is sold as Valtrex by GlaxoSmithKline, which sponsored the 2006 study. ---. On the Net:. American College of Obstetrics and Gynecology: ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Herpes Study Put Pregnant Women at Risk | Article from AP Online | …  -  Dec 2, 2006
Valacyclovir is sold as Valtrex by GlaxoSmithKline, which sponsored the 2006 study. ---. On the Net:. American College of Obstetrics and Gynecology: ... Pay-Per-View - Associated Press/AP Online - HighBeam Research

Drugs can lower risk of genital herpes recurrence  -  Aug 13, 2007
The researchers evaluated acyclovir, valacyclovir, and famciclovir, sold under the trade names Zovirax, Valtrex and Famvir, respectively, ... Reuters UK

Infectiousness Of HIV May Be Reduced By Suppressing Herpes Virus  -  Nov 18, 2007
Subjects were randomly assigned to the anti-HSV drug, valacyclovir 500 mg, ... Since the only intervention was daily valacyclovir to suppress HSV, ... Medical News Today - Medical News Today (press release)

Short-course therapy for recurrent genital herpes and herpes labialis:...  -  Jan 1, 2007
Three-day vs 5-day valacyclovir therapy. The efficacy of 3-day treatment with oral ... The 3-day valacyclovir treatment exhibited similar time to lesion ... Free with registration - Journal of Family Practice - AccessMyLibrary.com

Genital Herpes; Overview. | Article from NWHRC Health Center -...  -  Jun 20, 2008
Valacyclovir HSV Transmission ... transmission of genital herpes. ... Cortes M; Valacyclovir HSV Transmission Study ... of transmission of genital herpes. ... Pay-Per-View - NWHRC Health Center - Genital Herpes - HighBeam Research

Recent Developments in the Treatment of Cutaneous Viral Infections  -  Apr 17, 2006
Valacyclovir, a prodrug of acyclovir, has higher bioavailability ... Single-dose valacyclovir reduces healing time compared with placebo by 15% to 20% and ... Medscape

Genital Herpes; Diagnosis. | Article from NWHRC Health Center -...  -  Jun 20, 2008
Valacyclovir HSV Transmission ... transmission of genital herpes. ... Cortes M; Valacyclovir HSV Transmission Study ... of transmission of genital herpes. ... Pay-Per-View - NWHRC Health Center - Genital Herpes - HighBeam Research

Corticosteroids Judged Superior for Bell's Palsy  -  Oct 17, 2007
But a different antiviral agent, valacyclovir (Valtrex) might still offer benefit in early treatment of patients with severe or complete facial palsy, ... MedPage Today

Treatment of HSV-2 Coinfection Reduces HIV Shedding  -  Feb 8, 2006
..."In parallel to an impact of valacyclovir on genital HIV-1 shedding, we found that women from the valacyclovir group had a lower mean plasma HIV-1 RNA than ... Medscape

Suppressing herpes virus may decrease infectiousness of HIV  -  Nov 16, 2007
They were randomly assigned to the anti-HSV drug, valacyclovir 500 mg, ... Since the only intervention was daily valacyclovir to suppress HSV, ... TopNews

Oral antivirals and recurrent genital herpes.(PIPELINE PREVIEWS)(Brief...  -  Oct 1, 2007
Patients who were treated with acyclovir, valacyclovir, or famciclovir were 47% less likely to have a recurrence of genital herpes than those treated with ... Free with registration - Journal of Drugs in Dermatology - AccessMyLibrary.com

U. Minnesota: U. Minnesota researcher finds that existing drug might...  -  Oct 4, 2006
..."The kids that got Valacyclovir basically got better, faster," he said. ... As for Valacyclovir, it may be some time before it's widely prescribed. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com

Antiviral Therapy Following Dental Treatment May Inhibit Herpesviruses  -  Jun 7, 2005
In the study, valacyclovir, an antiviral drug, was administered to 125 ... Effect of prophylactic valacyclovir on the presence of human herpesvirus DNA in ... Infection Control Today

Emerging Issues in the Management of Herpes Simplex Virus Infections  -  Feb 6, 2007
The nucleoside antivirals acyclovir, famciclovir, and valacyclovir have all ... Acyclovir, famciclovir, and valacyclovir remain the standard of care and may ... Medscape

Herpes Treatment Lowers HIV In Co-Infected Men  -  Nov 19, 2007
The men were randomized to get placebo or valacyclovir (Valtrex) at 500 milligrams twice daily for eight weeks. Then, after a two-week washout period, ... MedPage Today

Herpes zoster and postherpetic neuralgia: prevention and management.  -  Sep 15, 2005
...(10) No differences have been found between famciclovir and valacyclovir. ... Valacyclovir and famciclovir usually are preferred because they are ... Free with registration - American Family Physician - AccessMyLibrary.com

Ranbaxy, GlaxoSmithKline reach accord  -  Aug 15, 2007
Valacyclovir is an antiviral drug used to treat genital herpes, cold sores and shingles. It is a prodrug — a pharmacological substance that is administered ... IndUS Business Journal

'Kissing disease' responds to newer form of old drug  -  Jan 12, 2006
Students on valacyclovir also had less severe symptoms, ... "This particular dose of valacyclovir helps these students to get better faster," says Balfour, ... macleans.ca

Treatment for an Acute Shingles Attack  -  Jun 19, 2008
Acyclovir (Zovirax), famciclovir (Famvir), and valacyclovir (Valtrex) are approved for shingles. Acyclovir is the oldest, most studied of these drugs, ... New York Times

Article: Genital Herpes; Diagnosis. - NWHRC Health Center - Genital …  -  Mar 16, 2005
Valacyclovir HSV Transmission ... transmission of genital herpes. ... Cortes M; Valacyclovir HSV Transmission Study ... of transmission of genital herpes. ... Pay-Per-View - NWHRC Health Center - Genital Herpes - HighBeam Research

… effect of high-dose acyclovir versus valacyclovir on persons with  -  Nov 1, 2007
The purpose of the research study is to evaluate the effectiveness of high-dose acyclovir compared to valacyclovir for the reduction of HSV-2 asymptomatic ... $4.95 - Journal of Drugs in Dermatology - ECNext

Group Says Herpes Study Put Pregnant Women at Risk  -  Dec 2, 2006
In the study, researchers at Parkland Hospital in Dallas gave 170 pregnant women the drug valacyclovir, sold as Valtrex by GlaxoSmithKline, ... Washington Post

Aids-Prävention: Herpesbehandlung senkt Konzentration von HI-Viren  -  Feb 22, 2007
London - Die Behandlung mit Valacyclovir besserte in einer randomisierten kontrollierten Studie ... Valacyclovir ist nachweislich nicht wirksam gegen HIV. ... Deutsches Ärzteblatt

Virus Herpes Simple (herpes oral y genital)  -  Mar 19, 2008
A diferencia de acyclovir, valacyclovir necesita ser procesado en el cuerpo ... Para brotes herpéticos leves a moderados, la dosis de valacyclovir es de 500 ... AIDSmeds.com HIV/AIDS Treatment News

Anti-herpes drug reduces need for Caesarean sections in infected women  -  Dec 7, 2006
Seven of the 170 women in the valacyclovir group, or 4 percent, ... There also were no differences in complications between the valacyclovir and placebo ... innovations report - Innovations-Report

Patient ignorance one root of herpes prevalence.(Infectious Diseases)  -  Aug 15, 2005
..."The study used valacyclovir, but you can substitute famciclovir or acyclovir and probably ... Studies have shown that one can use acyclovir, valacyclovir, ... Free with registration - Family Practice News - AccessMyLibrary.com

GlaxoSmithKline (GSK) announced in a press release that an update on ...  -  Apr 2, 2007
On February 1, 2007, Ranbaxy received Food and Drug Administration's approval for its generic valacyclovir product, and notified GSK that it sought to ... ag-IP-news Agency

Famciclovir for Herpes Labialis  -  Nov 29, 2006
...with alternative treatment regimens for recurrent HL, including oral valacyclovir (2 g twice daily for 1 day), topical acyclovir, and penciclovir cream. ... Medscape

Equine Herpesvirus: Valtrex Treatment Appears Successful  -  Feb 18, 2007
Recent research into the drug Valacyclovir (trade name Valtrex) seems to indicate ... The initial investigations of valacyclovir in the horse are strongly ... TheHorse.com

Doctors Say Circumcision Ritual Still Not Safe  -  Dec 15, 2006
Among other procedures, she proposed placing the anti-viral drug Valacyclovir on the circumcision wound. The drug is used to treat herpes symptoms in those ... Forward

Anti-herpes drug reduces need for Caesarean sections in infected women  -  Jul 29, 2006
Seven of the 170 women in the valacyclovir group, or 4 percent, ... There also were no differences in complications between the valacyclovir and placebo ... Virtual Medical Centre - The Virtual Medical Centre

Ignorance at root of herpes prevalence.(Clinical Rounds)  -  Aug 1, 2005
..."The study used valacyclovir, but you can substitute famciclovir or acyclovir and probably ... Studies have shown that one can use acyclovir, valacyclovir, ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

First-Time Generic Approvals: Focalin, Valtrex, Hydrodiuril  -  Feb 16, 2007
Valacyclovir is indicated for the treatment/suppression of genital herpes in immunocompetent individuals and for the suppression of recurrent genital herpes ... Medscape

Treatment for Genital Herpes  -  Oct 1, 2006
...(Acyclovir and famiciclovir are taken twice a day, valacyclovir once a day. ... Acyclovir and valacyclovir are also approved to treat an initial attack of ... HealthCentral.com

Antiviral helpful for genital herpes in pregnancy  -  Apr 5, 2006
..."The results of this trial with valacyclovir," Andrews told Reuters Health, "are similar to previous reports which have utilized acyclovir. ... RedOrbit

Diary of a Doc: New Strategies for HIV-Herpes Coinfection  -  Mar 2, 2007
It is well known that both acyclovir and valacyclovir – the drugs used to treat genital herpes in these studies—have no direct anti-HIV activity. ... AIDSmeds.com HIV/AIDS Treatment News

Back Pain Costs Patients $90 Billion a Year  -  Mar 31, 2005
For VALACYCLOVIR, Susan Edmonds at (206) 667-2896 or sedmonds@fhcrc.orgFor KIDS AND VIOLENCE, Karen Gardner at (718) 430-3101 or kgardner@aecom.yu.edu) WTOP

Oral antiviral therapy effective, convenient for acute infections  -  Nov 13, 2006
Also, she said, valacyclovir should be used only in immunocompetent patients on long-term treatment because of a risk of fatal hemolytic uremia in severely ... Ophthalmology Times

Now, Ranbaxy seeks peace with Takeda  -  Jun 22, 2008
This includes three independent litigation settlements with innovator companies GlaxoSmithKline (GSK) for Valacyclovir (Valtrex) and Sumatriptan (Imitrex) ... Business Standard

Brand Names/Synonyms:
Valacyclovir is also known by the following brand names and/or synonymsAcyclovir; BW 256U87; Valaciclovir; Valaciclovir Hcl; Valaciclovir Hydrochloride; Valacyclover Hydrochloric; Valacyclover Hydrochloride; Valacyclovir; Valacyclovir Hydrochloride; Valtrex; Zovirax

Drug Category:
Valacyclovir is categorized under the following by the FDA: Prodrugs; Antivirals; ATC:J05AB

Dosage Forms:
TABLET

Absorption:
After oral administration, valacyclovir hydrochloride is rapidly absorbed from the gastrointestinal tract. The absolute bioavailability of acyclovir after administration of valacyclovir is 54.5% ± 9.1%.

Interactions:
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Chemical IUPAC Name:
2-[(2-amino-6-oxo-3,9-dihydropurin-9-yl)methoxy]ethyl2-amino-3-methyl-butanoate





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