Valproic Acid

This page contains recent news articles, when available, and an overview of Valproic Acid but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Valproic Acid
(when available)

Pharmacology and use:
Valproic Acid is an anticonvulsant and mood-stabilizing drug used primarily in the treatment of epilepsy and bipolar disorder. It is also used to treat migraine headaches and schizophrenia. In epileptics, Valproic Acid is used to control absence seizures, tonic-clonic seizures (grand mal), complex partial seizures, and the seizures associated with Lennox-Gastaut syndrome. Valproic Acid is believed to affect the function of the neurotransmitter GABA (as a GABA transaminase inhibitor) in the human brain. Valproic Acid dissociates to the valproate ion in the gastrointestinal tract. For the treatment of Petit mal (simple and complex absence) seizures; Epilepsy

Mechanism Of Action:
Valproic Acid binds to and inhibits GABA transaminase. The drug's anticonvulsant activity may be related to increased brain concentrations of gamma-aminobutyric acid (GABA), an inhibitory neurotransmitter in the CNS, by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. inhibition of voltage-sensitive sodium channels.

News Articles on Valproic Acid

Valproate Sodium and related products (valproic acid and divalproex sodium)  -  ‎Dec 24, 2009‎
...and cardiovascular malformations, in babies exposed to valproate sodium and related products (valproic acid and divalproex sodium) during pregnancy. ... Ethiopian Review

San Luis Obispo man who declined aid after accident died of blunt force trauma ...  -  ‎Jan 5, 2010‎
...alcohol in Spisak's system, according to the toxicology report, and the drugs in his system were benzodiazepine, methadone trazodone and valproic acid. ... San Luis Obispo Tribune

FDA, Manufacturers Advise Physicians of Actions Involving Various Drugs  -  ‎Dec 11, 2009‎
The agency approved valproic acid for the treatment of epilepsy more than 30 years ago, but it more recently approved valproate for the treatment of bipolar ... AAFP News Now

Showdown at Commission of Inquiry – Fabro maintains innocence; Sosa says ...  -  ‎Dec 23, 2009‎
...(Dr. Sosa's specialization is neurology, and according to him, fentanyl, phenobarbital, Dilantin, and valproic acid - items he called “front-line� ... Amandala

How can alcoholism be managed?  -  ‎Nov 12, 2009‎
I recommend that he be placed on valproic acid if his liver is fine for anger issues and also send him to anger management groups. ... DoctorNDTV

Valproic Acid May Enhance Efficacy Of Vidaza For Myelodysplastic Syndromes  -  ‎Oct 21, 2009‎
A combination therapy of Vidaza (azacitidine) and valproic acid (Depakene) may be more effective than Vidaza alone for the treatment of myelodysplastic ... The MDS Beacon

BC ARTHRITIS STRENGTH  -  ‎Nov 10, 2009‎
Potentiates anticoagulants, hypoglycemics, methotrexate, acetazolamide, valproic acid, highly protein-bound drugs. Urinary alkalinizers, antacids ... Monthly Prescribing Reference

D-Pharm Taking Stroke Drug into China with $25.5M Deal  -  ‎Nov 10, 2009‎
Earlier in its pipeline, it has DP-VPA, a derivative of valproic acid, in development for epilepsy, manic-depressive disorder and migraine prophylaxis. Therapeutics Daily (press release) (registration)

D-Pharm Enters Into Collaboration With Wanbang Biopharmaceuticals to Increase ...  -  ‎Nov 13, 2009‎
DP-VPA, a prodrug of valproic acid, is in Phase II clinicaldevelopment. DP-460 is in preclinical development intended as an oral,disease-modifying therapy ... PharmiWeb.com (press release)

Esce a metà novembre un doppio di inediti e pezzi live dei BELLE & SEBASTIAN  -  ‎Oct 21, 2009‎
The following information is from their web site. tablet tutorials adipex retard cena Valproic Acid Syrup (Valproic Acid Oral Solution, USP) is available as ... ImpattoSonoro

Pharmaceutical Journal - Avoid folic acid antagonists in first trimester of ...  -  ‎Oct 20, 2009‎
Other folic acid antagonists, which are known to reduce serum and tissue concentrations of folate, such as carbamazepine, valproic acid, phenobarbital, ... DeHavilland (press release) (subscription)

Wanbang to Advance D-Pharm's Late-Stage Stroke Therapy in China  -  ‎Nov 9, 2009‎
Lead D-RAP candidate, DP-VPA, is a lipid-conjugated prodrug comprising valproic acid. DP-VPA has completed a Phase II trial in the treatment of epilepsy. ... Genetic Engineering News (press release)

New bipolar disorder research from Medical University of South Carolina described  -  ‎Nov 9, 2009‎
Her symptoms improved rapidly but partially with benzodiazepines and electroconvulsive therapy, and completely with addition of valproic acid, vitamin B-12, ... Behavioral Health Central (blog)

Folate Thought to Prevent Neural Tube Defects in Newborns  -  ‎Oct 24, 2009‎
...blockers,cimetidine, Bactrim (septra), and certain anti-seizure medications such as phenobarbital, phenytoin, tegretol ,primidone, and valproic acid. ... PR-CANADA.net (press release)

Forecast Insight - Epilepsy - Future market upgrade following new drug launches  -  ‎Oct 26, 2009‎
D-Pharm´s DP-VPA (a prodrug of valproic acid), has not made any known progress through clinical development since 2006. As a result, launch of DP-VPA is ... PR-Inside.com (Pressemitteilung)

HIV Treatment Raises Cure Hopes  -  Aug 13, 2005
The latest drug, valproic acid, shows more promise, said Dr. Warner Greene, ... Siliciano said he also doubts the valproic acid approach will solve the ... Wired News

Valproic Acid May Treat Alzheimer's  -  Oct 27, 2008
By Miranda Hitti. Oct. 27, 2008 -- Valproic acid, an epilepsy drug also used to treat bipolar disorder, may have benefits against Alzheimer's disease if ... WebMD

Valproic acid for epilepsy  -  Oct 29, 2007
These medicines usually require several doses each day. A newly approved, once-daily dose of divalproex sodium is also available (Depakote ER). ... WebMD

The histone deacetylase inhibitor valproic acid potently augments …  -  Nov 23, 2006
Correspondence: Dr W Helfrich, Laboratory for Tumor Immunology, Department of Pathology and Laboratory Medicine, Section Medical Biology, University Medical ... Nature.com

… Interaction of Lorazepam and Valproic Acid in Relation to UGT2B7 …  -  May 8, 2007
Chadwick, DW Concentration–effect relationships of valproic acid. Clin. ... Ethell, BT, Anderson, GD & Burchell, B. The effect of valproic acid on drug and ... Nature.com

Article: Anti-acid drugs tied to dementia in blacks - The Record...  -  Aug 5, 2007
With more widespread use of valproic acid, partly due to increasing use of the ... Article: Health Canada/Warning: Recall of Two Valproic Acid ... ... Pay-Per-View - The Record - HighBeam Research

Valproic acid taken with meropenem may result in seizures.(Drug-Drug ...  -  Jun 1, 2005
In addition to its primary use as an antiepileptic agent, valproic acid (Depakene, Depakote) has been used as monotherapy or combined with lithium ... Free with registration - Brown University Psychopharmacology... - AccessMyLibrary.com

… in a patient with Li–Fraumeni syndrome treated with valproic acid,...  -  Jan 26, 2006
The patient was treated with ATRA+theophyllamine+valproic acid and cells were ... Valproic acid has been used for HDAC inhibition in several studies. ... Nature.com

… Receives FDA Approval for Valproic Acid Delayed Release Softgel …  -  Jul 30, 2008
Banner Pharmacaps Inc., a leader in the pharmaceutical industry for the development of soft gelatin dosage form technology, today announced that the US Food ... Genetic Engineering News - Genetic Engineering News (press release)

Drug for other diseases may have use against AIDS  -  Aug 31, 2005
Then they added one more, valproic acid . Valproic acid is used to control ... But valproic acid has also been shown to block an enzyme that helps HIV, ... 中国日报 - 中国日报

Valproic acid.(Drugs, Pregnancy, And Lactation)  -  Apr 1, 2006
For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated ... Free with registration - Family Practice News - AccessMyLibrary.com

Valproic acid (Depakote) may help treat lupus  -  Nov 20, 2005
A common anti-seizure drug may be effective against certain conditions associated with lupus, according to animal research at Wake Forest University School ... News-Medical.net

Valproic Acid  -  Jul 26, 2008
Why it is prescribed (Indications) : Valporic acid is used, alone with other drugs, to control seizures and convulsions. ... MedIndia

Drugs, pregnancy, and lactation: valproic acid.(Obstetrics)  -  Mar 15, 2006
For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated ... Free with registration - OB GYN News - AccessMyLibrary.com

Anticonvulsant Divalproex Valproate Sodium Valproic Acid Antimanic …  -  Jul 28, 2005
Valproic acid, valproate sodium, and divalproex belong to the group of medicines called anticonvulsants. They are used to control certain types of seizures ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

VALPROIC ACID (Oral route, Parenteral route).(Drug overview)  -  May 1, 2007
Valproic acid, valproate sodium, and divalproex belong to the group of medicines called anticonvulsants. They are used to control certain types of seizures ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… Pharmacaps Gets FDA OK for Valproic Acid Delayed Release Softgel …  -  Aug 4, 2008
Banner Pharmacaps Gets FDA OK for Valproic Acid Delayed Release Softgel Capsules ... find Wireless News articles. Wireless News 08-04-2008 Banner Pharmacaps ... Pay-Per-View - Wireless News - HighBeam Research

Article: Valproic acid.(Drugs, Pregnancy, And Lactation) - Family...  -  Apr 1, 2006
Valproic acid.(Drugs, Pregnancy, And Lactation) ... find Family Practice News articles. For more than 20 years, the risk of neural tube defects (NTDs) ... Pay-Per-View - Family Practice News - HighBeam Research

Can Valproic Acid Help Deplete Latent Reservoirs of HIV?  -  Oct 20, 2005
In a proof-of-concept study, valproic acid and intensified antiretroviral therapy cleared HIV from resting CD4 cells in vivo. ... Medscape

… Approval of Stavzor(TM) Valproic Acid Delayed Release Capsules  -  Dec 26, 2007
Developmental products in psychiatry consist of Stavzorâ„¢ (delayed release valproic acid softgel), Lithium QD (once-daily lithium carbonate), and Stavzorâ„¢ ER ... RedOrbit

Valproic acid.(DRUGS, PREGNANCY, AND LACTATION) | Article from …  -  May 15, 2006
Valproic acid.(DRUGS, PREGNANCY, AND LACTATION) ... find Internal Medicine News articles. For more than 20 years, the risk of neural tube defects (NTDs) ... Pay-Per-View - Internal Medicine News - HighBeam Research

Valproic Acid May Be Better Than Divalproex for Psychiatric...  -  Feb 3, 2005
A quasi-experimental clinical trial suggests that initially giving inpatients generic valproic acid and changing to delayed-release divalproex, ... Medscape

… Issues Approvable Letter for Stavzor(TM) Delayed Release Valproic...  -  Oct 23, 2007
Pipeline products in psychiatry consist of Stavzor[TM] (delayed release valproic acid capsule), Lithium QD (once-daily lithium carbonate), and Stavzor[TM] ... Free with registration - Business Wire - AccessMyLibrary.com

valproic acid | Definition of valproic acid | HighBeam.com: Online …  -  Jul 12, 2006
Find out what valproic acid means: The Oxford American College Dictionary has the definition of valproic acid. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

FDA standards for generics are questioned  -  Mar 17, 2008
The same story incorrectly identified the brand name of the anti-seizure drug valproic acid as Felbatol. The correct brand name is Depakote. ... Los Angeles Times

Drugs, pregnancy, and lactation: valproic acid.(Obstetrics) | Article...  -  Mar 15, 2006
Drugs, pregnancy, and lactation: valproic acid.(Obstetrics) ... find OB GYN News articles. For more than 20 years, the risk of neural tube defects (NTDs) ... Pay-Per-View - OB GYN News - HighBeam Research

AIDS Cure Possible, Study Suggests  -  Aug 15, 2005
It makes use of an epilepsy drug -- valproic acid -- that flushes HIV out of ... To do this, they took advantage of the ability of valproic acid to inhibit ... FOXNews

Delayed-Release Valproic Acid Capsule, Stavzor, One Step Closer to …  -  Oct 25, 2007
By Rick Nauert PhD Senior News Editor. A new type of delayed-release valproic acid capsule is one step closer to receiving final approval for sale in the US ... PsychCentral.com

Neuroscience: An ageing view of myelin repair  -  Sep 25, 2008
When the mice were given the HDAC inhibitor valproic acid while on a cuprizone diet, ... Valproic acid had no obvious effect on other cell types, ... Nature.com

Valproic acid may help slow the progression of dementia  -  Mar 14, 2006
Researchers have found that a common anticonvulsant drug improved cognitive function and appeared to restore nerve cells in the brains of patients with ... News-Medical.net

Mixed Results on Epilepsy Drugs and Birth Defects  -  Mar 21, 2005
But long-time epilepsy drug valproic acid, or sodium valproate, ... The women taking valproic acid were nearly three times more likely to have an infant ... newswise.com

… /REMINDER/Warning: Recall of Two Valproic Acid Drugs, Depakene 500 ...  -  May 14, 2007
OTTAWA, ONTARIO--(CCNMatthews - May 14, 2007) - Health Canada is warning patients taking the anti-epilepsy medications Depakene 500 mg and ratio-VALPROIC ... ccnmatthews.com

Chemical Signature Of Manic Depression Discovered  -  Feb 10, 2008
The study also suggests that lithium and valproic acid work by restoring the balance of these neurotransmitters in the brain. ... sciencedaily.com

Valproic acid.(DRUGS, PREGNANCY, AND LACTATION)  -  May 15, 2006
For more than 20 years, the risk of neural tube defects (NTDs) associated with first-trimester exposure to valproic acid has been well known: The estimated ... $4.95 - Internal Medicine News - ECNext

Induction of folate receptor type in a bone marrow engraftment model...  -  Jun 7, 2007
...upregulate its expression 6, 7 and that this effect is potentiated by innocuous histone deacetylase (HDAC) inhibitors, including valproic acid (VPA). ... Nature.com

… University, discusses the use of Valproic Acid for AIDS treatment  -  Aug 12, 2005
I think now this study will trigger further investigation into whether Valproic Acid indeed would turn on these cells so the drugs can get at the virus. ... Pay-Per-View - NBC News: Today - Factiva, from Dow Jones

Chemical signature of manic depression discovered by scientists  -  Feb 6, 2008
The study also suggests that lithium and valproic acid work by restoring the balance of these neurotransmitters in the brain. ... Science Centric

… Canada/Warning: Recall of Two Valproic Acid Drugs, Depakene 500 mg...  -  May 11, 2007
OTTAWA, ONTARIO--(CCNMatthews - May 11, 2007) - Health Canada is warning patients taking the anti-epilepsy medications Depakene 500 mg and ratio-VALPROIC ... ccnmatthews.com

Combination therapy with DNA methyltransferase inhibitors in …  -  Aug 16, 2005
Valproic acid and phenylbutyrate are short-chain fatty acids that inhibit HDAC ... 11 evaluated decitabine plus valproic acid in 55 patients with leukemia. ... Nature.com

Researchers find easier way to make stem cells  -  Oct 12, 2008
Huangfu tried treating the cells first with valproic acid. ... Huangfu said the valproic acid unraveled the chromatin -- the physical structure of the ... Forbes

G1 cell-cycle arrest and apoptosis by histone deacetylase inhibition...  -  Apr 13, 2006
Valproic acid consistently decreased cell viability (Figure 1a) in MLL-AF9 ... p21 or CG2 siRNAs analysis of THP-1 cells treated with valproic acid (VPA) ... Nature.com

… sodium, Depakote, Depakene valproic acid (generic) (brand)...  -  Jun 1, 2005
COMMON USAGE: Divalproex is indicated for the treatment of manic disorders associated with bipolar disorder in adults. It is also indicated for the ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

Existing drugs show promise for treating end-stage renal disease in...  -  Nov 9, 2007
Mishra's theory was that valproic acid helps reduce activation of B cells, ... The study was designed to determine if valproic acid reduces B cell activity ... eurekalert.org

Detectors - detection systems in separation science, including mass …  -  Dec 11, 2006
Valproic acid (2-propylvaleric acid) is a small ionic molecule that can raise levels ... Like most drugs, valproic acid can cause a variety of side effects, ... separationsNOW.com - separationsNOW.com (press release)

Carnitine levels in valproic acid-treated psychiatric patients: a...  -  Sep 1, 2005
Carnitine levels in valproic acid-treated psychiatric patients: a cross-sectional study. Moreno FA, Macey H, Schreiber B. J Clin Psychiatry 2005;66:555-558. ... Free with registration - Alternative Medicine Review - AccessMyLibrary.com

Youngster shows improvement  -  Jul 23, 2007
Valproic acid, approved by the Food and Drug Administration to treat epilepsy, ... Because valproic acid and carnitine are already FDA-approved, ... $2.95 - Salt Lake Tribune, The - NewsBank

Small molecules boost reprogramming rates  -  Jul 3, 2008
Further analysis showed that valproic acid may help to create a state of gene ... When valproic acid was added to fibroblasts, some two-thirds of these ... Nature.com

Valproic acid and pancreatitis in a child.(Safety and Efficacy Issues)  -  Jun 22, 2006
Malaysia -- The Malaysia Adverse Drug Reactions Advisory Committee (MADRAC) has received a report of a 3 year-old girl who who was suspected to have ... Free with registration - WHO Drug Information - AccessMyLibrary.com

Existing Drugs Show Promise for Treating Renal Disease in Lupus  -  Nov 5, 2007
Mishra's theory was that valproic acid helps reduce activation of B cells, ... The study was designed to determine if valproic acid reduces B cell activity ... newswise.com

Stem Cell Research; Valproic acid enhances cytokine-induced expansion...  -  Apr 27, 2005
According to a study from Italy, "Ex vivo amplification of human hematopoietic stem cells (HSC) without loss of their self-renewing potential represents art ... Pay-Per-View - Immunotherapy Weekly - Factiva, from Dow Jones

Article: The Drugs in the Area's Water - The Washington Post |...  -  Mar 10, 2008
Article: Mood stabilizer valproic acid stimulates forebrain ... Drug Week; December 3, 2004 ; 700+ words ... ... net) -- The mood stabilizer valproic acid ... Pay-Per-View - Washington Post - HighBeam Research

Scientists Testing Drugs to Block AIDS Dementia  -  Oct 3, 2006
Topping the candidates are the epilepsy drug valproic acid and lithium, a drug long used in manic-depression. Both inhibit an enzyme, called GSK-3b. ... FOXNews

Stem Cell Research; Valproic acid enhances cytokine-induced expansion...  -  Apr 28, 2005
According to a study from Italy, "Ex vivo amplification of human hematopoietic stem cells (HSC) without loss of their self-renewing potential represents art ... Pay-Per-View - Blood Weekly - Factiva, from Dow Jones

Typical progression of myoclonic epilepsy of the Lafora type: a case ...  -  Jun 13, 2007
Juvenile myoclonic epilepsy was diagnosed and treatment with valproic acid initiated, which alleviated the myoclonus and decreased the frequency of the ... Nature.com

Article: New strategy shows promise in treating hidden HIV infection ...  -  Aug 11, 2005
The latest drug, valproic acid, shows more promise, said Dr. Warner Greene, ... Siliciano said he also doubts the valproic acid approach will solve the ... Pay-Per-View - AP Worldstream - HighBeam Research

Common Anti-seizure Drug Could Be Effective for Lupus Patients  -  Nov 8, 2005
..."Valproic acid may be a potential cost-effective disease-modifying agent in lupus," ... While physicians could prescribe valproic acid "off-label" to lupus ... newswise.com

Common anti-seizure drug could be effective for lupus patients  -  Nov 16, 2005
..."Valproic acid may be a potential cost-effective disease-modifying agent in lupus," ... While physicians could prescribe valproic acid "off-label" to lupus ... eurekalert.org

Article: Seizure Rx rash: a lethal combo.(Clinical Rounds) - Skin &...  -  Mar 1, 2005
Valproic acid Definition Valproic acid is an anticonvulsant (anti-seizure) drug. In the United States, valproic acid is also known as valproate, ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Article: New strategy shows promise in treating hidden HIV infection ...  -  Aug 12, 2005
Valproic acid Definition Valproic acid is an anticonvulsant (anti-seizure) drug. In the United States, valproic acid is also known as valproate, ... Pay-Per-View - AP Worldstream - HighBeam Research

Adverse Drug Reaction; Interaction between valproic acid and …  -  Feb 7, 2005
2005 FEB 7 - (NewsRx.com & NewsRx.net) -- The interaction between valproic acid and carbapenem antibiotics has been characterized. ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

NMR Knowledge Base - The NMR Resource  -  Feb 15, 2008
The researchers also conclude that lithium and valproic acid work by somehow restoring the balance of these neurotransmitters in the brain. ... spectroscopyNOW.com

… plasma concentrations higher when combined with valproic acid  -  Feb 2, 2005
According to recent research from the United States, "Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus ... Pay-Per-View - Immunotherapy Weekly - Factiva, from Dow Jones

Adverse Drug Reaction; Interaction between valproic acid and …  -  Feb 12, 2005
2005 FEB 12 - (NewsRx.com & NewsRx.net) -- The interaction between valproic acid and carbapenem antibiotics has been characterized. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Adverse Drug Reaction; Interaction between valproic acid and …  -  Feb 11, 2005
2005 FEB 11 - (NewsRx.com & NewsRx.net) -- The interaction between valproic acid and carbapenem antibiotics has been characterized. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Neuroscience; Valproic acid suppresses disease progression in ALS …  -  Mar 3, 2005
2005 MAR 3 - (NewsRx.com & NewsRx.net) -- Valproic acid suppresses disease progression in an amyotrophic lateral sclerosis model. ... Pay-Per-View - Blood Weekly - Factiva, from Dow Jones

Neuroscience; Valproic acid suppresses disease progression in ALS …  -  Mar 5, 2005
2005 MAR 5 - (NewsRx.com & NewsRx.net) -- Valproic acid suppresses disease progression in an amyotrophic lateral sclerosis model. ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Lupus, common anti-seizure drug may help patients  -  Nov 21, 2005
..."Valproic acid may be a potential cost-effective disease-modifying agent in lupus," ... While physicians could prescribe valproic acid "off-label" to lupus ... Dominican Today

Gene Expression; Gene expression cascades influence valproic acid- …  -  Jan 9, 2006
Massa and colleagues published their study in Pharmacogenetics and Genomics (Valproic acid-induced skeletal malformations: associated gene expression ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

… of Rhode Island, Kingston; Valproic acid selectively interferes...  -  Mar 30, 2005
According to published research from the United States, "We investigated whether antiepileptic valproic acid (VPA) might interfere with oxidative metabolism ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Utah study is offering hope for ill children | Article from Deseret...  -  May 6, 2005
Valproic acid has been used for a broad range of medical reasons, ... Valproic acid poses a greater risk for those under 2, so it was used in the older ... Pay-Per-View - Deseret News - HighBeam Research

… plasma concentrations higher when combined with valproic acid  -  Feb 5, 2005
According to recent research from the United States, "Valproic acid (VPA) has the potential to benefit patients suffering from human immunodeficiency virus ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Neuroscience; Valproic acid suppresses disease progression in ALS …  -  Feb 28, 2005
2005 FEB 28 - (NewsRx.com & NewsRx.net) -- Valproic acid suppresses disease progression in an amyotrophic lateral sclerosis model. ... Pay-Per-View - Proteomics Weekly - Factiva, from Dow Jones

View from the lab: journeys of the mind  -  Aug 17, 2005
Now another medicine, valproic acid, is available. That, too, turned up almost by mistake. It was first used to dissolve certain experimental drugs against ... Telegraph.co.uk

Cardiac Metabolism; Valproic acid selectively interferes with...  -  Apr 2, 2005
According to published research from the United States, "We investigated whether antiepileptic valproic acid (VPA) might interfere with oxidative metabolism ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Epilepsy Therapy; Genes linked to valproic acid-induced neural tube …  -  Jun 27, 2005
2005 JUN 27 - (NewsRx.com) -- Genes linked to valproic acid (VPA)-induced neural tube defects have been identified in a murine model. ... Pay-Per-View - Biotech Business Week - Factiva, from Dow Jones

Texas A&M University; Gene expression cascades influence valproic...  -  Jan 11, 2006
Massa and colleagues published their study in Pharmacogenetics and Genomics (Valproic acid-induced skeletal malformations: associated gene expression ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones

Epilepsy Therapy; Genes linked to valproic acid-induced neural tube …  -  Jul 1, 2005
2005 JUL 1 - (NewsRx.com) -- Genes linked to valproic acid (VPA)-induced neural tube defects have been identified in a murine model. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Enzymology; Valproic acid alters apoptosis signals in endothelial...  -  Apr 12, 2006
2006 APR 12 - (NewsRx.com) -- Valproic acid (VPA) alters apoptosis signals in endothelial cells. "The histone deacetylase (HDAC) inhibitor VPA was recently ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Gene Expression; Gene expression cascades influence valproic acid- …  -  Jan 12, 2006
Massa and colleagues published their study in Pharmacogenetics and Genomics (Valproic acid-induced skeletal malformations: associated gene expression ... Pay-Per-View - Gene Therapy Weekly - Factiva, from Dow Jones

Noven Gets FDA Nod  -  Dec 27, 2007
Noven's Stavzor, or valproic acid, is intended to treat manic episodes associated with ... Valproic acid delayed released capsules will be prescribed in 125 ... Forbes

Epilepsy drug can help Alzheimer's patients  -  Oct 31, 2008
The research showed that valproic acid also shrinks plaques in the brains of mice with a version of Alzheimer's disease; it even prompted damaged nerves to ... TopNews

Medicine; IN THE LAB; Filtering out the mystery surrounding liver...  -  Sep 26, 2005
...phenytoin (Dilantin), which is used to control seizures; the popular antibiotic amoxicillin; and a migraine and epilepsy drug, valproic acid (Depakote). ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

65--VALPROIC ACID 250MG, CAPSULES  -  Mar 3, 2006
The VA National Acquisition Center will issue Request for Proposal (RFP) VA-797-06-RP-0009 for the Department of Veterans Affairs (VA) and Department of ... Pay-Per-View - FedBizOpps - Factiva, from Dow Jones

New and generic drug approvals: Valproic Acid Syrup.  -  Oct 17, 2006
On 17 Oct 2006, the US Food and Drug Administration announced approval of ANDA 077960 for Valproic Acid Syrup. The product contains valproic acid at ... Pay-Per-View - US Food and Drug Administration News - Factiva, from Dow Jones

German Cancer Award 2006  -  Mar 23, 2006
The knowledge that a drug used as an antilepileptic agent, valproic acid, ... "Our studies have shown that valproic acid in its function as a histone ... Medical News Today - Medical News Today (press release)

Valproic acid, valproate and divalproex in the maintenance treatment...  -  Jul 1, 2007
Although lithium has been the most commonly used maintenance treatment in bipolar disorder for several decades, valproate is being used increasingly ... Medscape

… Administrative Code - 77 Ill. Adm. Code 790.9478 VALPROIC ACID ( …  -  Aug 10, 2005
77 Ill. Adm. Code 790.9478 VALPROIC ACID (Repealed) Repealed. (Source: Repealed at 17 Ill. Reg. 15916, effective September 20, 1993) ... Pay-Per-View - Illinois Administrative Code - Loislaw

The spectrum of valproic acid-associated pancreatitis.  -  Oct 1, 2006
SINCE THE FIRST report of valproic acid (VPA)-associated pancreatitis by Batalden et al (1) in 1979, there have been a number of case reports and small ... $4.95 - Pediatrics - ECNext

Best First-Choice Drugs for Epilepsy ID'd  -  Mar 22, 2007
It compared the older drug valproic acid (in the US, Depakote is the most ... "Valproate [the British term for valproic acid] is a much better drug at ... WebMD

Pregnancy and epilepsy: new hope from a  -  Apr 30, 2005
Two confirm the grave risks associated with valproic acid. ... No fewer than 16 children born to the valproic acid group were diagnosed with major ... National Review of Medicine

Potential cure for HIV.(Brief Article)  -  Oct 11, 2005
Valproic acid stops histone deacetylation, a process that allows HIV to "rest" in cells. If HIV is unable to lie dormant in cells, all HIV can be killed ... Free with registration - CMAJ: Canadian Medical Association... - AccessMyLibrary.com

Adverse Drug Reaction; Studies report mixed results on epilepsy drugs...  -  Apr 14, 2005
But long-time epilepsy drug valproic acid, or sodium valproate, ... Two studies The valproic acid study data were reported by DF Wyszynski, MD, ... Pay-Per-View - Women's Health Weekly - Factiva, from Dow Jones

Adverse Drug Reaction; Studies report mixed results on epilepsy drugs...  -  Apr 11, 2005
But long-time epilepsy drug valproic acid, or sodium valproate, ... Two studies The valproic acid study data were reported by DF Wyszynski, MD, ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Clinical utility of bile acid sequestrants in the treatment of...  -  Mar 1, 2006
Colesevelam HCl, unlike cholestyramine, did not decrease the absorption of valproic acid or the common cardiovascular agents warfarin, digoxin, ... Free with registration - Southern Medical Journal - AccessMyLibrary.com

Chemical signature of manic depression discovered by scientists  -  Feb 5, 2008
The study also suggests that lithium and valproic acid work by restoring the balance of these neurotransmitters in the brain. ... Biology News Net - Biology News Net (press release)

Hull parents arrested in girl's poisoning death  -  Feb 6, 2007
The medical examiner's office determined the girl died from "intoxication due to the combined effects" of the drugs clonidine, valproic acid (Depakote), ... Boston Globe

Testing new manic depression drugs in slime mould: an alternative to...  -  Apr 21, 2005
Valproic acid, another drug commonly used to treat both epilepsy and manic ... Current manic depression drugs like valproic acid have side-effects - an ... Medical News Today - Medical News Today (press release)

Testing new manic depression drugs in slime mould: an alternative to...  -  Apr 22, 2005
Valproic acid, another drug commonly used to treat both epilepsy and manic ... Current manic depression drugs like valproic acid have side-effects - an ... i-newswire.com

Anti-epileptic drug could help beat cancer  -  May 15, 2006
Valproic acid has a weak anticancer effect on its own but in this new combination it ... When they found out that valproic acid was a member of this group, ... Cancer Research UK - News & Resources

Low IPSS score and bone marrow hypocellularity in MDS patients...  -  May 17, 2007
Two other patients had evidence of hematological improvement following further therapy with valproic acid and valproic acid with all-trans retinoic acid. ... Nature.com

Brand Names/Synonyms:
Valproic Acid is also known by the following brand names and/or synonymsAcetic Acid, Dipropyl-; Acid; Alti-Valproic; Bruceine D; Convulex; DPA; Dapakene; Depacono; Depakene; Depakine; Depakote; Deproic; Dipropylacetic Acid; Divalproex; Divalproex Sodium; Dom-Valproic; Epilim; Ergenyl; Med Valproic; Mylproin; Myproic Acid; N-Dipropylacetic Acid; N-Dpa; Novo-Valproic; Nu-Valproic; Penta-Valproic; Pms-Valproic Acid; Pms-Valproic Acid E.C.; Propylvaleric Acid; SEMISODIUM VALPROATE; Sodium; Valproate; Valproate Semisodium; Valproic Acid; Valproic Acid Usp; Valproic Acid Usp24

Drug Category:
Valproic Acid is categorized under the following by the FDA: Antimanic Agents; GABA Agents; Anticonvulsants; Enzyme Inhibitors; ATC:N03AG01

Dosage Forms:
LIQUID; SYRUP

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
2-propylpentanoic acid





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