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VidarabineThis page contains recent news articles, when available, and an overview of Vidarabine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: Vidarabine (when available) Vidarabine is a synthetic purine nucleoside analogue with in vitro and in vivo inhibitory activity against herpes simplex virus types 1 (HSV-1), 2 (HSV-2), and varicella-zoster virus (VZV). The inhibitory activity of Vidarabine is highly selective due to its affinity for the enzyme thymidine kinase (TK) encoded by HSV and VZV. This viral enzyme converts Vidarabine into Vidarabine monophosphate, a nucleotide analogue. The monophosphate is further converted into diphosphate by cellular guanylate kinase and into triphosphate by a number of cellular enzymes. in vitro, Vidarabine triphosphate stops replication of herpes viral DNA. When used as a substrate for viral DNA polymerase, Vidarabine triphosphate competitively inhibits dATP leading to the formation of 'faulty' DNA. This is where Vidarabine triphosphate is incorporated into the DNA strand replacing many of the adenosine bases. This results in the prevention of DNA synthesis, as phosphodiester bridges can longer to be built, destabilizing the strand. For treatment of chickenpox - varicella, herpes zoster and herpes simplex Mechanism Of Action: Vidarabine stops replication of herpes viral DNA in 3 ways: 1) competitive inhibition of viral DNA polymerase, 2) incorporation into and termination of the growing viral DNA chain, and 3) inactivation of the viral DNA polymerase. News Articles on Vidarabine UAB's Richard Whitley named president of national infectious disease ... - Dec 11, 2009 More than three decades ago, Whitley helped develop vidarabine, the first drug to treat encephalitis caused by the herpes simplex virus. ... al.com (blog) UAB's Whitley Installed As President Of Infectious Diseases Society - Dec 13, 2009 Whitley is credited with helping to develop vidarabine, the first drug to treat encephalitis caused by the herpes simplex virus. The vidarabine breakthrough ... Medical News Today (press release) Vidarabine (Ophthalmic).(Drug overview) - Aug 1, 2006 Vidarabine (vye-DARE-a-been) ophthalmic preparations are used to treat virus infections of the eye. In deciding to use a medicine, the risks of using the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com Varicella-Zoster Virus; Vidarabine has more durable anti-VZV activity... - Apr 19, 2005 2005 APR 19 - (NewsRx.com) -- The antiviral effects of vidarabine on varicella-zoster virus (VZV) are more durable than those of acyclovir in vitro. ... Pay-Per-View - TB & Outbreaks Week - Factiva, from Dow Jones Varicella-Zoster Virus; Vidarabine has more durable anti-VZV activity... - Apr 22, 2005 2005 APR 22 - (NewsRx.com) -- The antiviral effects of vidarabine on varicella-zoster virus (VZV) are more durable than those of acyclovir in vitro. ... Pay-Per-View - Drug Week - Factiva, from Dow Jones Varicella-Zoster Virus; Vidarabine has more durable anti-VZV activity... - Apr 18, 2005 2005 APR 18 - (NewsRx.com) -- The antiviral effects of vidarabine on varicella-zoster virus (VZV) are more durable than those of acyclovir in vitro. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones Gendefekt kann Hirnentzündung auslösen - Sep 15, 2006 Seit der Einführung antiviraler Medikamente - Vidarabine im Jahre 1973 und Acyclovir 1981 - überleben die meisten Patienten, neurologische Folgeerkrankungen ... Spiegel Online Factiva Search - Apr 20, 2005 Toyama Medical and Pharmaceutical University; Vidarabine has more durable anti-VZV ... 2005 APR 20 - (NewsRx.com) -- The antiviral effects of vidarabine on ... Pay-Per-View - Biotech Week - Factiva, from Dow Jones Bone marrow transplantation from unrelated donors for patients with... - Oct 17, 2005 Viral encephalitis was suspected, so treatment with vidarabine was begun at a dose of 600 mg/day. However, the patient's consciousness was never restored ... Nature.com SRI International Awarded Defense Threat Reduction Agency (DTRA) … - Sep 22, 2008 SRI's research successes in anti-infectives include halofantrine, which is a marketed drug used to treat malaria, and vidarabine, which is an antiviral drug ... marketwire.com SLIPUPS ON STAPH - Feb 10, 2007 The vidarabine and idoxuridine recommended “to shorten the duration of rashâ€? are topical preparations for the eye. For patient 2, Dr. Meka cites extremely ... Cortlandt Forum Unique Genetic Susceptibility For Viral Encephalitis Pinpointed By... - Sep 19, 2006 Before the advent of anti-viral drugs vidarabine in 1973 and acyclovir in 1981, mortality rates reached up to 70 percent. While the introduction of ... Medical News Today - Medical News Today (press release) A young girl with blisters on her forehead.(PHOTO ROUNDS) - Jul 1, 2007 Immunosuppressed individuals may be treated with acyclovir, interferonalpha, and vidarabine. In this population the live, attenuated vaccine is safer and is ... $4.95 - Journal of Family Practice - ECNext New study pinpoints unique genetic susceptibility for viral encephalit... - Sep 15, 2006 Before the advent of anti-viral drugs vidarabine in 1973 and acyclovir in 1981, mortality rates reached up to 70 percent. While the introduction of ... eurekalert.org New Study Pinpoints Unique Genetic Susceptibility For Viral Encephalit... - Sep 25, 2006 Before the advent of anti-viral drugs vidarabine in 1973 and acyclovir in 1981, mortality rates reached up to 70 percent. While the introduction of ... sciencedaily.com BIOTECmarin: Glas aus Schwämmen - Nov 20, 2008 Jahren den Wirkmechanismus eines Schwamm-Enzyms aufgeklärt, das heute für das weltweit vertriebene Anti-Herpres-Medikament Vidarabine verwendet wird. ... biotechnologie.de Lutter contre un zona - Apr 3, 2007 Il administre un traitement antiviral (aciclovir, vidarabine, famciclovir) dès la phase éruptive et pendant une semaine. Ce traitement accélère la guérison, ... Dossier Familial Acute Respiratory Disease Associated with Adenovirus Serotype 14 - … - Nov 16, 2007 A number of antiviral drugs, including ribavirin, vidarabine, and cidofovir, have been used to treat adenoviral infections such as Ad14, but none have shown ... Pay-Per-View - MMWR. Morbidity and Mortality Weekly... - HighBeam Research Article: ISMP's list of error-prone abbreviations, symbols, and dose ... - Nov 1, 2005 100000 as 100000 units; 1000000 units) Drug Name AbbreviationsIntended Meaning Misinterpretation ARA A vidarabine Mistaken as cytarabine (ARA C) AZT ... Pay-Per-View - Nephrology Nursing Journal - HighBeam Research Article: Herpes hepatitis diagnosis is crucial during pregnancy.(Women... - Mar 15, 2006 That's because treatment with acyclovir or vidarabine is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, ... Pay-Per-View - Internal Medicine News - HighBeam Research Neonatal herpes in premature infants: a special problem.(COMMENTARY … - Dec 1, 2006 Vidarabine therapy of neonatal herpes simplex virus infection. Pediatrics. 1980;66:495-501. (9.) Kimberlin DW, Lin CY, Jacobs RF, et al. ... $4.95 - Pediatrics - ECNext Pennsylvania Code of Regulations - 28 Pa. Code § 6.1. Approved drugs. - Jul 16, 2005 ...(B) Vidarabine. (C) Trifluridine. (iv) Antivirals — oral. (A) Acyclovir. (B) Valacyclovir. (C) Famciclovir. (v) Antifungal and antiparasitic — topical only. ... Pay-Per-View - Pennsylvania Code of Regulations - Loislaw Wisconsin Administrative Code - RL 10.01 Definitions. - Jul 16, 2005 Vidarabine. 4. Acyclovir, an oral antiviral agent. (i) Anti-inflammatory agents. 1. Oral non-steroidal anti-inflammatory agents. a. Fenoprofen. b. ... Pay-Per-View - Wisconsin Administrative Code - Loislaw Article: Herpes hepatitis diagnosis lifesaving.(Clinical Capsules)(Bri... - Apr 15, 2006 That's because treatment with acyclovir or vidarabine is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, ... Pay-Per-View - Family Practice News - HighBeam Research ISMP's list of error-prone abbreviations, symbols, and dose designatio... - Nov 1, 2005 100000 as 100000 units; 1000000 units) Drug Name Abbreviations Intended Meaning Misinterpretation ARA A vidarabine Mistaken as cytarabine (ARA C) AZT ... $4.95 - Nephrology Nursing Journal - ECNext Herpes hepatitis diagnosis lifesaving.(Clinical Capsules)(Brief... - Apr 15, 2006 That's because treatment with acyclovir or vidarabine is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones Angiology; Prevention efforts reduce hepatitis B virus-associated … - Nov 15, 2005 Since 1983, treatment for patients with HBV markers has combined 2 weeks of CS followed by an antiviral agent (successively, vidarabine, interferon-alpha, ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones Article: Herpes hepatitis: timely diagnosis can be lifesaving.(Obstetr... - Mar 15, 2006 That's because treatment with acyclovir or vidarabine is lifesaving--and without it, one-half of affected mothers will die of fulminant hepatitis, ... Pay-Per-View - OB GYN News - HighBeam Research Oregon Regulations - 850-060-0225 Naturopathic Formulary … - Feb 1, 2006 ...(383) Valproic Acid; (384) Vancomycin; (385) Varenicline; (386) Verapamil; (387) Verdenafil HCL; (388) Vidarabine; (389) Vitamins (Oral & Injectable); ... Pay-Per-View - Oregon Regulations - Loislaw Brand Names/Synonyms: Vidarabine is also known by the following brand names and/or synonymsAdenine Arabinoside; Ara Atp; Ara-A; Ara-Atp; Ara-a Triphosphate; Araadenosine; Arabinofuranosyladenine Triphosphate; Arabinoside Adenine; Arabinosyl Adenine; Arabinosyl-Atp; Arabinosyladenine; Arabinosyladenine Triphosphate; Arasena-A; Spongoadenosine; Vidarabin; Vidarabine; Vidarabine Triphosphate; Vira-A Drug Category: Vidarabine is categorized under the following by the FDA: Antivirals; Antimetabolites; ATC:J05AB03; ATC:S01AD06 Dosage Forms: Not Available Absorption: Not Available Interactions: Not Available Chemical IUPAC Name: 2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol hydrate |
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