Zarontin

This page contains recent news articles, when available, and an overview of Zarontin but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Zarontin
(when available)

Pharmacology and use:
Used in the treatment of epilepsy. Ethosuximide suppresses the paroxysmal three cycle per second spike and wave activity associated with lapses of consciousness which is common in absence (petit mal) seizures. The frequency of epileptiform attacks is reduced, apparently by depression of the motor cortex and elevation of the threshold of the central nervous system to convulsive stimuli. For the treatment of petit mal epilepsy.

Mechanism Of Action:
Binds to T-type voltage sensitive calcium channels. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the "low-voltage activated (LVA)" group and are strongly blocked by mibefradil. A particularity of this type of channels is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

News Articles on Ethosuximide

Scriptlines: Zarontin caps.(shortage of Zarontin 250mg capsules...  -  Apr 29, 2006
Pfizer has warned pharmacists that stocks of Zarontin 250mg capsules (ethosuximide) are likely to run out in early May. The company has recommended that all ... Free with registration - Chemist & Druggist - AccessMyLibrary.com

Zarontin supply ensured as Italy's AIFA acts.  -  Jul 30, 2007
Zarontin supply ensured as Italy's AIFA acts. The Italian Pharmaceutical Agency (AIFA) has taken action to ensure current and future supplies of global drug ... $9.94 - Pharma Marketletter - Alacra Store

Longer Life, Less Aging With Seizure Drugs?  -  Jan 13, 2005
Two of the drugs, Zarontin and Tridione, are used to treat seizures in humans. ... Zarontin extended life span by three days. That's a 17% increase. ... WebMD

FINDINGS  -  Jan 14, 2005
A second antiseizure drug, ethosuximide, sold by Pfizer Inc. as Zarontin, boosted the length of the worms' lives by about 17 percent. ... Pay-Per-View - Washington Post - ProQuest Archiver

Two on the carpet over expired drugs  -  Jan 26, 2007
..."My daughter has been stable on Zarontin and hasn't had an epileptic seizure for a number of years now. She is worried that a change to her medicine would ... Independent Online

Details about the employee  -  Jul 18, 2007
Recentemente era venuta a conoscenza dell'AIFA la possibilità di sospensione della produzione dell'etosuccimide (Zarontin) da parte della casa produttrice ... Agipress

Torna farmaco contro l'epilessia  -  Aug 21, 2007
Il farmacista consegnerà ai pazienti il farmaco Petinimid, con allegato il foglio illustrativo di Zarontin in italiano. Il prodotto verrà ceduto ... Superando.it

FDA Adds Suicide Warning to Epilepsy Drugs  -  Dec 15, 2008
Tegretol, Tegretol XR); clorazepate (Tranxene); divalproex sodium (Depakote, Depakote ER, Depakene); ethosuximide (Zarontin); ethotoin (Peganone); ... Forbes

FDA requires suicide warning on some drugs  -  Dec 17, 2008
Klonopin, Tranxene, Depakote, Depakote ER, Depakene, Zarontin, Peganone, Felbatol, Neurontin, Lamictal, Vimpat, Keppra, Mesantoin, Celontin, Trileptal, ... Money Times - The Money Times

Article: FINDINGS - The Washington Post | HighBeam Research - FREE …  -  Jan 14, 2005
A second antiseizure drug, ethosuximide, sold by Pfizer Inc. as Zarontin, boosted the length of the worms' lives by about 17 percent. ... Pay-Per-View - Washington Post - HighBeam Research

Hospital 'disturbed' by medicine scandal  -  Jan 23, 2007
The drug, Zarontin, is a medication used to control epileptic seizures, with medical practitioners stipulating that it should not be used after its expiry ... Independent Online

St. Paul Pioneer Press : LIVER TESTS MANDATED TO AVOID SUDDEN …  -  Apr 13, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - St. Paul Pioneer Press - NewsBank

Article: Anti-seizure drugs help worms live longer, study says. - St....  -  Jan 14, 2005
But drugs that stop seizures in people, including those sold under the brand names Zarontin and Troxidone, also slowed aging in laboratory worms, ... Pay-Per-View - St. Louis Post-Dispatch - HighBeam Research

Anticonvulsant hypersensitivity syndromes can manifest on skin.(Clinic...  -  Dec 1, 2006
Cross-reactivity can be avoided by choosing a nonaromatic agent such as ethosuximide (Zarontin), gabapentin (Neurontin), tiagabine (Gabitril), or topiramate ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

Article: Anti-convulsant drugs slow aging process in worms, study...  -  Jan 13, 2005
But drugs that stop seizures in people, including those sold under the brand names Zarontin and Troxidone, also slowed aging in laboratory worms, ... Pay-Per-View - St. Louis Post-Dispatch - HighBeam Research

Washington Administrative Code - WAC 260-70-680 This section …  -  Mar 17, 2006
...mesylates Erthrityl tetranitrate Cardilate Esmolol Brevibloc Etamiphylline Ethacrynic Acid Edecrin Ethosuximide Zarontin Ethylestrenol Maxibolin, ... Pay-Per-View - Washington Administrative Code - Loislaw

The reason for those liver tests.  -  Mar 25, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... Free with registration - Sun Herald - AccessMyLibrary.com

Anti-epileptic drugs may help prevent and treat noise-induced hearing...  -  Mar 14, 2007
Bao and colleagues found that if they exposed mice to loud sounds and then gave them trimethadione (Tridione®) or ethosuximide (Zarontin®) — anticonvulsive ... eurekalert.org

New data on antiepileptic drugs.(DRUGS, PREGNANCY, AND …  -  Oct 15, 2006
...clorazepate [Tranxene], diazepam [Valium], and lorazepam [Ativan]) and succinimides (ethosuximide [Zarontin] and methsuximide [Celontin]). ... $4.95 - Internal Medicine News - ECNext

First-generation anticonvulsants.(Drugs, Pregnacy, And Lactation)( …  -  Sep 1, 2006
...clorazepate [Tranxene], diazepam [Valium], and lorazepam [Ativan]) and succinimides (ethosuximide [Zarontin] and methsuximide [Celontin]). ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

How to take Lisdexamfetamine from Consumer Reports Health.  -  Jan 7, 2007
...certain medications for seizures such as ethosuximide (Zarontin), phenobarbital, and phenytoin (Dilantin); meperidine (Demerol); methenamine (Hiprex, ... consumerreports.org

A great day for roundworms.(Indications)(Brief Article)  -  Mar 15, 2005
Then Ms. Evason exposed the round-worms to the anticonvulsant ethosuximide (Zarontin) and saw a 17% increasing longevity (from 16.7 days to 19.6 days) at a ... Free with registration - Family Practice News - AccessMyLibrary.com

Anti-Epileptic Drugs Could Help Prevent And Treat Noise-Induced …  -  Mar 17, 2007
Bao and colleagues found that if they exposed mice to loud sounds and then gave them trimethadione (Tridione®) or ethosuximide (Zarontin®) - anticonvulsive ... Medical News Today - Medical News Today (press release)

Divalproex sodium, Depakote, Depakene valproic acid (generic) (brand)...  -  Jun 1, 2005
...meropenem, ethosuximide (Zarontin), primidone (Mysoline), tolbutamide, phenytoin, amitriptyline/nortriptyline, warfarin (Coumadin), and zidovudine. ... Free with registration - Brown University Child and Adolescent... - AccessMyLibrary.com

How to take Dextroamphetamine and Amphetamine from Consumer …  -  Jan 6, 2007
...certain medications for seizures such as ethosuximide (Zarontin), phenobarbital (Luminal, Solfoton), and phenytoin (Dilantin); meperidine (Demerol); ... consumerreports.org

toremifene - MSN Health & Fitness - Medications  -  Apr 4, 2005
...a seizure medication such as carbamazepine (Tegretol), ethosuximide (Zarontin), or phenytoin (Dilantin). Your may require a dosage adjustment or special ... MSN Health & Fitness

ROGER SCHLUETER: SCIENCE COLUMN  -  Mar 13, 2007
Bao and his colleagues found that if they exposed mice to loud sounds and then gave them Tridione or Zarontin, two anticonvulsive medications, ... $2.95 - Belleville News-Democrat - NewsBank

A Guide to Interventions for Pediatric Seizure Disorders  -  Jul 1, 2005
11 Ethosuximide (Zarontin, Pfizer) is only effective against absence seizures. In general, the newer medications are used as ad. Psychiatric Times

Vagus nerve stimulation: treatment modality for epilepsy.(Research...  -  Feb 1, 2007
...ethosuximide (Zarontin[R]), gabapentin (Neurontin[R]), tiagabine (Gabitril[R]), topiramate (Topamax[R]), and valproate (Depacon[R]) (Glauser et al., ... $4.95 - MedSurg Nursing - ECNext

Southern Illinoisan : Lifestyles<br>  -  Sep 20, 2005
...dapsone, diclofenac (Voltaren, Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), gemfibrozil (Lopid), ... $2.95 - Southern Illinoisan - NewsBank

Southern Illinoisan : Lifestyles<br>  -  Mar 29, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - Southern Illinoisan - NewsBank

Press of Atlantic City, The : QUESTION & ANSWER FROM THE …  -  Mar 28, 2005
Arthrotec), efavirenz (Sustiva), ethotoin (Peganone), ethosuximide (Zarontin), felbamate (Felbatol), fenofibrate (Tricor), fluconazole (Diflucan), ... $2.95 - Press of Atlantic City, The - NewsBank

IN BRIEF: Epilepsy drugs withdrawn  -  Oct 1, 2005
Zarontin and Emeside capsules, both forms of ethosuximide, are to be withdrawn and there will no longer be a solid oral formulation. ... Pay-Per-View - Pulse - Factiva, from Dow Jones

A great day for roundworms.(Indications)(Brief Article) | Article...  -  Mar 15, 2005
Then Ms. Evason exposed the round-worms to the anticonvulsant ethosuximide (Zarontin) and saw a 17% increasing longevity (from 16.7 days to 19.6 days) at a ... Pay-Per-View - Family Practice News - HighBeam Research

Douleur : forum E-santé  -  Jul 17, 2005
J'ai essayé un tas d'autres anti-douleur, comme le Neurontin ou le Zarontin mais sans résultat. Aujourd'hui, mon spécialiste du bras m'a conseillé d'aller ... E-Santé.fr

Brand Names/Synonyms:
Zarontin is also known by the following brand names and/or synonymsAethosuximide; Asamid; Atysmal; C.I. 366; CI-366; Capitus; Cl 366; Emeside; Epileo Petit Mal; Ethosuccimide; Ethosuccinimide; Ethosuxide; Ethosuximide; Ethymal; Etomal; Etosuximid; Etosuximida; H 940; H-490; Mesentol; NSC-64013; PM 671; PM-671; Pemal; Pemalin; Pentinimid; Peptinimid; Petinimid; Petnidan; Piknolepsin; Pyknolepsinum; Ronton; Simatin; Succimal; Succimitin; Suxilep; Suximal; Suxin; Suxinutin; Thetamid; Thilopemal; Uritone; Urodeine; Zaraondan; Zarodan; Zarondan; Zarondan-Saft; Zarontin; Zartalin

Drug Category:
Zarontin is categorized under the following by the FDA: Anticonvulsants; Succinimides; ATC:N03AD01

Dosage Forms:
SYRUP

Absorption:
Not Available

Interactions:
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Chemical IUPAC Name:
3-ethyl-3-methyl-pyrrolidine-2,5-dione





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