Zidovudine

This page contains recent news articles, when available, and an overview of Zidovudine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Zidovudine
(when available)

Pharmacology and use:
Zidovudine is a nucleoside reverse transcriptase inhibitor (NRTI) with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Zidovudine is phosphorylated to active metabolites that compete for incorporation into viral DNA. They inhibit the HIV reverse transcriptase enzyme competitively and act as a chain terminator of DNA synthesis. The lack of a 3'-OH group in the incorporated nucleoside analogue prevents the formation of the 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated. For the treatment of Human immunovirus (HIV) infections

Mechanism Of Action:
Zidovudine, a structural analog of thymidine, inhibits the activity of HIV-1 reverse transcriptase (RT) both by competing with the natural substrate dGTP and by its incorporation into viral DNA.

News Articles on Zidovudine

Body fat loss study more proof of why d4T must go  -  ‎Dec 19, 2009‎
Most first-line regimens in resource-poor settings include either stavudine or zidovudine despite recent WHO recommendations to phase out stavudine. ... Times LIVE (blog)

Adult T-cell Leukemia/ Lymphoma: Complexities in Diagnosis and Novel Treatment ...  -  ‎Dec 17, 2009‎
Kchour G, Tarhini M, Kooshyar MM, et al: Phase 2 study of the efficacy and safety of the combination of arsenic trioxide, interferon alpha, and zidovudine ... Cancer Network

Mali gets tool to detect bogus medicine  -  ‎Dec 31, 2009‎
...the HIV therapy of lamivudine, zidovudine and nevirapine; anti-malarial quinidine; and the antibiotic rifampicin, to treat tuberculosis and leprosy. ... UPI.com

TB, pregnancy, most common reasons for treatment changes in African study  -  ‎Dec 10, 2009‎
Intolerance-related zidovudine substitutions were associated with baseline haemoglobin level and baseline tuberculosis status. There are usually no serious ... Aidsmap

Cost of HIV treatment in Kenya to rise  -  ‎Dec 15, 2009‎
...while those who have not developed any complication yet should be treated with Zidovudine (AZT) which costs Sh11,700 for a single patient annually. ... Capital FM

Widespread Crusted Lesions in a Patient With HIV—Diagnosis  -  ‎Dec 21, 2009‎
The patient started antiretroviral therapy (zidovudine, 600 mg/d; lamivudine, 300 mg/d; and efavirenz, 600 mg/d) and treatment with amphotericin B (1 mg/kg ... Archives of Dermatology

Reportlinker Adds The Future of Orphan Diseases Therapeutics - Market ...  -  ‎Dec 15, 2009‎
Flexible Market Exclusivity 4.5.3.10 Price Revisions 4.5.3.11 GSK's Retrovir (zidovudine) 4.5.3.12 Amgen's Epogen (erythropoietin) 4.5.3.13 Conclusion 5 ... IT News Online

Common Link Found Between HIV-Related Memory Loss And Alzheimer's Disease  -  ‎Dec 11, 2009‎
The most commonly used drug to treat ADC is zidovudine (Retrovir), which is used in high doses. However, other drugs that can cross the blood-brain barrier ... The AIDS Beacon (blog)

Kenya: Stavudine to Be Phased Out - Gradually  -  ‎Dec 10, 2009‎
The health body advised countries to instead adopt zidovudine (AZT) or tenofovir, both less toxic and equally effective ARVs. The Kenyan government will ... AllAfrica.com

SEXUALLY TRANSMITTED DISEASES:- THEIR NATURE AND CURE - THIRD PUBLICATION  -  ‎Dec 18, 2009‎
Examples of Anti-retroviral drugs are: Zidovudine (AZT or 31 Azido 31 deoxy thymidine) or retrovir, Nevirapine, Didanosine, Efavirenz, Lamivudine, ... Modern Ghana

South Africa: Improved PMTCT yields dramatic results  -  ‎Dec 10, 2009‎
With dual therapy, HIV-positive women started receiving the ARV drug, zidovudine (AZT), from 28 weeks of pregnancy, as well as a single dose of nevirapine. ... ReliefWeb (press release)

AFRIQUE DU SUD: Les résultats impressionnants de l'amélioration de la PTME  -  ‎Dec 14, 2009‎
Dans le cadre de la bithérapie, les femmes séropositives ont reçu de la zidovudine, un médicament antirétroviral aussi connu sous le nom d'AZT, ... IRINnews.org

Generic Name: Lamivudine/Zidovudine  -  ‎Nov 11, 2009‎
Combivir (generic name: Lamivudine/Zidovudine) is used, alone or with other medicines, to slow down the progression of human immunodeficiency virus (HIV) ... Pattaya Daily News

Generic Name: Zidovudine, Retrovis, Azidothymidine  -  ‎Nov 11, 2009‎
Retrovir (generic name: Zidovudine/Azidothymidine; brand name: Retrovis) is an antiviral agent which is highly active against retroviruses including the ... Pattaya Daily News

New Retrovir Dosing for Kids  -  ‎Nov 11, 2009‎
Dosing for the antiretroviral drug Retrovir (zidovudine) for children has been expanded and revised, according to the US Food and Drug Administration (FDA). ... AIDSmeds.com HIV/AIDS Treatment News

Combivir: The HIV Drug in Hasan's Shoe Box  -  ‎Nov 12, 2009‎
...and it contained the first-ever agent approved for the treatment of AIDS — zidovudine (better known as AZT) as well as lamivudine (3TC). ... TIME

Generic Name: Tenofovir, emtricitabine  -  ‎Nov 11, 2009‎
Do not take Truvada if you are already taking Atripla, Combivir (lamivudine/zidovudine), Emtriva, Epivir or Epivir-HBV (lamivudine), Epzicom (abacavir ... Pattaya Daily News

Antiretroviral activity of the aminothiol WR1065 against Human ...  -  ‎Nov 6, 2009‎
...to define the dose-response curve for that inhibition, and address the question of additive effects for the combination of WR1065 plus Zidovudine (AZT). ... 7thSpace Interactive (press release)

Postexposure Prophylaxis for HIV Infection  -  ‎Oct 28, 2009‎
Enrollment was not completed in a randomized, placebo-controlled trial of zidovudine (also known as azidothymidine, or AZT) for prophylaxis after ... New England Journal of Medicine (subscription)

How antiretroviral therapy prolongs life  -  ‎Oct 21, 2009‎
There are four types of ARV drugs: l Nucleoside reverse transcriptase inhibitors (NRTIs) such as Zidovudine (formerly called azidothymidine, AZT) interfere ... The Southern Times

Outlining Drug-Induced Anemia and Select Medications  -  ‎Oct 21, 2009‎
Zidovudine is a common cause of drug-induced anemia in HIV patients. Patients who develop zidovudine related anemia genrally present with a slow decline in ... National Anemia Action Council

Coalescing purpuric plaques  -  ‎Nov 10, 2009‎
His medications included Combivir (lamivudine/zidovudine) and nelfinavir. A biopsy revealed increased spindle cells with vascular slits. ... Clinical Advisor

Combination Antiretroviral Therapy Effective At Reducing HIV Resistance In ...  -  ‎Oct 27, 2009‎
The researchers report that the combination drug regimen -- which involved the addition of a twice-daily dose of zidovudine and lamivudine over several days ... Science Daily (press release)

Aranesp Increases Risk of Stroke for Some Patients: Study  -  ‎Nov 2, 2009‎
They are also used by HIV patients whose anemia is caused by AZT (zidovudine) and for patients about to undergo major non-heart surgery. ... AboutLawsuits.com

New HIV/Aids drug hits market  -  ‎Oct 23, 2009‎
ARVs traditionally fall into three classes of drugs: One, Nucleoside Reverse Transcriptase Inhibitors (NRTIs) such as Zidovudine- formerly called ... The Southern Times

Five-year follow up of genotypic resistance patterns in HIV-1 subtype C ...  -  ‎Oct 25, 2009‎
In contrast, the standard of care for all patients subsequently enrolled (2002-2007) included zidovudine/lamivudine (ZDV/3TC) (Group 2). ... 7thSpace Interactive (press release)

CAFC Continues to Struggle with How Title to Subject Inventions Works under ...  -  ‎Oct 27, 2009‎
...in the blood plasma of infected humans who are taking drugs such as zidovudine (AZT), which is hereafter referred to as the “HIV RNA assay invention. ... IPWatchdog.com

Maternal HIV-1 treatment protects against transmission to newborns  -  ‎Oct 20, 2009‎
The authors had reported in 2008 that daily use of either nevirapine or nevirapine and zidovudine from birth up to the age of 14 weeks in breastfeeding ... innovations report

GlaxoSmithKline to allow Apotex continue manufacturing their drug in Rwanda  -  ‎Oct 20, 2009‎
Apotex currently manufactures a fixed dose combination (FDC) antiretroviral (ARV), containing two molecules over which GSK has patent rights (zidovudine and ... News-Medical.net

Co-infection Nigeria : co-infection VIH/VHB et réponse au traitement  -  ‎Nov 4, 2009‎
...avaient démarré les ARV entre octobre 2004 et juin 2006 (stavudine ou zidovudine, lamivudine plus éfavirenz ou névirapine) avec un minimum de six mois ... vih.org

Quick Search by Organization  -  ‎Oct 19, 2009‎
...une association antirétrovirale à doses fixes qui contient deux molécules pour lesquelles GSK détient les droits de brevet (zidovudine et lamivudine). ... Canada NewsWire (press release)

Researchers find better HIV medication  -  Jan 19, 2006
The therapy was compared to the combination of zidovudine, ... However, those patients with no problems on the zidovudine-lamivudine therapy may not have to ... 新�网

… approval of co-packaged lamivudine/zidovudine fixed dose combinatio...  -  Jan 26, 2005
The Food and Drug Administration (FDA) has announced the tentative approval of a co-packaged antiretroviral drug regimen manufactured by Aspen Pharmacare of ... News-Medical.net

FDA Approves Four Generic Forms of Zidovudine for US Sales After …  -  Sep 21, 2005
FDA on Monday announced it has granted approval for four forms of the generic antiretroviral drug zidovudine to be sold in the US, after GlaxoSmithKline's ... Kaiser Health News

… -Boosted HIV Integrase Inhibitor and Zidovudine: Presented at AIDS...  -  Aug 16, 2006
..."The compound would likely be administered with zidovudine, so we wanted to ... Patients received the standard dose of zidovudine, at 300 mg twice daily ... DG News

A drug is effective if better than a harmless control  -  Apr 28, 2005
In the HIVNET 012 trial, a very short course of zidovudine was used as the ... Many studies had already reported that longer zidovudine regimens were more ... Nature.com

Aurobindo gets nod to market Zidovudine oral soln in SAfrica  -  Jun 19, 2007
Mumbai, June 19 (PTI): Drug maker Aurobindo Pharma today said it has got approval from Medicines Control Council (MCC) of South Africa to market Zidovudine, ... Free with registration - PTI - The Press Trust of India Ltd - AccessMyLibrary.com

India's Ranbaxy has 3 more AIDS drugs on WHO list  -  Sep 10, 2007
The Ranbaxy anti-retroviral drugs added to the list are tablet combinations of lamivudine and zidovudine with a single tablet of efavirenz, and two tablet ... Reuters India

Probe into drugs in South Africa  -  Aug 12, 2008
Certain types of Nevirapine, used by HIV-positive pregnant women, and Adco-Zidovudine (AZT) were recalled by Adcock Ingram over the weekend. ... BBC News

FDA OKs 3-Drug Combo Pill to Treat HIV  -  Jun 30, 2006
The twice-daily pills combine three drugs already widely used to treat human immunodeficiency virus: lamivudine, zidovudine and nevirapine. ... FOXNews

India's Strides Arcolab gets FDA nod for two HIV/AIDS new drug …  -  Jun 6, 2007
The company said the approvals are for the combination of Lamivudine/Stavudine 150 mg/40 mg tablets and Lamivudine/Zidovudine 150/300 mg tablets, ... Forbes

Packing error leads to huge Aids drug recall  -  Aug 9, 2008
The problem arose when a worker packed Nevirapine into boxes for Zidovudine (AZT). The Nevirapine blister packs were correctly labelled but the boxes had ... Independent Online

Mmegi Online ::> news we need to know  -  Jan 24, 2006
Zidovudine was the first antiretroviral drug, approved in 1987, ... Since 1998, zidovudine and lamivudine have been available in a single-pill formulation ... Mmegi Online

Aurobindo AIDS drug gets US FDA approval  -  Sep 13, 2005
With the approval, the drug, Zidovudine, a generic liquid version of a child-friendly ... Zidovudine is to be used with other antiretroviral agents for the ... Business Standard

2008 Asian of the Year is Thai pharmacist  -  Jan 26, 2008
If taken by HIV-positive women who are pregnant, Zidovudine has been proven to significantly reduce the risk of the mother-to-be passing on her disease to ... United Press International

ABACAVIR, LAMIVUDINE, AND ZIDOVUDINE (Oral route) - a-BAK-a-veer …  -  May 1, 2007
The three nucleoside analogue combination (abacavir sulfate/lamivudine/zidovudine) is intended only for patients whose regimen would otherwise include these ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… HIV medicines indinavir sulfate 400, zidovudine 300, lamivudine 300  -  Aug 31, 2006
Pune, August 30: THE long-awaited revival of Hindustan Antibiotics Ltd (HA) may prove to be a damp squib on the operational front for the first PSU ... Expressindia.com

Zidovudine (Systemic).  -  Jul 28, 2005
Zidovudine (zye-DOE-vue-deen) (also known as AZT) is used in combination with other anti-virus medicines in the treatment of the infection caused by the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Investigational Amdoxovir Plus Zidovudine Rapidly Reduces HIV Levels ...  -  Feb 7, 2008
By Ed Susman. BOSTON, MA -- February 7, 2008 -- The experimental nucleoside reverse transcriptase inhibitor amdoxovir appears to lower HIV levels rapidly ... DG News

Lamivudine and Zidovudine (Systemic).  -  Feb 1, 2006
Lamivudine ( la-MI-vyoo-deen) and zidovudine (zye-DOE-vyoo-deen ) combination is used in the treatment of human immunodeficiency virus (HIV) infection. ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Aurobindo drugs get US FDA nod  -  Sep 22, 2005
AZT, an anti-retroviral drug that is also known as Zidovudine, helps prevent the AIDS virus from reproducing in the body. It is often used in combination ... Business Standard

FDA Grants Aurobindo Approval for US Sale of Zidovudine Capsule  -  Apr 3, 2006
FDA on Friday granted Indian drug manufacturer Aurobindo Pharma approval to sell and market in the US a capsule dosage of the generic antiretroviral drug ... Kaiser Health News

Lamivudine and Zidovudine combination tentatively approved by FDA/ …  -  Jul 9, 2005
The Food and Drug Administration within the US Department of Health and Human Services (HHS/FDA) today announced the tentative approval of the fixed-dose ... Medical News Today - Medical News Today (press release)

Didanosine Similar in Efficacy to Zidovudine in HAART Therapies With ...  -  Sep 21, 2007
By Ed Susman. CHICAGO, IL -- September 21, 2007 -- Didanosine-based treatment appears to be as successful as zidovudine in maintaining suppression of HIV in ... DG News

Tenofovir Better Tolerated Than Zidovudine for PEP  -  Mar 20, 2008
Nonoccupational post-exposure prophylaxis (NPEP) regimens containing tenofovir were better tolerated and more likely to be completed than those containing ... AIDSmeds.com HIV/AIDS Treatment News

Aurobindo to sell AIDS drug in US  -  Mar 30, 2006
Aurobindo Pharma Ltd (APL) has announced that it has received final approval of the United States Food and Drug Administration (USFDA) for Zidovudine ... Hindu Business Line

Ranbaxy Receives USFDA Approval for Zidovudine Tablets  -  Jul 17, 2005
Ranbaxy Laboratories Limited (RLL) announced today that it has received tentative approval from the US Food and Drug Administration (USFDA) to manufacture ... i-newswire.com

Child Friendly Zidovudine Preparation for treating HIV infection...  -  Sep 12, 2005
It is only small things that are difficult to handle. Even when so much has been done to effectively treat diseases like cancer, treating a viral infection ... MedIndia

JAMA -- Breastfeeding Plus Infant Zidovudine Prophylaxis for 6 Months...  -  Aug 16, 2006
You are seeing this message because your Web browser does not support basic Web standards. Find out more about why this message is appearing and what you ... Journal of American Medical Association - Journal of American Medical Association...

Switching From Zidovudine- to Tenofovir-Based Therapy Preserves and …  -  Feb 6, 2008
By Maria Bishop. BOSTON, MA -- February 6, 2008 -- Patients with HIV who switch from a fixed-dose combination of zidovudine plus lamivudine tablets to a ... DG News

Kolkata group against GSK's AIDS patent  -  Aug 8, 2006
The NGO claimed that Combivir, a fixed-dose combination of two essential AIDS drugs - zidovudine and lamivudine, does not deserve an exclusive patent right ... Rediff

Aurobindo Receives Zidovudine Approval From MCC South Africa  -  Jun 22, 2007
Aurobindo Pharma announced that it received a marketing authorization approval from the Medicines Control Council (MCC) of South Africa to treat AIDS. ... FDA news - FDA news (subscription)

US FDA tentative nod for Aurobindo tablets  -  Jul 13, 2005
HYDERABAD: Aurobindo Pharma has received tentative approval from the US Food and Drug Administration for lamivudine and zidovudine, 150 mg and 300 mg ... The Hindu

Indian group opposes patenting of AIDS drug  -  Mar 30, 2006
...'We are objecting to the patenting of Combivir - a fixed-dose combination of the two essential AIDS drugs zidovudine and lamivudine - because it is not a ... Times of India

Africa: Africa: Tentative US Approval of Glaxo Aids Drug  -  Jul 14, 2005
Known chemically as zidovudine, Retrovir helps to prevent the HIV virus from multiplying. The low-cost versions of Glaxo's medicine are currently being ... AllAfrica.com

… debut.(Generic Drugs)(Hereto Drugs Ltd.'s zidovudine gets FDA...  -  May 19, 2008
Camber debut.(Generic Drugs)(Hereto Drugs Ltd.'s zidovudine gets FDA approval)(Brief article) ... find Chain Drug Review articles. Pay-Per-View - Chain Drug Review - HighBeam Research

Aurobindo Pharma gets registrations for ARVs from Botswana  -  Feb 23, 2007
The company has announced that the DRU (drugs regulatory unit) of Botswana has registered Lamivudine and Zidovudine tablet, Zidovudine oral solution 50 mg ... Myiris.com

Aurobindo Pharma ARV drug in WHO list  -  Dec 13, 2005
The other products are Zidovudine tablets 300 mg, Lamivudine tablets 150 mg and Lamivudine tablets 300 mg. Nevirapine is a key anti-retroviral drug in the ... Hindu Business Line

FDA approves first three-drug fixed-dose tablet for PEPFAR use  -  Jul 5, 2006
The recommended regimen for the lamivudine-zidovudine-nevirapine tablet is ... Zidovudine-containing fixed dose combinations were initially considered to be ... Aidsmap

Ranbaxy Receives Approval to Market Zidovudine Tablets.  -  Sep 20, 2005
PRINCETON, NJ, Sept. 20 /PRNewswire/ -- Ranbaxy Laboratories Limited (RLL) announced today that it has received approval from the US Food and Drug ... $4.95 - PR Newswire - ECNext

Learn about Zidovudine Injection from Consumer Reports Health.  -  Jan 8, 2006
Zidovudine can cause severe side effects, such as liver damage, blood toxicities, and muscle ... Full Alert. Your doctor has ordered zidovudine, ... consumerreports.org

… Receives Approval to Market Zidovudine Tablets. - PR Newswire | …  -  Sep 20, 2005
Ranbaxy Receives Approval to Market Zidovudine Tablets. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

HIV/AIDS Therapy; Zidovudine and didanosine dosing in children has …  -  Mar 14, 2006
2006 MAR 14 - (NewsRx.com) -- Scientists have developed a simplified weight-based method for pediatric drug dosing for zidovudine and didanosine in ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Tenofovir DF, Emtricitabine, Efavirenz May Be Superior to Zidovudine.....  -  Jul 28, 2005
...better disease control than combination zidovudine-lamivudine (Combivir) ... while combination zidovudine-lamivudine requires twice-daily dosing plus ... Medscape

… Efficacy of Abacavir Sulfate/Lamivudine/Zidovudine Alone in...  -  Oct 12, 2006
Combivir is a combination tablet containing lamivudine and zidovudine. ... Zidovudine has been associated with hematologic toxicity including neutropenia ... DG News

Ranbaxy Receives USFDA Approval for Zidovudine Tablets  -  Jul 14, 2005
Ranbaxy Laboratories Limited (RLL) announced today that it has received tentative approval from the US Food and Drug Administration (USFDA) to manufacture ... Medical News Today - Medical News Today (press release)

FDA CAPSULES  -  Apr 11, 2006
The FDA has approved the first generic capsule dosage form of the HIV/AIDS treatment zidovudine for marketing in the United States. ... Pay-Per-View - Newsday - ProQuest Archiver

Zidovudine Injection Side Effects from Consumer Reports Health.  -  Jan 8, 2006
Zidovudine can cause severe side effects, such as liver damage, blood toxicities, and muscle ... Full Alert. Zidovudine can cause severe side effects, ... consumerreports.org

Lowered AZT dose for low weight patients 'effective and reduces...  -  Aug 10, 2006
Lowering zidovudine (AZT) dosing to 200mg twice daily could reduce toxicity ... A previous single-dose pharmacokinetic study of zidovudine at 300 mg twice ... Aidsmap

Ranbaxy gets FDA tentative approval for zidovudine generic  -  Jul 21, 2005
New Delhi: Domestic pharma major Ranbaxy Laboratories (RL) has received the tentative approval for zidovudine tablets from the US Food and Drug ... expresspharmapulse.com

… : Ranbaxy Receives Tentative Approval for Zidovudine Tablets as...  -  Jul 14, 2005
Ranbaxy Receives Tentative Approval for Zidovudine Tablets as Part of the US President's Emergency Plan for AIDS Relief (PEPFAR) Initiative. from PR ... Pay-Per-View - PR Newswire - HighBeam Research

HIV/AIDS Vertical Transmission; Zidovudine crosses the placenta in...  -  Dec 5, 2005
According to a study from the People's Republic of China, "Zidovudine is one of the most common antiretroviral drugs used to prevent vertical transmission ... Pay-Per-View - OBGYN & Reproduction Week - Factiva, from Dow Jones

… to market generic version of Retrovir's zidovudine oral solution)(B...  -  Sep 26, 2005
Zidovudine is in the class of drugs called nucleoside reverse transcriptase inhibitors, which help keep the AIDS virus from reproducing. ... Free with registration - Drug Store News - AccessMyLibrary.com

Short-Course Perinatal Antiretroviral Regimens Combined With Infant- …  -  Aug 18, 2006
Her study offered HIV-infected women a prenatal treatment that combined zidovudine during the last 4 weeks of pregnancy and a single dose of nevirapine ... DG News

Postexposure Prophylaxis Better Tolerated on Stavudine Regimen: …  -  Jul 26, 2007
The score for worry was 6.8 in the zidovudine group compared with 2.3 in the stavudine ... Dr. Hawkins said nine patients experienced vomiting on zidovudine ... DG News

Zidovudine Capsules.(NEW & APPROVED)(Brief article)  -  May 15, 2006
The first generic capsule formulation of the nucleoside reverse transcriptase inhibitor zidovudine approved for US use. Generic tablet and oral solution ... $4.95 - Internal Medicine News - ECNext

No Advantage For Four-Drug Antiretroviral Regimen For Initial...  -  Aug 10, 2006
The study participants received either the medications zidovudine/lamivudine plus efavirenz (3-drug regimen) or zidovudine/lamivudine/abacavir plus ... newswise.com

Drug Delivery; Ethyl cellulose microspheres show promise as zidovudine...  -  Mar 7, 2006
Pharmaceutical researchers in India conducted a study "to formulate and evaluate microencapsulated controlled release preparations of zidovudine using ethyl ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

… Release: FDA tentatively approves generic zidovudine oral solution,...  -  Sep 9, 2005
FDA tentatively approves generic zidovudine oral solution, for HIV/AIDS; Treatment in association with the Presidents Emergency Plan for AIDS relief. from ... Pay-Per-View - M2 Presswire - HighBeam Research

Hyperpigmentation below 1% in HIV patients.(Clinical Rounds)  -  Feb 1, 2005
Dr. Murray and her associates at GlaxoSmithKline, Greenford, England, the corn pany that makes zidovudine, analyzed all of the company's sponsored trials ... Free with registration - Skin & Allergy News - AccessMyLibrary.com

New Gold Standard for Initial Antiretroviral Treatment of HIV...  -  Jan 17, 2006
Zidovudine was the first antiretroviral drug, approved in 1987, ... Since 1998, zidovudine and lamivudine have been available in a single-pill formulation ... newswise.com

FDA OK's Generic Retrovir for HIV  -  Mar 31, 2006
The agency said it has cleared for the US market zidovudine in capsule ... Approval of this additional dosage form of zidovudine should help reduce the cost ... RedOrbit

Article: Study Sets New Gold Standard for Initial Antiretroviral...  -  Jan 18, 2006
Article: Johns Hopkins gives zidovudine to infant in ... AIDS Alert; September 1, ... Article: Should health care workers use zidovudine prophylaxis? ... ... Pay-Per-View - Ascribe Higher Education News Service - HighBeam Research

FDA tentatively approves generic zidovudine oral solution, for...  -  Sep 9, 2005
The US Food and Drug Administration (FDA) within the US Department of Health and Human Services (HHS) today announced the tentative approval of zidovudine ... $4.95 - M2 Presswire - ECNext

… detects HIV-protease inhibitors lamivudine and zidovudine  -  Nov 22, 2005
2005 NOV 22 - (NewsRx.com) -- Micellar electrokinetic chromatography simultaneously detects HIV-protease inhibitors lamivudine and zidovudine in ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Study Sets New Gold Standard For Initial Antiretroviral Treatment Of...  -  Jan 25, 2006
Zidovudine was the first antiretroviral drug, approved in 1987, ... Since 1998, zidovudine and lamivudine have been available in a single-pill formulation ... sciencedaily.com

Initial Antiretroviral Treatment of HIV Infection  -  Mar 10, 2006
Zidovudine was the first antiretroviral drug, approved in 1987, ... Since 1998, zidovudine and lamivudine have been available in a single-pill formulation ... emaxhealth.com

zidovudine | Definition of zidovudine | HighBeam.com: Online Dictionar...  -  Jul 12, 2006
Find out what zidovudine means: The Oxford American College Dictionary has the definition of zidovudine. Research related newspaper, magazine, ... Pay-Per-View - Oxford American College Dictionary - HighBeam Research

ICAAC: No added benefit from adding AZT to nevirapine to prevent MTCT  -  Dec 19, 2005
Adding a short course of AZT (zidovudine, Retrovir) to nevirapine (Viramune) therapy does not reduce the rate of mother-to-child transmission of HIV, ... Aidsmap

NRTI-Associated Mitochondrial Toxicities and Abacavir Hypersensitivity  -  Feb 8, 2005
In vitro and enzymatic studies with zidovudine underestimated the clinical effect that ... Studying zidovudine in nonmitotic cells where zidovudine is only ... Medscape

New and generic drug approvals: Lamivudine/Zidovudine Tablets.  -  Sep 14, 2006
On 14 Sep 2006, the US Food and Drug Administration announced the tentative approval of ANDA 077411 for Lamivudine/Zidovudine Tablets. ... Pay-Per-View - US Food and Drug Administration News - Factiva, from Dow Jones

Ranbaxy gets US clearance for zidovudine.(Ranbaxy Laboratories Ltd.)(...  -  Sep 26, 2005
India's Ranbaxy Laboratories has received approval from the US Food and Drug Administration to manufacture and market tablets of the nucleoside reverse ... $4.95 - Pharma Marketletter - ECNext

New and generic drug approvals: Lamivudine and Zidovudine Tablets.  -  Sep 12, 2006
On 12 Sep 2006, the US Food and Drug Administration announced the tentative approval of ANDA 077558 for Lamivudine and Zidovudine Tablets. ... Pay-Per-View - US Food and Drug Administration News - Factiva, from Dow Jones

Article: Relenza, generic zidovudine.(NEW & APPROVED) - Skin & …  -  Jun 1, 2006
Relenza, generic zidovudine.(NEW & APPROVED) ... find Skin & Allergy News articles. Relenza (zanamivir for GlaxoSmithKline) An antiviral for prophylaxis of ... Pay-Per-View - Skin & Allergy News - HighBeam Research

Risk of death or HIV infection similar for two infant feeding...  -  Dec 1, 2006
All women were given zidovudine from 34 weeks of gestation until delivery. ... By the age of seven months, infants fed breast milk and given zidovudine had ... $4.95 - International Family Planning Perspectiv... - ECNext

References.(THE SELECTION AND USE OF ESSENTIAL MEDICINES)  -  Jan 1, 2007
Efavirenz plus zidovudine and lamivudine, efavirenz plus indinavir, and indinavir plus ... Adherence to combined lamivudine + zidovudine versus individual ... Free with registration - Technical Report Series - AccessMyLibrary.com

Africa: Daily HIV/Aids Report  -  Jul 2, 2008
Cipla's application for zidovudine was considered under the expedited review provisions of the President's Emergency Plan for AIDS Relief (Drug Industry ... AllAfrica.com

Striking a better bargain with HIV: new interventions needed to save ...  -  Jun 18, 2005
The researchers administered two daily antiviral drugs, zidovudine and lamivudine. ... The newborns further received daily zidovudine for the first week. ... Free with registration - Science News - AccessMyLibrary.com

Guidelines Updated on Managing Drug Interactions With HIV-Related TB  -  Feb 6, 2008
Pharmacokinetic concerns are a 50% decrease in zidovudine, with a possible effect on abacavir not yet evaluated. "Despite the complexity of these drug ... Medscape

Canadá, primer país en autorizar la exportación de medicamentos …  -  Oct 5, 2007
El beneficiario será Ruanda, que importará durante dos años 260.000 dosis de TriAvir, una combinación de Zidovudine, Lamivudine y Nevirapine. ... ADN.es

ADVENTRX Presents Positive Thiovir Preclinical Results.  -  Apr 3, 2006
The abstract entitled "Synergistic antiviral activity and additive cytotoxicity of Thiovir combined with zidovudine" was presented by Shani Waninger, Ph.D., ... $4.95 - PR Newswire - ECNext

Retrovir (zidovudine, AZT)  -  Mar 1, 2008
Retrovir es un medicamento anti-VIH que pertenece a la categoría de medicamentos anti-VIH llamados inhibidores nucleósidos de la transcriptasa reversa ... AIDSmeds.com HIV/AIDS Treatment News

Zimbabwe: Fears of Drug Resistance to HIV/Aids Medicines  -  May 10, 2008
The drugs reportedly in short supply are Zidovudine, Effavirenz (which is ... I am now supposed to be taking second line drugs, Kaletra and Zidovudine. ... AllAfrica.com

Antiretroviral Drug Resistance: Much More Common Than We Thought  -  Jul 27, 2005
...[7] Thus, short-course zidovudine/lamivudine therapy reduces but does not eliminate emergence of nevirapine resistance induced by single-dose therapy. ... Medscape

HIV/AIDS; Studies from the United States and People's Republic of...  -  May 17, 2006
Study 2: Zidovudine crosses the placenta in the first trimester of pregnancy. According to a study from the People's Republic of China, "Zidovudine is one ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

L'association lamivudine-zidovudine est plus efficace que la poursuite...  -  May 12, 2006
Staszewski S, Loveday C, Picazo JJ, et al., pour le Lamivudine European HIV Working Group. Safety and efficacy of lamivudine-zidovudine combination therapy ... EBM Journal (Abonnement)

美国研究人员å?‘现更有效的艾滋病è?¯ç‰©ç–—法  -  Jan 20, 2006
...医学院乔尔·加伦特为首的多国研究人员表示,他们在1年的治疗实践中�现,与目� 广泛使用的抗逆转录病毒�物治疗法,��用�多夫定(Zid�vudine)�拉米 ... ��

La trithérapie associant indinavir, zidovudine et lamivudine diminue...  -  May 12, 2006
Hammer SM, Squires KE, Hughes MD, et al., for the AIDS Clinical Trials Group 320 Study Team. A controlled trial of two nucleoside analogues plus indinavir ... EBM Journal (Abonnement)

FDA first-time generics approvals--2005.(Special Report)(Illustration)  -  Feb 27, 2006
...mg Tretinoin cream USP (emollient), Spear Pharmaceuticals 0.05% Zidovudine oral solution USP, 50 Aurobindo Pharma Ltd. mg/5 ml Zidovudine tablets USP, ... Free with registration - Chain Drug Review - AccessMyLibrary.com

FDA tentative generics approvals--2005.(Special Report)(Illustration)  -  Feb 27, 2006
Zidovudine tablets USP, 300 mg Ranbaxy Laboratories Ltd. Tramadol HCl and acetaminophen Teva Pharmaceuticals USA tablets, 37.5 mg/325 mg Fexofenadine HCl ... Free with registration - Chain Drug Review - AccessMyLibrary.com

… and Tenofovir Elucidates Route of Resistance in Abacavir-Zidovudine...  -  Dec 22, 2005
WASHINGTON, DC -- December 22, 2005 -- When HIV develops resistance to the combination antiretroviral drug Trizivir (zidovudine + lamivudine + abacavir) and ... DG News

A Multi-District Audit of the Management of HIV Infection in Pregnant...  -  Oct 29, 2005
A vaginal delivery occurred for one patient on zidovudine monotherapy; ... Specific information on the use of intravenous zidovudine was received in 12 out ... RedOrbit

HIV/AIDS Epidemiology; Reports add new data to HIV/AIDS epidemiology …  -  Oct 24, 2005
..."From HIV reverse-transcriptase sequences that had been obtained from treated patients," said the authors, "we derived evolutionary models for zidovudine, ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

HIV/AIDS Epidemiology; Reports add new data to HIV/AIDS epidemiology …  -  Oct 25, 2005
..."From HIV reverse-transcriptase sequences that had been obtained from treated patients," said the authors, "we derived evolutionary models for zidovudine, ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

HIV/AIDS Epidemiology; Reports add new data to HIV/AIDS epidemiology …  -  Oct 30, 2005
..."From HIV reverse-transcriptase sequences that had been obtained from treated patients," said the authors, "we derived evolutionary models for zidovudine, ... Pay-Per-View - Medical Letter on the CDC & FDA - Factiva, from Dow Jones

Drug Regimen Prevents AIDS Transmission Via Breast Milk  -  Jun 4, 2008
One regimen, known as the control group, included a single dose of the AIDS drug nevirapine (Viramune) plus one week of treatment with the drug zidovudine ... Washington Post

USPHS releases updated guidelines for management of occupational …  -  Dec 1, 2005
Zidovudine plus emtricitabine Zidovudine: see above (Emtriva) Emtricitabine: once-daily dosing; well tolerated; long intracellular half-life (40 hours); ... $4.95 - American Family Physician - ECNext

Article: FDA first-time generics approvals--2005.(Special Report)( …  -  Feb 27, 2006
...mg Tretinoin cream USP (emollient), Spear Pharmaceuticals 0.05% Zidovudine oral solution USP, 50 Aurobindo Pharma Ltd. mg/5 ml Zidovudine tablets USP, ... Pay-Per-View - Chain Drug Review - HighBeam Research

FDA tentative generics approvals--2005.(Special Report)(Illustration)...  -  Feb 27, 2006
Zidovudine tablets USP, 300 mgRanbaxy Laboratories Ltd. Tramadol HCl and ... (base)/ml; 4 ml vials Zidovudine tablets USP, 300 mgAurobindo Pharma Ltd. ... Pay-Per-View - Chain Drug Review - HighBeam Research

TRIZIVIR, First Tablet to Combine Three Medications for HIV, Receives...  -  May 16, 2005
Zidovudine has been associated with hematologic toxicity including neutropenia and severe anemia, particularly in patients with advanced HIV disease. ... RedOrbit

Advances in First-Line and "Switch" Antiretroviral Strategies  -  Jan 31, 2006
Future studies will optimize the quad- NRTI/NtRTI regimen approach (eg, using zidovudine/lamivudine/abacavir twice daily with tenofovir) and compare it ... Medscape

Brand Names/Synonyms:
Zidovudine is also known by the following brand names and/or synonymsAZT; Apo-Zidovudine; Azidothymidine; Aztec; Combivir; Compound S; Novo-Azt; Retrovir; Trizivir; ZIDOVUDINE EP III; Zidovudine

Drug Category:
Zidovudine is categorized under the following by the FDA: Anti-HIV Agents; Antimetabolites; Nucleoside and Nucleotide Reverse Transcriptase Inhibitors; ATC:J05AF01

Dosage Forms:
CAPSULE; LIQUID; SYRUP; TABLET

Absorption:
Rapid and alomost complete absorption from the gastrointestinal tract.

Interactions:
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Chemical IUPAC Name:
1-[4-azido-5-(hydroxymethyl)tetrahydrofuran-2-yl]-5-methyl-1H-pyrimidine-2,4-dione





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