Zonisamide

This page contains recent news articles, when available, and an overview of Zonisamide but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Zonisamide
(when available)

Pharmacology and use:
Zonisamide is used primarily as an anticonvulsant for the adjunctive treatment of epilepsy. The precise mechanism by which Zonisamide exerts its antiseizure effect is unknown, although it is believed that the drug blocks sodium channels which leads to the suppression of neuronal hypersynchronization (i.e. convulsions). Likewise Zonisamide has also been found not to potentiate syanptic activity by GABA (gamma amino butyric acid). Adjunctive treatment of partial seizures in adults with epilepsy.

Mechanism Of Action:
Zonisamide binds to sodium channels, voltage sensitive calcium channels and to a lesser extent carbonic anhydrase. This blocks or suppresses neuronal depolarization and hypersynchronization.

News Articles on Zonisamide

Vigabatrin (Sabril®): A New Epilepsy Drug -- With Strings Attached  -  ‎Dec 31, 2009‎
...oxcarbazepine (Trileptal®), pregabalin (Lyrica®), rufinamide (Banzel™), tiagabine (Gabitril®), topiramate (Topamax®), and zonisamide (Zonegran®). ... Medscape

Orexigen(R) Therapeutics Announces Third Quarter 2009 Financial Results  -  ‎Nov 4, 2009‎
The results of this trial demonstrated that patients completing 24 weeks of Empatic360 (bupropion SR 360mg/zonisamide SR 360 mg) therapy lost 9.9% of their ... Reuters

Ranbaxy to market Zonisamide  -  Jun 10, 2006
Ranbaxy Laboratories Ltd said that it has entered into a strategic partnership with the US-based Invagen Pharmaceuticals Inc for marketing Zonisamide ... Hindu Business Line

Wockhardt gets US nod for Zonisamide  -  Dec 26, 2005
According to a release issued by Wockhardt to the BSE on Monday, Zonisamide is the generic version of Dainippon's Zonegran capsules. ... Rediff

Cadila to sell Zonisamide in US  -  Oct 18, 2006
Cadila Healthcare Ltd (Zydus-Cadila) has received approval from the US Food and Drug Administration to market Zonisamide capsules in the American market, ... Hindu Business Line

Zonisamide for epilepsy  -  Oct 29, 2007
Zonisamide has been approved for treatment of partial seizures in people older than 16. It is not approved for use in children younger than 16. ... WebMD

Zonisamide Improves Motor Function in PD  -  Jan 3, 2007
January 3, 2007 — Results of a randomized trial show that the addition of zonisamide (Zonegran, Dainippon Sumitomo Pharma), an antiepileptic drug, ... Medscape

Orexigen(R) Therapeutics Initiates First Clinical Trial Of OREX-003...  -  Oct 3, 2008
7425571 providing broad coverage of the use of zonisamide either alone or in ... 7429580 which broadly covers zonisamide in combination with various ... Medical News Today - Medical News Today (press release)

Orexigen reaches settlement agreement with Eisai  -  Sep 19, 2007
T) over a previously resolved lawsuit related to the use of zonisamide for treating obesity. Under the settlement, the parties have released each other from ... Reuters

Apotex Receives Final Approval for Zonisamide Capsules  -  Dec 23, 2005
Apotex Corp. today announced that it has received final approval from the US Food and Drug Administration (FDA) for its Abbreviated New Drug Application ... RedOrbit

Zonisamide (Systemic).(Drug overview)  -  May 1, 2006
Zonisamide zoh-NIS-a-mide is used to control some kinds of seizures in the treatment of epilepsy. In deciding to use a medicine, the risks of taking the ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

… -Release Formulation Of Zonisamide Shows Improved Tolerability When  -  Jun 8, 2007
In the study, the SR formulation of zonisamide achieved a significant reduction in the ... Zonisamide SR is a key component in the Company's obesity product ... Medical News Today - Medical News Today (press release)

… With Refractory Headache Respond to Zonisamide: Presented at IHS  -  Oct 17, 2005
Used to treat pediatric epilepsy, the use of zonisamide has recently been ... Results show that 7 of 11 children responded positively to zonisamide at an ... DG News

Press Release: Ranbaxy to Market Zonisamide Capsules in US - PR …  -  Jun 9, 2006
Ranbaxy to Market Zonisamide Capsules in US from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Obesity drug shows promise in testing  -  Jul 25, 2007
Empatic, the company's experimental drug, is a combination of two drugs already approved by the Food and Drug Administration for different uses: zonisamide, ... San Diego Union - Tribune - San Diego Union Tribune

New anticonvulsant drugs show promise in dogs, cats  -  Mar 1, 2008
These drugs include gabapentin, felbamate, zonisamide and levitiracetam. ... Zonisamide has proven to be an effective add-on anticonvulsant drug in dogs, ... DVM 360

Press Release: Barr Receives Approval for Zonisamide Capsules, 25 mg,...  -  Dec 23, 2005
Barr Receives Approval for Zonisamide Capsules, 25 mg, 50 mg & 100 mg. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

Long-Term Treatment With Zonisamide Maintains Reduction in Seizure …  -  Aug 30, 2007
By Chris Berrie. BRUSSELS, BELGIUM -- August 30, 2007 -- Long-term treatment with the anti-epileptic drug (AED) zonisamide promotes substantial, ... DG News

No Apparent Safety Concerns With Zonisamide Monotherapy in Epileptics...  -  Apr 5, 2006
By Jill Stein. SAN DIEGO, CA -- April 5, 2006 -- Zonisamide is well tolerated as monotherapy in patients with newly diagnosed epilepsy and complex partial ... DG News

… Therapy; Carbamazepine pharmacokinetics not affected by zonisamide  -  Jan 31, 2005
..."The potential effects of zonisamide on carbamazepine pharmacokinetics (PK) have ... "In vitro human liver microsomes were incubated with zonisamide (200, ... Pay-Per-View - Clinical Trials Week - Factiva, from Dow Jones

… Clonazepam,Lithium,Depakote, Fluoxetine and zonisamide. I am still...  -  Jun 21, 2008
I have been taking Clonazepam .5mg as needed (for anixiey), Lithium Carb 300mg 3 x daily(bipolar), and Zonisamide 100mg 2x daily (For headaches) for over a ... HealthCentral.com

… Therapy; Carbamazepine pharmacokinetics not affected by zonisamide  -  Feb 5, 2005
..."The potential effects of zonisamide on carbamazepine pharmacokinetics (PK) have ... "In vitro human liver microsomes were incubated with zonisamide (200, ... Pay-Per-View - Obesity, Fitness & Wellness Week - Factiva, from Dow Jones

Zonisamide add ‐ on for drug ‐ resistant partial...  -  Jul 1, 2007
The majority of people with epilepsy have a good prognosis and their seizures can be well controlled with the use of a single antiepileptic agent, ... Medscape

… Announces Final FDA Approval for Zonisamide Capsules. - PR...  -  Dec 23, 2005
Mylan Announces Final FDA Approval for Zonisamide Capsules. from PR Newswire. Highbeam Research – FREE Trial. Pay-Per-View - PR Newswire - HighBeam Research

… Epidermal Necrolysis Due to Zonisamide Associated With Reactivation...  -  Jun 24, 2007
Background Recently, human herpesvirus 6 (HHV-6) reactivation has been frequently observed in patients with drug-induced hypersensitivity syndrome or drug ... Archives of Dermatology

Zonisamide Safe and Effective in Refractory Migraine: Presented at ENS  -  Jun 22, 2007
By Thomas S. May. RHODES, GREECE -- June 22, 2007 -- Zonisamide, a new anticonvulsant medication with multiple mechanisms of action, may be effectively used ... DG News

… Release: Study Suggests Zonegran(R) (zonisamide) Capsules Are Not ...  -  Apr 12, 2005
Study Suggests Zonegran(R) (zonisamide) Capsules Are Not Likely to Reduce the Effectiveness of a Combination Oral Contraceptive; Zonegran Does Not Affect ... Pay-Per-View - PR Newswire - HighBeam Research

Zonisamide capsules.  -  Aug 7, 2006
Ranbaxy will market zonisamide capsules through an agreement with Invagen Pharmaceuticals, Hauppauge, N.Y. Zonisamide, indicated as adjunctive therapy in ... $9.94 - Drug Topics - Alacra Store

… Sustained-Release Formulation of Zonisamide Shows Improved T  -  Jun 7, 2007
Orexigen(TM) is evaluating zonisamide SR as a novel component in EMPATIC(TM) Phase ... In the study, the SR formulation of zonisamide achieved a significant ... Pay-Per-View - PR Newswire - HighBeam Research

Zonisamide capsules.(NEW GENERICS)(Invagen Pharmaceuticals)(Brief …  -  Aug 7, 2006
Ranbaxy will market zonisamide capsules through an agreement with Invagen Pharmaceuticals, Hauppauge, NY Zonisamide, indicated as adjunctive therapy in the ... $4.95 - Drug Topics - ECNext

Study Suggests Zonegran(R) (Zonisamide) Capsules Are Not Likely to …  -  Apr 12, 2005
MIAMI BEACH, Fla., April 12 /PRNewswire/ -- New data presented today suggest Zonegran does not significantly reduce the effectiveness of oral contraceptives ... RedOrbit

Apotex gets final OK for zonisamide capsules.(Brief Article)  -  Jan 9, 2006
Canada's Apotex Corp says that it has received final approval from the US Food and Drug Administration for its Abbreviated New Drug Application for ... $4.95 - Pharma Marketletter - ECNext

New and generic drug approvals: Zonisamide Capsules. [3 tables in …  -  Aug 18, 2006
On 18 Aug 2006, the US Food and Drug Administration announced approval of ANDA 077813 for Zonisamide Capsules. The product contains zonisamide at 25mg, ... Pay-Per-View - US Food and Drug Administration News - Factiva, from Dow Jones

… conclude agreement regarding antiepileptic agent zonisamide in Asia  -  Apr 25, 2005
Zonisamide is an antiepileptic treatment created by Dainippon Pharmaceutical. Zonisamide is characterized by a wide antiseizure spectrum which is even ... Pay-Per-View - Pharma Business Week - Factiva, from Dow Jones

… conclude agreement regarding antiepileptic agent zonisamide in Asia  -  Apr 29, 2005
Zonisamide is an antiepileptic treatment created by Dainippon Pharmaceutical. Zonisamide is characterized by a wide antiseizure spectrum which is even ... Pay-Per-View - Drug Week - Factiva, from Dow Jones

Antiepilepsy drug treats binge-eating disorder  -  Jan 22, 2007
..."Zonisamide is a novel antiepileptic drug associated with weight loss." ... At follow-up, participants in the zonisamide group had a significantly greater ... Reuters

FDA first-time generics approvals--2005.(Special Report)(Illustration)  -  Feb 27, 2006
10 mg, 15 mg, 20 mg and 30 mg Azithromycin for injection, 500 American Pharmaceutical mg/vial Partners Inc. Zonisamide capsules, 25 mg, 50 mg Alphapharm Pty ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Orexigen Therapeutics, Inc. Receives Notice of Allowance for US Patent  -  Jul 29, 2008
Zonisamide appears to reverse the olanzapine effects on appetite pathways in ... If issued, this patent will also cover zonisamide in combination with other ... Lifescience-online

International Approvals: Zonegran, Taxol, Split-Influenza Vaccine  -  Mar 21, 2005
March 21, 2005 — The European Commission has approved zonisamide capsules for ... On March 16, the European Commission approved zonisamide (Zonegran hard ... Medscape

Barr Receives Approval for Zonisamide Capsules, 25 mg, 50 mg & 100 …  -  Dec 23, 2005
WOODCLIFF LAKE, NJ, Dec. 23 /PRNewswire-FirstCall/ -- Barr Pharmaceuticals, Inc. today announced that it's subsidiary, Barr Laboratories, Inc., has received ... $4.95 - PR Newswire - ECNext

zonisamide Dainippon phase change III, Japan (Parkinson disease).( …  -  Feb 28, 2005
Zonisamide (EXCEGRAN) is undergoing phase II/III trials in Japan with Dainippon for ... zonisamide, fenisoxine, E 2090, AD 810, CI 912, PD 110843, EXCEGRAN, ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Article: FDA first-time generics approvals--2005.(Special Report)( …  -  Feb 27, 2006
10 mg, 15 mg, 20 mg and 30 mg Azithromycin for injection, 500 American Pharmaceutical mg/vial Partners Inc. Zonisamide capsules, 25 mg, 50 mgAlphapharm Pty ... Pay-Per-View - Chain Drug Review - HighBeam Research

QUICK STUDY  -  Jan 11, 2007
They were randomly assigned to take zonisamide (25, 50 or 100 milligrams) or a placebo daily, ... Zonisamide was tested only as an adjunct treatment. ... Pay-Per-View - The Record - ProQuest Archiver

Press Release: Orexigen(R) Therapeutics Initiates First Clinical...  -  Oct 2, 2008
Two Milestones Reached in Zonisamide Patent Portfolio - ... 7425571 providing broad coverage of the use of zonisamide either alone or in combination with ... Pay-Per-View - PR Newswire - HighBeam Research

zonisamide Dainippon Sumitomo submitted for approval, Japan ( …  -  Nov 28, 2005
On 8 November 2005 Dainippon Sumitomo reported that an NDA for zonisamide (TREMODE) has been submitted to the Japanese Ministry of Health, Labor, ... Pay-Per-View - R & D Focus Drug News - Factiva, from Dow Jones

Epilepsy Drug May Treat Parkinson's  -  Jan 4, 2007
The epilepsy drug zonisamide may help curb the tremors and other movement ... Zonisamide is sold in the US generically and under the brand name Zonegran. ... WebMD

Loislaw Federal District Court Opinions - DUKE UNIVERSITY v. ELAN …  -  Jan 30, 2006
...fn1] Two physicians employed by Duke, Dr. Kishore Gadde and Dr. Ranga Krishnan, developed an interest in conducting research on the use of zonisamide to ... Pay-Per-View - Loislaw Federal District Court Opinions - Loislaw

Eisai Gets Rights on Antiepileptic Drug from Dainippon.  -  Mar 29, 2005
Eisai aims to release the drug, whose generic name is zonisamide, during the second half of 2006. Under the latest agreement, Eisai will take over Phase III ... Free with registration - Asia Africa Intelligence Wire - AccessMyLibrary.com

Press Release: OREXIGEN(R) Therapeutics Receives Notice of …  -  Jul 29, 2008
Zonisamide appears to reverse the olanzapine effects on appetite pathways in ... If issued, this patent will also cover zonisamide in combination with other ... Pay-Per-View - PR Newswire - HighBeam Research

Drug Improves Tremors, Involuntary Movements in Parkinson Patients  -  Dec 27, 2006
Researchers found at least 30 percent of patients taking zonisamide experienced a more than 30-percent reduction in their score on a rating scale used to ... newswise.com

Weight-loss drug combination associated with 15% weight loss in obese...  -  Oct 13, 2008
Fifty-six individuals randomly assigned to zonisamide 360 mg/bupropion 360 mg ... According to the results, the zonisamide/bupropion combination was also ... Endocrine Today

Nuovo farmaco contro l'epilessia  -  Jan 15, 2007
Il nuovo farmaco è a base di zonisamide, principio attivo presentato al ... La nuova molecola zonisamide si è dimostrata capace di agire appunto in casi ... TGCOM

Bloomberg Printer-Friendly Page  -  Nov 6, 2008
7425571 providing broad coverage of the use of zonisamide either alone or in ... 7429580 which broadly covers zonisamide in combination with various ... Bloomberg

Can antiepileptic drugs unmask a susceptibility to psychiatric...  -  Nov 18, 2008
These agents include barbiturates, topiramate, levetiracetam and zonisamide. A search of the literature reveals that psychiatric adverse events associated ... Nature.com

Sciscapeæ–°è?ž[Jan 04, 2007]: zonisamideå?¯ä»¥æ”¹å–„帕金森æ°?症病狀  -  Jan 4, 2007
...日本國立精神與神經中心的研究顯示,治療癲癇的藥物zonisamideå?¯ä»¥é¡¯è‘—改善帕金森æ°? 症病狀。 該中心å°?279å??帕金森æ°?症病患進行3個月的多所中心研究計劃(Multi-Center ... 科景网

La Zonisamide non presenta vantaggi rispetto agli altri farmaci …  -  Oct 1, 2007
Lunedì 1 Ottobre 2007 - Il trattamento di prima scelta nei pazienti con epilessia parziale è rappresentato dalla Carbamazepina ( Tegretol ) in monoterapia. ... XagenaSalute

Empaticâ„¢ Shows Long-Term Weight Loss, Improved Quality Of Life …  -  Oct 7, 2008
The primary objective of the Empatic trial was to determine optimal dose ratios of zonisamide SR and bupropion SR. The randomized, double-blinded trial of ... Medical News Today - Medical News Today (press release)

Wockhardt gets USFDA nod for epilepsy drug  -  Dec 27, 2005
Zonisamide is the generic or chemically similar version of Dainippon's Zonegran capsules and according to a note from Wockhardt, it is among the first to ... Hindu Business Line

Combination regimens may enhance weight loss.(Endocrinology)  -  Dec 1, 2006
Patients taking bupropion or zonisamide, with or without bupropion, ... At week 28, patients receiving zonisamide were rerandomized to continue on the ... Free with registration - Internal Medicine News - AccessMyLibrary.com

Article: Evidence-based psychiatric medicine: Oxcarbazepine for acute...  -  May 1, 2008
Effects Phenobarbital 39% Phenytoin 32% Levetiracetam 20% Oxcarbazepine 17% Zonisamide 16% Topiramate 14% Clobazam 13% Carbamazepine ... ... Pay-Per-View - Clinical Psychiatry News - HighBeam Research

Combination regimens enhance weight loss.(News)  -  Nov 15, 2006
Patients taking bupropion or zonisamide alone lost 3.6% and 6.5% of their ... At week 28, patients receiving zonisamide were rerandomized to continue on the ... Pay-Per-View - Family Practice News - Factiva, from Dow Jones

OREXIGEN(TM) Therapeutics Reports Detailed Results of Phase IIb Trial...  -  Oct 21, 2007
We feel this improvement is attributable to our novel and proprietary sustained release (SR) formulation of zonisamide. This tolerability profile ... Free with registration - Business Wire - AccessMyLibrary.com

Orexigen(TM) Therapeutics to Present Data on Contrave(TM) and …  -  Oct 18, 2007
Orexigen developed its own proprietary SR version of zonisamide to improve drug ... Bupropion and zonisamide each target reciprocal pathways in the ... Genetic Engineering News - Genetic Engineering News (press release)

PARKINSON'S DISEASE — a quick study  -  Jan 16, 2007
They were randomly assigned to take zonisamide (25, ... After three months, more than 30 percent of the people taking zonisamide showed improvement of 30 ... Casper Star Tribune - The Casper Star Tribune

EPILEPSY DRUG CUTS TREMORS  -  Feb 10, 2007
They were randomly assigned to take zonisamide (25, ... After three months, more than 30 percent of the people taking zonisamide showed improvement of 30 ... $2.95 - Myrtle Beach Sun News - NewsBank

Orexigen Therapeutics Announces Multiple Data Presentations at The …  -  Sep 29, 2008
MD Title: "Long Term Weight Loss from a Dose Optimization Study with Zonisamide SR and Bupropion SR" Time: 11:00-11:15 am MT Poster Presentation ... RedOrbit

Clarification on weight-loss therapy.(LETTERS)(Correction notice)(Lett...  -  Jan 15, 2007
In fact, Duke University and Dr. Gadde have claimed to have invented the combination of zonisamide with bupropion and filed a patent for this combination. ... $4.95 - Internal Medicine News - ECNext

Clarification on weight-loss therapy.(LETTERS)(Correction notice)(Lett...  -  Jan 15, 2007
In fact, Duke University and Dr. Gadde have claimed to have invented the combination of zonisamide with bupropion and filed a patent for this combination. ... Pay-Per-View - Internal Medicine News - HighBeam Research

Bipolar Disorder; Anticonvulsants in the treatment of bipolar mania...  -  May 3, 2006
The potential of zonisamide awaits further testing." Goodnick published the review in Expert Opinion on Pharmacotherapy (Anticonvulsants in the treatment ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Combination regimens enhance weight loss.(News) | Article from Family...  -  Nov 15, 2006
Patients taking bupropion or zonisamide alone lost 3.6% and 6.5% of their ... At week 28, patients receiving zonisamide were rerandomized to continue on the ... Pay-Per-View - Family Practice News - HighBeam Research

OREXIGEN(TM) Therapeutics Reports 48-Week Results of Phase IIb Trial …  -  Jan 7, 2008
Weight loss @ 48 weeks ------------------------ Zonisamide SR Bupropion SR ITT - Completers - Double Double Blind Blind Extension Extension ... Genetic Engineering News - Genetic Engineering News (press release)

The Use of Imaging in the Early Development of Neuropharmacological …  -  Jun 28, 2007
Imaging to evaluate safety of zonisamide and of eletriptan. Use of imaging to evaluate safety is exemplified by zonisamide. Zonisamide is indicated as ... Nature.com

Combo Drugs Prepare to Tap Underserved Obesity Market  -  Feb 18, 2008
The zonisamide inhibits neurons that contribute to the weight loss plateau by promoting energy storage and hunger when weight starts to drop off. ... BioWorld Online - BioWorld Online

Stock Market Update, IPO profiles, Earnings Call Transcripts,...  -  Dec 19, 2006
Excalia is a fixed dose combination of zonisamide SR and bupropion SR. The combination of zonisamide and bupropion, in the Company's screening model, ... 123Jump.com

Orexigen Reports Results From Phase IIb Empatic Trial  -  Oct 23, 2007
This downward slope was particularly pronounced in the highest dosage group (360 mg of bupropion/360 mg of zonisamide), Orexigen said. FDA news - FDA news (subscription)

Farmaci antiepilettici: Zonegran  -  Mar 28, 2008
Il principio attivo di Zonegran, Zonisamide, è un antiepilettico. ... Zonisamide agisce bloccando determinati pori localizzati sulla superficie delle ... XagenaSalute

Fat pill finds favour  -  Dec 28, 2006
Two drugs, zonisamide and bupropion, are used against epilepsy and smoking, so there was reduced danger of side-effects. ... NEWS.com.au

NRG seeks Encina plant upgrade  -  Sep 20, 2007
The matter was filed jointly by Orexigen and Duke to resolve a dispute over rights to the use of zonisamide to treat obesity. The parties have released one ... San Diego Union - Tribune - San Diego Union Tribune

Obese lose 14% of weight on novel combo drug.(Obesity) | Article from...  -  Dec 1, 2008
By 24 weeks, average weight loss ranged from 4.5% to 8.6% with the zonisamide-bupropion combination, according to Dr. Tollefson, and was higher in those who ... Pay-Per-View - Family Practice News - HighBeam Research

Press Release: New Survey Reveals Worrying Between Attacks Can …  -  Jun 8, 2006
The FDA's recommendations ... treatment with zonisamide can cause metabolic acidosis ... Article: US FDA warns that zonisamide increases risk of metabolic . ... Pay-Per-View - PR Newswire - HighBeam Research

Epilepsie : de nouveaux traitements  -  Sep 24, 2008
Parmi les plus récents, le zonisamide et le lacosamide ont été testés dans ... Le zonisamide a été approuvé par les autorités sanitaires européennes et ... Paris Match

약업신문 www.yakup.com  -  May 2, 2008
Gabapentin, topiramate, levetiracetam, zonisamide 등 최근� 출시� 2세대 항경련제 는 기존� 1세대 항경련제와 달리 혈중 단백결합률� 낮고 신장으로 배설�는 ... 약업신문

Orexigen reports positive phase II results for Excalia Combination- …  -  Oct 22, 2006
Excalia is a proprietary combination of bupropion, a dopamine and norepinephrine reuptake inhibitor, plus zonisamide, an approved anticonvulsant medication. ... PsychCentral.com

Small Cap Stocks to Watch.  -  Feb 28, 2008
Zonisamide is a key ingredient in Empatic, which is in the later stages of Phase II clinical development. Advanced Growing Systems (Pinksheets: AGWS) ... Free with registration - M2 Presswire - AccessMyLibrary.com

Practice Guidelines  -  Jan 15, 2005
The committee recommends that gabapentin, oxcarbazepine, lamotrigine, topiramate, tiagabine, levetiracetam, and zonisamide be considered as add-on therapy ... AAFP News Now

Orexigen Initiates Phase IIb Study of Obesity Drug  -  Jul 10, 2008
The efficacy of Empatic will be compared against zonisamide monotherapy, ... Empatic combines zonisamide and bupropion, two existing drugs that have been ... RedOrbit

American Health Packaging, Columbus, Ohio, (800) 707-4621, has …  -  Aug 6, 2007
Zonisamide capsules are available in 25-, 50-, and 100-mg strengths and are indicated for adjunct therapy in the treatment of partial seizures in adults ... Free with registration - Drug Topics - AccessMyLibrary.com

Glenmark Pharmaceuticals Ltd.(RX/GENERIC DRUGS--Profiles)( …  -  Sep 25, 2006
The company has received four ANDA approvals from the FDA--Fluconazole, Zonisamide, Meloxicam and Gabapentin. In fiscal year 2006 Zonisamide capsules ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Baclofen May Be Effective In Binge Eating Disorder and Bulimia Nervosa  -  Jan 1, 2008
Zonisamide in the treatment of binge-eating disorder: an open-label, prospective trial. J Clin Psychiatry. 2004 Jan;65(1):50-6. 3. McElroy SL, Shapira NA, ... MediNEWS.Direct!

FDA Warns Epilepsy Drugs May Raise Suicide Risk  -  Feb 1, 2008
Topiramate (marketed as Topamax), Valproate (marketed as Depakote, Depakote ER, Depakene, Depacon) and Zonisamide (marketed as Zonegran). ... Washington Post

Treatment of obesity: drugs or surgery?(Primary care update: brief …  -  Feb 1, 2005
Only 1 study examined the efficacy of zonisamide for weight loss. ... Zonisamide for weight loss in obese adults: a randomized controlled trial. JAMA. ... $4.95 - Consultant - ECNext

World pharma: Halted trials send Orexigen shares falling  -  Dec 8, 2008
To that end, it is discontinuing exploratory proof-of-concept Phase II studies of OREX-003 (zonisamide and olanzapine) in mitigating ... $34.00 - EIU Country Analysis - Alacra Store

New generics.  -  May 22, 2006
Zonisamide capsules, in 25-, 50-, and 100-mg strengths, from TEVA USA, North Wales, ... Zonisamide is used as adjunctive therapy in the treatment of partial ... $9.94 - Drug Topics - Alacra Store

A rash proposal for psychopharmacologists treating bipolar disorder: ...  -  Jun 1, 2005
Rashes are associated with several mood stabilizers, including lamotrigine but also valproic acid, carbamazepine, oxcarbazepine, and zonisamide. Pay-Per-View - Psychopharmacology Educational Updates - HighBeam Research

INDIAN NEWSPAPER HIGHLIGHTS - DEC 27, 2005.  -  Dec 27, 2005
Zonisamide is the generic or chemically similar version of Dainippon's Zonegran capsules and according to a note from Wockhardt, it is among the first to ... $4.95 - AsiaPulse News - ECNext

A rash proposal for psychopharmacologists treating bipolar disorder: ...  -  Jun 1, 2005
...rash with sulfonamides applies to an anticonvulsant increasingly used "off label" for bipolar disorder and weight loss, namely zonisamide (figure 1). ... Pay-Per-View - Clinical Psychiatry News - Factiva, from Dow Jones

Japan stock market week to April 4.(pharmaceutical index)  -  Apr 11, 2005
The company markets zonisamide in the USA after acquiring rights to the drug from Elan in March 2004, and also obtained marketing authorization for it from ... Pay-Per-View - Pharma Marketletter - Factiva, from Dow Jones

FDA has issued an alert for the anti-epileptic drugs.  -  Mar 1, 2008
...valproate (Depakote, Depakote ER, Depakene, and Depacon, Abbott; generic valproate), and zonisamide (Zonegran, Eisai; generic zonisamide). ... $9.94 - Formulary - Alacra Store

Guidelines for prescribing antiepileptic drugs.(Practice Guideline...  -  Jan 15, 2005
The committee recommends that gabapentin, oxcarbazepine, lamotrigine, topiramate, tiagabine, levetiracetam, and zonisamide be considered as add-on therapy ... $4.95 - American Family Physician - ECNext

Press Release: Small Cap Stocks to Watch. - M2 Presswire | HighBeam …  -  Feb 28, 2008
Zonisamide is a key ingredient in Empatic, which is in the later stages of Phase II clinical development. Read all of this article with a FREE trial ... Pay-Per-View - M2 Presswire - HighBeam Research

FDA has issued an alert for the anti-epileptic drugs.  -  Mar 1, 2008
...valproate (Depakote, Depakote ER, Depakene, and Depacon, Abbott; generic valproate), and zonisamide (Zonegran, Eisai; generic zonisamide). ... $9.94 - Formulary - Alacra Store

Press Release: Orexigen(R) Therapeutics Reviews Significant Data …  -  Oct 6, 2008
Empatic (see also Orexigen Therapeutics, Inc ... and meaningful weight loss that exceeds ... Administration, Weight Loss, Zonisamide, Orexigen Therapeutics ... Pay-Per-View - PR Newswire - HighBeam Research

Brand Names/Synonyms:
Zonisamide is also known by the following brand names and/or synonymsAD-810; Aleviatin; CHEMBANK2998; CI-912; Exceglan; Excegram; Excegran; Zonegran; Zonisamida [Spanish]; Zonisamide; Zonisamide [Usan:Ban:Inn:Jan]; Zonisamidum [Latin]

Drug Category:
Zonisamide is categorized under the following by the FDA: Antioxidants; Anticonvulsants; ATC:N03AX15

Dosage Forms:
Capsules or tablets

Absorption:
Time to peak concentration is 2.8-3.9 hours

Interactions:
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Chemical IUPAC Name:
benzo[d]isoxazol-3-ylmethanesulfonamide





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