Zyprexa

This page contains recent news articles, when available, and an overview of Zyprexa but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

Zyprexa
(when available)

Pharmacology and use:
Olanzapine, an atypical antipsychotic agent, is used to treat both negative and positive symptoms of schizophrenia, acute mania with bipolar disorder, agitation, and psychotic symptoms in dementia. Future uses may include the treatment of obsessive-compulsive disorder and severe behavioral disorders in autism. Structurally and pharmacologically similar to clozapine, olanzapine binds to alpha(1), dopamine, histamine H1, muscarinic, and serotonin type 2 (5-HT2) receptors. For the treatment of schizophrenia and manic depression (bipolar disorder)

Mechanism Of Action:
Olanzapine is an antagonist at types 1, 2, and 4 dopamine receptors, 5-HT receptor types 2A and 2C, muscarinic receptors 1 through 5, alpha(1)-receptors, and histamine H1-receptors. Olanzapine's antipsychotic effect is due to antagonism at dopamine and serotonin type 2 receptors, with greater activity at serotonin 5-HT2 receptors than at dopamine type-2 receptors. This may explain the lack of extrapyramidal effects. Olanzapine does not appear to block dopamine within the tubero-infundibular tract, explaining the lower incidence of hyperprolactinemia than with typical antipsychotic agents or risperidone. Antagonism at muscarinic receptors, H1-receptors, and alpha(1)-receptors also occurs with olanzapine.

News Articles on Olanzapine

Big Pharma's illegal marketing practices  -  14 Nov 2009
Drug maker Eli Lilly & Co. is now paying a $24 million civil settlement to the state of Utah for off-label marketing of their anti-psychotic Zyprexa. ... Examiner.com

Utah AG says state gets $24M in Zyprexa settlement  -  ‎Nov 11, 2009‎
Shurtleff says Zyprexa is approved for treatment of schizophrenia and bipolar disorder. But he says Lilly's sales force illegally promoted Zyprexa for uses ... The Associated Press

Lilly to Pay South Carolina $45 Million Over Zyprexa  -  ‎Oct 23, 2009‎
South Carolina sued Lilly in 2007, alleging the Indianapolis-based company marketed Zyprexa, approved for schizophrenia and bipolar disorder, for unapproved ... Bloomberg

Lilly Hires Astra Research Chief  -  ‎Nov 13, 2009‎
About $12.8 billion, or 57%, of Lilly's drug sales through 2013 will go off-patent as key drugs including antipsychotic Zyprexa lose patent protection, ... Wall Street Journal

Lilly Posts Third-Quarter Profit, Boosts Forecast  -  ‎Oct 21, 2009‎
Revenue from Zyprexa, the antidepressant Cymbalta, the cancer drug Alimta and impotence pill Cialis all increased. Lilly also reiterated plans to reduce ... Bloomberg

Weight Problems for Children on Psychiatric Drugs  -  ‎Oct 27, 2009‎
This has been my family's experience with Zyprexa. Our child has gained enormous amounts of weight on it, and continues to after years of taking the med. ... New York Times

Lilly CEO optimistic despite patent cliff  -  ‎Nov 9, 2009‎
N: Quote, Profile, Research, Stock Buzz) chief executive said on Monday the company will be able to weather the patent expiration on its Zyprexa ... Reuters

Business news in brief | Oil prices rise  -  ‎Nov 11, 2009‎
Shurtleff says Zyprexa is approved for treatment of schizophrenia and bipolar disorder. But he says Lilly promoted Zyprexa for uses not approved by the FDA, ... Kansas City Star

Novo's Victoza Awaits Final FDA Approval  -  ‎Nov 12, 2009‎
Eli Lilly sells a drug {ZYPREXA} that can cause diabetes and then turn a profit on the drugs that treat the condition that they may have caused in the first ... A Sweet Life, the source for the healthy diabetic (blog)

The truth about antipsychotic drugs and old people  -  ‎Nov 12, 2009‎
Lilly already had a criminal conviction for misbranding a drug when it broke the law again in promoting schizophrenia drug Zyprexa for off-label uses ... Telegraph.co.uk

Recent Ala. SC decision should apply to Zyprexa suit, attorneys argue  -  ‎Nov 6, 2009‎
BY JOHN O'BRIEN NEW YORK (Legal Newsline) - Before Eli Lilly & Co. decides to settle Mississippi Attorney General Jim Hood's Zyprexa lawsuit, ... Legal News Line

Drug Companies Find it Cost-Effective to Pay Fines and Keep Breaking Laws  -  ‎Nov 11, 2009‎
...and this year Eli Lilly pled guilty and paid $1.42 billion in fines and penalties for illegally marketing the schizophrenia drug Zyprexa. ... AllGov

UPDATE 1-Lilly snags AstraZeneca executive as new R&D head  -  ‎Nov 13, 2009‎
Sales of $5 billion-a-year Zyprexa are expected to plunge after its US patent lapses in October 2011 and Lilly's Gemzar cancer treatment will face generic ... 路透中国

Drug Makers Still Repeatedly Breaking the Law over "Off-Label" Promotion  -  ‎Nov 9, 2009‎
In January this year, to cite just one other example, Eli Lilly pleaded guilty to misrepresenting Zyprexa, a drug approved for the treatment of bipolar ... Psychology Today (blog)

South Carolina Settles Zyprexa Off-Label Marketing Case for $45 Million  -  ‎Oct 27, 2009‎
South Carolina did not participate in the collective suit by 32 states against Pfizer for its off-label marketing of the anti-psychotic drug, Zyprexa. ... Law Professor Blogs Network (blog)

Novartis rueful after Fanapt about-face  -  ‎Nov 9, 2009‎
Sales of Zyprexa, by comparison, the biggest money-maker, were $4.7 billion. Jimenez conceded that Fanapt is likely to be a relatively small player. ... Reuters India

Do You Know What Merck Did Last Summer? Drug Company Paid Experts $3.7 Million ...  -  ‎Oct 19, 2009‎
Drug Company Paid Experts $3.7 Million to Promote Drugs� Eli Lilly has made $38 billion on Zyprexa and it was way oversold and caused diabetes and in some ... Attorney at Law

Antipsychotic Drugs Can Cause Rapid Weight Gain in Kids  -  ‎Nov 3, 2009‎
This study looked at four of the most common antipsychotic medications used in children: Risperdal or risperidone made by Johnson & Johnson, Zyprexa or ... Fars News Agency

Six Reasons To Say No To Your Doctor  -  ‎Nov 12, 2009‎
Last year new schizophrenia drugs such as Seroquel from AstraZeneca ( AZN - news - people ) and Zyprexa from Eli Lilly ( LLY - news - people ) edged out ... Forbes

Critics question ethics of stepped-up pharma data mining  -  ‎Oct 26, 2009‎
By Anonymous | Posted 2:47am | October 27, 2009 Eli Lilly sells a drug {ZYPREXA} that can cause diabetes and then turn a profit on the drugs that treat the ... FierceHealthIT

REG-Lilly (Eli) & Co: Lilly Rpts Solid 3Q09; Rev Full-Year 09 EPS Guidance  -  ‎Oct 21, 2009‎
These charges included $1.477 billion related to the Zyprexa® investigations led by the US Attorney for the Eastern District of Pennsylvania, as well as the ... Reuters

CVS Drug Store Company Caught in Hidden Drug-Pushing Deal to Promote Zyprexa ...  -  ‎Nov 1, 2009‎
Advance PCS, a unit of CVS, agreed to send unsolicited mail to doctors promoting Zyprexa, even though it was under contract at the time to represent health ... Natural News.com (registration)

Children Gain Weight on Antipsychotic Medications  -  ‎Oct 31, 2009‎
Drugs/Medications included olanzapine (Zyprexa), quetiapine (Seroquel), risperidone (Risperadol) and aripiprazole (Abilify)—drugs sometimes used to treat ... Healia Health (blog)

Michael S. Burg Appointed as Co-Lead Counsel in the Yasmin/Yaz Multidistrict ...  -  ‎Nov 13, 2009‎
Mr. Burg has also served as a member of the Plaintiff Steering Committee for the Zyprexa Multidistrict Litigation in the Eastern District of New York, ... PR Newswire (press release)

Business briefs  -  ‎Oct 22, 2009‎
Lilly said its worldwide revenue rose 7 percent with its top-seller, the anti-psychotic Zyprexa, bringing in $1.2 billion, or 3 percent more than it did the ... News Sentinel

HOW FDA, BIG PHARMA, AND DOCTORS CAUSE INJURY FOR PROFIT  -  ‎Nov 4, 2009‎
Since Eli Lilly knew that Zyprexa caused diabetes and didn't let patients know this, they have already settled numerous “failure to warn� lawsuits totaling ... NewsWithViews.com

J&J rep says he promoted Risperdal off-label  -  ‎Oct 30, 2009‎
Eli Lilly's Zyprexa, AstraZeneca's Seroquel, and J&J's Risperdal have been at the center of liability lawsuits, government probes, and more. ... FiercePharma

Sales, Stat!  -  ‎Oct 28, 2009‎
Not coincidentally, 15 of the biggest recipients were psychiatrists; Lilly sells the Cymbalta antidepressant and the Zyprexa antipsychotic drugs. ... Portfolio.com

BEFORE THE BELL:US Stock Futures Down But Off Lows  -  ‎Oct 21, 2009‎
...(LLY) returned to the black in the third quarter, after last year's results were hurt by legal settlements for its star drug, the antipsychotic Zyprexa, ... Wall Street Journal

Lilly CEO Lechleiter touts pipeline  -  ‎Oct 23, 2009‎
Over the next several years, Eli Lilly will be facing generic competition for the antipsychotic Zyprexa, antidepressant Cymbalta and other blockbuster drugs ... FierceBiotech

Fitch Revises Eli Lilly & Co.'s Outlook to Negative  -  ‎Nov 13, 2009‎
Free cash flow moderated for the LTM period at the end of the third quarter of 2009 to $1.79 billion, weighed down by Zyprexa litigation payments in the ... PR-Inside.com (Pressemitteilung)

Sought-After Speaker, With Script Outlines From Eli Lilly  -  ‎Nov 3, 2009‎
...care professionals about disorders like schizophrenia and depression, which can be treated with the Lilly drugs Zyprexa and Cymbalta respectively. ... New York Times

Don't Cry for Me AstraZeneca  -  ‎Nov 2, 2009‎
This comes on the heals of the similar scandal at Eli Lilly over Zyprexa, leading to a $1.4 billion payment, and Pfizer's $2.3 billion payment, ... ThePopTort (blog)

AstraZeneca Pays Millions to Settle Seroquel Cases  -  ‎Oct 29, 2009‎
Earlier this year, Eli Lilly & Company paid $1.4 billion over its marketing of Zyprexa, another antipsychotic drug. And Pfizer announced it would pay $2.3 ... New York Times

The Expanding and Evolving Role of State Attorneys General in Drug and Device ...  -  ‎Nov 11, 2009‎
Both Alaska and West Virginia hired private counsel to handle their Zyprexa litigation. And a major plaintiff's law firm experienced in litigating with ... Linex Legal (registration)

Ask Dr. H: She's had digestive distress since gall bladder removal  -  ‎Nov 9, 2009‎
...and antipsychotic/bipolar medications like Seroquel, Zyprexa, Haldol, and Xanax. Mitchell Hecht is a physician specializing in internal medicine. ... Philadelphia Inquirer

Health Brief: October 29  -  ‎Oct 29, 2009‎
The study found psychotropic drugs like Zyprexa and rRsperdal can cause weight gain of about a pound a week. Experts aren't sure why the weight gain happens ... WBAY

Lawmakers Target Medicare and Medicaid Fraud  -  ‎Oct 28, 2009‎
In January, Eli Lilly & Co. settled with the department for $1.4 billion over the marketing of anti-psychotic drug Zyprexa. On Wednesday, Mr. Leahy and five ... Wall Street Journal

Troubled teens on powerful drugs  -  ‎Oct 28, 2009‎
...(Here, Albert, try some Zyprexa and you're sure to pass geography.) Fact is drugs are not the total answer. Many adults, however, are getting good results ... SmartPlanet.com

In the News  -  ‎Oct 27, 2009‎
...far of the 44 states that have sued the company for improperly marketing Zyprexa for off-label use, causing injuries costing taxpayers boatloads of money. ThePopTort (blog)

Genzyme slides on outlook; Antigenics plunges 40%  -  ‎Oct 21, 2009‎
...to a third-quarter profit as a result of higher sales in the 2009 quarter as well as year-earlier charges related to litigation over its drug Zyprexa. ... MarketWatch

Widespread Generic Erosion of Atypical Antipsychotics Will Cause the Bipolar ...  -  ‎Nov 5, 2009‎
...erosion of key antipsychotic agents such as AstraZeneca's Seroquel, Eli Lilly's Zyprexa, Bristol-Myers Squibb/Otsuka's Abilify and Pfizer's Geodon. ... Reuters

Is It Bipolar Disorder or Depression? Learn the Signs  -  ‎Nov 4, 2009‎
...antiseizure and mood stabilizing medications such as Depakote and Tegretol, as will as major tranquilizers such as Seroquel, Zyprexa and Abilify. ... FOXNews

Eli Lilly and Company Q3 2009 Earnings Call Transcript  -  ‎Oct 21, 2009‎
The Canadian Federal Court ruled that Lilly's Canadian compound patent for Zyprexa is invalid. We believe this decision is deeply flawed and that it is ... Seeking Alpha (blog)

Earnings Preview: Bristol-Myers 3Q earnings report  -  ‎Oct 21, 2009‎
...s Zyprexa. The drugs have combined sales of well over $15 billion a year. On the upside, the FDA in July approved Onglyza, a new diabetes drug developed ... The Associated Press

Biotech Giant Amgen Sued Over Kickback Schemes  -  ‎Nov 1, 2009‎
Eli Lilly & Co., earlier this year, paid a then record $1.4 billion to settle allegations of illegal marketing of Zyprexa, an anti-psychotic drug. ... The Epoch Times

Byetta gains approval as stand-alone diabetes drug  -  ‎Nov 2, 2009‎
Lilly's key products include antipsychotic Zyprexa, Cymbalta for depression and fibromyalgia, Gemzar and Alimta for cancer, Evista and Forteo for ... Indianapolis Star

Duty to Warn: The Fort Hood Murders/Suicide and the Taboo Question  -  ‎Nov 11, 2009‎
...snowed under not only with antidepressants and tranquilizers, but increasingly with antipsychotic drugs like Risperdal, Zyprexa, Geodon and Seroquel. ... The Baltimore Chronicle

Abbott joins the federal-probe parade  -  ‎Nov 9, 2009‎
And the settlements have been breaking records, what with Eli Lilly's $1.4 billion Zyprexa deal and Pfizer's $2.3 billion package of payments and fines. ... FiercePharma

Eli Lilly Agreed To Pay $24 Million Settlement To Utah (LLY)  -  ‎Nov 11, 2009‎
Zyprexa is approved for the treatment of schizophrenia and bipolar disorder. Shurtleff said that Eli Lilly illegally promoted the drug for uses not approved ... Trading Markets (press release)

Lilly Settles With 18,000 Over Zyprexa  -  Jan 5, 2007
By ALEX BERENSON. Eli Lilly agreed yesterday to pay up to $500 million to settle 18000 lawsuits from people who claimed they had developed diabetes or other ... New York Times

Eli Lilly to pay $62 million in Zyprexa settlement  -  Oct 7, 2008
CHICAGO, Oct 7 (Reuters) - Eli Lilly and Co (LLY.N) has agreed to pay $62 million to settle claims that it improperly marketed its top-selling Zyprexa ... Reuters

Lilly Settles Alaska Suit Over Zyprexa  -  Mar 26, 2008
By ALEX BERENSON. Eli Lilly has agreed to pay $15 million to the state of Alaska to settle a lawsuit claiming that the company's schizophrenia drug Zyprexa ... New York Times

Eli Lilly says New York Times' Zyprexa article short on facts  -  Dec 17, 2006
INDIANAPOLIS (AFX) - Eli Lilly and Co said important facts were missing from a New York Times article published today which reported that the company has ... Forbes

Court finds in favor of Eli Lilly on Zyprexa - MarketWatch  -  Apr 14, 2005
By Val Brickates Kennedy, MarketWatch. BOSTON (MarketWatch) -- After almost a year of deliberation, a federal court in Indiana has found Eli Lilly & Co. ... MarketWatch

Leading schizophrenia drug no better than older, cheaper kind  -  Sep 19, 2005
...s Zyprexa did slightly better, staying on the medicine longer before ... However, Zyprexa was far more likely than leading competitors to cause some ... USA Today

Lilly swings to loss on Zyprexa charge  -  Oct 23, 2008
By Val Brickates Kennedy, MarketWatch. BOSTON (MarketWatch) -- Eli Lilly & Co. posted a third-quarter loss Thursday, attributable to steep charges taken to ... MarketWatch

Lilly profit slumps, hurt by Zyprexa charge  -  Jan 31, 2007
By Ransdell Pierson. NEW YORK (Reuters) - Eli Lilly and Co. (LLY.N) said on Wednesday fourth-quarter earnings fell, hurt by a charge for a settlement with ... Reuters

Lilly could have a tough time shaking Zyprexa allegations - Dec. 18,...  -  Dec 18, 2006
By Aaron Smith, CNNMoney.com staff writer. NEW YORK (CNNMoney.com staff writer) -- Eli Lilly & Co. could have a rough time dealing with recent allegations ... CNNMoney.com

Eli Lilly to Pay $700M in Zyprexa Settlement  -  Jun 10, 2005
INDIANAPOLIS — Eli Lilly & Co. (LLY) has agreed to pay nearly $700 million to settle a majority of legal claims that labels on its anti-psychosis drug ... FOXNews

State: No alerts on Zyprexa side effects  -  Mar 6, 2008
By Dan Joling, AP Writer. ANCHORAGE, Alaska — Eli Lilly and Co. failed to adequately warn doctors and patients of dangerous side effects associated with its ... USA Today

Lilly says continued Zyprexa sales growth unlikely  -  Apr 16, 2007
NEW YORK, April 16 (Reuters) - Eli Lilly and Co. (LLY.N) said on Monday that strong first-quarter sales growth for its Zyprexa schizophrenia drug was due ... Reuters

Lilly's Zyprexa Keeps Analysts Edgy  -  Apr 20, 2006
By Robert Steyer. Eli Lilly (LLY - commentary - Cramer's Take) produced better-than-expected first-quarter earnings Thursday, but analysts continue to raise ... TheStreet.com - TheStreet.com (subscription)

Lilly subpoenaed on Zyprexa marketing  -  Jan 31, 2008
Eli Lilly & Co. said Wednesday that it received a subpoena in November from a US grand jury in Pennsylvania seeking documents involving the marketing of the ... Los Angeles Times

Lilly adds new warnings to antipsychotic Zyprexa  -  Oct 5, 2007
By Toni Clarke. BOSTON, Oct 5 (Reuters) - Eli Lilly & Co (LLY.N) said on Friday its antipsychotic Zyprexa was more likely than rival treatments to raise ... Reuters

Lilly Could Stabilize Zyprexa Performance By Year-End  -  Jul 22, 2005
Credit Suisse First Boston maintained an "outperform" rating on Eli Lilly (nyse: LLY - news - people ) after the pharmaceutical company posted ... Forbes

US drug agency investigating accuracy of Lilly's Zyprexa data  -  Apr 25, 2007
By Alex Berenson. NEW YORK — The Food and Drug Administration is examining whether Eli Lilly provided it with accurate data about the side effects of the ... New York Times

Connecticut joins states suing over Zyprexa  -  Mar 11, 2008
HARTFORD, Conn.—Connecticut is joining at least nine other states suing drug maker Eli Lilly and Co. over the antipsychotic drug Zyprexa. ... Boston Globe

Zyprexa, Zyrtec similarities causing confusion  -  Feb 9, 2005
INDIANAPOLIS - Eli Lilly and Co. has changed the labeling on its antipsychotic Zyprexa to avoid confusion with Pfizer Inc.'s allergy medicine Zyrtec after ... msnbc.com

Disparity Emerges in Lilly Data on Schizophrenia Drug  -  Dec 21, 2006
The original results showed that patients on Zyprexa, Lilly's pill for ... Those results indicated that patients taking Zyprexa were only slightly more ... New York Times

Lilly to appeal Canada, Germany rulings on Zyprexa  -  Jun 7, 2007
By Ransdell Pierson. NEW YORK, June 7 (Reuters) - Eli Lilly and Co. (LLY.N) said on Thursday it would appeal two recent court patent rulings that could ... Reuters

Article: US PANEL SUPPORTS ZYPREXA HOT STOCKS  -  Feb 8, 2008
A US advisory panel backed Eli Lilly's proposed long-acting form of the schizophrenia drug Zyprexa. Advisers to the Food and Drug Administration said the ... Pay-Per-View - International Herald Tribune - HighBeam Research

Zyprexa Data Removes Overhang On Lilly Shares  -  Sep 20, 2005
Credit Suisse First Boston maintained an "outperform" rating on Eli Lilly (nyse: LLY - news - people ) and said the stock is at an attractive entry point in ... Forbes

Lilly to Settle More Zyprexa Lawsuits  -  Jan 9, 2007
By RICK CALLAHAN, AP Writer. INDIANAPOLIS — Eli Lilly and Co. said Thursday it will settle about 18000 additional lawsuits alleging the drugmaker did not ... FOXNews

Lilly Faces New Suits Over Improper Zyprexa Marketing  -  Apr 20, 2006
By Karen Gullo and Margaret Cronin Fisk. April 20 (Bloomberg) -- Eli Lilly & Co., which settled litigation over its Zyprexa drug for $700 million last year, ... Bloomberg

Judge urges Eli Lilly to settle Zyprexa lawsuit  -  Jul 3, 2008
By Charles Wilson, AP Writer. INDIANAPOLIS — A federal judge in New York is urging Eli Lilly and Co. to settle a multibillion-dollar lawsuit filed by ... USA Today

Eli Lilly was concerned by Zyprexa side-effects from 1998  -  Jan 23, 2007
Eli Lilly, the American pharmaceutical giant that has consistently denied any link between Zyprexa, its antipsychotic drug, and diabetes, was concerned ... Times Online

FDA Rejects New Form of Lilly's Zyprexa  -  Feb 28, 2008
By TSC Staff. Eli Lilly (LLY) received a not approvable letter from the Food and Drug Administration for a new injection form of the schizophrenia treatment ... TheStreet.com - TheStreet.com (subscription)

Zyprexa hurt Lilly revenue growth in '05.  -  Jan 27, 2006
Jan. 27--Struggling to replace eroding sales from its No. 1 drug Zyprexa, Eli Lilly and Co. managed to post revenue growth of just 6 percent last year, ... Free with registration - Indianapolis Star - AccessMyLibrary.com

No Cure for Zyprexa Anxiety  -  Jun 23, 2005
By Robert Steyer. The schizophrenia drug Zyprexa is Eli Lilly's (LLY:NYSE) biggest source of sales and earnings, and it's also the biggest source of ... TheStreet.com - TheStreet.com (subscription)

Zyprexa, Cymbalta lead Lilly profit 6 pct higher  -  Oct 18, 2007
NEW YORK, Oct 18 (Reuters) - Eli Lilly and Co (LLY.N) on Thursday posted a 6 percent rise in quarterly profit on increased demand for its Cymbalta ... Reuters

Drug Files Show Maker Promoted Unapproved Use  -  Dec 18, 2006
By March 2001, about three months after the start of Viva Zyprexa, the campaign had led to ... Over all, sales of Zyprexa doubled between 1999 and 2002, ... New York Times

Report: Lilly, Govt Explore Zyprexa Deal  -  Jan 30, 2008
NEW YORK — Eli Lilly and Co. and federal prosecutors are exploring a settlement of an investigation into the drugmaker's marketing of its top seller, ... FOXNews

US judge rules Eli Lilly's patent valid — Dr Reddy's loses case on...  -  Apr 16, 2005
Olanzapine is the generic version of Eli Lilly's Zyprexa. ... Though Eli Lilly recorded a slow growth in Zyprexa sales, the drug had global sales of $4.42 ... Hindu Business Line

Lilly settles Zyprexa document disclosure case  -  Sep 7, 2007
BOSTON, Sept. 7 (Reuters) - Eli Lilly and Co (LLY.N) said on Friday it has agreed to settle a dispute with a former plaintiffs' expert witness in product ... Reuters

Lilly Patent for Zyprexa Valid, Appeals Court Rules  -  Dec 26, 2006
By Phil Milford and Rob Waters. Dec. 26 (Bloomberg) -- Eli Lilly & Co. won a US appeals court ruling upholding its patent on Zyprexa, the world's top- ... Bloomberg

Lilly's Monthly Zyprexa Causes Sleepiness, FDA Says  -  Feb 4, 2008
By Elizabeth Lopatto. Feb. 4 (Bloomberg) -- Eli Lilly & Co's once-a-month version of its top-selling antipsychotic medicine Zyprexa, while effective, ... Bloomberg

Generic firms clear Zyprexa hurdle.  -  Mar 30, 2005
Mar. 30--Two competitors of Eli Lilly and Co. were cleared to sell generic versions of Lilly's bestselling drug Zyprexa should they prevail in a federal ... Free with registration - Indianapolis Star - AccessMyLibrary.com

Mother Wonders if Psychosis Drug Helped Kill Son  -  Jan 4, 2007
At first, the psychiatric drug Zyprexa may have saved John Eric Kauffman's life, ... She is angry that Eli Lilly played down the risks of Zyprexa. ... New York Times

Big Pharma Baffled Again  -  Apr 3, 2006
Perphenazine was compared with Lilly's Zyprexa, Pfizer's Geodon, ... Researchers said Zyprexa outperformed its peers as well as the generic drug, ... TheStreet.com - TheStreet.com (subscription)

Judge to Unseal Documents on the Eli Lilly Drug Zyprexa  -  Sep 5, 2008
By MARY WILLIAMS WALSH. A federal judge in Brooklyn decided on Friday to unseal confidential materials about Eli Lilly's top-selling antipsychotic drug ... New York Times

Eli Lilly to appeal 'flawed' Canadian, German court rulings on Zyprexa...  -  Jun 7, 2007
Robert Armitage, Eli Lilly (nyse: LLY - news - people )'s senior vice-president and general counsel, said these rulings have no bearing on Zyprexa patents ... Forbes

Little Benefit Seen in Antipsychotics Used in Alzheimer's  -  Oct 12, 2006
Eli Lilly and Co. makes Zyprexa, AstraZeneca makes Seroquel, ... The new study found that Risperdal and Zyprexa seemed to help Alzheimer's patients more ... Pay-Per-View - Washington Post - ProQuest Archiver

Eli Lilly denies NYT report on Zyprexa  -  Mar 14, 2008
NEW YORK (Reuters) - Eli Lilly and Co on Friday denied a report in The New York Times that said a senior executive had encouraged the promotion of its ... Reuters

Lilly's Zyprexa Woes Could Spark 'Meaningful Declines'  -  Sep 7, 2005
Bear Stearns initiated coverage on Eli Lilly (nyse: LLY - news - people ) with a "peer perform" rating and said that despite strong growth and a robust ... Forbes

In Some States, Maker Oversees Use of Its Drug  -  Mar 23, 2007
At more than $300 for a monthly prescription, Zyprexa, which is used to treat ... So Eli Lilly, the maker of Zyprexa, offers to help states monitor doctors ... New York Times

Eli Lilly posts 3Q loss on Zyprexa settlement  -  Oct 24, 2008
INDIANAPOLIS (AP) — Drugmaker Eli Lilly said Thursday it took a loss in the third quarter on a charge of almost $1.5 billion for an expected settlement of ... USA Today

Lilly Makes Bid for Respect | Robert Steyer News | Print Financial & ...  -  Jul 20, 2005
As for neuroscience, Lilly is breathing a bit easier now that a patent challenge to its schizophrenia drug Zyprexa has been defeated (although the ... TheStreet.com - TheStreet.com (subscription)

Schizophrenia drug gets vote of confidence  -  Apr 2, 2006
But if Zyprexa doesn't work, he said, he'd recommend Clozaril. ... While the difference in that measure between Clozaril and Zyprexa was not significant by ... USA Today

Barr withdraws patent suit related to generic Zyprexa  -  Jun 11, 2007
June 11 (Reuters) - Barr Pharmaceuticals Inc.'s BRL.N unit said it withdrew a lawsuit related to its challenge of the patent of Eli Lilly's (LLY. ... Reuters

Lilly Waited Too Long to Warn About Schizophrenia Drug, Doctor...  -  Mar 8, 2008
Zyprexa, a drug for schizophrenia and bipolar disorder, ... Zyprexa was introduced in September 1996 and hailed as a breakthrough medicine for the treatment ... New York Times

Judge Says 'NYT' Reporter Conspired With Lawyer in Zyprexa Case  -  Feb 14, 2007
NEW YORK A US judge has stopped further disclosure of confidential documents that became the basis for a series of critical stories in The New York Times ... Editor & Publisher

Lilly's Zyprexa Woes May Spark 'Meaningful Declines'  -  May 4, 2006
Bear Stearns maintained a "peer perform" rating on Eli Lilly as the drug maker faces increasing lawsuits for schizophrenia treatment Zyprexa. ... Forbes

A Familiar Refrain at Lilly: The Pipeline  -  Oct 17, 2005
Although Zyprexa has survived a patent challenge, it has been in a long-term ... A recent federally sponsored study said Zyprexa is the most effective among ... TheStreet.com - TheStreet.com (subscription)

Lilly sees approval soon for long-acting Zyprexa  -  May 30, 2008
NEW YORK, May 29 (Reuters) - Eli Lilly and Co (LLY.N: Quote, Profile, Research) said on Thursday a long-acting form of its schizophrenia drug Zyprexa will ... Reuters India

Lilly May Need Stronger US Warning on Zyprexa Label  -  Jul 30, 2008
By Margaret Cronin Fisk and Elizabeth Lopatto. July 30 (Bloomberg) -- Eli Lilly & Co.'s current label warning on health risks linked to its antipsychotic ... Bloomberg

States Study Marketing Of Lilly Pill  -  Jan 20, 2007
Any fine or cost recovery could be sizable, because Zyprexa has been a ... More than 20 million people have taken Zyprexa since Lilly began selling the drug ... New York Times

Eli Lilly Jacks Up Guidance | Biotech/Pharmaceuticals | Financial...  -  Dec 9, 2005
Cymbalta, along with schizophrenia treatment Zyprexa, are two of Lilly's key ... Our goals are to further stabilize US Zyprexa sales and sustain modest ... TheStreet.com - TheStreet.com (subscription)

Lilly CEO: Zyprexa 2007 seen flat from 2006 - MarketWatch  -  Mar 14, 2007
By Val Brickates Kennedy, MarketWatch. BOSTON (MarketWatch) -- Eli Lilly & Co. Chief Executive Officer Sidney Taurel said Wednesday that because of ... MarketWatch

Lilly Responds to the Cost-Effectiveness Analysis of the CATIE …  -  Dec 1, 2006
Among the atypicals studied Zyprexa was found to be the most cost-effective. ... Cherri Miner, MD, Lilly US Medical Director for Zyprexa said, ... Free with registration - PR Newswire - AccessMyLibrary.com

Trials illustrate two views of best-selling schizophrenia medicine  -  Mar 24, 2008
In many patients, Zyprexa causes severe weight gain that can lead to ... But Lilly did not add a similar warning to Zyprexa labels in the United States. ... New York Times

Drug agency re-examining Lilly's Zyprexa data | Article from Internati...  -  Apr 26, 2007
Drug agency re-examining Lilly's Zyprexa data ... find International Herald Tribune articles. Alex Berenson International Herald Tribune 04-26-2007 The Food ... Pay-Per-View - International Herald Tribune - HighBeam Research

Lilly Shares Discount Rebound For Zyprexa, Cymbalta  -  Jul 20, 2006
Prudential Equity Group maintained a "neutral weight" rating on Eli Lilly ahead of the drugmaker's second-quarter earnings report, saying shares look fairly ... Forbes

Zyprexa in court .  -  Dec 16, 2007
Individual claims: Over the past two years, Eli Lilly has paid 2 billion to settle lawsuits from some 30000 people, most of whom claim Zyprexa caused them ... St. Petersburg Times - Google News Archive

A Sea Change For Schizophrenia Treatment?  -  Sep 16, 2005
Eli Lilly's Zyprexa rules the antipsychotic market, but US sales for the ... Most experts predict that Zyprexa will win, however--even naysayers such as ... Forbes

Lilly to Post 2008 Loss on ImClone Costs  -  Dec 11, 2008
...a charge of $1.33 per share Lilly expects to pay to resolve an investigation into the marketing of its biggest-selling drug, the anti-psychotic Zyprexa. ... ABC News

New Schizophrenia Drug Shows Promise in Trials  -  Sep 3, 2007
The troubled history of Zyprexa, another antipsychotic medicine from Lilly, ... When it introduced Zyprexa in 1996, Lilly hailed it as a breakthrough with ... New York Times

Eli Lilly Wins Dismissal of Zyprexa Shareholder Suits  -  Apr 30, 2008
By Patricia Hurtado and Bob Van Voris. April 30 (Bloomberg) -- A federal judge today dismissed a suit claiming Eli Lilly & Co. defrauded shareholders by ... Bloomberg

No Love For Lilly  -  Apr 21, 2008
Meanwhile, the company said Zyprexa gained just 1.0% in worldwide sales, ... International sales of Zyprexa were helped by favorable exchange rates. ... Forbes

Eli Lilly 4Q Earnings Rise Sharply  -  Jan 29, 2008
Zyprexa recorded $1.3 billion in sales during the fourth quarter of 2007, a 10 percent increase from the last quarter of 2006. ... FOXNews

Lilly Adds Label Warnings for Mental Illness Drug  -  Oct 5, 2007
Eli Lilly today added strong warnings to the label of Zyprexa, ... Lilly previously argued that Zyprexa had not been proven to cause high blood sugar at a ... New York Times

Secrecy's dangerous side effects; When legal settlements allow …  -  Feb 8, 2007
The documents contained evidence that Zyprexa caused large, ... In the Zyprexa cases, the documents eventually were exposed when Alaska attorney James B. ... Pay-Per-View - Los Angeles Times - ProQuest Archiver

Lilly Withstands US High Court Challenges to Zyprexa Patent  -  Oct 1, 2007
By Greg Stohr. Oct. 1 (Bloomberg) -- The US Supreme Court let stand a decision upholding Eli Lilly & Co.'s patent on Zyprexa, the world's top-selling ... Bloomberg

Lilly Fraudulently Marketed Zyprexa, Montana Claims  -  Mar 12, 2007
By Margaret Cronin Fisk. March 12 (Bloomberg) -- Eli Lilly & Co. was sued by the state of Montana over claims the company fraudulently marketed its ... Bloomberg

Lilly to Take Charge to Earnings Related to Pending Federal and State...  -  Oct 21, 2008
..."The government's investigation of Zyprexa has been ongoing for five years and we ... Zyprexa is indicated in the United States for the short- and long-term ... RedOrbit

Change urged in antipsychotic drugs for kids  -  Sep 15, 2008
The study compared two of the newer antipsychotics, Zyprexa from Eli Lilly and ... The children receiving Zyprexa gained so much weight that a government ... San Francisco Chronicle

Lilly Zyprexa-Claim Losses May Climb to $1.83 a Share  -  Mar 18, 2008
By Margaret Cronin Fisk. March 18 (Bloomberg) -- An adverse jury decision in Alaska may be the first step in tripling to more than $3 billion Eli Lilly & Co ... Bloomberg

Lilly May Face More Zyprexa Lawsuits After FDA Letter  -  Jun 29, 2007
By Rob Waters and Margaret Cronin Fisk. June 29 (Bloomberg) -- Eli Lilly & Co. may attract more lawsuits alleging it failed to warn users that a psychiatric ... Bloomberg

Lilly bullish on 2008 earnings  -  Dec 6, 2007
..."It is critical to understand life after Zyprexa. ... Lilly said its dependence on Zyprexa -- whose tendency to cause weight gain has hurt its US sales ... Reuters

Court upholds Lilly's patent on Zyprexa  -  Dec 27, 2006
Eli Lilly & Co. won a U.S. appeals court ruling upholding its patent on Zyprexa, the world's top-selling schizophrenia drug. The U.S. Court of Appeals for ... Pay-Per-View - Orlando Sentinel - ProQuest Archiver

Article: Lilly hid side effects, Alaska jury told Trial begins on...  -  Mar 7, 2008
The Alaska case is the first Zyprexa-related lawsuit to reach a jury trial and is being ... Even as the state's lawyers claimed that Zyprexa was dangerous, ... Pay-Per-View - International Herald Tribune - HighBeam Research

Lilly posts loss on charges for Zyprexa probes  -  Oct 23, 2008
By Ransdell Pierson. NEW YORK (Reuters) - Eli Lilly and Co (LLY.N) posted a third-quarter loss on Thursday as it booked $1.48 billion in charges for probes ... Reuters

Zyprexa Judge Decides Which Journalists Have First Amendment Rights  -  Jan 15, 2007
By Evelyn Pringle. The judge issuing injunctions in the Eli Lilly-Zyprexa-Documents case has decided that reporters at the New York Times enjoy the full ... OpEdNews

Psychosis Drug Risks Are Noted  -  Oct 19, 2005
Frail, elderly patients with Alzheimer's disease who are given widely used antipsychotic drugs such as Zyprexa and Risperdal have a higher risk of dying ... Washington Post

Fake batches of Eli Lilly drug Zyprexa found in UK  -  May 24, 2007
LONDON (Reuters) - Three counterfeit batches of Eli Lilly best-selling schizophrenia drug Zyprexa have been discovered in the British supply chain, ... Reuters UK

Analysis: Lilly delivers strong Q2  -  Jul 24, 2007
However, Zyprexa may begin to slip over the remainder of the year. "As we get into the back half of the ... Zyprexa sales rose 9 percent to $1.21 billion. ... United Press International

State of Utah sues Zyprexa maker  -  May 18, 2007
Posted: 11:43 AM- Some 1500 Utah adults with insurance coverage through Medicaid have developed diabetes because they took the antipsychotic drug Zyprexa, ... $2.95 - Salt Lake Tribune, The - NewsBank

Barr Gets Zyprexa OK | Business News | Financial Articles & Investing...  -  Nov 10, 2006
Barr Pharmaceuticals(BRL Quote) got tentative approval from the Food and Drug Administration for its generic version of Zyprexa tablets of 5mg, 10mg, ... TheStreet.com - TheStreet.com (subscription)

Lilly sees approval soon for long-acting Zyprexa  -  May 29, 2008
NEW YORK, May 29 (Reuters) - Eli Lilly and Co (LLY.N) said on Thursday a long-acting form of its schizophrenia drug Zyprexa will likely become available in ... Reuters

Cymbalta sales help Eli Lilly post strong quarterly earnings  -  Jul 22, 2006
Sales of Lilly's top-selling Zyprexa totaled $1.12 billion, a 2 percent increase ... US Zyprexa sales fell 1 percent to $542.9 million on lower demand, ... San Diego Union - Tribune - San Diego Union Tribune

Eli Lilly Zyprexa Lawsuit May Be Scaled Back, Judge Says  -  Apr 11, 2008
By Bob Van Voris. April 11 (Bloomberg) -- A US judge said he might scale back a lawsuit by purchasers of Eli Lilly & Co.'s top-selling drug Zyprexa and ... Bloomberg

Eli Lilly sees '07 profit lowered by 10 cents per share due to Icos...  -  Dec 7, 2006
Taurel said the company had stabilized the sales of anti-psychotic drug Zyprexa, which had been hurt by its side effect profile. ... San Diego Union - Tribune - San Diego Union Tribune

Article: 2 views on the use of antipsychotics Benefits weighed...  -  Mar 26, 2008
Zyprexa is currently the ... patients who have used Zyprexa in the United States. ... Article: Zyprexa Approved for Long-Term Therapy and Maintenance ... ... Pay-Per-View - International Herald Tribune - HighBeam Research

Zyprexa users eagerly await settlement payments.  -  Aug 10, 2006
Aug. 10--More than 8000 users of Eli Lilly and Co.'s top-selling drug should find out this month how much their pain and suffering is worth. ... Free with registration - Indianapolis Star - AccessMyLibrary.com

Lilly in Settlement Talks With US  -  Jan 30, 2008
Zyprexa has serious side effects and is approved only to treat people with ... But the company would be allowed to keep selling Zyprexa to Medicare and ... New York Times

EFF Says First Amendment Protects Links To Leaked Corporate …  -  Jan 9, 2007
..."Millions of patients around the world have benefited from Zyprexa and Lilly is concerned that this tragic story about a single patient could unnecessarily ... InformationWeek

Akzo drug helps control manic episodes in trial  -  May 22, 2007
After 2 days of treatment, both asenapine and Zyprexa provided ... That compared with 53 percent of those taking Zyprexa -- whose reported side effects ... Reuters

Lilly, Bristol-Myers Post Solid 3Q Sales Growth  -  Oct 23, 2008
...of almost $1.5 billion that it took in the quarter for a possible settlement of investigations into the marketing behind its top-selling drug Zyprexa. ... ABC News

Lilly, doctor reach agreement over leak  -  Sep 10, 2007
...'I had also seen information regarding the beneficial impact Zyprexa has on patients' lives.' A Times reporter wrote a number of articles starting late ... Forbes

Eli Lilly Posts Net Loss Amid Charges  -  Jan 31, 2005
Sales of schizophrenia treatment Zyprexa (search), Lilly's biggest product that has ... Sales of Zyprexa, fell 5 percent to $1.09 billion in the quarter. ... FOXNews

Brand Names/Synonyms:
Zyprexa is also known by the following brand names and/or synonymsCHEMBANK1855; OLANZAPINE, 99%; Olansek; Olanzapine; Olanzapine [Usan:Inn]; Symbyax; Zydis; Zyprexa; Zyprexa Intramuscular; Zyprexa Zydis

Drug Category:
Zyprexa is categorized under the following by the FDA: Antipsychotics; Antiemetics; Antipsychotics; ATC:N05AH03

Dosage Forms:
Oral tablets

Absorption:
well absorbed, with approximately 40% of the dose metabolized before reaching the systemic circulation

Interactions:
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Chemical IUPAC Name:
2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5]benzodiazepine





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