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alosetron HClThis page contains recent news articles, when available, and an overview of alosetron HCl but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: alosetron HCl (when available) Voriconazole is a triazole antifungal agent indicated for use in the treatment of fungal infections including invasive aspergillosis, esophageal candidiasis, and serious fungal infections caused by Scedosporium apiospermum (asexual form of Pseudallescheria boydii) and Fusarium spp. including Fusarium solani. Fungal plasma membranes are similar to mammalian plasma membranes, differing in having the nonpolar sterol ergosterol, rather than cholesterol, as the principal sterol. Membrane sterols such as ergosterol provide structure, modulation of membrane fluidity, and possibly control of some physiologic events. Voriconazole effects the formation of the fungal plasma membrane by indirectly inhibiting the biosynthesis of ergosterol. This results in plasma membrane permeability changes and inhibition of growth. For the treatment of esophageal candidiasis, invasive pulmonary aspergillosis, and serious fungal infections caused by Scedosporium apiospermum and Fusarium spp. Mechanism Of Action: Voriconazole binds and inhibits ergosterol synthesis by inhibiting CYP450-dependent 14-alpha sterol demethylase. The inhibition of 14-alpha sterol demethylase results in a depletion of ergosterol in fungal cell membrane. News Articles on Voriconazole Brand Names/Synonyms: alosetron HCl is also known by the following brand names and/or synonymsDRG-0301; VCZ; VFEND; Vfend; Voriconazole; Voriconazole [Usan:Ban:Inn] Drug Category: alosetron HCl is categorized under the following by the FDA: Antifungals; ATC:J02AC03 Dosage Forms: TABLET; Oral suspension; IV Injection Absorption: 96% Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 2-(2,4-difluorophenyl)-3-(5-fluoropyrimidin-4-yl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol |
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