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atorvastatin calciumThis page contains recent news articles, when available, and an overview of atorvastatin calcium but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: atorvastatin calcium (when available) Atorvastatin, a selective, competitive HMG-CoA reductase inhibitor, is used to lower cholesterol and triglycerides in patients with hypercholesterolemia and mixed dyslipidemia and in the treatment of homozygous familial hypercholesterolemia. Atorvastatin has a unique structure, long half-life, and hepatic selectivity, explaining its greater LDL-lowering potency compared to other HMG-CoA reductase inhibitors. For management as an adjunct to diet to reduce elevated total-C, LDL-C, apo B, and TG levels in patients with primary hypercholesterolemia and mixed dyslipidemia. Mechanism Of Action: Atorvastatin selectively and competitively inhibits the hepatic enzyme hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase. As HMG-CoA reductase is responsible for converting HMG-CoA to mevalonate, this results in a decrease in mevalonate, a precursor of cholesterol, and a subsequent decrease in hepatic cholesterol levels and increase in uptake of LDL cholesterol. News Articles on Atorvastatin Pfizer-Unilab row reaches retail sector - Oct 25, 2009 According to the letter, a copy of which was obtained by the Inquirer, Atorvastatin Calcium, the drug Pfizer marketed under the brand Lipitor and which ... Inquirer.net Pfizer-Unilab row - Nov 10, 2009 ...before the Regional Trial Court in Makati City after Unilab had started selling its generic atorvastatin calcium in August. ... Business Mirror New Data: Cholesterol Management Analysis of Upsher-Smith's Slo-Niacin(R ... - Oct 27, 2009 The objective was to study the lipid and anti-inflammatory effects of Slo-Niacin® 1.5 g/day and Lipitor® (atorvastatin calcium) 10 mg/day, given alone and ... Reuters Pfizer reports 3Q profit rise, revenue drop - Oct 20, 2009 Such drugs as the pain drug Lyrica (pregabalin) and the cholesterol-lowering drug Lipitor (atorvastatin calcium) had strong sales overseas, but primary-care ... Drug Store News (blog) Court Report - Oct 25, 2009 1997) based on Sandoz's filing of an ANDA to manufacture a generic version of Pfizer's Caduet® (atorvastatin calcium -- the active ingredient in ... Patent Docs (blog) Pfizer Sues Unilab Over Lipitor Drug - Oct 23, 2009 Pfizer sells the anti-hypertensive drug under the trade name Lipitor, and its generic name is atorvastatin calcium. Pascual said the patent of Lipitor in ... American Chronicle Brand Names/Synonyms: atorvastatin calcium is also known by the following brand names and/or synonymsAtorvastatin; Atorvastatin Calcium; Atorvastatin Calcium Salt; Atorvastatin, Calcium Salt; CCRIS 7159; CI 981; Cardyl; HSDB 7039; Lipitor; Sotis; Torvast; Tozalip; Xavator Drug Category: atorvastatin calcium is categorized under the following by the FDA: Anticholesteremic Agents; HMG-CoA Reductase Inhibitors; ATC:C10AA05 Dosage Forms: Tablets contain 10, 20, or 40mg atorvastatin Absorption: Atorvastatin is rapidly absorbed after oral administration. The absolute bioavailability of atorvastatin (parent drug) is approximately 14% and the systemic availability of HMG-CoA reductase inhibitory activity is approximately 30%. Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: 7-[2-(4-fluorophenyl)-5-(1-methylethyl)-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl]-3,5-dihydroxy-heptanoicacid |
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