cyclobenzaprine HCL

This page contains recent news articles, when available, and an overview of cyclobenzaprine HCL but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.


Overview:

cyclobenzaprine HCL
(when available)

Pharmacology and use:
Cyclobenzaprine, closely related to the antidepressant amitriptyline, is used as a skeletal muscle relaxant to reduce pain and tenderness to and improve mobility. Unlike dantrolene, cyclobenzaprine cannot be used to treat muscle spasm secondary to cerebral or spinal cord disease. For use as an adjunct to rest and physical therapy for relief of muscle spasm associated with acute, painful musculoskeletal conditions

Mechanism Of Action:
Like the tricyclic antidepressants, cyclobenzaprine exhibits anticholinergic activity, potentiation of norepinephrine, and antagonism of reserpine. Cyclobenzaprine does not directly act on the neuromuscular junction or the muscle but relieves muscle spasms through a central action, possibly at the brain stem level. Cyclobenzaprine binds to the serotonin receptor and is considered a 5-HT2 receptor antagonist that reduces muscle tone by decreasing the activity of descending serotonergic neurons.

News Articles on Cyclobenzaprine

India Ranbaxy gets FDA nod for cyclobenzaprine HCL  -  May 15, 2008
MUMBAI (Reuters) - Indian drugmaker Ranbaxy Laboratories Ltd (RANB.BO) has received approval from the US Food and Drug Administration for muscle relaxant ... Reuters UK

Aurobindo gets USFDA approval for Cyclobenzaprine HCL Tablets  -  Sep 29, 2008
Hyderabad-based Aurobindo Pharma has informed that it has secured approval from US Food and Drug Administration (USFDA) for marketing Cyclobenzaprine ... TopNews

Generics makers keep new products coming.(RX/GENERICS)(Statistical …  -  Sep 17, 2007
Glyburide-Metformin HCl $112943343.72 Teva USA Nabumetone $110522319.55 Danbury Cyclobenzaprine HCl $109782263.07 Mylan Phenytoin Sodium Extended ... Free with registration - Chain Drug Review - AccessMyLibrary.com

Press Release: Arena Pharmaceuticals Announces Positive Phase 2b …  -  Dec 13, 2005
FLEXERIL(R) (cyclobenzaprine HCl) 5 mg tablets, the newly approved muscle relaxant ... shelves across the nation. FLEXERIL 5 mg tablets are a new lower-dose ... Pay-Per-View - PR Newswire - HighBeam Research

… ; US FDA grants approval for cyclobenzaprine HCl tablets for pain...  -  Mar 27, 2006
Cyclobenzaprine HCl Tablets, USP is the generic version of McNeil Consumer & Specialty Pharmaceuticals' Flexeril Tablets, 5 mg. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Ranbaxy gets FDA nod for cyclobenzaprine HCL  -  May 15, 2008
Mumbai, May 15: : Indian drugmaker Ranbaxy Laboratories Ltd has received approval from the US Food and Drug Administration for muscle relaxant ... Financial Express

United States top 250 generic pharmaceuticals by sales, and …  -  Feb 4, 2008
Trinessa 89915565 148 Mylan Cyclobenzaprine HCl 88797108 149 Teva USA Tramadol HCl 88725730 150 Watson Labs. Metformin HCl 88576105 151 Mylan Meloxicam ... $20.00 - Chain Drug Review - Alacra Store

FDA tentative generics approvals--2005.(Special Report)(Illustration)  -  Feb 27, 2006
200 mg Zydus Pharmaceuticals USA Inc. OCTOBER Cyclobenzaprine HCl tablets USP, 5 Amide Pharmaceutical Inc. mg Gatifloxacin tablets 200 mg and 400 Teva ... Free with registration - Chain Drug Review - AccessMyLibrary.com

FDA tentative generics approvals--2005.(Special Report)(Illustration)...  -  Feb 27, 2006
200 mg Zydus Pharmaceuticals USA Inc. OCTOBER Cyclobenzaprine HCl tablets USP, 5Amide Pharmaceutical Inc. mg Gatifloxacin tablets 200 mg and 400 Teva ... Pay-Per-View - Chain Drug Review - HighBeam Research

Press Release: Six-Month Study Evaluated Effectiveness of Aripiprazole...  -  May 25, 2006
FLEXERIL(R) (cyclobenzaprine HCl) 5 mg tablets, the newly approved muscle relaxant ... shelves across the nation. FLEXERIL 5 mg tablets are a new lower-dose ... Pay-Per-View - PR Newswire - HighBeam Research

Press Release: New River Pharmaceuticals Provides Detail on A01 …  -  Jun 18, 2006
FLEXERIL(R) (cyclobenzaprine HCl) 5 mg tablets, the newly approved muscle relaxant ... shelves across the nation. FLEXERIL 5 mg tablets are a new lower-dose ... Pay-Per-View - PR Newswire - HighBeam Research

DJ HUGIN NEWS/Eurand Reports Recent Developments and Second …  -  Aug 7, 2008
EUR-1002 -- Amrix(r) (cyclobenzaprine HCl) * On June 17, 2008, the United States Patent and Trademark Office (USPTO) granted the Company US patent No. ... financial.de

First-Time Generic Approvals: Flexeril, Plavix, and AndroGel  -  Feb 21, 2006
21, 2006 -- The US Food and Drug Administration (FDA) has approved first-time generic formulations of cyclobenzaprine HCl 5-mg tablets for adjunctive use in ... Medscape

Data Shows That ADHD Patients on CONCERTA(R) (Methylphenidate …  -  Jun 28, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete ... $4.95 - PR Newswire - ECNext

Press Release: Mylan Announces Settlement of Paroxetine Hydrochloride...  -  Oct 23, 2007
Cyclobenzaprine HCl ER Capsules, a muscle relaxant ... to IMS Health. Currently, Mylan has 113 ANDAs pending FDA approval ... ... Pay-Per-View - PR Newswire - HighBeam Research

Mylan confirms first-to-file patent challenge of AMRIX capsules  -  Dec 1, 2008
Cyclobenzaprine HCl ER Capsules, a muscle relaxant introduced to the market in October 2007, had approximately $53 million in sales for the twelve months ... News-Medical.net

Athletics: Olympians Help Marathon Runners Prepare For 'Muscle Ache …  -  Jan 6, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete ... RunnersWeb

PRESS RELEASE: Cephalon Announces Agreement to Acquire AMRIX  -  Aug 23, 2007
..."Cyclobenzaprine HCl is the most widely prescribed muscle relaxant in the United States, representing 37 percent of the 45 million prescriptions for muscle ... FierceBiotech

United States top 190 multisource generic drugs ranked by sales in …  -  Sep 29, 2008
Ranitidine HCl 116 Danbury Cyclobenzaprine HCl 117 Barr Desmopressin acetate 118 Ivax Pharm. Fluoxetine HCl 119 Prasco Labs Zolpidem tartrate 120 Watson ... $20.00 - Chain Drug Review - Alacra Store

Acetaminophen Provides Pain Relief Equal to Ibuprofen in Treatment of...  -  Jun 4, 2005
Prescription products include CONCERTAо (methylphenidate HCl) and FLEXERILо (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete lines of ... Medical News Today - Medical News Today (press release)

Article: Top 190 multisource generics by manufacturer and NDC11 …  -  Sep 29, 2008
Ranitidine HCl 116Danbury Cyclobenzaprine HCl 117BarrDesmopressin acetate 118Ivax Pharm. Fluoxetine HCl 119Prasco Labs Zolpidem tartrate 120Watson Labs ... Pay-Per-View - Chain Drug Review - HighBeam Research

Acetaminophen, When Taken As Directed, is Safe for Patients With...  -  Mar 17, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... RedOrbit

Stock Commentary - New York - week to August 27, 2007.  -  Sep 3, 2007
Analysts at Robert W Baird like Cephalon's plan to buy North American marketing rights to Amrix (cyclobenzaprine HCl extended-release capsules) for $100.0 ... Free with registration - Pharma Marketletter - AccessMyLibrary.com

New Data Presented at European Society of Cardiology Congress 2005 …  -  Sep 6, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... RedOrbit

Acetaminophen, When Taken as Directed, is Safe for Patients with...  -  Mar 20, 2005
Prescription products include CONCERTA® ( methylphenidate HCl extended-release tablets ) and FLEXERIL® ( cyclobenzaprine HCl 5 mg tablets ). ... i-newswire.com

New Survey Indicates Majority of Americans Suffer from 'Sleep Slump'.  -  Mar 17, 2006
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... Free with registration - PR Newswire - AccessMyLibrary.com

Parents May Not Be Aware of FDA Guidelines for Treating Children With...  -  Sep 8, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... $4.95 - PR Newswire - ECNext

Press Release: Cephalon, Inc. Announces Agreement to Acquire AMRIX, …  -  Aug 23, 2007
..."Cyclobenzaprine HCl is the most widely prescribed muscle relaxant in the United States, representing 37 percent of the 45 million prescriptions for muscle ... Pay-Per-View - PR Newswire - HighBeam Research

Multisport: The Makers Of Tylenolо Name Chris Carmichael As …  -  Feb 3, 2005
Prescription products include CONCERTAо (methylphenidate HCl) and FLEXERILо (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete lines of ... RunnersWeb

Press Release: Abbott's Investigational SIMCOR(R) Offers Comparable …  -  Nov 4, 2007
FLEXERIL(R) (cyclobenzaprine HCl) 5 mg tablets, the newly approved muscle relaxant ... shelves across the nation. FLEXERIL 5 mg tablets are a new lower-dose ... Pay-Per-View - PR Newswire - HighBeam Research

McNeil Consumer & Specialty Pharmaceuticals Announces Agreement …  -  Sep 1, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) [CII] for attention deficit hyperactivity disorder and FLEXERIL(R) (cyclobenzaprine HCl) 5 ... $4.95 - PR Newswire - ECNext

Eurand Reports Fourth Quarter and Year-end 2007 Key Achievements …  -  Mar 6, 2008
Eurand also provided an update on Amrix(r) (cyclobenzaprine HCl), the only once-daily skeletal muscle relaxant which Eurand developed that is currently ... Lifescience-online

Factiva Search  -  Mar 28, 2006
Pain Management; U.S. FDA grants approval for cyclobenzaprine HCl tablets for pain relief. 28 March, 2006 Science Letter ... Pay-Per-View - Science Letter - Factiva, from Dow Jones

How effective are muscle relaxers?  -  Aug 10, 2008
Cyclobenzaprine hcl has the most recent and largest clinical trials demonstrating its benefit, but , diazepam and metaxalone also appear to be effective. ... MedIndia

POTPOURRI; Shoulder pain usually worsens without treatment | Article ...  -  Jan 19, 2006
...cyclobenzaprine HCL (Flexerill); anti-seizure medications like gabapentin (Neurontin); or Ultracet, a drug which combines the pain reliever tramadol ... Pay-Per-View - Filipino Reporter - HighBeam Research

Eurand to Be Issued US Patent for Amrix(R)  -  Jun 3, 2008
According to IMS, Cyclobenzaprine HCl is the most widely prescribed muscle relaxant in the US, representing 37 percent of the 45 million prescriptions ... RedOrbit

Tylenol(R) Awards $250,000 to Outstanding Healthcare Students.  -  Jan 20, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete ... $4.95 - PR Newswire - ECNext

Factiva Search  -  Mar 28, 2006
Pain Management; U.S. FDA grants approval for cyclobenzaprine HCl tablets for pain relief. 28 March, 2006 Life Science Weekly ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Press Release: Mylan Confirms First-to-File Patent Challenge Relating...  -  Dec 1, 2008
Cyclobenzaprine HCl ER Capsules, a muscle relaxant introduced to the market in October 2007, had approximately $53 million in sales for the twelve months ... Pay-Per-View - PR Newswire - HighBeam Research

McNeil Consumer & Specialty Pharmaceuticals Statement Regarding …  -  Sep 13, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete ... $4.95 - PR Newswire - ECNext

Expiration Dates Observed on Foods, But Not Always on Medications.  -  Sep 20, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl extended-release tablets) and FLEXERIL(R) (cyclobenzaprine HCl 5 mg tablets). ... $4.95 - PR Newswire - ECNext

Press Release: McNeil Consumer & Specialty Pharmaceuticals Statement …  -  Sep 13, 2005
Prescription products include CONCERTA(R) (methylphenidate HCl) and FLEXERIL(R) (cyclobenzaprine HCl) 5 mg. The company's OTC products include complete ... Pay-Per-View - PR Newswire - HighBeam Research

VGS Acquisition Corp acquires Fortes Financial Inc (pending) - Deal …  -  May 16, 2008
Muscle Relaxing Agents Products: Parafon Forte DSC (Chlorzoxazone) Flexeril (Cyclobenzaprine HCL…Scientific ChoICE Standard Boston Scientific Forte Boston ... Pay-Per-View - deals - Alacra Store

Mylan confirms first-to-file Amrix patent challenge.  -  Dec 8, 2008
...filing of an Abbreviated New Drug Application for cyclobenzaprine HCl extended-release capsules, 15mg and 30mg, the generic version of Amrix capsules. ... $9.94 - Pharma Marketletter - Alacra Store

Back Pain; Snow shoveling is a leading cause of back pain  -  Jan 17, 2005
On average, nearly 6 in 10 physicians (58%) say they prescribe a muscle relaxant, such as Flexeril (cyclobenzaprine HCl) 5 mg, at some point during therapy. ... Pay-Per-View - Health & Medicine Week - Factiva, from Dow Jones

Back Pain; Snow shoveling is a leading cause of back pain  -  Jan 23, 2005
On average, nearly 6 in 10 physicians (58%) say they prescribe a muscle relaxant, such as Flexeril (cyclobenzaprine HCl) 5 mg, at some point during therapy. ... Pay-Per-View - Medical Devices & Surgical Technology... - Factiva, from Dow Jones

Article: Dr Scott's surgery.(News) - Evening Chronicle (Newcastle, …  -  Apr 25, 2005
Article: Lower-dose Flexeril (cyclobenzaprine HCl) approved for ... Biotech Week; March 5, 2003 ; 700+ words ... ... and physical therapy for the relief of ... Pay-Per-View - Evening Chronicle - HighBeam Research

Brand Names/Synonyms:
cyclobenzaprine HCL is also known by the following brand names and/or synonymsCyclobenz; Cyclobenzaprine; Cyclobenzaprine Hcl; Flexeril; Flexiban; MK-130; Proeptatriene; Proheptatriene; RP-9715

Drug Category:
cyclobenzaprine HCL is categorized under the following by the FDA: Tranquilizing Agents; Muscle Relaxants; Antidepressants; Skeletal Muscle Relaxants; ATC:M03BX08

Dosage Forms:
D-shaped, film coated tablets

Absorption:
Well absorbed after oral administration

Interactions:
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Chemical IUPAC Name:
3-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-N,N-dimethyl-1-propanamine





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