mercaptopurine

This page contains recent news articles, when available, and an overview of mercaptopurine but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Myelosuppression Risk During Thiopurine Therapy Is Concern In patients with ...  -  ‎Dec 11, 2009‎
...and colleagues analyzed data from 1997 patients with inflammatory bowel disease who were new users of azathioprine or 6-mercaptopurine. ... ModernMedicine

Milk Thistle Cuts Liver Toxicity from ALL Chemotherapy  -  ‎Dec 14, 2009‎
So Kelly and colleagues assigned 50 children receiving treatment for ALL with a regimen of vincristine, methotrexate, 6-mercaptopurine or thioguanine, ... MedPage Today

The Genome Generation  -  ‎Dec 15, 2009‎
...the heart condition called long QT syndrome (beta blockers) and cancer (imatinib, irinotecan, 5-fluorouracil, mercaptopurine, or tamoxifen). ... Newsweek

Police trying to trace prescription drugs in handbag  -  ‎Nov 7, 2009‎
It contained a small brown bottle of Mercaptopurine, which is used to treat Crohn's disease. The tablets are dangerous if taken by anyone who is not ... Stoke & Staffordshire

IBD Drugs May Raise Skin Cancer Risk  -  ‎Oct 27, 2009‎
...“Thiopurines are mercaptopurine (Purinethol) and axathioprine (Imuran)�; “Biologics include imfliximab (Remicade) and others,� said WebMD. ... Newsinferno.com

ACG: Study Marks 10-Year History of Anti-TNF Therapy for Crohn's  -  ‎Oct 30, 2009‎
The patients received a variety of concomitant medications, the most common being prednisone (79%), azathioprine (72%), 6-mercaptopurine (34%), ... MedPage Today

Inflammatory bowel disease treatment increases risk of infection-related cancers  -  ‎Oct 20, 2009‎
The thiopurine azathioprine and its metabolite, 6-mercaptopurine, are used for their immunosuppressive properties to maintain remission in IBD. ... ecancermedicalscience

ULORIC(R) (febuxostat) Demonstrated Efficacy for Management of Hyperuricemia ...  -  ‎Oct 19, 2009‎
Important Safety Information -- ULORIC is contraindicated in patients being treated with azathioprine, mercaptopurine, or theophylline. ... PR-CANADA.net (press release)

有些IBD藥物會增加皮膚癌風險  -  ‎Nov 4, 2009‎
...巰基嘌呤藥物包括mercaptopurine(商å“?å??Purinethol)與azathioprine(商å“?å??Imuran)。生物製劑藥物,包括infliximab(商å“?å??Remicade)與其他。 * 長期使用,定義為使用1å¹´ ... 臺灣新浪網

Value of intravenous 6-mercaptopurine during continuation treatment...  -  Mar 3, 2005
Correspondence: Dr J Otten, Department of Pediatrics, Vrije Universiteit Brussel, Laarbeeklaan 101, 1090 Brussels, Belgium. Fax: +32 2 4775783; ... Nature.com

Chromosomal change during 6-mercaptopurine (6-MP) therapy in …  -  Oct 19, 2005
Among 11 JMML children, two had an abnormal karyotype, and nine had a normal karyotype at onset. In one patient with trisomy 8 and four patients with a ... Nature.com

Hepatotoxicity of 6-Mercaptopurine (6-MP) and Azathioprine (AZA) in …  -  May 14, 2006
Correspondence: Tram T Tran, MD, Cedars-Sinai Medical Center, 8635 West 3rd Street Suite 590, Los Angeles, CA 90048. 6-Mercaptopurine (6-MP) and ... Nature.com

No Advantage Found for 6-Thioguanine in Childhood ALL  -  Oct 13, 2006
So it emerged in a randomized trial comparing 6-mercaptopurine, the standard ... They concluded that 6-mercaptopurine should remain the thiopurine of choice ... MedPage Today

Infliximab Injection Side Effects from Consumer Reports Health.  -  Jan 4, 2007
These patients were also taking azathioprine (Imuran) or 6-mercaptopurine (Purinethol) when they developed this cancer. Your doctor or pharmacist will give ... consumerreports.org

Mylan Receives Approval for Mercaptopurine Tablets USP, 50 Mg  -  Jul 7, 2005
PITTSBURGH, July 7 /PRNewswire-FirstCall/ -- Mylan Laboratories Inc. today announced that the US Food and Drug Administration has granted approval for Mylan ... RedOrbit

Prophylthiouracil still confused with Purinethol (mercaptopurine).  -  Aug 11, 2008
Prophylthiouracil still confused with Purinethol (mercaptopurine). Medication errors continue to occur between the established name propylthiouracil, ... $9.94 - Drug Topics - Alacra Store

Dr. Paul Donohue .  -  Sep 16, 2005
Azathioprine and mercaptopurine are medicines directed toward con trolling the errant immune tern. Introduction of new medicines has brought hope to those ... Free-Lance Star - Google News Archive

Genotype and prognosis in childhood leukaemia  -  Apr 2, 2005
Thiopurine drugs such as mercaptopurine and thioguanine are used to treat malignancies such as acute lymphoblastic leukemias (ALLs), as well as rheumatic ... PHG Foundation

Is it possible to modify the clinical course of Crohn's disease?  -  Mar 4, 2008
In contrast to corticosteroids, azathioprine, mercaptopurine, methotrexate, ... (2000) A multicenter trial of 6-mercaptopurine and prednisone in children ... Nature.com

MyFox Wausau | Purinethol - Uses, Side Effects, Interactions,...  -  Mar 9, 2007
Mercaptopurine belongs to the group of cancer-fighting medications known as ... Mercaptopurine fights cancer by preventing the growth of cancer cells, ... MyFox Wausau

Evidence-Based Medicine (EBM) in Practice: Understanding Tests of …  -  Mar 22, 2005
Furthermore, an 18-month randomized trial of 6-mercaptopurine versus placebo ... Azathioprine, mercaptopurine and birth outcome: A population-based study. ... Nature.com

Pro32Thr Polymorphism of Inosine Triphosphate Pyrophosphatase Gene …  -  Aug 19, 2008
1,2,3 AZA is converted via a non-enzymatic reaction to 6-mercaptopurine, ... 15 AZA might be converted to 6-mercaptopurine non-enzymatically in patients ... Nature.com

Immunomodulators for inflammatory bowel disease  -  Oct 9, 2008
Immunomodulator medicines, such as azathioprine (AZA), 6-mercaptopurine (6-MP), ... It may take 4 months or more for azathioprine (AZA) and 6-mercaptopurine ... WebMD

Therapy Insight: the use of antirheumatic drugs during nursing  -  Nov 8, 2006
Azathioprine and its principal metabolite 6-mercaptopurine are metabolized ... Levels of 6-mercaptopurine were studied in the breast milk of five patients ... Nature.com

Using HapMap Tools in Pharmacogenomic Discovery: The Thiopurine …  -  Nov 7, 2006
Thiopurine medications such as mercaptopurine, thioguanine, and azathioprine are ... Mercaptopurine therapy intolerance and heterozygosity at the thiopurine ... Nature.com

Treatment outcome in adults with acute lymphoblastic leukemia: 50% …  -  May 24, 2007
Consolidation was daunorubicin, cytarabine and 6-thioguanine, followed by two courses of high-dose methotrexate and 6-mercaptopurine orally for 7 weeks. ... Nature.com

IMPDH1 promoter mutations in a patient exhibiting azathioprine …  -  Oct 17, 2006
Pharmacokinetics of 6-mercaptopurine in patients with inflammatory bowel ... Pharmacogenomics and metabolite measurement for 6-mercaptopurine therapy in ... Nature.com

The role of maintenance chemotherapy after autotransplantation for...  -  Apr 14, 2008
In total 70 patients received 6-mercaptopurine, 53 received methotrexate and 40 received vincristine-prednisone. The cumulative incidence of relapse at 7 ... Nature.com

Long-term molecular complete remission with IFN- in Ph+ adult acute …  -  Feb 14, 2008
...patients aged 55 years received standard maintenance treatment for 6 months (alternating vincristine/prednisone with methotrexate/6-mercaptopurine). ... Nature.com

Combined oral and topical mesalazine treatment for extensive ulcerativ...  -  Nov 30, 2005
Azathioprine or 6-mercaptopurine are often used as adjunctive agents to obtain or ... 5 Steroids, 5-ASAs, azathioprine, mercaptopurine, ciclosporin, ... Nature.com

Outcome of Surgical Versus Percutaneous Drainage of Abdominal and …  -  May 3, 2006
The use of immunomodulators (6-mercaptopurine, azathioprine, ... Two of the five patients on 6-mercaptopurine/azathioprine subsequently required bowel ... Nature.com

Gene expression overlap affects karyotype prediction in pediatric...  -  Apr 5, 2007
A comparison of early intensive methotrexate/mercaptopurine with early intensive alternating combination chemotherapy for high-risk B-precursor acute ... Nature.com

New tacks to reduce outpatient chemo errors.(PROFESSIONAL …  -  Oct 23, 2006
Description of prescribing errors Indicated Prescribed and medication dose * administered medication * Mercaptopurine, Mercaptopurine, 100 mg daily 112 mg ... $4.95 - Drug Topics - ECNext

Treatment of Children With Acute Lymphocytic Leukemia  -  Aug 19, 2007
Most treatment plans use methotrexate and 6-mercaptopurine, given as pills, often along with vincristine, which is given intravenously, and a steroid ... ACS News Center

Crohn's Disease Medications - Crohn's Disease Health Information - NY...  -  Feb 20, 2008
Azathioprine (Imuran, Azasan) and 6-mercaptopurine (6-MP, Purinethol) are the ... These drugs are quicker-acting than azathiopine and 6-mercaptopurine. ... New York Times

Toxic hepatitis  -  Dec 17, 2008
Mercaptopurine is used to treat certain types of cancer. Both can cause liver damage. This usually occurs soon after starting on the drugs, but the damage ... CNN International

Induction and Maintenance in Luminal/Fistulizing Crohn's Disease  -  Jun 15, 2006
The immunosuppressive agents 6-mercaptopurine or azathioprine, in addition to broad-spectrum antibiotics, are first-line therapies for fistulizing disease. ... Medscape

How useful is thiopurine metabolite monitoring in pediatric inflammato...  -  Aug 2, 2007
Azathioprine and 6-mercaptopurine (6-MP) are effective drugs for inducing remission in patients with IBD. These drugs are metabolized to 6-thiouric acid, ... Nature.com

Are children with lesser-risk B-lineage acute lymphoblastic leukemia ...  -  Sep 6, 2007
From weeks 15 to 130, continuation therapy was given with oral 6-mercaptopurine (75 mg/m 2 daily), intramuscular methotrexate (20 mg/m 2 weekly), ... Nature.com

Ulcerative colitis  -  Oct 4, 2005
Azathioprine (Imuran) and mercaptopurine (Purinethol). ... Because azathioprine and mercaptopurine act slowly, they're sometimes initially combined with a ... cnn.com

A case of acute loss of vision as the presenting symptom of Crohn's …  -  Mar 6, 2007
Once remission was achieved, it was maintained with mercaptopurine. ... Maintenance therapy with mercaptopurine (6MP) was prescribed at 1 mg/kg body ... Nature.com

New frontiers: if you're not yet familiar with immunopharmacology, …  -  Mar 1, 2006
The antileukemia drug mercaptopurine (Purinethol) is one example. Because of genetic variations that alter the enzyme thiopurine methyltransferase, ... Pay-Per-View - RN - Factiva, from Dow Jones

Treatment for Ulcerative Colitis - WebMD  -  Nov 3, 2008
6-mercaptopurine [6-MP], or cyclosporine) or infliximab to suppress your immune system. But steroids are usually not used as long-term therapy. ... WebMD

Infliximab-induced disseminated histoplasmosis in a patient with...  -  Nov 29, 2007
The patient had been receiving antimetabolite therapy with 6-mercaptopurine and maintenance therapy with infliximab for over a year. ... Nature.com

Pharmacovigilance in a genomic era  -  Jan 17, 2006
27 As adverse drug responses to mercaptopurine and thioguanine can be fatal, there has been significant attention focused on the use of genetic testing ... Nature.com

Heterozygosity at the TPMT gene locus, augmented by mutated MTHFR …  -  Nov 6, 2008
The clinical relevance of 6-mercaptopurine (6-MP) dose reduction in prevention of thiopurine-induced toxicity is well established in patients homozygous for ... Nature.com

Pediatric Cancer Cases Trigger FDA Safety Review of TNF Blockers  -  Jun 4, 2008
TNF blockers (along with other immunosuppressive medicines such as methotrexate, azathioprine or 6-mercaptopurine), when they were ages 18 or less." ... MedPage Today

Abnormal Hepatic Biochemistries in Patients With Inflammatory Bowel …  -  Jun 5, 2006
The use of other medications, such as sulfasalazine, corticosteroids, azathioprine/6-mercaptopurine, methotrexate, and infliximab did not differ between the ... Nature.com

INFLIXIMAB (Injection route, Intravenous route) - in-FLIX-i-mab.(Drug...  -  May 1, 2007
They were also taking azathioprine or 6-mercaptopurine. The connection between infliximab and this cancer is unclear. Many medicines have not been studied ... Free with registration - USP DI-Volume II, Advice for the... - AccessMyLibrary.com

Business & Finance; Pharmaceutical company announces preliminary …  -  Aug 9, 2005
Mercaptopurine Tablets, which are the generic version of Teva Pharmaceuticals' Purinethol Tablets, 50 mg, had North American sales of approximately $89.5 ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Salicylates may cause diarrhea in ulcerative colitis patients.(Digesti...  -  Apr 15, 2007
For immunomodulator treatment of ulcerative colitis, Dr. Sandier prefers either 6-mercaptopurine or azathioprine. But he cautioned that patients who start ... Free with registration - Family Practice News - AccessMyLibrary.com

Recommended Treatments For Fistulas In Crohn's Disease  -  May 8, 2006
Immunomodulators such as azathioprine and 6-mercaptopurine, or methotrexate should be given early in the disease. They are an effective agent both in ... Medical News Today - Medical News Today (press release)

Corticosteroids Linked to Increased Mortality Rate in IBD  -  Jun 24, 2008
..."Corticosteroids, azathioprine (AZA), 6-mercaptopurine (6-MP), methotrexate, and antitumor necrosis factor (TNF)-α agents are effective and widely used to ... Medscape

Article: Lean, mean, glean machine - Jerusalem Post | HighBeam …  -  Feb 25, 2005
Article: WIPO: Inventors in Israel Develop Novel Mercaptopurine ... US Fed News Service, Including US State News; October 16, 2008 ; 414 words . ... Pay-Per-View - Jerusalem Post - HighBeam Research

Health Canada Endorsed Important Safety Information on Remicade ( …  -  Jul 27, 2006
Both azathioprine and 6-mercaptopurine are known mutagens, and azathioprine has been classified as a human carcinogen.3 There have also been three reports ... DG News

What are the pulmonary manifestations of inflammatory bowel disease? ...  -  Jun 1, 2007
6-Mercaptopurine Mesalamine Methotrexate Methylprednisolone Netilmicin Prednisone Sulfasalazine --- REFERENCES 1. Greenstein AJ, Janowitz HD, Sachar DB. ... $4.95 - Journal of Respiratory Diseases - ECNext

Infliximab: hepatosplenic T cell lymphoma.(Safety and Efficacy Issues)  -  Jun 22, 2006
Both azathioprine and 6-mercaptopurine are known mutagens, and azathioprine has been classified as a human carcinogen. In Canada, approximately 38 000 ... Free with registration - WHO Drug Information - AccessMyLibrary.com

Ulcerative colitis guidelines favor combo Rx.(Gastroenterology)(Clinic...  -  Feb 1, 2007
Relapses during steroid treatment can be treated with azathioprine and 6-mercaptopurine. Virtually all patients require maintenance therapy, and the goal is ... $4.95 - Internal Medicine News - ECNext

The laboratory's role in pharmacogenetic testing.  -  May 1, 2008
Many laboratories now offer this test as a preventive measure for patients receiving azathioprine or 6-mercaptopurine. TPMT inactivates both of these drugs, ... $9.94 - Medical Laboratory Observer - Alacra Store

NOD2/CARD15 Gene Variants Are Linked to Failure of Antibiotic …  -  May 22, 2007
Concomitant therapy with azathioprine/6-mercaptopurine (AZA/6-MP) and ... Treatment of Crohn's disease with 6-mercaptopurine: A long-term, ... Nature.com

A Special Drug Just for You, at the End of a Long Pipeline  -  Nov 8, 2005
One of the oldest examples of a pharmacogenetic test is for 6-mercaptopurine, or 6MP, a drug used to some forms of childhood leukemia and inflammatory bowel ... New York Times

Crohn Disease; Treatments for fistulas in Crohn disease presented, …  -  May 31, 2006
Immunomodulators such as azathioprine and 6-mercaptopurine, or methotrexate should be given early in the disease. They are an effective agent both in ... Pay-Per-View - Life Science Weekly - Factiva, from Dow Jones

Lymphomes sévères observés avec Remicade® (infliximab) associé à …  -  Jun 15, 2006
Des cas de lymphomes spécifiques et sévères touchant le foie et la rate ont été observés aux Etats-Unis chez quatre enfants et deux jeunes adultes atteints ... InformationHospitaliere.com

New age of medicine: Treatment tailored to your DNA, enzymes  -  Nov 13, 2005
One of the oldest examples of a pharmacogenetic test is for 6-mercaptopurine, or 6MP, a drug used to treat some forms of childhood leukemia and inflammatory ... San Francisco Chronicle

Arsenic trioxide boosts survival in leukemia  -  Jun 4, 2007
Patients who achieved remission progress to maintenance therapy with all-trans retinoic acid with or without 6-mercaptopurine and methotrexate for 1 year. ... Reuters UK

5-ASA, '국한ë?œ 궤양성 대장염-궤양성 ì§?장염'ì—? 효과  -  Jan 2, 2008
...잘 알려진 대로 스테로�드는 관해를 유지하는 ��는 효과가 없기 때문� 스테로�드 �존성�나 저항성� 궤양성 대장염� 경우 azathioprine�나 6-mercaptopurine ... 디지틀보사

Role of chelates in treatment of cancer.(Drug overview)  -  Apr 1, 2007
...*Cytotoxic action of palladium and platinum complexes[sup] [51] of 6-mercaptopurine and thioguanine - Pd(MP)[sub] 2*2H[sub] 2 O, Pt(MP)[sub] 2 H[sub] 2 O ... Free with registration - Indian Journal of Cancer - AccessMyLibrary.com

Dr. Charlotte Tan, 84, Oncologist, Dies  -  Apr 6, 2008
With Dr. Burchenal and others, Dr. Tan held clinical trials of the drug 6-mercaptopurine, which suppresses the body's immune response and has since been ... New York Times

Press Release: Research and Markets: World Market for Colony …  -  May 3, 2005
Article: Azathioprine/mercaptopurine: Myelosuppression, treated with ... Reactions Weekly; October 25, 2008 ; 496 words ... ... mercaptopurine, respectively ... Pay-Per-View - PR Newswire - HighBeam Research

M. Lois Murphy, 91, Dies; Leader in Cancer Research  -  Apr 27, 2008
...cancer specialists, she helped test the safety and effectiveness of 6-mercaptopurine, which turned out to be signally effective in treating leukemia. ... New York Times

Clinical Trials Update: Nov. 24, 2008  -  Nov 24, 2008
...treated with or have failed treatment with: oral 5-aminosalicylates, oral corticosteroids, 6-mercaptopurine, or Imuran, you may qualify for this study. ... ABC News

Dr. Joseph H. Burchenal, 93, Who Devised Cancer-Drug Therapy, Dies  -  Mar 16, 2006
An early success involved the treatment of leukemia in children with the compound 6-mercaptopurine. Dr. Burchenal and other researchers found that the drug, ... New York Times

Crohn's patients plea for study  -  Nov 15, 2008
The study will test whether a drug, 6-Mercaptopurine (6-MP), which is currently given to ease symptoms of an attack, could also be used to prevent ... BBC News

Antibiotics and flare of inflammatory bowel disease: threat or...  -  Jun 24, 2005
A flare was defined as a new prescription for corticosteroids, mesalamine, azathioprine or 6-mercaptopurine following a period of four months without a ... Nature.com

Therapeutic research in untreated acute promyelocytic leukemia  -  Apr 21, 2005
6 mercaptopurine (6MP) and methotrexate. The rationale for such prolonged maintenance is the European APL group's demonstration, in their APL93 study, ... Nature.com

Artist transformed daughter's leukemia fight into images in clay  -  Sep 3, 2008
It's filled with a detailed list of procedures and pills, with long, scary names such as doxorubicin, mercaptopurine and methotrexate. ... Virginian-Pilot - Virginian Pilot

Late first relapses in APL treated with all-trans-retinoic acid- and ...  -  Mar 16, 2006
1, 2 With maintenance combining continuous 6-mercaptopurine (6MP) and methotrexate (MTX) to intermittent ATRA and possibly with early introduction of ... Nature.com

Prolonged molecular remission in PML-RAR-positive acute promyelocytic...  -  Jul 21, 2005
She was kept on ATRA until day 152 following documentation of molecular remission and then commenced on maintenance with 6-mercaptopurine (6-MP, ... Nature.com

Thiopurine-Induced Myelotoxicity in Patients With Inflammatory Bowel ...  -  Nov 14, 2007
Probably, the most important and potentially lethal adverse event of azathioprine (AZA) and mercaptopurine (MP) is myelosuppression. ... Nature.com

What is the optimal management approach for pediatric patients with …  -  May 2, 2008
5 Additionally, more than 60% of pediatric patients with ulcerative colitis who need corticosteroid treatment are now treated with 6-mercaptopurine early in ... Nature.com

Pharmacogenomics: methods and protocols  -  May 16, 2006
...with the most quoted examples being thiopurine methyltransferase (TPMT) genotype affecting the metabolism of mercaptopurine, and association between the ... Nature.com

A Comprehensive Approach to Evaluate Nutritional Status in Crohn's …  -  Jan 31, 2007
Immunossuppression with azathioprine or 6-mercaptopurine is now a common practice in corticosteroids-dependent patients or in those who relapse more than ... Nature.com

Frequency and risk factors for thrombosis in idiopathic myelofibrosis:...  -  Nov 24, 2005
...erythropoietin (20 patients), prednisone (15 patients), 6-mercaptopurine (10 patients), anagrelide (five patients), interferon alpha (five patients), ... Nature.com

Ulcerative Colitis - Medications  -  Nov 3, 2008
For severe cases, stronger treatment with medicines that suppress the immune system (such as azathioprine [AZA], 6-mercaptopurine [6-MP], or cyclosporine), ... WebMD

Outcomes after HLA-matched sibling transplantation or chemotherapy in...  -  Nov 22, 2007
Continuation therapy for both protocols included daily 6-mercaptopurine and weekly intramuscular methotrexate for 6 weeks alternating with 4-weekly ... Nature.com

Is there a role for apheresis in gastrointestinal disorders?  -  Jan 14, 2005
10 In another preliminary study we confirmed that biweekly treatment of GCAP was as effective as 6-mercaptopurine in maintaining remission of ulcerative ... Nature.com

Therapy-related, donor-derived AML responding to a second allogeneic ...  -  Jun 25, 2007
The boy was treated with dexamethasone, vincristine, L-asparaginase, cytarabine, CY, methotrexate, 6-mercaptopurine, teniposide (1000 mg/m 2 ) and etoposide ... Nature.com

Cytomegalovirus Is Frequently Reactivated and Disappears Without …  -  Feb 5, 2006
...conventional immunosuppressive therapies for UC, such as prednisolone (PSL), cyclosporine A (CsA), 6-mercaptopurine (6-MP), and apheresis ( 20,21 ). ... Nature.com

Right prescription may be in your genes.  -  Oct 25, 2005
And in rare cases, the usually safe dose of mercaptopurine, a drug used to treat leukemia, can cause the death of a child who has an unusual change in a ... Free with registration - Kansas City Star - AccessMyLibrary.com

Methotrexate Following Unsuccessful Thiopurine Therapy in Pediatric …  -  Apr 24, 2007
The thiopurines, azathioprine and 6-mercaptopurine, are traditional first-line immunomodulatory agents in adult and pediatric Crohn's disease, ... Nature.com

Overt testicular disease at diagnosis of childhood acute lymphoblastic...  -  Jun 23, 2005
Consolidation therapy consisted of daily oral administration of 6-mercaptopurine and weekly administration of high-dose methotrexate (2 g/m 2 ) for 2 weeks. ... Nature.com

Crohn's colitis versus ulcerative colitis: should surveillance for...  -  Oct 29, 2008
...(1999) Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine. Am J Gastroenterol 94: 3248–3253 | Article | PubMed ... Nature.com

Crohn's disease  -  Oct 9, 2008
...colitis that has not improved (refractory disease) when treated with corticosteroids, aminosalicylates, antibiotics, azathioprine, or 6-mercaptopurine. ... WebMD

Cyclosporine for inflammatory bowel disease  -  Nov 3, 2008
Cyclosporine tends to work more quickly than other immunosuppressive medicines, such as azathioprine or 6-mercaptopurine, during an acute attack of IBD. 1 ... WebMD

Therapeutic Drug Use in Women With Crohn's Disease and Birth …  -  Jul 4, 2006
...for CD medication: no drugs (reference group), 5-aminosalicylic acid (5-ASA)/sulfasalazine, steroids, and azathioprine (AZA)/6-mercaptopurine (6-MP). ... Nature.com

A case of fistulizing Crohn's disease and erythema nodosum managed …  -  Oct 5, 2007
She was on no medications during remission of her Crohn's disease owing to a history of interstitial pneumonitis whilst on 6-mercaptopurine, intolerance to ... Nature.com

Cost-Effectiveness of 5-Aminosalicylic Acid Therapy for Maintenance...  -  Oct 23, 2006
In both arms, the failure to induce remission led to other treatments, as needed: prednisone, parenteral corticosteroids, cyclosporine, 6-mercaptopurine, ... Nature.com

Should probiotics be given as an adjunct to standard maintenance …  -  Oct 17, 2005
...months before the study, probiotic supplement use <30 days before the study and the use immunomodulating agents except azathioprine or 6-mercaptopurine. ... Nature.com

Cancer Health Center  -  Nov 26, 2008
Later treatment can include ATRA with or without methotrexate and 6-mercaptopurine. Or if a first round of ATRA and chemotherapy does not work, ... WebMD

Risk factors of central venous lines-related thrombosis in children...  -  Feb 1, 2007
...doses of 5000 UI/m 2 , every 3 days) and intrathecal (IT) chemotherapy, followed by 6-mercaptopurine, cytarabine, cyclophosphamide and IT chemotherapy. ... Nature.com

Karyotypic abnormalities create discordance of germline genotype and ...  -  Jul 24, 2005
...were measured in leukemia cells collected 20 h after start of an intravenous infusion of mercaptopurine (1 gm -2 ) in 76 individuals with B-lineage ALL. ... Nature.com

Risk factors for and management of sirolimus-associated pneumonitis...  -  Dec 31, 2007
...(2007) Severe pulmonary toxicity after azathioprine/6-mercaptopurine initiation for the treatment of inflammatory bowel disease. J Clin Gastroenterol 41: ... Nature.com

Incidence of adverse reactions to azathioprine in patients with Crohn'...  -  Jul 15, 2005
Exclusion criteria included 6-mercaptopurine therapy, a history of adverse reactions to azathioprine and coexistent Crohn's disease or autoimmune hepatitis. ... Nature.com

Presentation and Disease Course in Early- Compared to Later-Onset …  -  Jan 1, 2008
The 6–17 yr of age patients were more likely to be treated with antibiotics (P < 0.001), 6-mercaptopurine/azathioprine (P < 0.001), infliximab (P= 0.001), ... Nature.com

A Randomized Prospective Trial of Endoscopic Ultrasound to Guide …  -  Dec 26, 2007
Medical treatment was maximized with 6-mercaptopurine (1.0–1.5 mg/kg) or azathioprine (2.0–2.5 mg/kg), ciprofloxacin (1000 mg a day) or metronidazole (1500 ... Nature.com

Crohn's disease researchers in plea for study volunteers  -  Nov 17, 2008
This new study at the university will test whether a drug, 6-Mercaptopurine (6-MP), which is currently given to ease symptoms of an attack, could also be ... Scotsman

Adult ALL: treatment outcome and prognostic factors in an Indian …  -  Jun 7, 2007
The final maintenance consisted of daily mercaptopurine (6-MP) and weekly oral MTx for 24 months. This maintenance was intensified with monthly pulses of ... Nature.com

A 36 year-old male with ulcerative colitis and renal failure <!-...  -  Nov 11, 2007
He was treated in the past with steroids, Remicade (infliximab), and 6-mercaptopurine (6-MP). More recently he was treated with Asacol (mesalamine) that was ... Nature.com

Side effects could be genetic  -  Jun 13, 2007
St. Jude's been using pharmacogenetics for more than 13 years to determine a safe dose of the anti-leukemia medicine drug Mercaptopurine. ... Memphis Commercial Appeal





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