nefazodone hydrochloride

This page contains recent news articles, when available, and an overview of nefazodone hydrochloride but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.

Overview:

nefazodone hydrochloride (when available)

Pharmacology and use:
Nefazodone, an antidepressant synthetically derived phenylpiperazine, is used to treat major depression. Although it is structurally similar to trazodone, nefazodone has a mechanism of action different from other antidepressants and, hence, lacks the risk for major cardiovascular toxicity seen with tricyclics and insomnia and inhibition of REM sleep seen with the selective serotonin reuptake inhibitors. For the treatment of depression

Mechanism Of Action:
Within the serotonergic system, nefazodone acts as an antagonist at type 2 serotonin (5-HT₂) post-synaptic receptors and, like fluoxetine-type antidepressants, inhibits pre-synaptic serotonin (5-HT) reuptake. These mechanisms increase the amount of serotonin available to interact with 5-HT receptors. Within the noradrenergic system, nefazodone inhibits norepinephrine uptake minimally. Nefazodone also antagonizes alpha(1)-adrenergic receptors, producing sedation, muscle relaxation, and a variety of cardiovascular effects. Nefazodone's affinity for benzodiazepine, cholinergic, dopaminergic, histaminic, and beta or alpha(2)-adrenergic receptors is not significant.

News Articles on Nefazodone

Suicide Rates Have Decreased With Increased Use of SSRIs - Feb 7, 2005
...prescriptions for SSRIs and other new-generation non-SSRI antidepressants, such as nefazodone hydrochloride, mirtazapine, bupropion hydrochloride, ... Medscape

FDA warns of buying Accutane online.(E-MARKETING) | Article from … - May 1, 2007
...about prescribing errors involving AstraZeneca's Seroquel (quetiapine fumarate) and Bristol-Myers Squibb's Serzone (nefazodone hydrochloride). ... Pay-Per-View - Medical Marketing & Media - HighBeam Research

Brand Names/Synonyms:
nefazodone hydrochloride is also known by the following brand names and/or synonymsCHEMBANK1803; Dutonin; Nefazodona [Spanish]; Nefazodone; Nefazodone Hcl; Nefazodone Hydrochloride; Nefazodonum [Latin]; Serzone

Drug Category:
nefazodone hydrochloride is categorized under the following by the FDA: Antidepressants; Analgesics; Serotonin Agents; ATC:N06AX06

Dosage Forms:
Tablets

Absorption:
rapidly and completely absorbed, its absolute bioavailability is low, about 20%

Interactions:
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Chemical IUPAC Name:
2-[3-[4-(3-chlorophenyl)piperazin-1-yl]propyl]-5-ethyl-4-(2-phenoxyethyl)-2,4-dihydro-1,2,4-triazol-3-one

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