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topotecan hydrochlorideThis page contains recent news articles, when available, and an overview of topotecan hydrochloride but does not offer medical advice. You should contact your physician with regard to any health issues or concerns.Overview: topotecan hydrochloride (when available) Topotecan, a semi-synthetic derivative of camptothecin (a plant alkaloid obtained from the Camptotheca acuminata tree), is an anti-tumor drug with topoisomerase I-inhibitory activity similar to irinotecan. Topotecan interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal cells may also be affected by the medicine, other effects may also occur. Unlike irinotecan, topotecan is found predominantly in the inactive carboxylate form at neutral pH and it is not a prodrug. For the treatment of metastatic carcinoma of the ovary and small cell lung cancer following the failure of first-line chemotherapy. Mechanism Of Action: Topotecan has the same mechanism of action as irinotecan. Topoisomerase I relieves torsional strain in DNA by inducing reversible single strand breaks. Topotecan binds to the topoisomerase I-DNA complex and prevents religation of these single strand breaks. The cytotoxicity of topotecan is thought to be due to double strand DNA damage produced during DNA synthesis when replication enzymes interact with the ternary complex formed by topotecan, topoisomerase I and DNA. Mammalian cells cannot efficiently repair these double strand breaks. News Articles on Topotecan Featured Clinical Trial: Defining Optimal Therapy for Metastatic and Recurrent ... - Dec 15, 2009 Phase III Randomized Study of Paclitaxel in Combination with Cisplatin or Topotecan Hydrochloride with Versus without Bevacizumab in Patients with Stage IVB ... NCI Cancer Bulletin … Showed Oral Hycamtin(R) (Topotecan Hydrochloride) Clinically... - May 17, 2005 ORLANDO, Fla., May 17 /PRNewswire-FirstCall/ -- Results from two new, investigational Phase III clinical trials showed that oral Hycamtin(R) was clinically ... Pay-Per-View - PR Newswire - HighBeam Research Press Release: GlaxoSmithKline Application Accepted by the FDA to … - Feb 17, 2006 SmithKline Beecham's (NYSE: SBH) Hycamtin(TM) (topotecan hydrochloride) ... FDA) today recommended approval of Hycamtin(R) (topotecan hydrochloride for ... Pay-Per-View - PR Newswire - HighBeam Research Press Release: GlaxoSmithKline Announces Expanded Indication for … - Jun 15, 2006 SmithKline Beecham's (NYSE: SBH) Hycamtin(TM) (topotecan hydrochloride) ... FDA) today recommended approval of Hycamtin(R) (topotecan hydrochloride for ... Pay-Per-View - PR Newswire - HighBeam Research EBSCOhost Connection: Drug Approved for Late-Stage Cervical Cancer. - Sep 1, 2006 ...other organs and is not likely to respond to treatment with surgery or radiation. Hycamtin, or topotecan hydrochloride, s manufactured by GlaxoSmithKline. Subscription - FDA Consumer - EBSCO Publishing FDA approves drug for late cervical cancer - Jun 28, 2006 Hycamtin in 1996 for treating ovarian cancer and in 1998 for small-cell lung cancer. GlaxoSmithKline makes Hycamtin, also called topotecan hydrochloride. msnbc.com Drugs get OK - Sep 25, 2006 The US Food and Drug Administration has approved a combination of topotecan hydrochloride and cisplatin to treat women with late-stage cervical cancer or ... Deseret News Tekmira Partner Hana Biosciences Achieves Clinical Progress in 2007 - Oct 23, 2007 ...and for product candidates Marqiboยฎ (vincristine sulfate injection, OPTISOME(TM)), and Brakiva(TM) (topotecan hydrochloride injection, OPTISOME(TM)). ... Web Services Journal - Web Services Journal Tekmira Pharmaceuticals Releases Third Quarter 2007 Operating Results - Nov 14, 2007 A Phase 1 trial by Hana investigating Brakiva TM (topotecan hydrochloride injection, OPTISOME TM ; formerly INX-0076) as a treatment for solid tumors. ... marketwire.com Cancer drug receives expanded approval to treat late-stage cervical … - Jun 15, 2006 GlaxoSmithKline makes Hycamtin, also called topotecan hydrochloride. The drug treatment is not a cure, but can provide a life-prolonging option for women. ... Free with registration - America's Intelligence Wire - AccessMyLibrary.com Drugs get OK | Article from Deseret News (Salt Lake City) | HighBeam ... - Sep 25, 2006 The US Food and Drug Administration has approved a combination of topotecan hydrochloride and cisplatin to treat women... Pay-Per-View - Deseret News - HighBeam Research Expert outlines why universal HPV vaccination is needed.(Infectious … - Aug 15, 2008 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... Pay-Per-View - Internal Medicine News - HighBeam Research Corrections.(Correction Notice) | Article from Internal Medicine News... - Mar 1, 2005 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... Pay-Per-View - Internal Medicine News - HighBeam Research Competitors by Product Report - Nov 1, 2008 Hana Biosciences, Inc. (HNAB) Products:. Brakiva (Topotecan Hydrochloride Injection). Helix Biopharma Corp. (HBP:CA) Products:. L-DOS47 (Urease) ... $75.00 - Revere Reports - Revere Hana Biosciences Receives $30 Million Funding Commitment from … - Oct 31, 2007 OPTISOME[TM]) and plans to commence a Phase 1 clinical trial with Brakiva[TM] (topotecan hydrochloride injection, OPTISOME[TM]) this year. ... $4.95 - Business Wire - ECNext FDA Approves First Drug Treatment for Late-Stage Cervical Cancer - Jun 17, 2006 This week it approved a combination of Hycamtin (topotecan hydrochloride) and cisplatin for use as the first drug treatment for women with late-stage cancer ... SeniorJournal.com Cancer Society supports HPV vaccine for middle-school girls.(News)( … - Feb 15, 2007 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... Pay-Per-View - Internal Medicine News - HighBeam Research How to field patient questions about Gardasil and Zostavax.(Infectious... - Dec 15, 2007 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... Pay-Per-View - Internal Medicine News - HighBeam Research Attacking Cervical Cancer - Jul 26, 2006 The newly approved treatment for women with advanced cervical cancer is a combination of topotecan hydrochloride and cisplatin, and may be prescribed when a ... Journal of American Medical Association - Journal of American Medical Association... Cervical cancer screening choices.(LETTERS)(Letter to the editor) | … - Sep 15, 2007 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... Pay-Per-View - Internal Medicine News - HighBeam Research Topotecan/cisplatin for late-stage cervical cancer.(Regulatory Action... - Mar 22, 2006 United States of America -- The Food and Drug Administration (FDA) has approved a combination of topotecan hydrochloride (Hycamtin[R]) and cisplatin for use ... Free with registration - WHO Drug Information - AccessMyLibrary.com ์์?์คํ๊ฒฐ๊ณผ ์?ผ์ฐจ ์น๋ฃ์ ๋ก ๋ฃ์ง์๋ ์์ธํ?ฌ์ฑ ํ??์ ์ ?์?์ฆ? - May 16, 2008 GSK๋ ์ ๋ฝ์ฐํฉ์ผ๋ก๋ถํฐ ํญ์์ ํ์?ด์บํด(Hycamtin: topotecan hydrochloride)์? ๋ํด ์ข ๋ ์?ผ์ฐจ ์น๋ฃ์ฝ์ผ๋ก ๋ฃ์ง ์๋ ์์ธํ?ฌ์ฑ ํ??์ ์น๋ฃ์ ๋ก ํ๊ฐ ๋ฐ์๋ค๊ณ ๋ฐํ ... ๋ฉ๋ํ?ฌ๋ด์ค Researchers Stop Tumor Growth in Mice, Ready to Join Others in... - Jul 5, 2006 This week it approved a combination of Hycamtin (topotecan hydrochloride) and cisplatin for use as the first drug treatment for women with late-stage cancer ... SeniorJournal.com Article: Thalidomide aids topotecan efficacy in ovarian ca.(News) -... - May 15, 2006 Topotecan is available under the trade name Hycamtin, and may also be referred to as topotecan hydrochloride or topotecan HCl. ... Pay-Per-View - OB GYN News - HighBeam Research First drug treatment for late-stage cervical cancer approved - Jun 18, 2006 The US Food and Drug Administration has approved a combination of Hycamtin (topotecan hydrochloride) and cisplatin for use as the first drug treatment for ... News-Medical.net Press Release: FDA approves first drug treatment for late-stage... - Jun 15, 2006 The U.S. Food and Drug Administration has approved a combination of Hycamtin (topotecan hydrochloride) and cisplatin for use as the first drug treatment for ... Pay-Per-View - M2 Presswire - HighBeam Research Article: Cancer drug receives expanded approval to treat late-stage … - Jun 15, 2006 GlaxoSmithKline makes Hycamtin, also called topotecan hydrochloride. The drug ... Read all of this article with a FREE trial ... Pay-Per-View - AP Worldstream - HighBeam Research Drug combo for cervical cancer.(PRODUCTS) - Oct 1, 2006 The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women with stage IVB (incurable), recurrent, ... $4.95 - Internal Medicine News - ECNext Press Release: Perceptronix Receives Health Canada License for Early ... - Aug 21, 2006 Oncology (ASCO), Hycamtin(TM) (topotecan hydrochloride for ... suffering from advanced squamous cell lung cancer, a subtype of non-small cell lung cancer. ... Pay-Per-View - PR Newswire Europe - HighBeam Research Article: Drug combo for cervical cancer.(PRODUCTS) - Internal... - Oct 1, 2006 ...find Internal Medicine News articles. The combination of Hycamtin (topotecan hydrochloride) and cisplatin is approved for the treatment of women w... Pay-Per-View - Internal Medicine News - HighBeam Research Article: Cancer Drug Usage Expanded - AP Online | HighBeam Research … - Jun 15, 2006 GlaxoSmithKline makes Hycamtin, also called topotecan hydrochloride. The drug treatment is ... Read all of this article with a FREE trial ... Pay-Per-View - AP Online - HighBeam Research Drug approved for late-stage cervical cancer.(Hycamtin from … - Sep 1, 2006 The FDA has approved a combination of Hycamtin (topotecan hydrochloride) and cisplatin for use as the first drug treatment for women with late-stage cancer ... $4.95 - FDA Consumer - ECNext Press Release: Perceptronix Receives Health Canada License for Early ... - Aug 21, 2006 Oncology (ASCO), Hycamtin(TM) (topotecan hydrochloride for ... suffering from advanced squamous cell lung cancer, a subtype of non-small cell lung cancer. ... Pay-Per-View - PR Newswire - HighBeam Research Brand Names/Synonyms: topotecan hydrochloride is also known by the following brand names and/or synonymsHycamptamine; Hycamptin; Hycamtin; TOPOTECAN, HYCAMTIN; TPT; TTC; Topotecan; Topotecan Hcl; Topotecan Hydrochloride; Topotecan Lactone; Topotecane [Inn-French]; Topotecanum [Inn-Latin] Drug Category: topotecan hydrochloride is categorized under the following by the FDA: Antineoplastic Agents; Enzyme Inhibitors; ATC:L01XX17 Dosage Forms: POWDER FOR SOLUTION Absorption: Not Available Interactions: [an error occurred while processing this directive] Chemical IUPAC Name: (S)-10-[(dimethylamino) methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3', 4' |
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